Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: A single-center analysis of 2570 patients

Abstract Background: Fibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to determine the incidence of TBI-associated hypofibrinogenemia in patients with TBI and to evaluate the prognostic value of fibrinogen level with respect to mortality and clinical outcomes. Methods: A total of 2570 consecutive TBI patients were retrospectively studied. Prognostic evaluations were determined using the Glasgow Outcome Score (GOS) assessment 3 months after injury. The shape of the relationship between fibrinogen level and mortality or outcome was examined using cubic spline functions. Logistic regression analyses were conducted to identify the association between fibrinogen level and 3-month functional outcomes.Results: Fibrinogen concentrations < 2 g/L were observed in 992 (38.6%) patients at the time of admission. Multivariate analyses showed that for patients with fibrinogen levels < 2.0 g/L, those levels were an independent prognostic factor for 3-month mortality (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.89–0.93; P < .001). By contrast, for patients with fibrinogen levels < 2.5 g/L, the levels were an independent prognostic factor for favorable outcomes at 3 months (OR, 1.654; 95% CI, 1.186–2.306; P = .003). Similar results were also seen for patients with fibrinogen levels > 3.0 g/L, with the levels being an independent prognostic factor for favorable outcomes at 3 months (OR, 0.771; 95% CI, 0.607–0.979; P = .033). Conclusions: Fibrinogen is an independent prognostic factor for clinical outcomes in TBI patients. Maintaining the level of fibrinogen between 2.5 and 3 g/L may improve clinical outcomes in patients with TBI.

Download Full-text

Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: a single-center analysis of 2570 patients

World Journal of Emergency Surgery ◽

10.1186/s13017-020-00332-1 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Ke Lv ◽

Qiang Yuan ◽

Pengfei Fu ◽

Gang Wu ◽

Xing Wu ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Prognostic Factor ◽

Clinical Outcomes ◽

Fibrinogen Level ◽

Independent Prognostic Factor ◽

Trauma Patients ◽

Disease Prognosis ◽

Time Of Admission ◽

The Relationship

Abstract Background Fibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to determine the incidence of TBI-associated hypofibrinogenemia in patients with TBI and to evaluate the prognostic value of fibrinogen level with respect to mortality and clinical outcomes. Methods A total of 2570 consecutive TBI patients were retrospectively studied. Prognostic evaluations were determined using the Glasgow Outcome Score (GOS) assessment 3 months after injury. The shape of the relationship between fibrinogen level and mortality or outcome was examined using cubic spline functions. Logistic regression analyses were conducted to identify the association between fibrinogen level and 3-month functional outcomes. Results Fibrinogen concentrations < 2 g/L were observed in 992 (38.6%) patients at the time of admission. Multivariate analyses showed that for patients with fibrinogen levels < 2.0 g/L, those levels were an independent prognostic factor for 3-month mortality (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.89–0.93; P < .001). By contrast, for patients with fibrinogen levels < 2.5 g/L, the levels were an independent prognostic factor for favorable outcomes at 3 months (OR, 1.654; 95% CI, 1.186–2.306; P = .003). Similar results were also seen for patients with fibrinogen levels > 3.0 g/L, with the levels being an independent prognostic factor for favorable outcomes at 3 months (OR, 0.771; 95% CI, 0.607–0.979; P = .033). Conclusions Fibrinogen is an independent prognostic factor for clinical outcomes in TBI patients. Maintaining the level of fibrinogen between 2.5 and 3 g/L may improve clinical outcomes in patients with TBI.

Download Full-text

Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: A single-center analysis of 2570 patients

10.21203/rs.3.rs-47508/v3 ◽

2020 ◽

Author(s):

Ke Lv ◽

Qiang Yuan ◽

Pengfei Fu ◽

Gang Wu ◽

Xing Wu ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Prognostic Factor ◽

Clinical Outcomes ◽

Fibrinogen Level ◽

Independent Prognostic Factor ◽

Trauma Patients ◽

Disease Prognosis ◽

Time Of Admission ◽

The Relationship

Abstract Background: Fibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to determine the incidence of TBI-associated hypofibrinogenemia in patients with TBI and to evaluate the prognostic value of fibrinogen level with respect to mortality and clinical outcomes. Methods: A total of 2570 consecutive TBI patients were retrospectively studied. Prognostic evaluations were determined using the Glasgow Outcome Score (GOS) assessment 3 months after injury. The shape of the relationship between fibrinogen level and mortality or outcome was examined using cubic spline functions. Logistic regression analyses were conducted to identify the association between fibrinogen level and 3-month functional outcomes.Results: Fibrinogen concentrations < 2 g/L were observed in 992 (38.6%) patients at the time of admission. Multivariate analyses showed that for patients with fibrinogen levels < 2.0 g/L, those levels were an independent prognostic factor for 3-month mortality (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.89–0.93; P < .001). By contrast, for patients with fibrinogen levels < 2.5 g/L, the levels were an independent prognostic factor for favorable outcomes at 3 months (OR, 1.654; 95% CI, 1.186–2.306; P = .003). Similar results were also seen for patients with fibrinogen levels > 3.0 g/L, with the levels being an independent prognostic factor for favorable outcomes at 3 months (OR, 0.771; 95% CI, 0.607–0.979; P = .033). Conclusions: Fibrinogen is an independent prognostic factor for clinical outcomes in TBI patients. Maintaining the level of fibrinogen between 2.5 and 3 g/L may improve clinical outcomes in patients with TBI.

Download Full-text

The relationship of psychological and cognitive factors and opioids in the development of the postconcussion syndrome in general trauma patients with mild traumatic brain injury

Journal of the International Neuropsychological Society ◽

10.1017/s1355617706060978 ◽

2006 ◽

Vol 12 (06) ◽

Cited By ~ 49

Author(s):

SUSANNE MEARES ◽

E. ARTHUR SHORES ◽

JENNIFER BATCHELOR ◽

IAN J. BAGULEY ◽

JENNIFER CHAPMAN ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Cognitive Factors ◽

Trauma Patients ◽

Postconcussion Syndrome ◽

General Trauma ◽

Relationship Of ◽

The Relationship

Download Full-text

Influence of Concomitant Injuries on Outcome of Traumatic Brain Injury

Bangladesh Critical Care Journal ◽

10.3329/bccj.v8i1.47704 ◽

2020 ◽

Vol 8 (1) ◽

pp. 24-28

Author(s):

Md Aminul Islam ◽

Shamantha Afreen ◽

Al Amin Salek

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Head Injury ◽

Prognostic Factor ◽

Length Of Hospital Stay ◽

Whole Body ◽

Trauma Patients ◽

Good Recovery ◽

Concomitant Injuries ◽

The Brain

Traumatic brain injury (TBI) is a leading cause of death and disability in trauma patients. Patients with TBI frequently sustain concomitant injuries in extra cranial regions. The effect of severe extracranial injury (SEI) on the outcome of TBI is controversial. We retrospectively enrolled 129 patients with head injury Total patients were dichotomized into isolated TBI (n = 90) and TBI associated with SEI (n = 39). The differences in severity and outcome between these two groups were analyzed. Mortality was 8.89 % in the isolated TBI group and 20.28 % in TBI with SEI group (P = 0.0719), but the Glasgow Outcome Scale (GOS) in terms of Good Recovery (GR) was more in the isolated TBI group (P = 0.0004). Adjusting for age, GCS, and length of hospital stay, SEI was a strong prognostic factor for mortality. It is important to manage not only the brain but the whole body in the treatment of TBI patients with SEI. Bangladesh Crit Care J March 2020; 8(1): 24-28

Download Full-text

Fever as an independent prognostic factor in traumatic brain injury

Romanian Neurosurgery ◽

10.33962/roneuro-2020-067 ◽

2020 ◽

pp. 424-426

Author(s):

Sanjeev Chhabra ◽

Srikrishna Majhi ◽

Saha Sabyasachi

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Prognostic Factor ◽

Glasgow Outcome Scale ◽

Poor Prognosis ◽

Temperature Monitoring ◽

Independent Prognostic Factor ◽

High Fever ◽

Clinical Prognosis

Traumatic Brain Injury (TBI) patients more often than not develop fever within the first few days of their hospitalization. Studies report that causes are variable and according to the pathogenesis, fever may be harmful or protective. The study was conducted to correlate the development of fever with clinical prognosis. Throughout the study spanning 6 months, a total of 98 patients of TBI were included. In the first 48 hours, 54 patients did not develop fever (temperature >37?), 20 patients recorded temperatures between 37? and 39?; and 24 patients developed high fever (39?). On regular temperature monitoring and follow up, it was found that patients developing fever relatively early during hospitalization were more likely to end up with a poor outcome (Glasgow outcome scale 4 to 5). Therefore, fever is independently a predictor of poor prognosis in TBI patients and should be managed diligently in the first few days.

Download Full-text

The relationship between brain tissue oxygen partial pressure thresholds and microdialysis markers of ischaemia in traumatic brain injury

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0561 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S561-S561

Author(s):

Jurgens Nortje ◽

Peter J Hutchinson ◽

David A Zygun ◽

Pippa G Al-Rawi ◽

Mark T O'Connell ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Oxygen Partial Pressure ◽

Partial Pressure ◽

Brain Tissue ◽

Tissue Oxygen ◽

Brain Tissue Oxygen ◽

The Relationship ◽

Tissue Oxygen Partial Pressure

Download Full-text

NEUROPSYCHOLOGICAL CHANGES IN PATIENTS WITH A CONSEQUENCE OF TRAUMATIC BRAIN INJURY

JOURNAL OF NEUROLOGY AND NEUROSURGICAL RESEARCH ◽

10.26739/2181-0982-2020-3-9 ◽

2020 ◽

Vol 3 (1) ◽

pp. 44-46

Author(s):

Istatillo Shodjalilov ◽

◽

Saoda Igamova ◽

Aziza Djurabekova

Keyword(s):

Traumatic Brain Injury ◽

Cognitive Impairment ◽

Brain Injury ◽

Neuropsychological Testing ◽

Anxiety And Depression ◽

Psychopathological Symptoms ◽

Neuropsychological Changes ◽

The Relationship

The incidence of cognitive impairment in TBI is high, depending on the severity. At the same time, psychopathological symptoms in the form of asthenia, increased anxiety and depression are encountered among patients with TBI. The work studied the relationship between cognitive and psychopathological symptoms in patients with TBI using neuropsychological testing on scales.

Download Full-text