Head and neck tumors angiogenesis imaging with 68Ga-NODAGA-RGD in comparison to 18F-FDG PET/CT: A pilot study.

Abstract Background : Angiogenesis plays an important role in head and neck squamous cell carcinomas (HNSCC) progression. This pilot study was designed to compare the distribution of 68 Ga-NODAGA-RGD PET/CT for imaging α v β 3 integrins involved in tumor angiogenesis to 18 F-FDG PET/CT in patients with HNSCC. Material and methods : Ten patients (aged: 58.4 ± 8.3 years [range: 44–73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both 68 Ga -NODAGA-RGD and 18 F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation. Results : All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher 18 F-FDG SUV max in comparison to 68 Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1 g/mL, p=0.0017) and SUV mean (8.2 ± 3.1 versus 2.0 ± 0.8 g/mL, p=0.0017). Both 18 F-FDG and 68 Ga-NODAGA-RGD uptake were neither correlated with grade, HPV nor p16 protein expression (p≥0.17). Conclusion : All HNSCC tumors were detected with both tracers with higher uptake with 18 F-FDG, however. 68 Ga-NODAGA-RGD has a different spatial distribution than 18 F-FDG bringing different tumor information.

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Head and neck tumors angiogenesis imaging with 68Ga-NODAGA-RGD in comparison to 18F-FDG PET/CT: a pilot study

EJNMMI Research ◽

10.1186/s13550-020-00638-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Steve Durante ◽

Vincent Dunet ◽

François Gorostidi ◽

Periklis Mitsakis ◽

Niklaus Schaefer ◽

...

Keyword(s):

Pilot Study ◽

Head And Neck ◽

Fdg Pet ◽

Head And Neck Tumors ◽

Neck Tumors ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

BMC Cancer ◽

10.1186/s12885-015-1154-8 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 22

Author(s):

Manil Subesinghe ◽

Andrew F Scarsbrook ◽

Steven Sourbron ◽

Daniel J Wilson ◽

Garry McDermott ◽

...

Keyword(s):

Head And Neck Cancer ◽

Pilot Study ◽

Head And Neck ◽

Functional Imaging ◽

Neck Cancer ◽

Fdg Pet ◽

Imaging Parameters ◽

Pet Ct ◽

Fdg Pet Ct ◽

Ct And Mri

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FDG PET/CT in Treatment Response Evaluation of Head and Neck Tumors

Nuclear Medicine Seminars ◽

10.4274/nts.galenos.2021.0013 ◽

2021 ◽

Vol 7 (2) ◽

pp. 139-145

Author(s):

Burcu Esen Akkaş

Keyword(s):

Head And Neck ◽

Treatment Response ◽

Fdg Pet ◽

Head And Neck Tumors ◽

Response Evaluation ◽

Treatment Response Evaluation ◽

Neck Tumors ◽

Pet Ct ◽

Fdg Pet Ct

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Comparison of 18F-FDG PET/CT scan and 99mTc-MDP bone scintigraphy in detecting bone metastasis in head and neck tumors

Nuclear Medicine Communications ◽

10.1097/mnm.0000000000000479 ◽

2016 ◽

Vol 37 (6) ◽

pp. 583-588 ◽

Cited By ~ 5

Author(s):

Naima K. Al-Bulushi ◽

Mohei-Eldin Abouzied

Keyword(s):

Bone Metastasis ◽

Ct Scan ◽

Head And Neck ◽

Bone Scintigraphy ◽

Fdg Pet ◽

Neck Tumors ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Pet Ct Scan

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PET findings in lymphomatosis and gliomatosis of the brain: a comparison of C-11 methionine PET/CT and F-18 FDG PET/CT

Acta Radiologica ◽

10.1177/0284185120966710 ◽

2020 ◽

pp. 028418512096671

Author(s):

Noriaki Tomura ◽

Toshiyuki Saginoya ◽

Hiromi Goto

Keyword(s):

Fdg Pet ◽

Standard Uptake Value ◽

Rank Test ◽

Ct Findings ◽

Positron Emission ◽

Pet Ct ◽

Signed Rank Test ◽

Almost All ◽

Fdg Pet Ct ◽

The Brain

Background Positron emission tomography (PET) findings for gliomatosis and lymphomatosis have been rarely reported. Purpose To compare PET/computed tomography (CT) findings using 11C-methionine (MET) from PET/CT findings using 18F-fluorodeoxy glucose (FDG) for patients with lymphomatosis or gliomatosis of the brain. Material and Methods Participants comprised all 10 patients with lymphomatosis or gliomatosis of the brain treated at our institution in the past 12 years. Underlying pathologies comprised intravascular lymphoma (n = 1), lymphomatosis (n = 3), and gliomatosis (n = 6). All cases were pathologically diagnosed. In seven patients, both MET-PET/CT and FDG-PET/CT were performed simultaneously in a single study. In three patients, only FDG-PET/CT was performed. The degree of tracer accumulation to the lesion was evaluated qualitatively. Quantitatively, the ratio of maximum standard uptake value (SUVmax) in tumor to that in normal tissue (T/N ratio) was measured and compared between FDG and MET. Results Qualitatively, MET accumulated to part of the lesion in six of seven patients and almost all of the lesion in one in seven patients. FDG accumulated to part of the lesion in three of ten patients and almost all of the lesion in one of ten patients. No FDG accumulation was seen in the lesion in six patients. Quantitatively, mean ± SD T/N ratio was significantly higher with MET (2.11 ± 0.63) than with FDG (1.18 ± 0.84; P < 0.05, Wilcoxon signed-rank test). Conclusion In lymphomatosis and gliomatosis, FDG accumulates in only part of the lesion. FDG is thus less suitable than MET for depicting these lesions.

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Improved detection of in-transit metastases of malignant melanoma with BSREM reconstruction in digital [18F]FDG PET/CT

European Radiology ◽

10.1007/s00330-021-07852-7 ◽

2021 ◽

Author(s):

Virginia Liberini ◽

Michael Messerli ◽

Lars Husmann ◽

Ken Kudura ◽

Hannes Grünig ◽

...

Keyword(s):

Malignant Melanoma ◽

Expectation Maximization ◽

Fdg Pet ◽

Metabolic Tumor Volume ◽

Rank Test ◽

Pet Ct ◽

Signed Rank Test ◽

Melanoma Patients ◽

Fdg Pet Ct ◽

In Transit

Abstract Objectives To compare block sequential regularized expectation maximization (BSREM) and ordered subset expectation maximization (OSEM) for the detection of in-transit metastasis (ITM) of malignant melanoma in digital [18F]FDG PET/CT. Methods We retrospectively analyzed a cohort of 100 [18F]FDG PET/CT scans of melanoma patients with ITM, performed between May 2017 and January 2020. PET images were reconstructed with both OSEM and BSREM algorithms. SUVmax, target-to-background ratio (TBR), and metabolic tumor volume (MTV) were recorded for each ITM. Differences in PET parameters were analyzed with the Wilcoxon signed-rank test. Differences in image quality for different reconstructions were tested using the Man-Whitney U test. Results BSREM reconstruction led to the detection of 287 ITM (39% more than OSEM). PET parameters of ITM were significantly different between BSREM and OSEM reconstructions (p < 0.001). SUVmax and TBR were higher (76.5% and 77.7%, respectively) and MTV lower (49.5%) on BSREM. ITM missed with OSEM had significantly lower SUVmax (mean 2.03 vs. 3.84) and TBR (mean 1.18 vs. 2.22) and higher MTV (mean 2.92 vs. 1.01) on OSEM compared to BSREM (all p < 0.001). Conclusions BSREM detects significantly more ITM than OSEM, owing to higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM. Key Points • In melanoma patients, [18F]FDG PET/CT helps to detect in-transit metastases (ITM), and their detection is improved by using BSREM instead of OSEM reconstruction. • BSREM is particularly useful in small lesions.

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