scholarly journals Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019

2021 ◽  
Author(s):  
Xingxing Zhang ◽  
Danfeng Yu ◽  
Wenwen Cai ◽  
Weiqing Ruan
Keyword(s):  
Cervical Cancer ◽  
Health Problem ◽  
Burden Of Disease ◽  
Control Strategies ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Effective Prevention ◽  
Life Years ◽  
Disease Study

Abstract Background Cervical cancer remains an important global health problem. This article aims to analysis the trend of cervical cancer at global, regional, and national level from 1990 to 2019, which would inform the health decision-making. Methods Data on cervical cancer was extracted from the Global Burden of Disease study 2019. The trends of cervical cancer burden were estimated using estimated annual percentage change (EAPC) and age-standardized rate (ASR). Results Globally, the decreasing trends in incidence, death, and disability adjusted life years (DALYs) of cervical cancer were observed worldwide from 1990 to 2019, with the respective EAPCs were − 0.38 (95% confidence interval [CI]: -0.41 to -0.34), -0.93 (95%CI: -0.98 to -0.88), and − 0.95 (95CI%: -1.00 to -0.90). Meanwhile, decreasing trends were also seen in most sociodemographic index (SDI) areas and geographic regions, particularly the trends of death and DALYs in Central Latin America, in which the respective EAPCs were − 2.61 (95%CI: -2.76 to -2.46) and − 2.48 (95%CI: -2.63 to -2.32). However, pronounced increasing trends occurred in the incidence in East Asia (EAPC = 1.33; 95%CI: 1.12 to 1.55). At the national level, the decreasing trends of cervical cancer were observed in most countries/territories, particularly the DALYs in Maldives (EAPC=-5.06; 95%CI: -5.40 to -4.72). Whereas increasing trend were seen in Lesotho, Zimbabwe, and Bulgaria. Conclusions Slowly decreasing trends of cervical cancer were demonstrated worldwide from 1990 to 2019. Cervical cancer remains a substantial health problem globally, which required the more effective prevention and control strategies.

scholarly journals Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xingxing Zhang ◽  
Qingle Zeng ◽  
Wenwen Cai ◽  
Weiqing Ruan
Keyword(s):  
Cervical Cancer ◽  
Health Problem ◽  
Burden Of Disease ◽  
Control Strategies ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Effective Prevention ◽  
Life Years ◽  
Disease Study

Abstract Background Cervical cancer is an important global health problem. In this study we aimed to analyze trends in cervical cancer at the global, regional, and national levels from 1990 to 2019, to inform health service decision-making. Methods Data on cervical cancer was extracted from the Global Burden of Disease study, 2019. Trends in cervical cancer burden were assessed based on estimated annual percentage change (EAPC) and age-standardized rate (ASR). Results Globally, decreasing trends were observed in incidence, death, and disability adjusted life years (DALYs) of cervical cancer from 1990 to 2019, with respective EAPCs of − 0.38 (95% confidence interval [CI]: − 0.41 to − 0.34), − 0.93 (95%CI: − 0.98 to − 0.88), and − 0.95 (95 CI%: − 1.00 to − 0.90). Meanwhile, decreasing trends were detected in most sociodemographic index (SDI) areas and geographic regions, particularly death and DALYs in Central Latin America, with respective EAPCs of − 2.61 (95% CI: − 2.76 to − 2.46) and − 2.48 (95% CI: − 2.63 to − 2.32); hhowever, a pronounced increasing trend in incidence occurred in East Asia (EAPC = 1.33; 95% CI: 1.12 to 1.55). At the national level, decreasing trends in cervical cancer were observed in most countries/territories, particularly DALYs in the Maldives (EAPC = − 5.06; 95% CI: − 5.40 to − 4.72), Whereas increasing trends were detected in Lesotho, Zimbabwe, and Bulgaria. Conclusions Slowly decreasing trends in cervical cancer were detected worldwide from 1990 to 2019. Cervical cancer remains a substantial health problem for women globally, requiring more effective prevention and control strategies.

scholarly journals The global, regional, and national burden and trends of NAFLD in 204 countries and territories: an analysis from Global Burden of Disease 2019

2022 ◽  
Author(s):  
Huilong Chen ◽  
Yuan Zhan ◽  
Jinxiang Zhang ◽  
Sheng Cheng ◽  
Yuhao Zhou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Burden Of Disease ◽  
Control Strategies ◽  
Cost Effective ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Effective Prevention ◽  
Nonalcoholic Fatty Liver ◽  
Life Years ◽  
Disease Study

Abstract Background Nonalcoholic fatty liver disease (NAFLD) poses a substantial socioeconomic burden and is becoming the fastest-growing driver of chronic liver disease, potentially accompanied by a poor prognosis. We aim to elucidate the global and regional epidemiologic changes in NAFLD during the past thirty years and explore the relevant causes. Methods Data on NAFLD incidence, prevalence, death, and disability-adjusted life-years (DALYs) were extracted from the Global Burden of Disease Study 2019. In addition, we also investigated the correlation between the NAFLD burden and the social development degree. Finally, the associations of the three common comorbidities with NAFLD were determined. Results Globally, the incidence and prevalence of NAFLD both increased drastically from 1990 to 2019, mainly affecting young adults. Meanwhile, the deaths and DALYs increased significantly as well, dominating the aged group. However, the overall age-standardized death rate (ASDR) and DALY rate presented decreasing trends. Moreover, the sociodemographic index (SDI) appeared to have obvious negative associations with the age-standardized prevalence rate (ASPR), ASDR and age-standardized DALYs, indicating a more serious NAFLD burden in less developed regions. Finally, we found that the incidence and prevalence of NAFLD were positively related to those of diabetes mellitus type 2 (DM2), stroke and ischaemic heart disease (IHD). Conclusions NAFLD is leading to increasingly serious health challenges worldwide. Comprehensive acquisition of the epidemiologic pattern for NAFLD and the identification of high-risk comorbidities may help policy-makers and clinical physicians develop cost-effective prevention and control strategies, especially in countries with a high NAFLD burden.

Global, regional, and national burden of other musculoskeletal disorders 1990–2017: results from the Global Burden of Disease Study 2017

Rheumatology ◽  
2020 ◽  
Author(s):  
Saeid Safiri ◽  
Ali Asghar Kolahi ◽  
Marita Cross ◽  
Kristin Carson-Chahhoud ◽  
Amir Almasi-Hashiani ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
National Level ◽  
Point Prevalence ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Prevalence Estimates ◽  
National Burden ◽  
Disease Study

Abstract Objectives To describe the level and trends of point prevalence, deaths and disability-adjusted life years (DALYs) for other musculoskeletal (MSK) disorders, i.e. those not covered by specific estimates generated for RA, OA, low back pain, neck pain and gout, from 1990 to 2017 by age, sex and sociodemographic index. Methods Publicly available modelled estimates from the Global Burden of Disease (GBD) 2017 study were extracted and reported as counts and age-standardized rates per 100 000 population for 195 countries and territories between 1990 and 2017. Results Globally, the age-standardized point prevalence estimates and deaths rates of other MSK disorders in 2017 were 4151.1 and 1.0 per 100 000. This was an increase of 3.4% and 7.2%, respectively. The age-standardized DALY rate in 2017 was 380.2, an increase of 3.4%. The point prevalence estimate was higher among females and increased with age. This peaked in the 65–69 year age group for both females and males in 2017, followed by a decreasing trend for both sexes. At the national level, the highest age-standardized point prevalence estimates in 2017 were seen in Bangladesh, India and Nepal. The largest increases in age-standardized point prevalence estimates were observed in Romania, Croatia and Armenia. Conclusion The burden of other MSK disorders is proven to be substantial and increasing worldwide, with a notable intercountry variation. Data pertaining to specific diseases within this overarching category are required for future GBD MSK estimates. This would enable policymakers to better allocate resources and provide interventions appropriately.

scholarly journals Burden of Eating Disorders in China, 1990-2019: An Updated Systematic Analysis of the Global Burden of Disease Study 2019

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhitao Li ◽  
Lili Wang ◽  
Haixia Guan ◽  
Cheng Han ◽  
Peng Cui ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Burden Of Disease ◽  
National Level ◽  
Epidemiological Data ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Systematic Analysis ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study

Background: Eating disorders, including anorexia nervosa (AN) and bulimia nervosa (BN), are complex mental disorders. A better understanding of the burden of eating disorders is essential for improving their management. Information about the burden of eating disorders at the national level in China remains unclear.Methods: This is a systematic analysis of the Global Burden of Disease Study (GBD) 2019. The sex- and age-specific prevalence, incidence, and disability-adjusted life years (DALYs) of eating disorders in China were estimated by systematically reviewing all available epidemiological data and inputting these data into a Bayesian meta-regression tool (DisMod-MR 2.0). Trends in the age-standardized prevalence, incidence, and DALYs due to AN and BN were assessed from 1990 to 2019.Results: The age-standardized incidence rate (ASIR), prevalence rate (ASPR), and DALY rate per 100,000 population were estimated to be 13.22 (95% UI, 9.35–18.23), 38.08 (95% UI: 26.37–55.73), and 8.38 (95% UI, 4.87–13.35) for AN and 130.05 (95% UI, 84.02–187.13), 75.21 (95% UI, 48.52–105.97), and 16.16 (95% UI, 9.23–25.40) for BN, respectively, in 2019. The prevalence, incidence, and DALY rate of AN peaked at 15–19 years old. The prevalence and DALY rate of BN peaked at 30–34 years old. Females had a higher burden of AN and a lower burden of BN than males. The ASIR, ASPR, and DALY significantly increased by 1.3% (95% CI: 1.3–1.4%), 1.6% (95% CI, 1.5–1.6%), and 1.6% (95% CI, 1.5–1.7%) for AN and 1.4% (95% CI: 1.4–1.4%), 2.0% (95% CI, 2.0–2.1%), and 2.0% (95% CI, 2.0–2.1%) for BN, respectively, from 1990 to 2019 in China. In addition, the increments in all the age-standardized measures of BN were higher in males than in females.Conclusions: The burden of eating disorders in China showed unexpected patterns that varied by sex and age, with increasing trends of AN and BN from 1990 to 2019. More attention should be given to improving the burden of BN in males in China.

scholarly journals Trends Analysis of Non-Hodgkin Lymphoma at the National, Regional, and Global Level, 1990–2019: Results From the Global Burden of Disease Study 2019

2021 ◽  
Vol 8 ◽  
Author(s):  
Wenwen Cai ◽  
Qingle Zeng ◽  
Xingxing Zhang ◽  
Weiqing Ruan
Keyword(s):  
Hodgkin Lymphoma ◽  
Burden Of Disease ◽  
Hematologic Malignancy ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Non Hodgkin Lymphoma ◽  
Life Years ◽  
Disease Study ◽  
Increasing Trends

Background: Non-Hodgkin lymphoma is a common hematologic malignancy. This article aimed to estimate the trends of non-Hodgkin lymphoma (NHL) globally from 1990 to 2019.Methods: Data on the NHL burden were explored from the Global Burden of Disease study 2019. The trends of NHL burden were estimated using age-standardized rate (ASR) and estimated annual percentage change (EAPC).Results: The ASR of NHL incidence showed an increasing trend worldwide from 1990 to 2019, with an EAPC of.56 [95% CI: 0.45–0.66]. Meanwhile, increasing trends were observed in both sexes and in most geographic regions, particularly East Asia (EAPC = 3.57, 95% CI: 3.29–3.86). The most pronounced increasing trends were seen in Georgia (EAPC = 4.7, 95% CI: 4.20–5.21), followed by Belarus and Uzbekistan. However, death and disability-adjusted life years (DALYs) caused by NHL showed decreasing trends globally, in which the respective EAPCs were −0.09 (95% CI: −0.17 to −0.02) and −0.28 (95% CI: −0.35 to −0.22). Decreasing trends were mainly seen in high and high-middle sociodemographic index (SDI) areas. At the national level, the largest increasing trends of death and DALYs were observed in Georgia, in which the respective EAPCs were 4.54 (95% CI: 4.01–5.07) and 4.97 (95% CI: 4.42–5.52).Conclusions: Decreasing trends of death and DALYs caused by NHL were observed worldwide from 1990 to 2019, but NHL remains a substantial challenge globally. The findings would inform the strategies for reducing the burden of NHL.

scholarly journals Secular Trends in the Epidemiologic Patterns of Thyroid Cancer in China Over Three Decades: An Updated Systematic Analysis of Global Burden of Disease Study 2019 Data

2021 ◽  
Vol 12 ◽  
Author(s):  
Yongze Li ◽  
Jianming Piao ◽  
Min Li
Keyword(s):  
Thyroid Cancer ◽  
Burden Of Disease ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Birth Cohorts ◽  
Analytical Strategy ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study

BackgroundThyroid cancer is the most common malignant endocrine disease worldwide. The changing epidemiologic pattern of thyroid cancer at the national level in China has remained unknown over the last three decades.MethodsFollowing the general analytical strategy used in the Global Burden of Disease Study (GBD) 2019, the age- and sex-specific incidence, mortality, and prevalence rates of thyroid cancer in China were analyzed. Trends in the incidence, mortality, prevalence, and disability-adjusted life years (DALYs) due to thyroid cancer from 1990 to 2019 were assessed by joinpoint regression analysis. Age, period, and cohort effects on incidence were estimated by an age-period-cohort model.ResultsFrom 1990 to 2019, the age-standardized prevalence and incidence rates significantly increased in both males and females, and the age-standardized mortality rate decreased in females but increased in males. Moreover, the increments in all the age-standardized measures of thyroid cancer in China were higher in males than in females. The age effect showed that those aged 40–44 years had the highest relative risk (RR) among females, and the RR increased with age among males. The incidence increased with time and began to substantially increase in 2009. The cohort effect showed that the incidence decreased in successive birth cohorts.ConclusionsThe burden of thyroid cancer in China showed unexpected patterns that varied by sex, age, and year. Notably, males had higher average annual percentage changes in thyroid cancer incidence and mortality rates than females. More attention should be given to improving the thyroid cancer burden in males in China.

scholarly journals India’s Performance in Controlling Visceral Leishmaniasis as Compared to Brazil Over Past Three Decades: Findings From Global Burden of Disease Study

2021 ◽  
Author(s):  
DEEPAK DHAMNETIYA ◽  
Ravi Prakash Jha ◽  
Shalini . ◽  
Krittika Bhattacharyya
Keyword(s):  
Visceral Leishmaniasis ◽  
Burden Of Disease ◽  
Rate Of Change ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Mortality And Morbidity ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study ◽  
Incidence Prevalence

Abstract Visceral leishmaniasis (VL) is a neglected tropical disease which contributes to the mortality and morbidity significantly in India and Brazil. This study was planned to compare the trends of incidence, prevalence, death and disability-adjusted life years (DALY) of VL burden in India and Brazil from 1990 to 2019 using Global burden of disease study (GBD) data. The metrics are presented as age-standardized rates per 100,000 inhabitants with their respective uncertainty intervals (95%UI) and relative percentages of change. The decline in the Incidence rate is more in case of India (16.82 cases per 100,000 in 1990 to 0.60cases in 2019) as compared to Brazil (3.12 cases per 100,000 in 1990 to 2.65 cases in 2019). The annualized rate of change in number of prevalent cases for India is -0.95 (95% UI, -0.98 to -0.91) whereas for Brazil it is -0.06 (95% UI, -0.41 to 0.52). The annualized rate of change in number of DALY for India is -0.94 (95% UI, -0.96 to -0.92) whereas for Brazil it is -0.09 (95% UI, -0.25 to 0.28). The annualized rate of change in number of deaths for India is -0.93 (95% UI, -0.95 to -0.92) whereas for Brazil it is increasing i.e. 0.04 (95% UI, -0.12 to 0.51). India achieves significant reduction in the age standardized incidence, prevalence, mortality and DALY of VL as compare to Brazil during the period of 1990 to 2019. A multi-centric study is required to assess bottleneck in the existing strategies of VLSCP in Brazil.

scholarly journals Global, Regional, National, and Subnational Big Data to Inform Health Equity Research: Perspectives from the Global Burden of Disease Study 2017

2019 ◽  
Vol 29 (Suppl 1) ◽  
pp. 159-172 ◽  
Author(s):  
Ali H. Mokdad ◽  
George A. Mensah ◽  
Varsha Krish ◽  
Scott D. Glenn ◽  
Molly K. Miller-Petrie ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Burden Of Disease ◽  
High Body Mass Index ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Healthy Life ◽  
Research Perspectives ◽  
Life Years ◽  
Disease Study

Objectives: Everyone deserves a long and healthy life, but in reality, health outcomes differ across populations. We use results from the Global Burden of Disease Study 2017 (GBD 2017) to report patterns in the burden of diseases, injuries, and risks at the global, regional, national, and subnational level, and by sociodemographic index (SDI), from 1990 to 2017.Design: GBD 2017 undertook a systematic analysis of published studies and available data providing information on prevalence, incidence, remission, and excess mortal­ity. We computed prevalence, incidence, mortality, life expectancy, healthy life expectancy, years of life lost due to prema­ture mortality, years lived with disability, and disability-adjusted life years with 95% uncertainty intervals for 23 age groups, both sexes, and 918 locations, including 195 countries and territories and subnational locations for 16 countries from 1990 to 2017. We also computed SDI, a summary indicator combining measures of income, education, and fertility.Results: There were wide disparities in the burden of disease by SDI, with smaller burdens in affluent countries and in specific regions within countries. Select diseases and risks, such as drug use disorders, high blood pressure, high body mass index, diet, high fasting plasma glucose, smoking, and alco­hol use disorders warrant increased global attention and indicate a need for greater investment in prevention and treatment across the life course.Conclusions: Policymakers need a com­prehensive picture of what risks and causes result in disability and death. The GBD provides the means to quantify health loss: these findings can be used to examine root causes of disparities and develop pro­grams to improve health and health equity.Ethn Dis. 2019;29(Suppl 1): 159-172; doi:10.18865/ed.29.S1.159.

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