scholarly journals Are there variations in hotspots in clinical malaria in pregnancy and neonatal malaria? Evidence from Ghana

2021 ◽  
Author(s):  
Naa-Korkor Allotey ◽  
Kofi Osae ◽  
Wahjib Mohammed ◽  
Agnes Millicent Kotoh ◽  
Ernest Kenu
Keyword(s):  
Public Health Problem ◽  
Routine Data ◽  
Clinical Malaria ◽  
Northern Region ◽  
Malaria In Pregnancy ◽  
Data Sets ◽  
Significant Public Health ◽  
Gis Software ◽  
Congenital Malaria ◽  
In Pregnancy

Abstract BackgroundMalaria in pregnancy (MIP) is a significant public health problem, and affects both mother and foetus. MIP has both direct and indirect effects. These direct effects attributed to malaria in pregnancy are clinical malaria in pregnancy and congenital malaria. Although there has been a steady decline of malaria in pregnancy (MIP); reducing from 9% in 2004 to 1.4% in 2016, the decline, does not seem equitable across the country. There was therefore a need to identify areas where clinical MIP and neonatal was high and target them for interventions (neonatal malaria was used because data for malaria was available only for the first 28 days). As a result, this study sought to use routine data to identify areas of high transmission (hotspots) for clinical malaria in pregnancy and neonatal malaria (extrapolating for congenital malaria hotspots).Methods Clinical MIP and neonatal malaria (suspected and confirmed) data were retrieved from the national routine database. Using expected pregnancy and all clinical malaria cases as the denominators of clinical malaria in pregnancy and clinical malaria respectively, the per 1000 cases of malaria in pregnancy and percentage neonatal malaria were calculated for both conditions. These two data sets were fed into ARC GIS software and hotspots spatially determined for both conditions from 2014 to 2016. ResultsVariations in hotspots were identified both chronologically and geospatially for clinical MIP and neonatal malaria respectively. Nevertheless, stable hotspots were found for clinical malaria in pregnancy for the three years and stable hotspots also identified for Neonatal malaria for two years. Congenital malaria was extrapolated from neonatal malaria data only for Bole District in the Northern Region of Ghana for 2015.Conclusions:Hotspots for malaria in pregnancy show marked variation year on year both for clinical malaria in pregnancy and neonatal malaria and vary geospatially. The differences in hotspots in clinical malaria in pregnancy and neonatal malaria also show that neonatal malaria cannot be attributed to congenital malaria and therefore is not the effect of malaria in pregnancy. However, stable hotspots for clinical malaria in pregnancy should be targeted for intervention.

scholarly journals Are There Variations in Hotspots in Clinical Malaria in Pregnancy and Neonatal Malaria? Evidence From Ghana

2021 ◽  
Author(s):  
NAA-KORKOR ALLOTEY ◽  
Kofi Osae ◽  
Wahjib Mohammed ◽  
Agnes Millicent Kotoh ◽  
Ernest Kenu
Keyword(s):  
Public Health Problem ◽  
Routine Data ◽  
Clinical Malaria ◽  
Northern Region ◽  
Malaria In Pregnancy ◽  
Data Sets ◽  
Significant Public Health ◽  
Gis Software ◽  
Congenital Malaria ◽  
In Pregnancy

Abstract BackgroundMalaria in pregnancy (MIP) is a significant public health problem, and affects both mother and foetus. MIP has both direct and indirect effects. These direct effects attributed to malaria in pregnancy are clinical malaria in pregnancy and congenital malaria. Although there has been a steady decline of malaria in pregnancy (MIP); reducing from 9% in 2004 to 1.4% in 2016, the decline, does not seem equitable across the country. There was therefore a need to identify areas where clinical MIP and neonatal was high and target them for interventions (neonatal malaria was used because data for malaria was available only for the first 28 days). As a result, this study sought to use routine data to identify areas of high transmission (hotspots) for clinical malaria in pregnancy and neonatal malaria (extrapolating for congenital malaria hotspots).Methods Clinical MIP and neonatal malaria (suspected and confirmed) data were retrieved from the national routine database. Using expected pregnancy and all clinical malaria cases as the denominators of clinical malaria in pregnancy and clinical malaria respectively, the per 1000 cases of malaria in pregnancy and percentage neonatal malaria were calculated for both conditions. These two data sets were fed into ARC GIS software and hotspots spatially determined for both conditions from 2014 to 2016. ResultsVariations in hotspots were identified both chronologically and geospatially for clinical MIP and neonatal malaria respectively. Nevertheless, stable hotspots were found for clinical malaria in pregnancy for the three years and stable hotspots also identified for Neonatal malaria for two years. Congenital malaria was extrapolated from neonatal malaria data only for Bole District in the Northern Region of Ghana for 2015.Conclusions:Hotspots for malaria in pregnancy show marked variation year on year both for clinical malaria in pregnancy and neonatal malaria and vary geospatially. The differences in hotspots in clinical malaria in pregnancy and neonatal malaria also show that neonatal malaria cannot be attributed to congenital malaria and therefore is not the effect of malaria in pregnancy. However, stable hotspots for clinical malaria in pregnancy should be targeted for intervention.

scholarly journals A brief review on features of falciparum malaria during pregnancy

2017 ◽  
Author(s):  
Alexandre Manirakiza ◽  
Eugène Serdouma ◽  
Richard Norbert Ngbalé ◽  
Sandrine Moussa ◽  
Samuel Gondjé ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Public Health Problem ◽  
Malaria In Pregnancy ◽  
Sub Saharan Africa ◽  
Malaria During Pregnancy ◽  
Concurrent Infections ◽  
Tropical Areas ◽  
Sub Saharan ◽  
Protection Against Infection ◽  
In Pregnancy

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

scholarly journals Epidemiological profile of patients served due to official accidents in the north of Brazil, Amazon Region, in the period from 2009 to 2019

2020 ◽  
pp. 47-59
Author(s):  
Larissa Queiroz Costa Carneiro ◽  
Isabela Menezes Barbosa ◽  
Igor de Souza Cardoso ◽  
Cláudio Alberto Gellis de Mattos Dias ◽  
Euzébio de Oliveira ◽  
...  
Keyword(s):  
Rural Areas ◽  
Public Health Problem ◽  
Secondary Data ◽  
Northern Region ◽  
Protective Equipment ◽  
The North ◽  
Unified Health System ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
Epidemiological Profile

Ophidian accidents are a significant public health problem worldwide, due to both their frequency and morbidity and mortality. In Brazil, during the years 2009 to 2019 there were 313,139 registered cases, of which 151,565 occurred in the North Region, making explicit the importance of studying this disease in that Region. The objective of the present study is to determine the epidemiological profile of the affected patients (age and sex), the accident itself (UF, month, year, time to attend) and the snake gender of the accidents that occurred in the Northern region of Brazil. Secondary data were obtained through access to the Information Department of the Brazilian Unified Health System (DATASUS), at the electronic address www.datasus.gov.br, in the SIH / SUS Hospital Information System. It was found that the accidents occurred mainly in rural areas, with men, in socioeconomically active age, caused by snakes of the Bothrops genus. Several cases could be classified as accidents at work, these could be avoided or minimized with appropriate personal protective equipment and guidelines.

scholarly journals Problem of Malaria Infection

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Soebaktiningsih .
Keyword(s):  
Public Health ◽  
Plasmodium Falciparum ◽  
Combination Treatment ◽  
Health Problem ◽  
Molecular Basis ◽  
Malaria Infection ◽  
Public Health Problem ◽  
Malaria In Pregnancy ◽  
Tropical Country ◽  
In Pregnancy

Malaria is still Public Health Problem in tropical country. Failure of Mefloquine – Artesunate combination treatment of uncomplicated Plasmodium falciparum beginning to fail is due to the delayed clearance times and elevated Artesunate IC50, suggest thatArtesunate resistance may be emerging on background of Mefloquine resistance ( Rogers et al 2009). Pathogenesis of malaria in pregnancy is related to the ability of Plasmodium falciparum intra erythrocyte to sequester in the placenta. Study to understand the molecular basis of susceptibility to malaria in pregnancy has been advanced through the discovery of Chondroitin Sulfat A (CSA) molecule that support the accumulation of infected erythrocytes (IE) by Plasmodium falciparum in the placenta

scholarly journals Impact of Insecticide Treated Nets and Intermittent Preventive Treatment in Reducing Malaria Morbidity among Pregnant Women in Gombe, Nigeria

2020 ◽  
Vol 24 (7) ◽  
pp. 1279-1282
Author(s):  
R. Ali ◽  
M.A. Qadeer ◽  
B. Mohammed ◽  
A. Sarki
Keyword(s):  
Pregnant Women ◽  
Malaria Parasite ◽  
Intermittent Preventive Treatment ◽  
Public Health Problem ◽  
Preventive Treatment ◽  
Malaria In Pregnancy ◽  
Major Public Health Problem ◽  
Insecticide Treated Nets ◽  
The Difference ◽  
In Pregnancy

Malaria in pregnancy is a major public health problem affecting women fetuses and new borns. Many studies highlight the critical importance of continuing the use of Insecticide Treated Nets (ITN) and Intermittent Preventive Treatment In Pregnancy (IPTp) among pregnant women to reduce the adverse consequences of malaria in pregnancy. This study was conducted in order to determine malaria prevalence in relation to the use ofITN and IPTp among the pregnant women in the study area. Five (5) ml of blood was obtained from each participant by the use of a sterile syringe and placed in a sterile EDTA container for laboratory analysis. The malaria parasite was detected by microscopic examination of Giemsa-stained thick blood films. Information on the use of ITN and IPTP was collected using administered questionnaire. A high prevalence of 78.4% was observed among the studied population. Although 74.4% of those that use ITN were positive for malaria parasite as against the 83.6% of those that reported not using the ITN, the difference was statistically not significant (p<0.05). 70.0% of those reported using IPTp were positive however, higher percentage was observed for those reported not using IPTp (83.7.0%). The difference was statistically significant in this case. This study has shown the influence of malaria prevention method during pregnancy on malaria infection and the need for targeted preventive starategies when  designing and implementing policies aimed at improving uptake of these measures during pregnancy in Gombe. Keywords: malaria, pregnant women, ITN, Gombe, IPTp  

scholarly journals Placental Plasmodium Parasitemia and Pregnancy Outcome In Asymptomatic Parturients at Term In A Tertiary Institution South East Nigeria

2021 ◽  
Author(s):  
Wilson Ndukwe Nwigboji ◽  
John Okafor Egede ◽  
Peace Chinyere Igwe ◽  
Matthew Nwali Igwe ◽  
Gregory Chinedu Nwigwe ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcome ◽  
Placental Malaria ◽  
Malaria In Pregnancy ◽  
Sub Saharan Africa ◽  
Categorical Variables ◽  
Maternal Anaemia ◽  
Congenital Malaria ◽  
In Pregnancy

Abstract Background: Malaria in pregnancy is a major public health problem in sub-Saharan Africa and can result in placental malaria with its associated adverse pregnancy outcomes.Method: This was a case control study involving 190 consenting, asymptomatic, booked parturients, recruited consecutively at 36 week. The aim was to determine the effect of placental malaria on pregnancy outcome in asymptomatic women delivering at term. The participants were screened for malaria parasites using peripheral blood film. Based on their results, the participants were grouped into parasitemia positive cases (Group 1) and parasitemia negative controls (Group 2). Both groups were then followed up in the clinic till they presented in labour at term. In labour, participants’ peripheral venous blood sample were collected and used to determine intrapartum haematocrit and peripheral parasitemia. After delivery, cord blood and a section of the placenta were collected for investigation. Data analysis: Collected data were analysed using Statistical Product and service solutions (SPSS) software (version 20). Numerical variables were presented as mean and standard deviation (Mean SD), while categorical variables were presented as numbers and percentages. Chi-square test(X2) was used to compare qualitative variables. Odds ratio (OR) and Confidence interval(CI) were used to observe the odds of outcomes. A p-value 0.05 was considered statistically significant.Results: The prevalence of placental malaria and congenital malaria were 41.05% and 29.47% respectively. Birth weight, APGAR score, NICU admission or congenital malaria were not statistically significant between the two groups. The mean birth weight was 3.16 ± 0.5 kg while 17.89% had low birth weight. There was also no significant difference between the two groups in terms of the association of placental parasitaemia and maternal anaemia or dose of IPT taken. There was no significant association between placental parasitaemia and low parity. Multivariate logistic regression analysis of maternal anaemia and low birth weight showed significant placental parasitaemia in both cases (p = 0.004). Conclusion: Placental parasitaemia is a major complication of malaria in pregnancy and is associated with adverse feto-maternal effects. Early booking and uptake of intermittent preventive therapy with sulphadoxine-pyrimethamine may help reduce the adverse effects.

scholarly journals Forecasting Confirmed Malaria Cases in Northwestern Province of Zambia: A Time Series Analysis Using 2014–2020 Routine Data

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Dhally M. Menda ◽  
Mukumbuta Nawa ◽  
Rosemary K. Zimba ◽  
Catherine M. Mulikita ◽  
Jim Mwandia ◽  
...  
Keyword(s):  
Time Series ◽  
Time Series Data ◽  
Moving Average ◽  
Health Information System ◽  
Public Health Problem ◽  
Routine Data ◽  
Series Data ◽  
District Health ◽  
Significant Public Health ◽  
Parsimonious Model

Background. Malaria remains a significant public health problem, especially in resource-poor settings. We aimed to forecast the year 2021 monthly confirmed malaria cases in the northwestern province of Zambia. Methods. The total number of confirmed monthly malaria cases recorded at health facilities over the past 7-years period (January 2014 to December 2020) was taken from the District Health Information System version 2 (DHIS.2) database. Box–Jenkins autoregressive integrated moving average (ARIMA) was used to forecast monthly confirmed malaria cases for 2021. STATA software version 16 was used for analyzing the time series data. Results. Between 2014 and 2020, there were 3,795,541 confirmed malaria cases in the northwestern province with a monthly mean of 45,185 cases. ARIMA (2, 1, 2) (0, 1, 1)12 was the best fit and the most parsimonious model. The forecasted mean monthly confirmed malaria cases were 60,284 (95%CI 30,969–121,944), and the total forecasted confirmed malaria cases were 723,413 (95%CI 371,626–1,463,322) for the year 2021. Conclusion. The forecasted confirmed malaria cases suggest that there will be an increase in the number of confirmed malaria cases for the year 2021 in the northwestern province. Therefore, there is a need for concerted efforts to prevent and eliminate the disease if the goal to eliminate malaria in Zambia by 2030 is to be realized.

Countering COVID-19 vaccine hesitancy in pregnancy: the “4 Cs”

2021 ◽  
Author(s):  
Lydia Shook ◽  
Thomas Kishkovich ◽  
Andrea Edlow
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
Professional Organizations ◽  
Vaccine Hesitancy ◽  
Safety And Efficacy ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
The Cost ◽  
In Pregnancy

Despite evidence to support the safety and efficacy of COVID-19 vaccination in pregnancy, and clear recommendations from professional organizations and the CDC for pregnant people to get vaccinated, COVID-19 vaccine hesitancy in pregnancy remains a significant public health problem. The emergence of the highly transmissible B.1.617.2 (Delta) variant among primarily unvaccinated people has exposed the cost of vaccine hesitancy. In this commentary, we explore factors contributing to COVID-19 vaccine hesitancy in pregnancy and potential solutions to overcome them.

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