The association between bone metabolism markers and hypertension in osteoporotic patients
Abstract Background. Hypertension may be related to osteoporosis through increasing parathyroid hormone (PTH) and catecholamines which promote osteoclast differentiation and bone resorption. There are previous studies on the relationship between hypertension and bone turnover markers but they are still unclear. The aim of the case study is to examine the association between hypertension and the level of bone metabolism markers in osteoporotic patients. Methods. A cross-sectional study of 518 subjects was done to see the association between hypertension and the level of osteocalcin (OC), bone-specific alkaline phosphatase (B-ALP), Tartrate-resistant acid phosphatase (TRAP.5B) and 25-hydroxy vitamin D(25-OHD). All of the subjects were divided into two groups for analyzation: with or without hypertension. Subgroup analysis was based on sex for further analysis. The associations were assessed by the univariate analysis and multivariate regression analysis. Potential confounders were also adjusted for multivariate regression analysis. Results. There were 243(46.9%) osteoporosis patients with hypertension. Both univariate and multivariate analysis have suggested that lower OC and 25-OHD levels were associated with hypertension. The potential confounders-adjusted OC level was significantly lower in hypertensive female group than that in the female without hypertension group(β= -0.20, 95%CI= -0.37 to -0.03, P = 0.02 in final adjust model). The potential confounders-adjusted 25-OHD level was significantly lower in hypertensive male group than that in male without hypertension group (β= -0.34, 95%CI= -0.58 to -0.10, P = 0.01 in final adjust model). The B-ALP and TRACP.5B levels were positively associated with hypertension in univariate or multivariate analysis. In subgroup analysis, there was a consistent correlation between hypertension and B-ALP level in females and male subjects, but there was no consistent correlation between consistent correlation and TRACP.5B. However, all the correlations had no statistical significance for the B-ALP and TRACP.5B. Conclusions. In this study, hypertension was associated with low level of OC in female group and hypertension was associated with low level of 25-OHD level in male which show that OC and 25-OHD may play a role in bone loss.