scholarly journals Secular Trends in the Epidemiologic Patterns of Thyroid Cancer in China Over Three Decades: An Updated Systematic Analysis of Global Burden of Disease Study 2019 Data

2021 ◽  
Vol 12 ◽  
Author(s):  
Yongze Li ◽  
Jianming Piao ◽  
Min Li
Keyword(s):  
Thyroid Cancer ◽  
Burden Of Disease ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Birth Cohorts ◽  
Analytical Strategy ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study

BackgroundThyroid cancer is the most common malignant endocrine disease worldwide. The changing epidemiologic pattern of thyroid cancer at the national level in China has remained unknown over the last three decades.MethodsFollowing the general analytical strategy used in the Global Burden of Disease Study (GBD) 2019, the age- and sex-specific incidence, mortality, and prevalence rates of thyroid cancer in China were analyzed. Trends in the incidence, mortality, prevalence, and disability-adjusted life years (DALYs) due to thyroid cancer from 1990 to 2019 were assessed by joinpoint regression analysis. Age, period, and cohort effects on incidence were estimated by an age-period-cohort model.ResultsFrom 1990 to 2019, the age-standardized prevalence and incidence rates significantly increased in both males and females, and the age-standardized mortality rate decreased in females but increased in males. Moreover, the increments in all the age-standardized measures of thyroid cancer in China were higher in males than in females. The age effect showed that those aged 40–44 years had the highest relative risk (RR) among females, and the RR increased with age among males. The incidence increased with time and began to substantially increase in 2009. The cohort effect showed that the incidence decreased in successive birth cohorts.ConclusionsThe burden of thyroid cancer in China showed unexpected patterns that varied by sex, age, and year. Notably, males had higher average annual percentage changes in thyroid cancer incidence and mortality rates than females. More attention should be given to improving the thyroid cancer burden in males in China.

scholarly journals Burden of Thyroid Cancer From 1990 to 2019 and Projections of Incidence and Mortality Until 2039 in China: Findings From Global Burden of Disease Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Fang Cheng ◽  
Juan Xiao ◽  
Chunchun Shao ◽  
Fengyan Huang ◽  
Lihua Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Burden Of Disease ◽  
Cohort Analysis ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Essential Information ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study

Projecting the burden of thyroid cancer (TC) over time provides essential information to effectively plan measures for its management and prevention. This research obtained data from the Global Burden of Disease (GBD) Study from between 1990 and 2019 to model how TC will affect China until 2039 by conducting the Bayesian age-period-cohort analysis. The number of new TC cases in China was 10,030 in 1990, 39,080 in 2019, and is projected to be 47,820 in 2039. This corresponds to 3,320, 7,240, and 4,160 deaths, respectively. Disability-adjusted life years (DALYs) cases increased from 103,490 in 1990 to 187,320 in 2019. The age-standardized rate (ASR) of incidence increased from 1.01 to 2.05 during 1990-2019 and was projected to increase to 3.37 per 100,000 person-years until 2039. The ASR of mortality (ASMR) remained stable during the study period and was projected to have a mild decline from 0.39 to 0.29/100,000 during 2020-2039. Although the ASMR in male patients has maintained increasing at a rate of 2.2% per year over the past 30 years, it is expected to decline at a rate of 1.07% per year in 2019-2039. The most significant increase in crude incidence occurred in people aged 45-65 from 1990 to 2019, however, this will shift into young people aged 10-24 from 2020 to 2039. In addition, the proportion of deaths and DALYs caused by obesity increased from 1990 to 2019 and affected men more than women. In conclusion, a substantial increase in counts of incidence of TC in China is projected over the next two decades, combined with the slightly declining mortality, indicating that rational health policies are needed in the future to cope with the increasing number of TC patients, especially among males and adolescents.

Global, regional, and national burden of other musculoskeletal disorders 1990–2017: results from the Global Burden of Disease Study 2017

Rheumatology ◽  
2020 ◽  
Author(s):  
Saeid Safiri ◽  
Ali Asghar Kolahi ◽  
Marita Cross ◽  
Kristin Carson-Chahhoud ◽  
Amir Almasi-Hashiani ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
National Level ◽  
Point Prevalence ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Prevalence Estimates ◽  
National Burden ◽  
Disease Study

Abstract Objectives To describe the level and trends of point prevalence, deaths and disability-adjusted life years (DALYs) for other musculoskeletal (MSK) disorders, i.e. those not covered by specific estimates generated for RA, OA, low back pain, neck pain and gout, from 1990 to 2017 by age, sex and sociodemographic index. Methods Publicly available modelled estimates from the Global Burden of Disease (GBD) 2017 study were extracted and reported as counts and age-standardized rates per 100 000 population for 195 countries and territories between 1990 and 2017. Results Globally, the age-standardized point prevalence estimates and deaths rates of other MSK disorders in 2017 were 4151.1 and 1.0 per 100 000. This was an increase of 3.4% and 7.2%, respectively. The age-standardized DALY rate in 2017 was 380.2, an increase of 3.4%. The point prevalence estimate was higher among females and increased with age. This peaked in the 65–69 year age group for both females and males in 2017, followed by a decreasing trend for both sexes. At the national level, the highest age-standardized point prevalence estimates in 2017 were seen in Bangladesh, India and Nepal. The largest increases in age-standardized point prevalence estimates were observed in Romania, Croatia and Armenia. Conclusion The burden of other MSK disorders is proven to be substantial and increasing worldwide, with a notable intercountry variation. Data pertaining to specific diseases within this overarching category are required for future GBD MSK estimates. This would enable policymakers to better allocate resources and provide interventions appropriately.

scholarly journals Burden of Eating Disorders in China, 1990-2019: An Updated Systematic Analysis of the Global Burden of Disease Study 2019

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhitao Li ◽  
Lili Wang ◽  
Haixia Guan ◽  
Cheng Han ◽  
Peng Cui ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Burden Of Disease ◽  
National Level ◽  
Epidemiological Data ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Systematic Analysis ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study

Background: Eating disorders, including anorexia nervosa (AN) and bulimia nervosa (BN), are complex mental disorders. A better understanding of the burden of eating disorders is essential for improving their management. Information about the burden of eating disorders at the national level in China remains unclear.Methods: This is a systematic analysis of the Global Burden of Disease Study (GBD) 2019. The sex- and age-specific prevalence, incidence, and disability-adjusted life years (DALYs) of eating disorders in China were estimated by systematically reviewing all available epidemiological data and inputting these data into a Bayesian meta-regression tool (DisMod-MR 2.0). Trends in the age-standardized prevalence, incidence, and DALYs due to AN and BN were assessed from 1990 to 2019.Results: The age-standardized incidence rate (ASIR), prevalence rate (ASPR), and DALY rate per 100,000 population were estimated to be 13.22 (95% UI, 9.35–18.23), 38.08 (95% UI: 26.37–55.73), and 8.38 (95% UI, 4.87–13.35) for AN and 130.05 (95% UI, 84.02–187.13), 75.21 (95% UI, 48.52–105.97), and 16.16 (95% UI, 9.23–25.40) for BN, respectively, in 2019. The prevalence, incidence, and DALY rate of AN peaked at 15–19 years old. The prevalence and DALY rate of BN peaked at 30–34 years old. Females had a higher burden of AN and a lower burden of BN than males. The ASIR, ASPR, and DALY significantly increased by 1.3% (95% CI: 1.3–1.4%), 1.6% (95% CI, 1.5–1.6%), and 1.6% (95% CI, 1.5–1.7%) for AN and 1.4% (95% CI: 1.4–1.4%), 2.0% (95% CI, 2.0–2.1%), and 2.0% (95% CI, 2.0–2.1%) for BN, respectively, from 1990 to 2019 in China. In addition, the increments in all the age-standardized measures of BN were higher in males than in females.Conclusions: The burden of eating disorders in China showed unexpected patterns that varied by sex and age, with increasing trends of AN and BN from 1990 to 2019. More attention should be given to improving the burden of BN in males in China.

scholarly journals Burden of Oral Cancer on the 10 Most Populous Countries from 1990 to 2019: Estimates from the Global Burden of Disease Study 2019

2022 ◽  
Vol 19 (2) ◽  
pp. 875
Author(s):  
Shu-Zhen Zhang ◽  
Long Xie ◽  
Zheng-Jun Shang
Keyword(s):  
United States ◽  
Oral Cancer ◽  
Burden Of Disease ◽  
The United States ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study ◽  
Female Subjects

Background: Oral cancer (OC) is a common tumour that poses a threat to human health and imposes a heavy burden on countries. This study assessed the burden imposed by OC on the 10 most populous countries from 1990 to 2019 on the basis of gender, age and socio-demographic index. Methods: Data on incidence, mortality, disability-adjusted life years (DALY) and corresponding age-standardised rates (ASR) for OC in the 10 most populous countries from 1990 to 2019 were derived from the Global Burden of Disease Study 2019. Estimated annual percentage changes were calculated to assess the trends of morbidity, mortality and DALY. The indicator that served as a proxy for survival rate was the supplement of mortality-to-incidence ratio (SMIR) (1 − (M/I)). Results: The number of new cases, deaths and DALY have increased in all 10 countries in the past 30 years. Trends in age-standardised incidence rates (ASIR), age-standardised mortality rate (ASMR) and age-standardised DALY for OC in the 10 most populous countries varied. The SMIR increased in all countries, with most countries having an SMIR between 30% and 50%. In 2019, the United States had the highest SMIR at 76%, whereas Russia had the lowest at 21.7%. Incidence and mortality were close between male and female subjects in Japan, Indonesia, Mexico, India, Bangladesh and Pakistan. The incidence and mortality in male subjects in the United States, Russia, China and Brazil were two or more times those of female subjects. Gender difference was highest among patients aged 40–69 years. Conclusion: Trends and gender differences in ASIR, ASMR and age-standardised DALY for OC vary in the 10 most populous countries. Government cancer programs are often expensive to run, especially in countries with large populations. Policy makers need to take these differences into account when formulating policies.

scholarly journals Trends Analysis of Non-Hodgkin Lymphoma at the National, Regional, and Global Level, 1990–2019: Results From the Global Burden of Disease Study 2019

2021 ◽  
Vol 8 ◽  
Author(s):  
Wenwen Cai ◽  
Qingle Zeng ◽  
Xingxing Zhang ◽  
Weiqing Ruan
Keyword(s):  
Hodgkin Lymphoma ◽  
Burden Of Disease ◽  
Hematologic Malignancy ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Non Hodgkin Lymphoma ◽  
Life Years ◽  
Disease Study ◽  
Increasing Trends

Background: Non-Hodgkin lymphoma is a common hematologic malignancy. This article aimed to estimate the trends of non-Hodgkin lymphoma (NHL) globally from 1990 to 2019.Methods: Data on the NHL burden were explored from the Global Burden of Disease study 2019. The trends of NHL burden were estimated using age-standardized rate (ASR) and estimated annual percentage change (EAPC).Results: The ASR of NHL incidence showed an increasing trend worldwide from 1990 to 2019, with an EAPC of.56 [95% CI: 0.45–0.66]. Meanwhile, increasing trends were observed in both sexes and in most geographic regions, particularly East Asia (EAPC = 3.57, 95% CI: 3.29–3.86). The most pronounced increasing trends were seen in Georgia (EAPC = 4.7, 95% CI: 4.20–5.21), followed by Belarus and Uzbekistan. However, death and disability-adjusted life years (DALYs) caused by NHL showed decreasing trends globally, in which the respective EAPCs were −0.09 (95% CI: −0.17 to −0.02) and −0.28 (95% CI: −0.35 to −0.22). Decreasing trends were mainly seen in high and high-middle sociodemographic index (SDI) areas. At the national level, the largest increasing trends of death and DALYs were observed in Georgia, in which the respective EAPCs were 4.54 (95% CI: 4.01–5.07) and 4.97 (95% CI: 4.42–5.52).Conclusions: Decreasing trends of death and DALYs caused by NHL were observed worldwide from 1990 to 2019, but NHL remains a substantial challenge globally. The findings would inform the strategies for reducing the burden of NHL.

scholarly journals Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xingxing Zhang ◽  
Qingle Zeng ◽  
Wenwen Cai ◽  
Weiqing Ruan
Keyword(s):  
Cervical Cancer ◽  
Health Problem ◽  
Burden Of Disease ◽  
Control Strategies ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Effective Prevention ◽  
Life Years ◽  
Disease Study

Abstract Background Cervical cancer is an important global health problem. In this study we aimed to analyze trends in cervical cancer at the global, regional, and national levels from 1990 to 2019, to inform health service decision-making. Methods Data on cervical cancer was extracted from the Global Burden of Disease study, 2019. Trends in cervical cancer burden were assessed based on estimated annual percentage change (EAPC) and age-standardized rate (ASR). Results Globally, decreasing trends were observed in incidence, death, and disability adjusted life years (DALYs) of cervical cancer from 1990 to 2019, with respective EAPCs of − 0.38 (95% confidence interval [CI]: − 0.41 to − 0.34), − 0.93 (95%CI: − 0.98 to − 0.88), and − 0.95 (95 CI%: − 1.00 to − 0.90). Meanwhile, decreasing trends were detected in most sociodemographic index (SDI) areas and geographic regions, particularly death and DALYs in Central Latin America, with respective EAPCs of − 2.61 (95% CI: − 2.76 to − 2.46) and − 2.48 (95% CI: − 2.63 to − 2.32); hhowever, a pronounced increasing trend in incidence occurred in East Asia (EAPC = 1.33; 95% CI: 1.12 to 1.55). At the national level, decreasing trends in cervical cancer were observed in most countries/territories, particularly DALYs in the Maldives (EAPC = − 5.06; 95% CI: − 5.40 to − 4.72), Whereas increasing trends were detected in Lesotho, Zimbabwe, and Bulgaria. Conclusions Slowly decreasing trends in cervical cancer were detected worldwide from 1990 to 2019. Cervical cancer remains a substantial health problem for women globally, requiring more effective prevention and control strategies.

scholarly journals The global burden of nasopharyngeal carcinoma from 2009 to 2019: an observational study based on the Global Burden of Disease Study 2019

2021 ◽  
Author(s):  
Hao Yu ◽  
Xin Yin ◽  
Yiran Mao ◽  
Meiqin Chen ◽  
Qiuying Tang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Incidence Rate ◽  
Burden Of Disease ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Mortality Trends ◽  
Life Years ◽  
Number Of Patients ◽  
Incidence And Mortality ◽  
Disease Study

Abstract Purpose The incidence and mortality rate of nasopharyngeal carcinoma (NPC) has changed in recent years. Our goal is to determine the epidemiological pattern of NPC to help policymakers allocate limited medical resources. Methods Detailed information about NPC from 2009 to 2019 was collected from the Global Burden of Disease 2019 database. Age-standardized rates (ASRs) and corresponding estimated annual percentage changes (EAPCs) were calculated to assess NPC’s incidence and mortality trends. Results Globally, there was a consistent increase in the NPC incidence cases from 2009 to 2019 (from 121.65 × 103 cases in 2009 to 176.50 × 103 cases in 2019, increasing by 45.09%). The age-standardized incidence rate (ASIR) of NPC increased from 1.81 in 2009 to 2.12 in 2019 (EAPC = 1.59, 95% CI 1.36–1.81). On the contrary, the mortality of NPC showed a downward trend (ASDR: 0.93 in 2009 and 0.86 in 2019; EAPC = − 0.63, 95% CI − 0.78 to − 0.48), and it was negatively correlated with the social demographic index (SDI) in most regions. Both incidence and mortality rates of high-incidence territories tended to be stable or decline. Males had significantly higher incidence and mortality of NPC than females. The number of patients with onset age greater than 50 years old accounted for the highest proportion. We found that smoking, occupational exposure to formaldehyde, and alcohol use were the main risk factors for NPC-related mortality. Conclusion Globally, the incidence rate of NPC has been slightly increasing, while the mortality and disability-adjusted life years (DALYs) have been decreasing. NPC burden in high-middle and middle SDI areas was the heaviest. The current prevention strategy should be repositioned, and some countries should formulate more targeted approaches to reduce the current burden of NPC.

scholarly journals Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019

2021 ◽  
Author(s):  
Xingxing Zhang ◽  
Danfeng Yu ◽  
Wenwen Cai ◽  
Weiqing Ruan
Keyword(s):  
Cervical Cancer ◽  
Health Problem ◽  
Burden Of Disease ◽  
Control Strategies ◽  
National Level ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Effective Prevention ◽  
Life Years ◽  
Disease Study

Abstract Background Cervical cancer remains an important global health problem. This article aims to analysis the trend of cervical cancer at global, regional, and national level from 1990 to 2019, which would inform the health decision-making. Methods Data on cervical cancer was extracted from the Global Burden of Disease study 2019. The trends of cervical cancer burden were estimated using estimated annual percentage change (EAPC) and age-standardized rate (ASR). Results Globally, the decreasing trends in incidence, death, and disability adjusted life years (DALYs) of cervical cancer were observed worldwide from 1990 to 2019, with the respective EAPCs were − 0.38 (95% confidence interval [CI]: -0.41 to -0.34), -0.93 (95%CI: -0.98 to -0.88), and − 0.95 (95CI%: -1.00 to -0.90). Meanwhile, decreasing trends were also seen in most sociodemographic index (SDI) areas and geographic regions, particularly the trends of death and DALYs in Central Latin America, in which the respective EAPCs were − 2.61 (95%CI: -2.76 to -2.46) and − 2.48 (95%CI: -2.63 to -2.32). However, pronounced increasing trends occurred in the incidence in East Asia (EAPC = 1.33; 95%CI: 1.12 to 1.55). At the national level, the decreasing trends of cervical cancer were observed in most countries/territories, particularly the DALYs in Maldives (EAPC=-5.06; 95%CI: -5.40 to -4.72). Whereas increasing trend were seen in Lesotho, Zimbabwe, and Bulgaria. Conclusions Slowly decreasing trends of cervical cancer were demonstrated worldwide from 1990 to 2019. Cervical cancer remains a substantial health problem globally, which required the more effective prevention and control strategies.

scholarly journals The Global, Regional, and National Burden and Trends of Infective Endocarditis From 1990 to 2019: Results From the Global Burden of Disease Study 2019

2021 ◽  
Author(s):  
Huilong Chen ◽  
Yuan Zhan ◽  
Kaimin Zhang ◽  
Liyuan Chen ◽  
Juan Zhan ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Burden Of Disease ◽  
Temporal Trend ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Incidence And Mortality ◽  
Disease Study

Abstract Introduction: Infective endocarditis (IE) causes in-mounting incidence and mortality, as well as serious socioeconomic burden in different regions and countries. To compare and interpret the IE burden and temporal trends in the globe and different regions, we conducted this study to report the incidence, death, and disability-adjusted life years (DALYs) from 1990 to 2019. Methods: Data of incidences, deaths and DALYs were extracted and analyzed from the Global Burden of Disease Study 2019. Estimated annual percentage changes (EAPC) were adopted to quantify the change trends of age-standardized rates (ASRs). Besides, potential contributors of serious IE burden were also evaluated including age, gender, social-demographic index (SDI), and ASIR in 1990.Results: In the globe, the number of IE cases increased by 128% from 478,000 in 1990 to 1,090,530 in 2019, and the deaths increased sharply from 28,750 in 1990 to 66,320 in 2019, and both presented the upward temporal trend annually. Whereas the EAPC of age-standardized DALYs demonstrated a negative temporal trend despite of increasing DALYs from 1,118,120 in 1990 to 1,723,590 in 2019. Moreover, graver IE burden was prone to males and aged patients. Meanwhile, different SDI regions had different disease burden, correlation analyses indicated that SDI presented a positive association with ASIR (R=0.58, P<0.0001), no association with ASDR (R=-0.06, P=0.10), and negative association with age-standardized DALYs rate (R=-0.40, P<0.0001). Finally, we discovered the positive associations of EAPC of ASRs with SDI in 2019, while little associations with ASIR in 1990.Conclusion: Generally, the overall burden of infective endocarditis is ever-increasing, and the incidence, mortality and disability-adjusted life years present a huge heterogeneity in gender, age and different regions. The results may be useful for policy makers and medical staffs in response to endocarditis and to formulate cost-effective interventional measures.

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