scholarly journals Effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men: a randomized crossover study

2020 ◽  
Author(s):  
Yuka Kawakami ◽  
Arisa Yasuda ◽  
Motoki Hayashi ◽  
Misuzu Akiyama ◽  
Toshihiko Asai ◽  
...  
Keyword(s):  
Uric Acid ◽  
Crossover Study ◽  
Green Tea ◽  
Medical Information ◽  
University Hospital ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Registration Number ◽  
The University ◽  
Randomized Crossover Study

Abstract Background Alcohol consumption is associated with hyperuricemia and gout. Previous studies have indicated a role for green tea catechins in uric acid (UA) metabolism. This study aimed to elucidate the effect of green tea catechins in terms of enhancing urinary excretion of UA and xanthine/hypoxanthine (Xa/HX) after alcohol ingestion.Methods In a randomized crossover study, 10 healthy subjects consumed test meals, including a Japanese distilled spirit (Shōchū) with water (SW) or Shōchū with catechin-rich green tea (SC), each containing 20 g of alcohol. The SC contained 617 mg of total catechin. Serum and urine UA and Xa/HX concentrations were measured. Blood samples were collected after 2.5 h, and urine samples were collected between 0 and 5 h after consuming the test meal.Results Urine UA and Xa/HX excretions were significantly higher in the SC group than in the SW group ( P < 0.05). UA clearance and fractional UA excretion tended to increase more in the SC group than in the SW group. No significant differences in S-UA and S-Xa/Hx concentrations were observed between the SW and SC groups.Conclusions Based on these observations, it was concluded that green tea catechins can enhance the excretion of UA and Xa/HX, even though alcohol is ingested.Trial registration The protocol was approved by the Ethics Committee of the University of Shizuoka and registered with UMIN (University Hospital Medical Information Network in Japan). Trial registration number: UMIN000040076. Registered 7 April 2020 – Retrospectively registered, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000045687

scholarly journals Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men

2020 ◽  
Author(s):  
Yuka Kawakami ◽  
Arisa Yasuda ◽  
Motoki Hayashi ◽  
Misuzu Akiyama ◽  
Toshihiko Asai ◽  
...  
Keyword(s):  
Uric Acid ◽  
Green Tea ◽  
Acid Metabolism ◽  
Acute Effect ◽  
Alcohol Ingestion ◽  
Total Serum ◽  
Japanese Men ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Randomized Crossover Study

Abstract Alcohol consumption is associated with hyperuricemia and gout. Previous studies have indicated a role for green tea catechins in uric acid (UA) metabolism. This study aimed to elucidate the acute effect of green tea catechins in terms of enhancing urinary excretion of UA and xanthine/hypoxanthine (Xa/HX; UA precursors) after alcohol ingestion. In a randomized crossover study, ten healthy Japanese subjects consumed test meals, including a Japanese distilled spirit (Shōchū) with water (SW) or Shōchū with catechin-rich green tea (SC), each containing 20 g of alcohol. The SC contained 617 mg of catechin in total. Serum and urine UA and Xa/HX concentrations were measured. Blood samples were collected after 2.5 h, and urine samples were collected between 0 and 5 h after consuming the test meal. Urine UA and Xa/HX excretions were significantly higher in the SC group than in the SW group. UA clearance and fractional UA excretion tended to increase more in the SC group than in the SW group. No significant differences in serum UA and Xa/Hx concentrations were observed between two groups. It was concluded that green tea catechins can enhance the excretion of UA and Xa/HX, even though alcohol is ingested.

scholarly journals Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men

2020 ◽  
Author(s):  
Yuka Kawakami ◽  
Arisa Yasuda ◽  
Motoki Hayashi ◽  
Misuzu Akiyama ◽  
Toshihiko Asai ◽  
...  
Keyword(s):  
Uric Acid ◽  
Green Tea ◽  
Acid Metabolism ◽  
Acute Effect ◽  
Alcohol Ingestion ◽  
Total Serum ◽  
Japanese Men ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Randomized Crossover Study

Abstract Objective: Alcohol consumption is associated with hyperuricemia and gout. Previous studies have indicated a role for green tea catechins in uric acid (UA) metabolism. This study aimed to elucidate the acute effect of green tea catechins in terms of enhancing urinary excretion of UA and xanthine/hypoxanthine (Xa/HX; UA precursors) after alcohol ingestion.Methods: In a randomized crossover study, ten healthy Japanese subjects consumed test meals, including a Japanese distilled spirit (Shōchū) with water (SW) or Shōchū with catechin-rich green tea (SC), each containing 20 g of alcohol. The SC contained 617 mg of catechin in total. Serum and urine UA and Xa/HX concentrations were measured. Blood samples were collected after 2.5 h, and urine samples were collected between 0 and 5 h after consuming the test meal.Results: Urine UA and Xa/HX excretions were significantly higher in the SC group than in the SW group. UA clearance and fractional UA excretion tended to increase more in the SC group than in the SW group. No significant differences in serum UA and Xa/HX concentrations were observed between two groups.Conclusions: It was concluded that green tea catechins can enhance the excretion of UA and Xa/HX, even though alcohol is ingested.

scholarly journals Acute effect of green tea catechins on uric acid metabolism after alcohol ingestion in Japanese men

2021 ◽  
Author(s):  
Yuka Kawakami ◽  
Arisa Yasuda ◽  
Motoki Hayashi ◽  
Misuzu Akiyama ◽  
Toshihiko Asai ◽  
...  
Keyword(s):  
Uric Acid ◽  
Green Tea ◽  
Acid Metabolism ◽  
Acute Effect ◽  
Alcohol Ingestion ◽  
Japanese Men ◽  
Tea Catechins ◽  
Green Tea Catechins

Green tea catechins attenuate high-fat diet effects related to obesity and diabetes without effect hypothalamic expression of TLR4 pathway or serotoninergic 1B and 2C receptors

2013 ◽  
Author(s):  
Marcos Hiromu Okuda ◽  
de Santana Aline Alves ◽  
Mayara Franzoi Moreno ◽  
Ana Claudia Hachul ◽  
Nelson Inacio Neto ◽  
...  
Keyword(s):  
Green Tea ◽  
High Fat Diet ◽  
High Fat ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Obesity And Diabetes

The Protective Effects of Green Tea Catechins in the Management of Neurodegenerative Diseases: A Review

2019 ◽  
Vol 16 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Hanieh Shaterzadeh Yazdi ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathways ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Main Role ◽  
Related Factor ◽  
Protective Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
And Control

Background: The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of this study is to review the effects of green tea catechins against the Neurodegenerative Diseases. Methods: In this study, we extensively reviewed all articles on the terms of Green tea, catechins, CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017. Results: The present study found that catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers which possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-&amp;#954;B and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Conclusion: The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.<P&gt;

Neuroprotection of green tea catechins on surgical menopause-induced overactive bladder in a rat model

2012 ◽  
Vol 19 (3) ◽  
pp. 346-354 ◽  
Author(s):  
Yung-Shun Juan ◽  
Shu-Mien Chuang ◽  
Cheng-Yu Long ◽  
Chung-Hwan Chen ◽  
Robert M. Levin ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Green Tea ◽  
Rat Model ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Surgical Menopause
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