scholarly journals Comparison of Bromocriptine and Hydroxyethyl Starch for Reducing Ohss in in Vitro Fertilization Patients: A Retrospective Study

2021 ◽  
Author(s):  
Qiaoli Zhang ◽  
Yanmin Ma ◽  
Xiaomeng Bu ◽  
Chanwei Jia ◽  
Yanjun Liu ◽  
...  
Keyword(s):  
Renal Function ◽  
Retrospective Study ◽  
Hydroxyethyl Starch ◽  
Clinical Effectiveness ◽  
Oocyte Retrieval ◽  
Rectal Administration ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization

Abstract Background: The ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication associated with controlled ovarian hyperstimulation (COS) during assisted reproductive technology (ART) treatment, and effective preventive measures are urgently needed. The dopamine agonist can mitigate OHSS incidence through a decreased vascular permeability via reduced vascular endothelial growth factor (VEGF) production. This study evaluated the clinical effectiveness of bromocriptine, an alternative DA, for prevention of OHSS in high risk women.Methods: The retrospective study population consisted of women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles with GnRH antagonist protocols, at risk of OHSS. The study group included 52 women given 2.5 mg bromocriptine daily by rectal insertion for 5 days beginning on the day of oocyte retrieval; the control group included 52 women given 500 ml intravenous (I.V.) hydroxyethyl starch (HES) daily for 5 days also beginning on the day of oocyte retrieval. The outcomes of ovarian stimulation, incidence and severity of OHSS, blood-related indicators, biochemical indicators (liver and renal function), and coagulation and fibrinolytic activities were compared.Results: The groups were not significantly different in age, estradiol concentration on the day of human chorionic gonadotropin injection, or number of retrieved oocytes. The occurrence of mild (13.46% vs 15.48%) and moderate (7.69% vs 5.77%) OHSS were not significantly different between bromocriptine and HES groups (P>0.05). No cases of severe or late OHSS were recorded in either group. Only hemocratin levels were significantly higher and activated partial thromboplastin time was significantly lower in the bromocriptine group (P<0.05) compared to the HES group on Day 5 after oocyte retrieval. No difference in liver or renal function was found between groups.Conclusions: Prophylactic rectal administration of bromocriptine was as effective as I.V. HES for prevention of OHSS.

scholarly journals Oxidative Stress Reduction by Midazolam Premedication during Oocyte Retrieval Procedure: Pilot Study

2021 ◽  
Vol 10 (4) ◽  
pp. 855
Author(s):  
Maja Pešić ◽  
Katarina Kličan-Jaić ◽  
Marinko Vučić ◽  
Krunoslav Kuna ◽  
Andro Košec ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pilot Study ◽  
In Vitro Fertilization ◽  
Stress Reduction ◽  
Catalase Activity ◽  
Oocyte Retrieval ◽  
Control Group ◽  
Medical Problems ◽  
Vitro Fertilization

Infertility is one of the major medical problems nowadays. Couples who opt for In Vitro Fertilization (IVF) face a great deal of stress which certainly affects the outcome of the procedure. Therefore, we aimed to reduce the stress during the oocyte retrieval procedure by applying midazolam. Total oxidant (TOC) and antioxidant (TAC) capacities of serum, as well as glutathione (GSH) content and catalase activity, were measured in both control and midazolam groups. Follicular fluid was also tested for oxidant capacity and IL1β. Results implied that the midazolam group increased TAC at the end of the procedure. At the same time, the control group decreased GSH at the beginning of the procedure, and both groups decreased catalase activity at the end of the procedure. The results imply that stress during the procedure affects oxidative and antioxidative parameters of the patients, but did not affect the frequency of the pregnancy at the end of this pilot study. Yet, the results imply that oxidative and antioxidative mechanisms during IVF should be investigated in detail as they could affect the outcome of IVF.

scholarly journals Frozen vs. Fresh Cycles IVF Outcomes: Retrospective study from an Indonesian IVF centre

2021 ◽  
Author(s):  
Wiryawan Permadi ◽  
Hartanto Bayuaji ◽  
Kevin Tjandraprawira ◽  
Dian Tjahyadi ◽  
Harris Harlianto ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Secondary Data ◽  
Oocyte Retrieval ◽  
Vitro Fertilization ◽  
Indonesian Population ◽  
Biochemical Pregnancy ◽  
Significant Difference ◽  
Cycle Group ◽  
Recruitment Period

Abstract Objective to compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018−31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (112/351) frozen cycles. AMH was significantly higher in frozen cycle group (p = 0.04). Ovulatory disorder was significantly higher in frozen cycle group (p = 0.001). Among patients aged ≤ 30, fresh cycle group had significantly higher LBR (p = 0.02). Among those with ovulatory disorder, LBR was significantly higher with frozen cycle. No significant LBR difference was noted with other infertility causes. When stratified according to pregnancy order, frozen cycle patients had significantly higher birth lengths (p = 0.03) but not length of gestation nor neonatal birthweights. There was no significant difference in the proportion of biochemical pregnancy resulting in LBR (p = 0.08).

scholarly journals Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Ying Huang ◽  
Yong Zhao ◽  
Ling Yan ◽  
Yun-Hai Chuai ◽  
Ling-Ling Liu ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Controlled Ovarian Hyperstimulation ◽  
Endocrine Function ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
The Status ◽  
Pcos Group ◽  
Ovarian Syndrome

Background. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes.Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH) process.Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal endocrine function composed the control group. All participants underwent GnRH agonist standard long protocol, and plasma HCY, FVIII, FX, and D-dimer levels as well as hormone parameters were measured at day of full downregulation, hCG priming, and embryos transfer.Results. On day of full downregulation, FX levels were significantly higher in PCOS group (P<0.01). On hCG priming day, FX and estrogen levels in PCOS group were higher than in the control group and FVIII levels were significantly lower on day of embryos transfer whereas FX and E2 levels were significantly higher in PCOS group.Conclusion. Hypercoagulable state during peri-implantation phase would probably lead to poor microcirculation of endometrium and be one of the most important disadvantages of successful implantation and subsequent clinical pregnancy.

Recent Techniques used in Reproductive Medicine: Outcomes for Gametes Manipulation

2020 ◽  
Vol 16 ◽  
Author(s):  
Masoumeh Ghafarzadeh
Keyword(s):  
In Vitro Fertilization ◽  
Intracytoplasmic Sperm Injection ◽  
Reproductive Medicine ◽  
Assisted Reproductive Technologies ◽  
Oocyte Retrieval ◽  
Reproductive Technologies ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
Live Births

: Assisted Reproductive Technologies (ART) has significantly improved the chances of pregnancy. In Vitro Fertilization (IVF) remains the most widely used ART procedure, which involves a series of steps like ovarian hyperstimulation followed by vaginal oocyte retrieval and in vitro fertilization of the oocytes with sperm, culture of the embryos, and the final transfer of the embryo to the recipient or surrogate recipient. Intracytoplasmic sperm injection (ICSI), another form of ART, is developed to circumvent the problems encountered in IVF. However, the studies have indicated that only about one-third of ART cycles result in live births. This review is designed to provide a comprehensive idea about advances in reproductive medicine in terms of preparation of gametes and implantation.

Severe ovarian hyperstimulation despite prophylactic albumin at the time of oocyte retrieval for in vitro fertilization and embryo transfer*

1995 ◽  
Vol 64 (3) ◽  
pp. 641-643 ◽  
Author(s):  
Tanmoy Mukherjee ◽  
Alan B. Copperman ◽  
Benjamin Sandler ◽  
Maria Bustillo ◽  
Larry Grunfeld
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Oocyte Retrieval ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization

scholarly journals Correlation Between Vascular Endothelial Growth Factor (VEGF) and Ovarian Hyperstimulation Syndrome (OHSS); A Retrospective Study.

2020 ◽  
pp. 1-13
Keyword(s):  
Retrospective Study ◽  
In Vitro Fertilization ◽  
Ovarian Hyperstimulation Syndrome ◽  
Clinical Parameter ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
Significant Difference ◽  
Duration Of Hospitalization ◽  
Endothelial Growth Factor

Abstract Purpose: In the context of in vitro fertilization treatment ovarian hyperstimulation syndrome can lead to a serious illness. Its pathogenesis is not fully understood, but is associated with several cytokines, enzymes and growth factors. VEGF is considered among others to be a significant factor. The aim of the present study was to investigate whether there are correlations between VEGF serum concentrations and clinical and biochemical parameters of ovarian hyperstimulation syndrome. Thus, VEGF could be used as a clinical parameter of ovarian hyperstimulation syndrome. Methods: Three patient groups were formed in which VEGF measurements were performed. In the first group, patients with ovarian hyperstimulation syndrome after stimulation treatment and hospitalization were examined. In the second group, patients with stimulation for in vitro fertilization but without OHSS were considered and in the third group, patients without stimulation treatment were recorded. The groups were comparatively statistically evaluated. Results: There was a clear association between the VEGF scores and duration of hospitalization in the diseased patients. The VEGF determinations did not differentiate between stimulated patients with and without ovarian hyperstimulation syndrome. However, there was a significant difference between stimulated and unstimulated patients. Conclusion: The determination of VEGF seems to be of limited use as a clinically useful parameter for the assessment and prognosis of ovarian hyperstimulation syndrome. Methodological weakness of the retrospective study design should be a reason for caution in interpreting the results.

Sign in / Sign up

Export Citation Format

Share Document