Empiric and Conservative Strategy in The Interventional Management of Late Post-Pancreatoduodenectomy Hemorrhage With Negative Angiographic Result
Abstract Background: The aim of the study was to review the outcome of patients who underwent interventional procedures with negative angiographic results for post-PD hemorrhage. Empiric and conservative interventional strategies were compared. Methods: The consecutive patients who underwent interventional procedures for post-PD hemorrhage in our center between Jan 2016 and Jun 2020 were evaluated. 21 cases were enrolled into this study with negative angiographic results. Two different strategies, empiric and conservative, were applied. Clinical data, including age, sex, pathological diagnosis, lab test results, clinical presentation and onset time of bleeding after surgery, technical and clinical outcome was obtained from the medical records and follow up data. Results: All patients in our series presented with delayed post-PD hemorrhage. In the empiric group, embolization was performed at the hepatic artery in 11 cases and at the left gastric artery (LGA) in 1. Two patients died of hemorrhage recurrence despite embolization during the follow up. Two patients required laparotomy and recovered in this group. Recurrence rate was 33.3% (4/12) in this group and mortality rate was 16.7% (2/12). In the conservative group, one patient required re-angiography with bleeding from the hepatic artery revealed 10 days after the first angiography. Hepatic artery embolization and subsequent relaparotomy was required. Another two patients required relaparotomy for hemorrhage recurrence. Recurrence rate was 33.3% (3/9) in this group and all these 3 cases required relaparotomy as definite treatment. Conclusion: Prompt decision making is required when negative result demonstrated during the angiography for post PD hemorrhage, and the surgeons’ judgement is mandatory. Both empiric and conservative treatment may be effective as indicated when negative angiography presented. Great caution is required following the interventional procedure, because recurrence rate after both treatment methods is significant despite negative angiography.