scholarly journals Risk factors for severity of thrombocytopenia in full term infants: a single center study

2020 ◽  
Author(s):  
Amira M Saber ◽  
Shereen P Aziz ◽  
Al Zahraa E Almasry ◽  
Ramadan A Mahmoud
Keyword(s):  
Lupus Erythematosus ◽  
Neonatal Sepsis ◽  
Complete Blood Count ◽  
Mode Of Delivery ◽  
Full Term ◽  
Common Finding ◽  
Inclusion Criteria ◽  
Common Cause ◽  
Postoperative State ◽  
Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Severe NT occurred in 52.73% of cases. The most common cause of NT was neonatal sepsis, followed by a postoperative state. Furthermore, severe NT, when compared to mild/moderate NT associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions and had increased mortality.

scholarly journals Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

2020 ◽  
Author(s):  
Amira M Saber ◽  
Shereen P Aziz ◽  
Al Zahraa E Almasry ◽  
Ramadan A Mahmoud
Keyword(s):  
Lupus Erythematosus ◽  
Neonatal Sepsis ◽  
Complete Blood Count ◽  
Mode Of Delivery ◽  
Full Term ◽  
Common Finding ◽  
Inclusion Criteria ◽  
Term Infants ◽  
Postoperative State ◽  
Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Thrombocytopenia is a frequent challenge between neonatologists. The most common causes of NT in FT infants were neonatal sepsis, followed by postoperative state. Furthermore, when severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with the bad general condition of these patients due to their original disease.

scholarly journals Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

2020 ◽  
Author(s):  
Amira M Saber ◽  
Shereen P Aziz ◽  
Al Zahraa E Almasry ◽  
Ramadan A Mahmoud
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Mode Of Delivery ◽  
Full Term ◽  
Common Finding ◽  
Inclusion Criteria ◽  
Term Infants ◽  
Common Cause ◽  
Postoperative State ◽  
Platelet Transfusions

Abstract Background Neonatal thrombocytopenia (NT) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors and outcomes of severe NT in full term (FT) infants. Method: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases were recorded. Furthermore, neonatal data such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, blood count and outcomes for neonates admitted to the NICU were recorded. Results In total, 55 FT infants with NT met the inclusion criteria. In all, 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 37.03%), followed by a postoperative state (5 cases, 9.25%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT, when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P = 0.001), needed more platelet transfusions (P = 0.001) and had higher rates of mortality (P = 0.001). Conclusion Severe NT occurred in 52.73% of cases. The most common cause of NT was neonatal sepsis, followed by a postoperative state. Furthermore, severe NT, when compared to mild/moderate NT associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions and had increased mortality.

scholarly journals Risk factors for severity of thrombocytopenia in full term infants: a single center study

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Amira M. Saber ◽  
Shereen P. Aziz ◽  
Al Zahraa E. Almasry ◽  
Ramadan A. Mahmoud
Keyword(s):  
Risk Factors ◽  
Lupus Erythematosus ◽  
Neonatal Intensive Care ◽  
Complete Blood Count ◽  
Mode Of Delivery ◽  
Full Term ◽  
Common Finding ◽  
Inclusion Criteria ◽  
Term Infants ◽  
Platelet Transfusions

Abstract Background Neonatal thrombocytopenia (NT) (platelet count < 150 × 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants. Methods During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded. Results In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P = 0.001) and had higher rates of mortality (P = 0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P = 0.001). Conclusion Severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.

scholarly journals Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

2020 ◽  
Author(s):  
Amira M Saber ◽  
Shereen P Aziz ◽  
Al Zahraa E Almasry ◽  
Ramadan A Mahmoud
Keyword(s):  
Risk Factors ◽  
Lupus Erythematosus ◽  
Neonatal Intensive Care ◽  
Complete Blood Count ◽  
Mode Of Delivery ◽  
Full Term ◽  
Common Finding ◽  
Inclusion Criteria ◽  
Term Infants ◽  
Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.

scholarly journals Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

2020 ◽  
Author(s):  
Amira M Saber ◽  
Shereen P Aziz ◽  
Al Zahraa E Almasry ◽  
Ramadan A Mahmoud
Keyword(s):  
Risk Factors ◽  
Lupus Erythematosus ◽  
Neonatal Intensive Care ◽  
Complete Blood Count ◽  
Mode Of Delivery ◽  
Full Term ◽  
Common Finding ◽  
Inclusion Criteria ◽  
Term Infants ◽  
Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.

Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience

2019 ◽  
Vol 70 (8) ◽  
pp. 3008-3013
Author(s):  
Silvia Maria Stoicescu ◽  
Ramona Mohora ◽  
Monica Luminos ◽  
Madalina Maria Merisescu ◽  
Gheorghita Jugulete ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Neonatal Intensive Care ◽  
Complete Blood Count ◽  
Clinical Manifestations ◽  
Receiver Operating Curve ◽  
Predictive Values

Difficulties in establishing the onset of neonatal sepsis has directed the medical research in recent years to the possibility of identifying early biological markers of diagnosis. Overdiagnosing neonatal sepsis leads to a higher rate and duration in the usage of antibiotics in the Neonatal Intensive Care Unit (NICU), which in term leads to a rise in bacterial resistance, antibiotherapy complications, duration of hospitalization and costs.Concomitant analysis of CRP (C Reactive Protein), procalcitonin, complete blood count, presepsin in newborn babies with suspicion of early or late neonatal sepsis. Presepsin sensibility and specificity in diagnosing neonatal sepsis. The study group consists of newborns admitted to Polizu Neonatology Clinic between 15th February- 15th July 2017, with suspected neonatal sepsis. We analyzed: clinical manifestations and biochemical markers values used for diagnosis of sepsis, namely the value of CRP, presepsin and procalcitonin on the onset day of the disease and later, according to evolution. CRP values may be influenced by clinical pathology. Procalcitonin values were mainly influenced by the presence of jaundice. Presepsin is the biochemical marker with the fastest predictive values of positive infection. Presepsin can be a useful tool for early diagnosis of neonatal sepsis and can guide the antibiotic treatment. Presepsin value is significantly higher in neonatal sepsis compared to healthy newborns (939 vs 368 ng/mL, p [ 0.0001); area under receiver operating curve (AUC) for presepsine was 0.931 (95% confidence interval 0.86-1.0). PSP has a greater sensibility and specificity compared to classical sepsis markers, CRP and PCT respectively (AUC 0.931 vs 0.857 vs 0.819, p [ 0.001). The cut off value for presepsin was established at 538 ng/mLwith a sensibility of 79.5% and a specificity of 87.2 %. The positive predictive value (PPV) is 83.8 % and negative predictive value (NPV) is 83.3%.

Management of recurrent urinary infection

1967 ◽  
Vol 5 (10) ◽  
pp. 37-39
Keyword(s):  
Urinary Infection ◽  
Chronic Pyelonephritis ◽  
Common Finding ◽  
Common Cause ◽  
Urinary Infections ◽  
Women And Children

Recurrent urinary infections, particularly common in women and children, can lead to or be evidence of chronic pyelonephritis - a common finding at necropsy and a common cause of uraemic death, but often undiagnosed in life.

A Cross-Sectional Observational Study on Neonatal Thrombocytopenia in a Teaching Hospital in Telangana

2021 ◽  
Vol 8 (06) ◽  
pp. 337-341
Author(s):  
Rajesh Khanna Pulmamidi ◽  
Ramya Madhuri Yendamuri
Keyword(s):  
Observational Study ◽  
Teaching Hospital ◽  
Neonatal Sepsis ◽  
Late Onset ◽  
Birth Asphyxia ◽  
Predisposing Factors ◽  
Maternal Factors ◽  
Cross Sectional ◽  
Common Cause ◽  
Neonatal Thrombocytopenia

BACKGROUND Neonatal thrombocytopenia is one of the most common haematological abnormalities in neonates occurring in 1 to 2 % of healthy term neonates. Various risk factors like sepsis, prematurity, and birth asphyxia are known to be associated with this condition. Maternal factors also predispose to this condition. Early detection and appropriate management is of utmost importance to prevent complications. The aim of the study is to evaluate the predisposing factors for neonatal thrombocytopenia in a teaching hospital. METHODS This was a cross sectional observational study done in the Department of Peadiatrics, MediCiti Institute of Medical Sciences, Medchal, Telangana, for a duration of one year i.e., from January 2019 to December 2019. A total of 60 neonates with thrombocytopenia were studied for onset of thrombocytopenia, severity based on platelet counts, aetiology and for contributing maternal factors. RESULTS Early onset thrombocytopenia (< 3 days of age) was seen in 46.6 % (28 / 60) and late onset thrombocytopenia (3 - 28 days) in 53.3 % (32 / 60). The most common cause for neonatal thrombocytopenia was neonatal sepsis 30 % (10 / 60), followed by birth asphyxia. Common maternal predisposing factors were pregnancyinduced hypertension and pregnancy-induced diabetes mellitus. CONCLUSIONS Neonatal thrombocytopenia is one of the most common clinical problems in neonates. It can be of early or late onset type and has fetal and maternal predisposing factors. Neonatal sepsis is one of the most common cause for neonatal thrombocytopenia followed by birth asphyxia which is a preventable cause. Early diagnosis and thorough evaluation are needed to prevent complications. KEYWORDS Neonatal Thrombocytopenia, Neonatal Sepsis

Effect of Mode of Delivery, Parity and Umbilical Blood Gas on First Meconium Passage in Full-Term Healthy Neonates

Neonatology ◽  
1994 ◽  
Vol 66 (2-3) ◽  
pp. 146-149 ◽  
Author(s):  
Hiroshi Tateishi ◽  
Yoshitada Yarnauchi ◽  
Itsuro Yamanouchi ◽  
Mohamed T. Khasba
Keyword(s):  
Mode Of Delivery ◽  
Full Term ◽  
Blood Gas ◽  
Umbilical Blood
Sign in / Sign up

Export Citation Format

Share Document