scholarly journals Primary Extraskeletal Osteosarcoma of Sigmoid Mesocolon: A Case Report and a Review of the Literature

Author(s):  
Xinyang Nie ◽  
Weihua Fu ◽  
Chuan Li ◽  
Lu Li ◽  
Weidong Li

Abstract Background: Extraskeletal osteosarcoma (ESOS) is a very rare mesenchymal malignancy, characterized by the production of osteoid, bone or chondroid material and typically located in the soft tissue without attachment to skeletal bones and periosteum. One of the things that ESOS originated from mesentery is much rarer. Case presentation: A 75-year female with a more than 4-months history of pain in the left lower abdomen. Abdominal computerized tomography and magnetic resonance imaging revealed a large, irregular and solid-cystic mass, which largest diameter was 11.5cm. The tumor was radically removed during open operation. The tumor was composed of abundant osteoid and polyhedral-shaped tumor cells with high atypia and high mitotic activity microscopically. The final pathological diagnosis was osteoblastic osteosarcoma, arising from the sigmoid mesocolon with negative margins. The patient was followed up 5 months after surgery and found no signs of systemic metastasis Conclusion: Given the rarity of cases of mesenteric ESOS, diagnosis mainly depended on pathology findings or should be taken into consideration when the mesenteric mass was found. Its most effective treatment had not been determined, with surgical excision was generally accepted. Negative surgical margin may be an important factor affecting the prognosis.

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xinyang Nie ◽  
Weihua Fu ◽  
Chuan Li ◽  
Li Lu ◽  
Weidong Li

Abstract Background Extraskeletal osteosarcoma (ESOS) is a rare mesenchymal malignancy, which produces osteoid, bone, or chondroid material and is located in the soft tissue without attachment to skeletal bones and periosteum. One of the things that ESOS originated from mesentery is much rarer. Case presentation A 75-year female had a history of pain in the left lower abdomen for more than 4 months. Abdominal computerized tomography (CT) and magnetic resonance imaging revealed a large, irregular, and solid-cystic mass (largest diameter was 11.5 cm). The tumor was radically removed during an open operation. It was composed of abundant osteoid and polyhedral-shaped tumor cells with high atypia and high mitotic activity microscopically. The final pathological diagnosis was osteoblastic osteosarcoma, arising from the sigmoid mesocolon with negative margins. A 9-month follow-up by CT exhibited signs of peritoneal metastasis. Conclusions Given the rarity of cases of mesenteric ESOS, diagnosis mainly depended on pathology findings or should be taken into consideration when the mesenteric mass was found. Its most effective treatment had not been determined, with surgical excision being generally accepted. Ensuring negative surgical margins may be an important factor affecting prognosis.


2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Yunus Oc ◽  
Muhammed Sefa Ozcan ◽  
Hasan Basri Sezer ◽  
Bekir Eray Kilinc ◽  
Osman Tugrul Eren

In most of the cases trauma is the leading etiology and the nontraumatic myositis ossificans (MO) is a very rare condition. We present an MO case without any trauma occurring. A 36-year-old female patient with a history of pain and restriction of range of motion of the left hip was admitted. Hip motions were restricted with 10–60° of flexion, 10° of internal rotation, 20° of external rotation, 10° of abduction, and 10° of adduction. There was no history of trauma and familial involvement. The biopsy of the lesion revealed mature bone tissue confirming our diagnosis of MO. The mass was removed surgically and postoperatively the patient was treated with a single dose radiotherapy with 800 gyc. MO is a benign and well differentiated bone formation or in other words heterotopic ossification of the muscle tissue. It has a prevalence of less than 1/1 million. Trauma is the most frequent etiological factor seen in almost 60–75% of the cases. Nontraumatic MO is very rare in the literature. Our patient had no history of trauma or familial involvement. Combination of the surgical excision with radiotherapy in the treatment of the MO of the hip may give satisfactory results.


FACE ◽  
2021 ◽  
pp. 273250162110536
Author(s):  
Joshua Harrison ◽  
Samantha Marley ◽  
Shawhin Shahriari ◽  
Christian Bowers ◽  
Anil Shetty

We report a rare case of an extramedullary plasmacytoma (EMP) in the frontal sinus with an indolent clinical presentation. Although a history of trauma was absent, the initial diagnosis was a mucocele, based on the radiological findings. Upon surgical excision, the patient was found to have an EMP. EMP, a form of solitary plasmacytoma, has a significantly high rate of conversion to multiple myeloma. This mandates long-term follow-up, even after successful radiotherapy and/or resection. While radiation therapy is generally considered a first line treatment for EMP, surgical intervention may provide optimal treatment in complicated cases. This case presentation highlights the prognosis of patients diagnosed with EMP.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jingwen Hui ◽  
Yun Zhao ◽  
Lei Zhang ◽  
Jinyong Lin ◽  
Hong Zhao

Abstract Background Extraskeletal osteosarcoma is a malignant tumour composed of an osteoid and/or cartilaginous matrix; it arises in soft tissues without connection to the skeleton, and to our knowledge, this type of tumour is extremely rare. Case presentation The present study reports a 57-year-old man with primary orbital extraskeletal osteosarcoma who presented with a history of painful swelling in the left orbit that had occurred for 11 months. Imaging of the orbit showed an atypical, well-defined heterogeneous mass attached to the posterior globe of the left orbit. The patient underwent an anterior orbitotomy and complete excision of the tumour. The mass was originated from neither the globe nor the bony orbital wall but from the soft tissue. Histopathology demonstrated an extraskeletal osteosarcoma. After 13 months of follow-up, there was apparent recurrence of the tumour. The medical history showed no complaints of previous trauma or radiotherapy. Conclusions ESOS is a highly malignant tumour. Immunosuppression, trauma and adjuvant radiotherapy are possible predisposing factors in the development of this tumour. Prompt recognition and thorough treatment are essential for preventing orbital lesions and presence of metastasis from other organs.


2018 ◽  
Vol 85 (4) ◽  
pp. 182-185
Author(s):  
Costantino Ricci ◽  
Martina S Rossi ◽  
Roberta De Stefano ◽  
Michelangelo Fiorentino ◽  
Francesco Vasuri

Case presentation: A 55-year-old man with a history of basaloid squamous cell carcinoma of the oropharynx with laterocervical lymph node metastases 6 years before (and treated with chemoradiation) presented with flank pain and hematuria. Computed tomography scan found a renal lesion, with radiological features more suspicious for primitive renal neoplasia. Histopathological and immunohistochemical examination after surgical excision revealed a basaloid squamous cell carcinoma involving renal parenchyma. Conclusion: Basaloid squamous cell carcinoma is a rare tumor but with a high percentage of distant metastasis, and it is mandatory, also for a general pathologist, to know this disease. Moreover, in a patient with renal metastases, any type of cancer should be taken into account, and this case is emblematic of why the previous medical history is crucial for differential diagnosis.


2020 ◽  
Vol 26 (1) ◽  
Author(s):  
P. A. Egharevba ◽  
O. Omoseebi ◽  
A. I. Okunlola ◽  
O. A. Omisanjo

Abstract Background Leiomyomas are benign smooth muscle tumours predominantly found in the uterus. Rarely, they may be located in the ovaries, scrotum, bladder, lungs, vascular structures and spermatic cord. Case presentation We managed a 39-year-old man who presented with a year history of progressive right-sided hemiscrotal swelling. The right scrotal mass was excised, and histology showed scrotal leiomyoma. Conclusion Scrotal leiomyoma is very rare and challenging to diagnose pre-operatively as a cause of scrotal swelling, but it is amenable to surgical excision.


2019 ◽  
Vol 25 (1) ◽  
Author(s):  
J. Pineda-Murillo ◽  
J. A. Lugo-García ◽  
G. Martínez-Carrillo ◽  
J. Torres-Aguilar ◽  
C. Viveros-Contreras ◽  
...  

Abstract Background The Buschke–Löwenstein tumor comes from the confluence of multiple condyloma acuminata and is clinically manifested by warty, exophytic, ulcerated lesions, with aggressive behavior, rapid growth, invasion and destruction of adjacent structures. Case presentation A 57-year-old man with type II diabetes mellitus, high blood pressure and a history of high-risk sexual behavior with multiple partners was evaluated in the urology department for multiple penile lesions of verrucous appearance and fetid odor of 10 months of evolution. Biopsy of the lesion was performed revealing a giant condyloma acuminatum. Conclusions Radical surgical excision with wide surgical margins remains the first line of treatment. Close follow-up of these patients is crucial given the complexity and tumor recurrence.


2021 ◽  
Author(s):  
Basma Morsy ◽  
Eglal Moussa ◽  
Nourhan Aly ◽  
Enas Omar ◽  
Samar El Achy

Abstract BackgroundPleomorphic adenoma (PA) is the most common benign salivary gland tumor. Many factors have been implicated in the etiology of PA, one of which is genetic alteration in PLAG1 and HMGA2 genes. Few cases were reported about PAs appearing in patients with history of trauma or denture wear.Case presentationA 73-year-old female patient presented to the clinic with a gradually increasing mass that appeared two months ago in the upper left labial vestibule. The patient reported wearing a maxillary complete denture for 15 years. Clinical examination revealed a typical denture fissuratum, so surgical excision was the treatment of choice. Upon excision, a fully encapsulated mass was exposed and sent for histological and immunohistochemical analyses that confirmed a final diagnosis of PA.ConclusionThis case suggests a contributory role for trauma in the development of PA, following DNA alterations or through oxidative stress resulting from Chronic Mechanical Irritation (CMI).


2009 ◽  
Vol 45 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Juri Ota ◽  
Jacqueline W. Pearce ◽  
Michael J. Finn ◽  
Gayle C. Johnson ◽  
Elizabeth A. Giuliano

This case series constitutes a report of dacryops in multiple Labrador retrievers and the use of smooth-muscle actin immunostaining to confirm the lacrimal duct origins of the cyst wall. Three Labrador retrievers were presented with a history of a slowly enlarging mass adjacent to the left medial canthus. Ultrasonography of the masses revealed they were each spherical, thin-walled cystic structures. Aspiration cytology was performed in two cases revealing mixed inflammation and absence of detectable microorganisms. Dacryocystorhinography of the left nasolacrimal system performed in two cases revealed a normal nasolacrimal system that was closely associated, but not communicating with, the cystic mass in both cases. Surgical excision of all cysts was curative. Histopathology and positive immunohistochemical staining for smooth-muscle actin confirmed a diagnosis of dacryops in all cases.


BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Qingfang Zhao ◽  
Hui Lu

Abstract Background Giant cell tumor of the tendon sheath (GCTTS) is a benign soft tissue (synovial membrane) tumor that rarely involves the hands or wrists. And Tendon impairment caused by GCTTS is extremely rare. Case presentation Here, we reported a case of a 60-year-old female with a 10-year history of gradually increasing mass in her left dorsal wrist. The EIP tendon was partially impaired by the mass.The patient was treated with surgical excision of the mass and reconstruction of the EIP tendon. The histopathological examination suggested the presence of GCTTS. After surgery, the patient had adequate functional recovery and no tumor recurrence after 2 years’ follow-up. Conclusion GCTTS in hands and wrists rarely damages the tendon. Early diagnosis and proactive interventions may likely contribute to good prognostic outcomes.


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