Association of Sarcopenic Obesity and Body Composition With Metabolically Unhealthy Overweight/Obese Phenotypes Among Iranian Women: A Cross-Sectional Study

Abstract Objectives Obesity is a major risk factor for metabolic syndrome, with its prevalence has increased over the past decade. Major changes in body composition with aging have a significant effect on many clinical outcomes. Sarcopenic obesity consists of both the presence of abnormal adipose tissue with a deficit of muscle mass. Results Of the 241 subjects in this study (average age 35.32 years), 176 (73.03%) were classified as MUO phenotype. Based on this study, the prevalence of sarcopenic obesity was 7.88%. We found that high fat-free mass was more strongly and significantly associated with MUO phenotype. Furthermore, we found that individuals with high fat-free mass and high skeletal muscle mass had a significantly low prevalence of MUO phenotype. A significant positive correlation between metabolic phenotypes and sarcopenic obesity was also observed after all potential covariates were adjusted for. These results of this study suggest that increased adiposity and decreased skeletal muscle mass are associated with unfavorable metabolic traits among overweight and obese Iranian women. SO was also found to be associated with a greater risk of developing MUO phenotype.

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Association of sarcopenic obesity and body composition with metabolically unhealthy overweight/obese phenotypes among Iranian women: A cross-sectional study

10.21203/rs.3.rs-122982/v1 ◽

2020 ◽

Author(s):

Aliyu Tijani Jibril ◽

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Niloufar Rasaei ◽

Khadijeh - Mirzaei

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Cross Sectional Study ◽

Fat Free Mass ◽

Sarcopenic Obesity ◽

Sectional Study ◽

High Fat ◽

Cross Sectional

Abstract Background Obesity is a major risk factor for metabolic syndrome, with its prevalence has increased over the past decade. Major changes in body composition with aging have a significant effect on many clinical outcomes. Sarcopenic obesity consists of both the presence of abnormal adipose tissue with a deficit of muscle mass. Methods This cross-sectional study was conducted among a total of 241 overweight/obese women aged between 18–48 years in Tehran, Iran, registered by the use of the multistage cluster random sampling method. Blood samples were taken following standard procedures. Body composition was assessed through a multi-frequency bioelectrical impedance analyzer. The metabolic risk was assessed according to Karelis criteria and the subjects were classified as either MHO or MUO phenotypes. Results Of the 241 subjects in this study (average age 35.32 years), 176 (73.03%) were classified as MUO phenotype. Based on this study, the prevalence of sarcopenic obesity was 7.88%. We found that high fat-free mass was more strongly and significantly associated with MUO phenotype. Furthermore, we found that individuals with high fat-free mass and high skeletal muscle mass had a significantly low prevalence of MUO phenotype. A significant positive correlation between metabolic phenotypes and sarcopenic obesity was also observed after all potential covariates were adjusted for. Conclusion These results of this study suggest that increased adiposity and decreased skeletal muscle mass are associated with unfavorable metabolic traits among overweight and obese Iranian women. SO was also found to be associated with a greater risk of developing MUO phenotype.

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Body composition and energy intake — skeletal muscle mass is the strongest predictor of food intake in obese adolescents: The HEARTY trial

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2015-0479 ◽

2016 ◽

Vol 41 (6) ◽

pp. 611-617 ◽

Cited By ~ 37

Author(s):

Jameason D. Cameron ◽

Ronald J. Sigal ◽

Glen P. Kenny ◽

Angela S. Alberga ◽

Denis Prud’homme ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Body Weight ◽

Muscle Mass ◽

Energy Intake ◽

Skeletal Muscle Mass ◽

Fat Free Mass ◽

Cross Sectional ◽

Percentage Body Fat ◽

Obese Adolescents

There has been renewed interest in examining the relationship between specific components of energy expenditure and the overall influence on energy intake (EI). The purpose of this cross-sectional analysis was to determine the strongest metabolic and anthropometric predictors of EI. It was hypothesized that resting metabolic rate (RMR) and skeletal muscle mass would be the strongest predictors of EI in a sample of overweight and obese adolescents. 304 post-pubertal adolescents (91 boys, 213 girls) aged 16.1 (±1.4) years with body mass index at or above the 95th percentile for age and sex OR at or above the 85th percentile plus an additional diabetes risk factor were measured for body weight, RMR (kcal/day) by indirect calorimetry, body composition by magnetic resonance imaging (fat free mass (FFM), skeletal muscle mass, fat mass (FM), and percentage body fat), and EI (kcal/day) using 3 day food records. Body weight, RMR, FFM, skeletal muscle mass, and FM were all significantly correlated with EI (p < 0.005). After adjusting the model for age, sex, height, and physical activity, only FFM (β = 21.9, p = 0.007) and skeletal muscle mass (β = 25.8, p = 0.02) remained as significant predictors of EI. FFM and skeletal muscle mass also predicted dietary protein and fat intake (p < 0.05), but not carbohydrate intake. In conclusion, with skeletal muscle mass being the best predictor of EI, our results support the hypothesis that the magnitude of the body’s lean tissue is related to absolute levels of EI in a sample of inactive adolescents with obesity.

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Body composition as a predictor of sunitinib toxicity in patients with renal cell carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e15566 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e15566-e15566

Author(s):

Samantha Cushen ◽

Aoife M Ryan ◽

MinYuen Teo ◽

Peter MacEneaney ◽

Patrick McLaughlin ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Muscle Mass ◽

Renal Cell ◽

Skeletal Muscle Mass ◽

Cell Cancer ◽

Drug Dose ◽

Fat Free Mass ◽

Cross Sectional ◽

Overweight Group

e15566 Background: Sunitinib is a standard first-line option for metastatic renal cell cancer (mRCC). Identification of biomarkers associated with outcome or toxicity is a challenge. Body composition is a prognostic factor in cancer and sarcopenia is associated with treatment toxicity and survival. We investigated if body composition by CT scan predicted dose limiting toxicity (DLT) from sunitinib in mRCC. Methods: Patients (pts) with mRCC receiving sunitinib 50mg as 1stline therapy between 2007-2012 were included. Ethical approval was obtained and prospectively maintained databases analysed. Skeletal muscle cross-sectional area at L3 was measured by CT. Sarcopenia was defined using published cut offs. Toxicity was assessed after 4 cycles of drug (CTCAE, v4.0). Results: 55 pts (43 male), mean age 64yrs (±10.6) were included. 67% were overweight/obese (BMI>25kg/m2). Sarcopenia was present in 33% (56% of normal BMI, 44% overweight group). Overall 40 pts (73%) experienced DLT (51% M, 100% F, p<0.016). DLT occurred in <6 months in 53% (44% M vs 83% F, p<0.016) and these pts were older (mean 68 yrs vs 60 yrs, p<0.01), had lower skeletal muscle mass (51.8 cm2/m2 vs 59.4 cm2/m2, p<0.012), and fat free mass (FFM) (51.4kg vs 57.7kg, p<0.03), and received higher drug dose in mg/kg FFM (1.01 vs 0.89, p<0.02). Common toxicities were GI (65%) and fatigue (47%). Of pts <25th percentile skeletal muscle mass 92% experienced DLT, higher than pts >75th percentile (p<0.05). Pts <25th percentile had an average of 5 toxicities vs 2 in those >75th percentile (p<0.003). All toxicities were more common in muscle wasted patients (p<0.05). 77% (n=10) of pts receiving a drug dose >75th percentile (1.105mg/FFM) experienced DLT in <6 months vs 44% (n=17) receiving a dose <75thpercentile (<1.099mg/FFM; p<0.037). Conclusions: Sarcopenia is prevalent in patients with mRCC, is easily measured, is an occult condition in pts with normal/high BMI, and is a significant predictor of DLT in pts receiving 1st line sunitinib. Our results highlight the potential use of baseline body composition to predict toxicity. The role of sarcopenia in targeted therapy is evolving and its potential to predict toxicity should be further studied.

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Cutoff values for appendicular skeletal muscle mass and strength in relation to fear of falling among Brazilian older adults: cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2017.0049030517 ◽

2017 ◽

Vol 135 (5) ◽

pp. 434-443 ◽

Cited By ~ 5

Author(s):

Ricardo Aurélio Carvalho Sampaio ◽

Priscila Yukari Sewo Sampaio ◽

Luz Albany Arcila Castaño ◽

João Francisco Barbieri ◽

Hélio José Coelho Júnior ◽

...

Keyword(s):

Older Adults ◽

Skeletal Muscle ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Fear Of Falling ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Appendicular Skeletal Muscle ◽

Appendicular Skeletal Muscle Mass

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Abnormal body composition in patients with adrenal adenomas

Acta Endocrinologica ◽

10.1530/eje-21-0458 ◽

2021 ◽

Author(s):

Danae Delivanis ◽

Maria Daniela Hurtado Andrade ◽

Tiffany Cortes ◽

Shobana Athimulam ◽

Aakanksha Khanna ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Muscle Mass ◽

Visceral Fat ◽

Cushing Syndrome ◽

Cross Sectional Study ◽

Cortisol Secretion ◽

Muscle Area ◽

Cross Sectional ◽

Skeletal Muscle Area

Objective: Increased visceral fat and sarcopenia are cardiovascular risk factors that may explain increased cardiovascular morbidity and frailty in patients with adrenal adenomas. Our objective was to compare body composition measurement of patients with adrenal adenomas to referent subjects without adrenal disease Design: Cross-sectional study, 2014-2018 Methods: Participants were adults with nonfunctioning adrenal tumor (NFAT), mild autonomous cortisol secretion (MACS) and Cushing syndrome (CS), and age, sex and body mass index 1:1 matched referent subjects without adrenal disorders. Main outcome measures were body composition measurements calculated from abdominal computed tomography imaging. Intraabdominal adipose tissue and muscle mass measurements were performed at the 3rd lumbar spine level. Results: Of 227 patients with adrenal adenomas, 20 were diagnosed with CS, 76 with MACS and 131 with NFAT. Median age was 56 years (range, 18-89), and 67% were women. When compared to referent subjects, patients with CS, MACS, and NFAT demonstrated a higher visceral fat (odds ratio (OR) of 2.2 [95% CI 0.9-6.5], 2.0 [1.3-3.2], and 1.8 [1.2-2.7] and a lower skeletal muscle area (OR of 0.01 [95% CI 0-0.09], 0.31 [0.18-0.49], and 0.3 [1.2-2.7]), respectively. For every 1 mcg/dL cortisol increase after overnight dexamethasone, visceral fat/muscle area ratio increased by 2.3 (P=0.02) and mean total skeletal muscle area decreased by 2.2cm2 (P=0.03). Conclusion: Patients with adrenal adenomas demonstrate a lower muscle mass and a higher proportion of visceral fat when compared to referent subjects, including patients with NFAT. Even a subtle abnormality in cortisol secretion may impact health of patients with adenomas.

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Prevalence of Sarcopenia and Association with Lifestyle Patterns in Patients with Type 2 Diabetes Mellitus (P01-025-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz028.p01-025-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Tatiana de Paula ◽

Mauren de Freitas ◽

Vanessa Lopes ◽

Maria Elisa Miller ◽

Karen Araujo ◽

...

Keyword(s):

Type 2 Diabetes ◽

Skeletal Muscle ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Meta Analysis ◽

Cross Sectional Study ◽

Cross Sectional ◽

Logistic Regression Models ◽

Type 2 Dm

Abstract Objectives The aim of the study was to establish the prevalence of sarcopenia and associated factors in elderly with type 2 diabetes (DM) in southern Brazil. Methods A cross-sectional study was performed in 240 patients with type 2 DM. The diagnosis of sarcopenia was performed according to EWGSOP criteria. Muscle mass was calculated by skeletal muscle mass index (appendicular skeletal muscle mass/height² - Inbody® bioimpendance). Muscle strength was assessed by manual grip strength (Jamar® dynamometer) and physical performance was assessed by the sit and lift test. Patients with type 2 DM with age ≥60 years and with the ability to ambulate were selected. Patients with recent cardiovascular events, serum creatinine >2.0 mg/dl, use of corticosteroids and BMI >40 kg/m² were excluded. The sample size was 240 patients based on meta-analysis who found 17% sarcopenia in elderly patients without DM. Results We included 240 patients aged 68.4 ± 5.5 years, 53.2% were women and the duration of DM was 15 (8–22) years, the BMI was 29.4 ± 4.4 kg/m². The prevalence of sarcopenia was 21% and men had more sarcopenia (75%). Patients with sarcopenia walk less [3541 (2227–4574) vs. 4521 (3037–5678) steps, P = 0.013], drink more alcohol [21 (56.8%) vs. 71 (31.8%); P < 0.034] and have lower total cholesterol levels [146 ± 41 Vs. 168 ± 43; P = 0.007] than the group without sarcopenia. In multivariate logistic regression models, walking < 3760 steps [OR = 2868; CI 95% 1.331–6.181] and male [OR = 5285; CI 95% 2261–12,350], were associated with sarcopenia. Conclusions The prevalence of sarcopenia was 21%, higher than in patients without diabetes (17%). In this group of patients, lower physical activity, and male sex were associated with sarcopenia. Funding Sources FIPE n. 160467; CAPES.

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Fat mass and skeletal muscle mass in hip-fracture women: A cross-sectional study

Maturitas ◽

10.1016/j.maturitas.2006.11.003 ◽

2007 ◽

Vol 56 (4) ◽

pp. 404-410 ◽

Cited By ~ 20

Author(s):

Marco Di Monaco ◽

Fulvia Vallero ◽

Roberto Di Monaco ◽

Rosa Tappero ◽

Alberto Cavanna

Keyword(s):

Skeletal Muscle ◽

Hip Fracture ◽

Muscle Mass ◽

Fat Mass ◽

Skeletal Muscle Mass ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Intensive Sports Nutrition Program Improving Body Composition and Energy Intake among Elite Combat Sport Athletes

Amerta Nutrition ◽

10.20473/amnt.v5i2.2021.127-132 ◽

2021 ◽

Vol 5 (2) ◽

pp. 127

Author(s):

Aprilia Kusumawardhani ◽

Farapti Farapti ◽

Mahmud Aditya Rifqi ◽

Sri Adiningsih

Keyword(s):

Skeletal Muscle ◽

Body Composition ◽

Nutrition Education ◽

Muscle Mass ◽

Energy Intake ◽

Skeletal Muscle Mass ◽

Fat Free Mass ◽

Sport Nutrition ◽

Combat Sport ◽

Before And After

ABSTRAK Latar Belakang :Gizi olahraga merupakan aspek penting dalam mengatur asupan makanan dan komposisi tubuh untuk mencapai performa yang optimal. Studi epidemiologis menunjukkan sebagian besar asupan atlet tidak adekuat dan dapat mempengaruhi komposisi tubuh yang ideal.Tujuan :Tujuan dari penelitian ini adalah untuk menganalisis pengaruh pendampingan gizi olahraga terhadap komposisi tubuh dan asupan energi atlet bela diri.Metode :Pendampingan gizi intensif dilakukan selama empat bulan (Juni- September 2019). Pengukuran komposisi tubuh dilakukan 2 kali, yakni sebelum dan sesudah intervensi dengan menganalisis hasil pengukuran dari alat BIA (Bio Impadance Analyzer) tipe MBCA (Medical Body Compotiton Analyzer) 515/514 merk seca©. Variabel yang dianalisis diantaranya, total asupan kalori sehari diukur menggunakan instrumen Recall-24 jam, komposisi tubuh diukur dengan alat BIA yakni Fat Mass (FM), Fat Free Mass (FFM) dan Skeletal Muscle Mass (SMM). Pendampingan gizi dilakukan oleh ahli gizi olahraga yang mengunjungi 24 responden setiap bulan dan memberikan materi pendidikan gizi, memberikan makanan sehat dan memberikan konseling permasalahan gizi atlet.Hasil : Hasil penelitian ini menunjukkan adanya peningkatan secara signifikan pada asupan energi total (1496,2±654,4 menjadi 1688,5±679,8, p= 0,002). Pada komposisi tubuh terjadi peningkatan pada FFM dan SMM yakni (56,57 ± 9,91 kg vs 57,01 ± 9,53, p = 0,032) dan (27,49 ± 5,58 vs 27,75 ± 5,31, p = 0,005) dan tidak ada perbedaan signifikan dalam variabel FM.Kesimpulan : Kesimpulan dari percobaan ini adalah pendampingan gizi secara intensif dapat meningkatkan asupan energi total, FFM dan SMM pada atlet bela diri. Kata Kunci : Komposisi tubuh, pendampingan gizi, asupan energiABSTRACTBackground :Sports nutrition is very urgent to improve nutrition knowledge, dietary intake and body composition to achieve an optimum athletic performance. Epidemiological studies showed most athletes lack of getting adequate intake and maintaining an ideal body composition.Objective :This study aims to analyze the effect of sport nutrition education on body composition and energy intake among elite combat sport athletes.Methods :Intensive sport nutrition was conducted for four months June until September 2019. Body composition was assessed for 2 times, before and after intervention using bioelectric impedance analysis (BIA), with seca© brand 515/514 type of stainless steel electrodes.Measurement of energy intake with recall 24 hours before and after the intervention. The variables studied were Fat Mass (FM), Fat Free Mass (FFM), Skeletal Muscle Mass (SMM) and energy intake.The professional sport nutritionist and dietitians visited 24 subjects every month by teaching nutrition education, bringing the healthy food, and facilitating the counseling about sport nutrition.Result :Energy intake increased significantly (1496,2±654,4 to 1688,5±679,8, p= 0,002). FFM and SMM increased significantly pre to post (56.57±9.91 kg vs 57.01±9.53, p=0.032) and (27.49±5.58 vs 27.75±5.31, p=0.005) respectively, meanwhile no significant differences in FM variable.Conclusion : Our findings indicate that intensive sport nutritionimproved energy intake, FFM and SMM among elite combat sport athletes. Keywords : Body compotition, sport nutririon education, energy intake

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AB0251 SARCOPENIA IN MOROCCAN POPULATION WITH RHEUMATOID ARTHRITIS: PREVALENCE AND PREDICTIVE FACTORS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4448 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1425.2-1425

Author(s):

E. Jalila ◽

H. Azzouzi ◽

I. Linda

Keyword(s):

Rheumatoid Arthritis ◽

Skeletal Muscle ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Cross Sectional Study ◽

Whole Body ◽

Sectional Study ◽

Mineral Density ◽

Cross Sectional ◽

Lean Muscle Mass

Background:Patients with rheumatoid arthritis (RA) were at risk for altered body composition with higher prevalence of sarcopenia compared to the general population. Low lean muscle mass may constitute an additional risk factor for altered bone density in RA patients.Objectives:We aimed to study the prevalence of sarcopenia and to assess its predictive factors in Moroccan patients with RA.Methods:We conducted a cross-sectional study over two months in our department of rheumatology. All RA patients fulfilled ACR/EULAR 2010 criteria. We performed a whole-body dual-energy X-ray absorptiometry (DXA) to measure lean mass, fat mass and bone mass in the whole body and body parts. The appendicular skeletal muscle mass was assessed using the sum of skeletal muscle mass in the arms and legs. The relative skeletal muscle mass index (RSMI) was calculated from the appendicular skeletal mass divided by the square of the patient’s height (kg/m2). According to Baumgartner et al, sarcopenia was defined as a relative SMI <5.5 kg/m2on women and <7.26 kg/m2on men. Body mass index (BMI) was measured and patients were classified according to World Health Organization. Disease activity and functional disability were measured using the 28-joint Disease Activity Score (DAS28) with CRP and the Health Assessment Questionnaire (HAQ). Comorbidities and medication use including corticosteroids were also recorded. Data was entered and processed using the IBM SPSS Statistics 20. A univariate analysis as well as multivariate regressions were carried out to assess the association between sarcopenia and lumbar spine and femoral neck (FN) bone mineral density (BMD) and RA characteristics.Results:We included 70 (87.5%) women and 10 (12.5%) men with a mean age of 53.59 ±10.96 years old. They had a mean disease duration of 12.35± 8.68, a mean DAS 28 CRP of 2.64±1.34, a mean HAQ of 0.94±0.63 and a mean RSMI of 5.75±1.17. Women had a mean RSMI of 6.33±1.04 while men had a mean RSMI of 5.66±1.17. The prevalence of sarcopenia in our population was 47.4% (37), of whom 81.1% (30) women.In univariate regression analysis, sarcopenia was associated with normal BMI (OR: 8.59, 95% CI [3.054-24.182], p= 0.000), DAS 28 CRP (OR: 1.78, 95% CI [1.203-2.657], p= 0.004), HAQ (OR: 2.15, 95% CI [1.165-5.433], p= 0.019), lumbar spine BMD (OR: 0.001, 95% CI [0.00001-0.043], p= 0.0004) and FN BMD (OR: 0.000006, 95% CI [0.000-0.002], p= 0,00008 at right FN and OR: 0.00009, 95% CI [0.000001-0.010], p=0.000 at left FN, respectively).In multiple regression analysis, sarcopenia was associated with normal BMI (OR: 11.56, 95% CI [2.754–48.598]), p=0.001 and FN BMD (OR: 0.00, 95% CI [0.000–0.084], p = 0.006).Conclusion:In the present study, sarcopenia was common among RA patients and associated with normal BMI and femoral neck BMD, emphasizing the importance of this modifiable risk factor. Further studies are needed to identify effective means to improve lean muscle mass in patients with RA.References:[1]Mochizuki T et al. Sarcopenia-associated factors in Japanese patients with rheumatoid arthritis: A cross-sectional study. Geriatr. Gerontol. Int. 2019;19 (9), 907-912[2]Okano T et al. Loss of lean body mass affects low bone mineral density in patients with rheumatoid arthritis -results from the TOMORROW study-, Modern Rheumatology. 2017;27(6):1-19.[4]Peggy M. Cawthon. Assessment of Lean Mass and Physical Performance in Sarcopenia. Journal of Clinical Densitometry. 2015;18(4):467-71.Disclosure of Interests:None declared

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