Association of depressive symptoms and subjective memory complaints with the incidence of cognitive impairment in older adults with high blood pressure

Abstract Cognitive health is a rising public health concern in the U.S. Currently, approximately 5.7 million older adults suffer from Alzheimer’s disease (AD), and by the year 2050 this number is expected to increase to 14 million. Subjective memory complaints (SMC) are shown to be an early indicator of cognitive decline, and accordingly included as a clinical criterion for diagnoses of MCI, an indicator of pre-dementia states, and a research criterion for AD diagnoses. Among older adults, depressive symptoms hinder the accuracy of memory self-ratings. However, there has yet to be consensus regarding the nature of how depressive symptoms may condition the relationship between SMC and cognitive performance. The aims of the present study are to both investigate whether SMC is related to episodic memory and to determine whether depressive symptoms act as a moderator for the relationship between SMC and episodic memory among older adults. This research used nationally representative sample of 8,123 older adults aged 65 and older who completed the Leave Behind Questionnaire in the 2012 and 2014 waves of the Health and Retirement Study. Linear regression was performed and results showed that there was a significant main effect of SMC on episodic memory performance, in that older adults with increased SMC have worse episodic memory. There was also a significant moderating effect of depressive symptoms, in that depressive symptoms cause older adults to underestimate their memory abilities. In order to use SMC as a tool for early detection efforts it is critical to understand these complex relationships.

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Memory Compensation Strategies in Older People with Mild Cognitive Impairment

Journal of the International Neuropsychological Society ◽

10.1017/s1355617719000912 ◽

2020 ◽

Vol 26 (1) ◽

pp. 86-96

Author(s):

Pinghsiu Lin ◽

Haley M. LaMonica ◽

Sharon L. Naismith ◽

Loren Mowszowski

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Daily Life ◽

Well Being ◽

Strategy Use ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Memory Strategy

AbstractObjectives:With the rapid growth of the older population worldwide, understanding how older adults with mild cognitive impairment (MCI) use memory strategies to mitigate cognitive decline is important. This study investigates differences between amnestic and nonamnestic MCI subtypes in memory strategy use in daily life, and how factors associated with cognition, general health, and psychological well-being might relate to strategy use.Methods:One hundred forty-eight participants with MCI (mean age = 67.9 years, SD = 8.9) completed comprehensive neuropsychological, medical, and psychological assessments, and the self-report ‘Memory Compensation Questionnaire’. Correlational and linear regression analyses were used to explore relationships between memory strategy use and cognition, general health, and psychological well-being.Results:Memory strategy use does not differ between MCI subtypes (p > .007) despite higher subjective everyday memory complaints in those with amnestic MCI (p = .03). The most marked finding showed that increased reliance-type strategy use was significantly correlated with more subjective memory complaints and poorer verbal learning and memory (p < .01) in individuals with MCI. Moreover, fewer subjective memory complaints and better working memory significantly predicted (p < .05) less reliance strategy use, respectively, accounting for 10.6% and 5.3% of the variance in the model.Conclusions:In general, the type of strategy use in older adults with MCI is related to cognitive functioning. By examining an individual’s profile of cognitive dysfunction, a clinician can provide more personalized clinical recommendations regarding strategy use to individuals with MCI, with the aim of maintaining their day-to-day functioning and self-efficacy in daily life.

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Prevalence and correlates of subjective memory complaints in Vietnamese adults

International Psychogeriatrics ◽

10.1017/s104161021700254x ◽

2017 ◽

Vol 30 (7) ◽

pp. 1039-1048 ◽

Cited By ~ 4

Author(s):

Oanh L. Meyer ◽

Amanda Leggett ◽

Siwei Liu ◽

Ngoc H. Nguyen

Keyword(s):

Cognitive Impairment ◽

Depressive Symptoms ◽

Cross Sectional Study ◽

Functional Health ◽

Future Research ◽

Regression Analyses ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Cross Sectional ◽

Memory Complaints

ABSTRACTBackground:Low- and middle-income countries such as Vietnam are home to a majority of the world's population with dementia, yet little is known regarding how individuals in these countries perceive memory problems that might be indicative of cognitive impairment. This study examined the prevalence and correlates of subjective memory complaints (SMCs) in Vietnamese adults in Da Nang, Vietnam.Methods:A stratified sample of 600 adults (aged ≥ 55 years) living in Da Nang, Vietnam, and surrounding areas were recruited to participate in a cross-sectional study. Students and faculty from the National Technical Medical College Number 2 administered questionnaires in participants’ homes regarding socio-demographic characteristics, functional health, social support, cognitive and mental health, and SMCs. Descriptive and stepwise regression analyses examined the prevalence and correlates of SMCs.Results:Approximately 64% of the sample reported at least poor memory and 39% said that memory interfered with their daily life at least somewhat. Multivariate regression analyses (adjusted for all covariates) showed that depressive symptoms, cognitive impairment, self-rated health and pain, and material hardship were associated with SMCs.Conclusions:Prevalence of SMCs as well as depressive symptoms was high in this Vietnamese population. Although future research using more detailed measures of subjective memory and which include longitudinal data are required, the need for physicians to routinely assess Vietnamese patients for depression, SMCs, and cognitive impairment may be warranted.

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Examining Internet and eHealth Practices and Preferences: Survey Study of Australian Older Adults With Subjective Memory Complaints, Mild Cognitive Impairment, or Dementia

Journal of Medical Internet Research ◽

10.2196/jmir.7981 ◽

2017 ◽

Vol 19 (10) ◽

pp. e358 ◽

Cited By ~ 26

Author(s):

Haley M LaMonica ◽

Amelia English ◽

Ian B Hickie ◽

Jerome Ip ◽

Catriona Ireland ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Survey Study ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints

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Psychiatric Disorders and Mild Cognitive Impairment in Older Veterans With Subjective Memory Complaints

Innovation in Aging ◽

10.1093/geroni/igaa057.944 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 295-295

Author(s):

Mia Delgadillo ◽

Megan Frank ◽

Aidan Boese ◽

Tilman Schulte ◽

J Kaci Fairchild

Keyword(s):

Older Adults ◽

Substance Use ◽

Cognitive Impairment ◽

Anxiety Disorder ◽

Psychiatric Disorder ◽

Psychiatric Disorders ◽

Substance Use Disorders ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints

Abstract Psychiatric disorders pose a unique risk for Alzheimer’s disease (AD). Prior research indicates psychiatric disorders in MCI increase AD vulnerability. Less research has been done to understand how psychiatric disorders may affect the development of MCI. Understanding these potentially modifiable risk factors is important as they may represent a potential target of intervention for secondary prevention of AD. The present study examines the relationship between psychiatric disorders and amnestic MCI (aMCI) in a sample of Veterans with subjective memory complaints. The sample included 150 older adults with subjective memory complaints (90% male, age = 70.6±8.2). aMCI diagnosis was based upon performance on the delayed recall trials of the Rey Auditory Verbal Learning Test and Logical Memory II of the Wechsler Memory Scale-4th edition. Psychiatric disorders (e.g., Mood Disorders, Anxiety Disorders, and Substance Use Disorders) were assessed using the Mini Neuropsychiatric Interview for DSM-IV. Logistic regression modeling demonstrated that diagnosis of anxiety disorders, but not mood or substance use disorders, was significantly associated with aMCI status. Specifically, older adults with an anxiety disorder were less likely to have aMCI than those older adults without an anxiety disorder. Additional analyses revealed that within those with aMCI (n=107), persons with a psychiatric disorder were significantly younger than those without a psychiatric disorder by an average of 6 years. These findings support prior research on the complex relationship of anxiety and cognitive impairment as well as suggest that those with psychiatric disorders may be at risk for developing aMCI at younger ages.

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Subjective memory complaints, depressive symptoms and instrumental activities of daily living in mild cognitive impairment

International Psychogeriatrics ◽

10.1017/s1041610215001945 ◽

2015 ◽

Vol 28 (3) ◽

pp. 487-494 ◽

Cited By ~ 21

Author(s):

Seon Young Ryu ◽

Sang Bong Lee ◽

Tae Woo Kim ◽

Taek Jun Lee

Keyword(s):

Cognitive Impairment ◽

Depressive Symptoms ◽

Mild Cognitive Impairment ◽

Activities Of Daily Living ◽

Daily Living ◽

Retrospective Memory ◽

Subjective Memory Complaints ◽

Cognitive Measures ◽

Subjective Memory ◽

Memory Complaints

ABSTRACTBackground:The diagnostic relevance of subjective memory complaints (SMCs) in mild cognitive impairment (MCI) remains to be unresolved. The aim of this study is to determine clinical correlates of SMCs in MCI. Furthermore, we examined whether there are the differences due to different aspects of complaints (i.e. prospective memory (PM) versus retrospective memory (RM) complaints).Methods:We examined the cross-sectional associations between SMCs and depressive symptoms, instrumental activities of daily living (IADL), and cognitive measures in sixty-six individuals with MCI (mean age: 65.7 ± 8.01 years). The criteria for MCI included SMCs, objective cognitive impairment, normal general cognitive function, largely intact functional activities, and absence of dementia. SMCs were assessed using the Prospective and Retrospective Memory Questionnaire (PRMQ), which contains 16 items describing everyday memory failure of both PM and RM.Results:SMC severity (i.e. PRMQ total score) was associated with stronger depressive symptoms and worse IADL performance. SMCs were not related to cognitive measures. For PM and RM subscores, both depressive symptoms and IADL were related to the PRMQ-PM and -RM scores. The main contributors to these PM and RM scores were depressive symptoms and IADL impairment, respectively.Conclusions:This study suggests that SMCs are more associated with depressive symptoms and IADL problems than with cognitive performance in individuals with MCI. Furthermore, while PM and RM complaints are related to both depressive symptoms and IADL, the differences between these main contributors suggest that RM complaints based on IADL could be more associated with the organically driven pathological features of MCI.

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High Mean Arterial Pressure is Associated with Better Cognitive Function in Older Adults with Subjective Memory Complaints

10.21203/rs.3.rs-167226/v1 ◽

2021 ◽

Author(s):

Ada Wai Tung Fung ◽

Allen Ting Chun Lee ◽

Sukling Ma

Keyword(s):

Blood Pressure ◽

Older Adults ◽

Cognitive Function ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Cognitive Performance ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Global Cognitive Function

Abstract Background: Hypertension has been shown to be a major risk factor for cognitive decline, but little is known about its association with subjective memory complaints (SMC) in late life. The study is to examine if hypertension is associated with SMC and to explore which blood pressure (BP) is more important in this group.Methods: 497 non-demented older adults aged 60 years or older were interviewed. Hypertension is defined as a BP higher than 130/80 mmHg or on antihypertensive medication. SMC are measured by a validated 5-item Abbreviate Memory Inventory for the Chinese (AMIC) assessing subjective memory deficits in the past month. Cognitive performance was measured by a neurocognitive battery assessing global cognitive function and executive function (EF). Linear regression was performed to examine how different BP associate with AMIC and cognitive performance with adjustment for sociodemographic and physical factors.Results: Hypertensive group had a lower AMIC than normal control (t=-2.1, p=.033). Systolic blood pressure (SBP) (B=-.008, 95% CI -.014 – -.002, p=.006) and mean arterial pressure (MAP) (B=-.011, 95% CI -.020– -.002 p=.014) were associated with AMIC. SBP was only associated global cognitive function (B= .008, 95% CI .000 – .015, p=.038), but MAP was associated with global cognitive function (B=.017, 95% CI .006 – .029, p=.003) and EF (B= 0.16, 95% CI .001 – .030, p=.036). Conclusions: High MAP was associated with better cognitive function in older adults with SMC. The findings highlight the need to be cautious when managing BP in older adults yet not to compromise their current cognitive function.

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