Impact of Factors on Acute Radiation Oral Mucositis for Nasopharyngeal Carcinoma Patients Treated with Concurrent Intensity-Modulated Radiation Therapy and Chemoradiotherapy:A Retrospective Study

Background To retrospectively studied the medical records in the latest 4 years in order to investigate the occurrence and influencing factors of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy. Methods Between January 2014 and December 2018, 262 patients with non-metastatic nasopharyngeal carcinoma treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy were enrolled in the study.The patients' age,gender,body mass index,smoking,diabetes,clinical stage, hematological parameters before radiotherapy before radiotherapy(leukocyte count,erythrocyte count,hemoglobin level,platelet count,lymphocyte count, neutrophil count),PGTV, PCTV1, PCTV2, induction chemotherapy, concurrent chemotherapy interval(weekly or three-weekly chemotherapy) and the concurrent chemotherapeutic drugs (single cisplatin or single lobaplatin or docetaxel plus cisplatin regimen) were examined, and the associations of variables with oral mucositis were analyzed by multivariate logistic regression analysis. Results Only platelet count before radiotherapy is the risk factor for grade 2 and higher acute oral mucositis(p = 0.028) with an odds ratio of 1.005 (95% CI: 1.001–1.009).There was no difference in the risk of grade 2 and higher oral mucositis between the single platinum regimen and docetaxel plus cisplatin regimen.The study also found similar responses to oral mucositis between weekly regimen and three-weekly regimen. Conclusion The present retrospective study demonstrated that certain factor may predispose patients with with nasopharyngeal carcinoma treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy to develop oral mucositis.