Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Thrombocytopenia is a frequent challenge between neonatologists. The most common causes of NT in FT infants were neonatal sepsis, followed by postoperative state. Furthermore, when severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with the bad general condition of these patients due to their original disease.

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Risk factors for severity of thrombocytopenia in full term infants: a single center study

10.21203/rs.3.rs-26188/v2 ◽

2020 ◽

Author(s):

Amira M Saber ◽

Shereen P Aziz ◽

Al Zahraa E Almasry ◽

Ramadan A Mahmoud

Keyword(s):

Lupus Erythematosus ◽

Neonatal Sepsis ◽

Complete Blood Count ◽

Mode Of Delivery ◽

Full Term ◽

Common Finding ◽

Inclusion Criteria ◽

Common Cause ◽

Postoperative State ◽

Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Severe NT occurred in 52.73% of cases. The most common cause of NT was neonatal sepsis, followed by a postoperative state. Furthermore, severe NT, when compared to mild/moderate NT associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions and had increased mortality.

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Risk factors for severity of thrombocytopenia in full term infants: a single center study

Italian Journal of Pediatrics ◽

10.1186/s13052-021-00965-1 ◽

2021 ◽

Vol 47 (1) ◽

Author(s):

Amira M. Saber ◽

Shereen P. Aziz ◽

Al Zahraa E. Almasry ◽

Ramadan A. Mahmoud

Keyword(s):

Risk Factors ◽

Lupus Erythematosus ◽

Neonatal Intensive Care ◽

Complete Blood Count ◽

Mode Of Delivery ◽

Full Term ◽

Common Finding ◽

Inclusion Criteria ◽

Term Infants ◽

Platelet Transfusions

Abstract Background Neonatal thrombocytopenia (NT) (platelet count < 150 × 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants. Methods During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded. Results In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P = 0.001) and had higher rates of mortality (P = 0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P = 0.001). Conclusion Severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.

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Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

10.21203/rs.3.rs-26188/v4 ◽

2020 ◽

Author(s):

Amira M Saber ◽

Shereen P Aziz ◽

Al Zahraa E Almasry ◽

Ramadan A Mahmoud

Keyword(s):

Risk Factors ◽

Lupus Erythematosus ◽

Neonatal Intensive Care ◽

Complete Blood Count ◽

Mode Of Delivery ◽

Full Term ◽

Common Finding ◽

Inclusion Criteria ◽

Term Infants ◽

Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.

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Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

10.21203/rs.3.rs-26188/v1 ◽

2020 ◽

Author(s):

Amira M Saber ◽

Shereen P Aziz ◽

Al Zahraa E Almasry ◽

Ramadan A Mahmoud

Keyword(s):

Neonatal Sepsis ◽

Neonatal Intensive Care ◽

Mode Of Delivery ◽

Full Term ◽

Common Finding ◽

Inclusion Criteria ◽

Term Infants ◽

Common Cause ◽

Postoperative State ◽

Platelet Transfusions

Abstract Background Neonatal thrombocytopenia (NT) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors and outcomes of severe NT in full term (FT) infants. Method: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases were recorded. Furthermore, neonatal data such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, blood count and outcomes for neonates admitted to the NICU were recorded. Results In total, 55 FT infants with NT met the inclusion criteria. In all, 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 37.03%), followed by a postoperative state (5 cases, 9.25%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT, when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P = 0.001), needed more platelet transfusions (P = 0.001) and had higher rates of mortality (P = 0.001). Conclusion Severe NT occurred in 52.73% of cases. The most common cause of NT was neonatal sepsis, followed by a postoperative state. Furthermore, severe NT, when compared to mild/moderate NT associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions and had increased mortality.

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Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

10.21203/rs.3.rs-26188/v5 ◽

2020 ◽

Author(s):

Amira M Saber ◽

Shereen P Aziz ◽

Al Zahraa E Almasry ◽

Ramadan A Mahmoud

Keyword(s):

Risk Factors ◽

Lupus Erythematosus ◽

Neonatal Intensive Care ◽

Complete Blood Count ◽

Mode Of Delivery ◽

Full Term ◽

Common Finding ◽

Inclusion Criteria ◽

Term Infants ◽

Platelet Transfusions

Abstract Background: Neonatal thrombocytopenia (NT) (platelet count <150 x 109/L) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, risk factors, and outcomes of severe NT in full term (FT) infants.Methods: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data, such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases, including diabetes mellitus, pre-eclampsia, systemic lupus erythematosus, and immune thrombocytopenic purpura, were recorded. Furthermore, neonatal data, such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, complete blood count measurements, and outcomes for neonates admitted to the NICU, were recorded.Results: In total, 55 FT infants with NT met the inclusion criteria, and 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 36.35%), followed by a postoperative state (5 cases, 9.09%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT needed more platelet transfusions (P=0.001) and had higher rates of mortality (P=0.001) when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P=0.001).Conclusion: Severe NT compared to mild/moderate NT, associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions, and had increased mortality. Further research is needed to explain which of these complications related to severity of thrombocytopenia or were associated with original disease of the babies.

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Immunity Modification of Full Term Infants According to the Type of Feeding and Mode of Delivery

Case Medical Research ◽

10.31525/ct1-nct04256356 ◽

2020 ◽

Author(s):

Keyword(s):

Mode Of Delivery ◽

Full Term ◽

Term Infants

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Asthma and Mode of Birth Delivery: A Study in 5-Year-Old Dutch Twins

Twin Research and Human Genetics ◽

10.1375/twin.11.2.156 ◽

2008 ◽

Vol 11 (2) ◽

pp. 156-160 ◽

Cited By ~ 5

Author(s):

Toos C. E. M. van Beijsterveldt ◽

Dorret I. Boomsma

Keyword(s):

Gestational Age ◽

Mode Of Delivery ◽

Underlying Mechanism ◽

Full Term ◽

Asthma Prevalence ◽

Birth Cohorts ◽

Term Infants ◽

Mode Of Birth ◽

History Of ◽

The Relationship

AbstractSeveral studies report caesarean section (CS) to be a risk factor for childhood asthma. We used data from a large cohort of 5-year-old twins to examine the relationship between mode of birth delivery and asthma. The extent to which an infant is exposed to maternal vaginal flora may protect against the risk of developing asthma. Therefore, we expect a lower rate of asthma in twins born by vaginal delivery (VD) than those born by CS, and a lower rate of asthma in first-born twins compared to second-born twins by VD. Information on mode of delivery was obtained at the time of birth in a survey completed by the mother shortly after delivery. Information on history of asthma diagnosis by a physician was obtained by parental report when the twins were 5 years old. Complete data were available for 6330 first-born and 5438 second-born twins from birth cohorts 1991–2000. Full term first-born twins born by CS had a significantly higher risk of asthma compared to those born by VD, odds ratio = 1.59 (95% CI = 1.23–2.06). No significant differences were observed between CS and VD first-born twins when gestational age was less than 37 weeks, and no significant differences were observed between CS and VD second-born twins at any gestational age. No differences in asthma prevalence were found between first- and second-born twins both born by VD. CS may increase the risk of asthma to full term infants, however, the underlying mechanism is unclear.

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STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT

PEDIATRICS ◽

10.1542/peds.27.3.378 ◽

1961 ◽

Vol 27 (3) ◽

pp. 378-389

Author(s):

Marvin Cornblath ◽

Angelita F. Ganzon ◽

Demetrios Nicolopoulos ◽

Gloria S. Baens ◽

Richard J. Hollander ◽

...

Keyword(s):

Cesarean Section ◽

Carbohydrate Metabolism ◽

Newborn Infant ◽

Saline Solution ◽

Mode Of Delivery ◽

Capillary Blood ◽

Full Term ◽

Elective Cesarean Section ◽

Term Infants ◽

Elective Cesarean

Sugars in capillary blood were measured during the first hours of life in full-term infants delivered vaginally and by cesarean section. Pretreatment with dextrose solution for mothers delivered vaginally did not affect the course of the sugar in blood significantly Pretreatment with dextrose or saline solution for mothers delivered by cesarean section produced significant differences in the course of the infants' sugar in blood when compared to each other. Full-term infants delivered vaginally who were more than 6 hours old had a greater hyperglycemic response to glucagon, 30 µg/kg, than infants less than 3 hours of age. Full-term infants delivered by elective cesarean section without previous labor responded to 30 µg/kg of glucagon with a diminished hyperglycemia as compared to infants delivered vaginally. An exposure to labor influenced the neonates' response to glucagon, whereas neither pretreatment of the mother nor the course of sugar in blood were associated with this response. With large doses of glucagon, 300 µg/kg, the response differences associated with mode of delivery and maturity were not found to be significant.

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Comparison of blood glucose levels in breastfed vs. formula-fed low birth weight infants

Paediatrica Indonesiana ◽

10.14238/pi49.1.2009.15-9 ◽

2009 ◽

Vol 49 (1) ◽

pp. 15

Author(s):

Eli Tua Pangaribuan ◽

Bugis M. Lubis ◽

Pertin Sianturi ◽

Emil Azlin ◽

Guslihan D. Tjipta

Keyword(s):

Blood Glucose ◽

Birth Weight ◽

Low Birth Weight ◽

Low Birthweight ◽

Mode Of Delivery ◽

Full Term ◽

Low Birth Weight Infants ◽

Term Infants ◽

Glucose Levels ◽

Blood Glucose Levels

Background Low birth weight infants are defined as babies withbirth weight less than 2500 grams. Low birth weight infants tendto suffer from hypoglycemia compared to full term infants. Theincidence of hypoglycemia in newborns varies between 1.3 and 3per 1000 live births. Blood glucose levels in formula-fed infantsare lower than those in breastfed infants.Objective To compare blood glucose levels in breastfed andformula-fed low birth weight infants.Methods A cross sectional study was conducted between February2007 and June 2007 at Pirngadi and H. Adam Malik GeneralHospital in Medan, North Sumatra, Indonesia. All low birthweight babies were classified into two groups: the breastfed andformula-fed. Each group consisted of 32 infants. Capillary bloodwas collected using heel pricks at 1, 48, and 72 hours after birth,and plasma glucose was evaluated using the Glucotrend2 bloodglucose test.Results The breastfed low birth weight infants had significantlyhigher blood glucose levels (P=0.002) than formula-fed low birthweight infants. Mode of delivery was related to blood glucose level.Infant delivered by caesarean section had significantly differentblood glucose levels at 1 hour (P=0.005) and 72 hours afterbirth (P=0.027). The full-term infants had significantly higherblood glucose level (P=0.007) than the small for gestational ageinfants.Conclusions Generally, low birth weight infants have hypoglycemiaafter first hour of delivery. Breastfed low birth weight infants havehigher blood glucose levels than formula-fed low birth weightinfants.

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