High Mean Arterial Pressure is Associated with Better Cognitive Function in Older Adults with Subjective Memory Complaints

Abstract Background: Hypertension has been shown to be a major risk factor for cognitive decline, but little is known about its association with subjective memory complaints (SMC) in late life. The study is to examine if hypertension is associated with SMC and to explore which blood pressure (BP) is more important in this group.Methods: 497 non-demented older adults aged 60 years or older were interviewed. Hypertension is defined as a BP higher than 130/80 mmHg or on antihypertensive medication. SMC are measured by a validated 5-item Abbreviate Memory Inventory for the Chinese (AMIC) assessing subjective memory deficits in the past month. Cognitive performance was measured by a neurocognitive battery assessing global cognitive function and executive function (EF). Linear regression was performed to examine how different BP associate with AMIC and cognitive performance with adjustment for sociodemographic and physical factors.Results: Hypertensive group had a lower AMIC than normal control (t=-2.1, p=.033). Systolic blood pressure (SBP) (B=-.008, 95% CI -.014 – -.002, p=.006) and mean arterial pressure (MAP) (B=-.011, 95% CI -.020– -.002 p=.014) were associated with AMIC. SBP was only associated global cognitive function (B= .008, 95% CI .000 – .015, p=.038), but MAP was associated with global cognitive function (B=.017, 95% CI .006 – .029, p=.003) and EF (B= 0.16, 95% CI .001 – .030, p=.036). Conclusions: High MAP was associated with better cognitive function in older adults with SMC. The findings highlight the need to be cautious when managing BP in older adults yet not to compromise their current cognitive function.

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Association of depressive symptoms and subjective memory complaints with the incidence of cognitive impairment in older adults with high blood pressure

European Geriatric Medicine ◽

10.1007/s41999-019-00185-1 ◽

2019 ◽

Vol 10 (3) ◽

pp. 413-420 ◽

Cited By ~ 6

Author(s):

Miguel Germán Borda ◽

José Manuel Santacruz ◽

Dag Aarsland ◽

Sandy Camargo-Casas ◽

Carlos Alberto Cano-Gutierrez ◽

...

Keyword(s):

Blood Pressure ◽

Older Adults ◽

Cognitive Impairment ◽

Depressive Symptoms ◽

High Blood Pressure ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints

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SUBJECTIVE MEMORY COMPLAINTS AND COGNITIVE PERFORMANCE: THE MODERATING ROLE OF DEPRESSIVE SYMPTOMS

Innovation in Aging ◽

10.1093/geroni/igz038.2425 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S654-S654

Author(s):

Elizabeth A Gallagher

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Episodic Memory ◽

Cognitive Performance ◽

Memory Performance ◽

Health Concern ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

The Relationship

Abstract Cognitive health is a rising public health concern in the U.S. Currently, approximately 5.7 million older adults suffer from Alzheimer’s disease (AD), and by the year 2050 this number is expected to increase to 14 million. Subjective memory complaints (SMC) are shown to be an early indicator of cognitive decline, and accordingly included as a clinical criterion for diagnoses of MCI, an indicator of pre-dementia states, and a research criterion for AD diagnoses. Among older adults, depressive symptoms hinder the accuracy of memory self-ratings. However, there has yet to be consensus regarding the nature of how depressive symptoms may condition the relationship between SMC and cognitive performance. The aims of the present study are to both investigate whether SMC is related to episodic memory and to determine whether depressive symptoms act as a moderator for the relationship between SMC and episodic memory among older adults. This research used nationally representative sample of 8,123 older adults aged 65 and older who completed the Leave Behind Questionnaire in the 2012 and 2014 waves of the Health and Retirement Study. Linear regression was performed and results showed that there was a significant main effect of SMC on episodic memory performance, in that older adults with increased SMC have worse episodic memory. There was also a significant moderating effect of depressive symptoms, in that depressive symptoms cause older adults to underestimate their memory abilities. In order to use SMC as a tool for early detection efforts it is critical to understand these complex relationships.

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Physical activity domains and cognitive function over three years in older adults with subjective memory complaints: Secondary analysis from the MAPT trial

Journal of Science and Medicine in Sport ◽

10.1016/j.jsams.2017.07.019 ◽

2018 ◽

Vol 21 (1) ◽

pp. 52-57 ◽

Cited By ~ 5

Author(s):

Philipe de Souto Barreto ◽

Sandrine Andrieu ◽

Yves Rolland ◽

Bruno Vellas

Keyword(s):

Physical Activity ◽

Older Adults ◽

Cognitive Function ◽

Secondary Analysis ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints

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“Shall We Dance?” Older Adults’ Perspectives on the Feasibility of a Dance Intervention for Cognitive Function

Journal of Aging and Physical Activity ◽

10.1123/japa.2017-0203 ◽

2018 ◽

Vol 26 (4) ◽

pp. 553-560

Author(s):

Cecilie Thøgersen-Ntoumani ◽

Anthony Papathomas ◽

Jonathan Foster ◽

Eleanor Quested ◽

Nikos Ntoumanis

Keyword(s):

Older Adults ◽

Cognitive Function ◽

Memory Loss ◽

Future Research ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Social Dance ◽

Memory Complaints ◽

Semistructured Interviews ◽

Dance Intervention

We explored perceptions of social dance as a possible intervention to improve cognitive function in older adults with subjective memory complaints. A total of 30 participants (19 females; mean age = 72.6 years; SD = 8.2) took part in the study. This included 21 participants who had self-reported subjective memory complaints and nine spouses who noticed spousal memory loss. Semistructured interviews were conducted, and a thematic analysis was used to analyze the data. Three main themes were constructed: (a) dance seen as a means of promoting social interaction; (b) chronic illness as a barrier and facilitator to participation; and (c) social dance representing nostalgic connections to the past. Overall, the participants were positive about the potential attractiveness of social dance to improve cognitive and social functioning and other aspects of health. In future research, it is important to examine the feasibility of a social dance intervention among older adults with subjective memory complaints.

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Subjective Memory Complaints, Cognitive Performance, and Psychological Factors in Healthy Older Adults

American Journal of Alzheimer s Disease & Other Dementias® ◽

10.1177/1533317513504817 ◽

2013 ◽

Vol 28 (8) ◽

pp. 776-783 ◽

Cited By ~ 60

Author(s):

Susanne I. Steinberg ◽

Selamawit Negash ◽

Mary D. Sammel ◽

Hillary Bogner ◽

Brian T. Harel ◽

...

Keyword(s):

Older Adults ◽

Cognitive Performance ◽

Psychological Factors ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Healthy Older Adults ◽

Memory Complaints

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Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance

Innovation in Aging ◽

10.1093/geroni/igab046.2272 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 594-594

Author(s):

Isabela Marquez ◽

Carlos Cano ◽

Elkin Garcia-Cifuentes

Keyword(s):

Older Adults ◽

Cognitive Performance ◽

Older Adult ◽

Well Being ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Cognitive Risk ◽

Confounding Variables ◽

Overall Mortality

Abstract Cognitive decline and dementia have a significant impact older adult. Motor Cognitive Risk Syndrome (MCRS) is a pre-dementia stage where slow gait speed and subjective memory complaints are present. MCRS increases the risk of frailty, dementia, disability, falls and overall mortality. We used data from the SABE Colombia study (Health, Well-Being, and Aging) conducted in 2015 in adults aged 60 years and older. After adjusting for confounding variables MCRS was associated with MMSE (OR 0.90, CI 0.82-0.99), pre-frail (OR 9.1, CI 3.26-25.47) and frail (OR 21.38, CI 6.30-72.57). This study found a prevalence of 5.45% of MCRS in Colombian older adults. We found an associations between cognitive performance (MMSE), frailty and MCRS. Our results increase the awareness of a pre-dementia stages different to Mild Cognitive Impairment (MCI), as these individuals are at greater risk than those with MCI to develop dementia.

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P3-333: SUBJECTIVE MEMORY COMPLAINTS AND COGNITIVE PERFORMANCE IN A POPULATION OF HEALTHY OLDER ADULTS ATTENDING PRIMARY CARE CENTERS IN SANTIAGO, CHILE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.1694 ◽

2006 ◽

Vol 14 (7S_Part_23) ◽

pp. P1208-P1208

Author(s):

Teresa Parrao ◽

Daniela Thumala ◽

Patricia Lillo ◽

Gonzalo Forno ◽

Helene Amieva ◽

...

Keyword(s):

Older Adults ◽

Primary Care ◽

Cognitive Performance ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Healthy Older Adults ◽

Memory Complaints

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White Matter Hyperintensities and Apolipoprotein E Affect the Association Between Mean Arterial Pressure and Objective and Subjective Cognitive Functioning in Older Adults

Journal of Alzheimer s Disease ◽

10.3233/jad-210695 ◽

2021 ◽

pp. 1-14

Author(s):

Youjin Jung ◽

Raymond P. Viviano ◽

Sanneke van Rooden ◽

Jeroen van der Grond ◽

Serge A.R.B. Rombouts ◽

...

Keyword(s):

Blood Pressure ◽

Older Adults ◽

Cognitive Function ◽

Mean Arterial Pressure ◽

White Matter ◽

Arterial Pressure ◽

Cognitive Functioning ◽

White Matter Hyperintensities ◽

Whole Brain ◽

The Relationship

Background: White matter hyperintensities (WMH) show a robust relationship with arterial pressure as well as objective and subjective cognitive functioning. In addition, APOE ɛ4 carriership may influence how arterial pressure affects cognitive functioning. Objective: To determine the role of region-specific WMH burden and APOE ɛ4 carriership on the relationship between mean arterial pressure (MAP) and cognitive function as well as subjective cognitive decline (SCD). Methods: The sample consisted of 87 cognitively unimpaired middle-aged to older adults aged 50–85. We measured WMH volume for the whole brain, anterior thalamic radiation (ATR), forceps minor, and superior longitudinal fasciculus (SLF). We examined whether WMH burden mediated the relationship between MAP and cognition (i.e., TMT-A score for processing speed; Stroop performance for executive function) as well as SCD (i.e., Frequency of Forgetting (FoF)), and whether APOE ɛ4 carriership moderated that mediation. Results: WMH burden within SLF mediated the effect of MAP on Stroop performance. Both whole brain and ATR WMH burden mediated the effect of MAP on FoF score. In the MAP–WMH–Stroop relationship, the mediation effect of SLF WMH and the effect of MAP on SLF WMH were significant only in APOE ɛ4 carriers. In the MAP–WMH–FoF relationship, the effect of MAP on whole brain WMH burden was significant only in ɛ4 carriers. Conclusion: WMH burden and APOE genotype explain the link between blood pressure and cognitive function and may enable a more accurate assessment of the effect of high blood pressure on cognitive decline and risk for dementia.

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