scholarly journals Postpartum dyslipidemia and the potential predictors in women with history of gestational diabetes mellitus

2020 ◽  
Author(s):  
Ling Pei ◽  
Huangmeng Xiao ◽  
Fenghua Lai ◽  
Zeting Li ◽  
Zhuyu Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Receiver Operating Characteristic ◽  
Maternal Age ◽  
Operating Characteristic ◽  
Lipid Level ◽  
Early Postpartum ◽  
History Of ◽  
Receiver Operating

Abstract Aims/Introduction: To analyze the incidence of early postpartum dyslipidemia and the potential predictors among women with history of gestational diabetes mellitus (GDM).Materials and Methods: This was a retrospective study. 589 women diagnosed with GDM were recruited and followed up at 6-12 weeks after delivery. The general demographic and metabolic data during pregnancy were collected. Participants were divided into the normal lipid group and dyslipidemia group according to the postpartum lipid level. Demographic and metabolic parameters were compared. Multivariate logistic regression was performed to analyze the potential predictors for the early postpartum dyslipidemia. Receiver operating characteristic (ROC) curve was conducted to determine the cut-off values.Results: 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with history of GDM. The cut-offs of maternal age, SBP, HbA1c and LDL-C were 35 years, 5.1% and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity（63.9%）and specificity(69.2%）with highest area under the receiver operating characteristic curve（AUC) (0.696). When LDL-C was combined with age, SBP and HbA1c, the AUC reached to 0.733.Conclusions: Women with history of GDM should be screened lipid metabolism after delivery, particularly those with maternal age >35 years, SBP>123mmHg before labor, HbA1c>5.1%, or LDL-C>3.56mmol/L in the second trimester of pregnancy.

scholarly journals Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

2020 ◽  
Author(s):  
Ling Pei ◽  
Huangmeng Xiao ◽  
Fenghua Lai ◽  
Zeting Li ◽  
Zhuyu Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Age ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Lipid Levels ◽  
Early Postpartum ◽  
History Of ◽  
Operating Characteristic Curve

Abstract Background: This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM).Methods: This was a retrospective study. 589 women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester and the early postpartum period. Participants were divided into the normal lipid group and dyslipidemia group according to postpartum lipid levels. Demographic and metabolic parameters were analyzed. Multiple logistic regression was performed to analyze the potential predictors for early postpartum dyslipidemia. A receiver operating characteristic curve (ROC) was calculated to determine the cut-off values.Results: A total of 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with a history of GDM. The cut-offs of maternal age, SBP, HbA1c values, and LDL-C levels were 35 years, 123mmHg, 5.1%, and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity (63.9%) and specificity (69.2%), with the highest area under the receiver operating characteristic curve (AUC) (0.696). When LDL-C was combined with age, SBP, and HbA1c, the AUC reached to 0.733.Conclusions: A lipid metabolism evaluation should be recommended in women with a history of GDM after delivery, particularly those with a maternal age > 35 years, SBP > 123 mmHg before labor, HbA1c value > 5.1%, or LDL-C levels > 3.56 mmol/L in the second trimester of pregnancy.

scholarly journals Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Ling Pei ◽  
Huangmeng Xiao ◽  
Fenghua Lai ◽  
Zeting Li ◽  
Zhuyu Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Age ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Lipid Levels ◽  
Early Postpartum ◽  
History Of ◽  
Operating Characteristic Curve

Abstract Background This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM). Methods This was a retrospective study. Five hundred eighty-nine women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75 g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester and the early postpartum period. Participants were divided into the normal lipid group and dyslipidemia group according to postpartum lipid levels. Demographic and metabolic parameters were analyzed. Multiple logistic regression was performed to analyze the potential predictors for early postpartum dyslipidemia. A receiver operating characteristic curve (ROC) was calculated to determine the cut-off values. Results A total of 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with a history of GDM. The cut-offs of maternal age, SBP, HbA1c values, and LDL-C levels were 35 years, 123 mmHg, 5.1%, and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity (63.9%) and specificity (69.2%), with the highest area under the receiver operating characteristic curve (AUC) (0.696). When LDL-C was combined with age, SBP, and HbA1c, the AUC reached to 0.733. Conclusions A lipid metabolism evaluation should be recommended in women with a history of GDM after delivery, particularly those with a maternal age > 35 years, SBP > 123 mmHg before labor, HbA1c value > 5.1%, or LDL-C levels > 3.56 mmol/L in the second trimester of pregnancy.

scholarly journals Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

2020 ◽  
Author(s):  
Ling Pei ◽  
Huangmeng Xiao ◽  
Fenghua Lai ◽  
Zeting Li ◽  
Zhuyu Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Age ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Lipid Levels ◽  
Early Postpartum ◽  
History Of ◽  
Operating Characteristic Curve

Abstract Background : This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM). Methods : This was a retrospective study. 589 women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester and the early postpartum period. Participants were divided into the normal lipid group and dyslipidemia group according to postpartum lipid levels. Demographic and metabolic parameters were analyzed. Multiple logistic regression was performed to analyze the potential predictors for early postpartum dyslipidemia. A receiver operating characteristic curve (ROC) was calculated to determine the cut-off values. Results: A total of 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with a history of GDM. The cut-offs of maternal age, SBP, HbA1c values, and LDL-C levels were 35 years, 123mmHg, 5.1%, and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity (63.9%) and specificity (69.2%), with the highest area under the receiver operating characteristic curve (AUC) (0.696). When LDL-C was combined with age, SBP, and HbA1c, the AUC reached to 0.733. Conclusions: A lipid metabolism evaluation should be recommended in women with a history of GDM after delivery, particularly those with a maternal age > 35 years, SBP > 123 mmHg before labor, HbA1c value > 5.1%, or LDL-C levels > 3.56 mmol/L in the second trimester of pregnancy.

scholarly journals Simple Model to Predict Gestational Diabetes in Nulliparous Women in Early Pregnancy

2021 ◽  
Author(s):  
Juan Jesus FERNANDEZ ALBA ◽  
Maria CASTILLO LARA ◽  
Jose Manuel JIMENEZ HERAS ◽  
Rocio MORENO CORTES ◽  
CARMEN GONZALEZ MACIAS ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
First Trimester ◽  
Nulliparous Women ◽  
First Trimester Of Pregnancy ◽  
Receiver Operating

Abstract BackgroundThe aim of this study was to develop a simple tool using anthropometric, clinical, and analytical variables to predict the risk of gestational diabetes mellitus in the first trimester of pregnancy.MethodsA historical cohort study was conducted with 1,946 Caucasian nulliparous pregnant women at the Department of Obstetrics and Gynecology of the University Hospital of Puerto Real (Cádiz/Spain). The predictive model used was a multivariate logistic regression evaluated by 10-fold cross-validation with five iterations. Receiver-operating characteristic and prediction recall curves were plotted with the predictions of the model. Optimal cut-off points of the receiver-operating characteristic curve were estimated using the Youden Index and minimum distance to point 1,1.ResultsThe final logistic regression model included both maternal weight and height, thyroid-stimulating hormone, family history of diabetes mellitus or hypertension, and the presence of chronic hypertension as predictive variables. The model showed an accuracy of 0.93 and a receiver-operating characteristic area under the curve of 0.791.ConclusionsThis report provides a tool to predict the onset of gestational diabetes mellitus in nulliparous women during the first trimester of pregnancy. This tool is more accurate than the currently available tools and can facilitate the implementation of preventative interventions.

scholarly journals Idade como fator de risco para diabetes mellitus gestacional/ Age as a risk factor for gestational diabetes mellitus

2019 ◽  
Vol 18 (2) ◽  
Author(s):  
Grasiela Martins Barros ◽  
Thais Medeiros Lima Guimarães ◽  
Lyvia Da Silva Figueiredo ◽  
Marcos Venícios de Oliveira Lopes ◽  
Helen Campos Ferreira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Receiver Operating Characteristic ◽  
Rio De Janeiro ◽  
Operating Characteristic ◽  
Receiver Operating

Objetivo: Investigar o ponto de corte da idade para detecção de diabetes mellitus gestacional (DMG). Método: Estudo caso-controle com 416 gestantes acompanhadas no ambulatório de pré-natal de uma maternidade no Rio de Janeiro, RJ, Brasil. A análise da curva receiver operating characteristic foi aplicada aos dados para evidenciar valores com otimização da sensibilidade em função da especificidade. Resultados: Estima-se que a razão de chance de uma mulher com idade ≥25 anos desenvolver diabetes mellitus gestacional é 2,3 vezes maior. A idade ≥22,5 anos foi identificada como ponto que maximiza a chance para a diabetes mellitus gestacional. A chance de uma mulher com idade maior ou igual a 22,5 anos apresentar esta doença é 3,0 vezes maior do que em outra mulher com idade menor. Conclusão: O ponto de corte de idade que sugere necessidade de maior monitoramento de glicemia em gestantes é de 22,5 anos.

scholarly journals Study of Risk Factors for Conegnital Heart Defect in a Tertiary Level Hospital

2018 ◽  
Vol 27 (1) ◽  
pp. 51-56
Author(s):  
Ferdousi Hossain Poly ◽  
Syeda Afroza ◽  
Hasanur Rahman ◽  
Md Imran Hassan
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Age ◽  
Congenital Heart ◽  
Heart Defects ◽  
Medical College ◽  
History Of ◽  
The Difference

A congenital heart defect is a heart problem which is present at birth, caused by improper development of the heart during fetal development. In majority of cases there is no known reason for the heart to develop improperly. Some type of congenital heart defects are related to chromosomal abnormality(5-6%), some are to single gene defect(3-5%) or environmental factors(2%). In 85-90% of cases there is no identifiable cause and are generally considered to be caused by multifactorial inheritance. There are some maternal factors which have some role in cardiovascular malformations. These include high maternal age(above 30 years), maternal obesity, consanguinity among the parents, fever during pregnancy, gestational diabetes mellitus, smoking, alcohol consumption, ingestion of any teratogenic drug including homeopathy and herbal medicine. Objective of the study: To evaluate the risk factors associated with congenital heart disease. Methodology: A case control study was conducted at paediatric department of Sir Salimullah Medical College & Mitford Hospital following approval of the protocol from 1st January 2013 to 30th June 2014. Children fulfilling the inclusion criteria-(0-5 year old children of both sexes admitted in paediatric units of Mitford Hospital with any type of congenital heart disease confirmed by echocardiography) were considered as cases. A similar number of age and sex matched children admitted in Mitford Hospital without any cardiac defect were considered as controls. Data were collected by questionnaire. Results: The results show that majority of the cases are male. Maternal age (27.09 ± 4.63) and BMI (24.10 ± 2.28) both are significantly higher in cases than those of controls. Among the cases 31.8% mothers had consanguineous marriage (p=0.001) and 27.1% mothers had history of fever during pregnancy whereas it was present in 9.3% mothers of controls, the difference is significant statistically (p=0.001). Among the cases 34.6% mothers had history of gestational diabetes mellitus and only 18.9% controls had so and the difference is significant statistically (p=0.014). Conclusion: Relatively old age and more weight during pregnancy, consanguinity between parents, fever during pregnancy, history of gestational diabetes mellitus are the main risk factors of congenital heart defects in children J Dhaka Medical College, Vol. 27, No.1, April, 2018, Page 51-56

scholarly journals Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 464
Author(s):  
Vendula Bartáková ◽  
Beáta Barátová ◽  
Lukáš Pácal ◽  
Veronika Ťápalová ◽  
Silvie Šebestová ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Glucose Intolerance ◽  
Risk Score ◽  
Smoking History ◽  
Family History Of Diabetes ◽  
Early Postpartum ◽  
History Of

The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.

scholarly journals The effects of gestational diabetes mellitus with advanced maternal age on the metabolite profiles of serum and urine

2020 ◽  
Author(s):  
Xiaoling He ◽  
Xiaojing Hu ◽  
Bai-yu Luo ◽  
Yinyin Xia ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Age ◽  
Arachidic Acid ◽  
Advanced Maternal Age ◽  
Maternal Plasma ◽  
Gas Chromatography Mass Spectrometry ◽  
Third Trimester ◽  
History Of

Abstract Background: Gestational diabetes mellitus (GDM) is characterized by impaired glucose tolerance in pregnancy and without a history of diabetes mellitus. It can lead to adverse maternal and neonatal outcomes. The incidence of GDM is closely related to maternal age, but there are only a few pregnancy-related metabolomic studies involving advanced maternal age (AMA) in China.Methods: 20 GDM and 20 normal pregnant participants(≥35 years old) were recruited from the Complex Lipids in Mothers and Babies (CLIMB) study. Maternal plasma and urine metabolomes collected at the first and third trimester were analyzed using gas chromatography-mass spectrometry (GC-MS). Results: Of the metabolites identified using GC–MS, 165 metabolites and 192 metabolites were found in plasma and urine respectively. However, urine metabolomic profiles were unable to distinguish GDM from controls, while there were 14 and 39 significantly different metabolites in plasma of the two groups in first and third trimester. Especially, by combining seven metabolites including cysteine, malonic acid, stearic acid, alanine, 11,14-eicosadienoic acid, 2-methyloctadecanoic acid, and arachidic acid using multivariant receiver operating characteristic(ROC) models, we were capable of discriminating GDM from healthy pregnancies with an area under curve (AUC) of 0.928 at early gestation.Conclusion: This study explores metabolomic profiles between GDM and normal pregnancies longitudinally. Several metabolites have the potential to be biomarkers to predict GDM with AMA. Besides, the discordant metabolome profiles between the two groups could be helpful to understand the etiology of elderly GDM.

scholarly journals Incidence and risk factors of gestational diabetes mellitus in antenatal mothers in Goa, India

2019 ◽  
Vol 8 (2) ◽  
pp. 586
Author(s):  
Rini R. Naik ◽  
Guruprasad Pednekar ◽  
Jagadish Cacodcar
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Age ◽  
Maternal Obesity ◽  
Past History ◽  
Family History Of Diabetes ◽  
History Of

Background: Gestational Diabetes Mellitus (GDM) accounts for almost 90% of all pregnancies complicated by diabetes. Its prevalence in the Indian population ranges from 5.5% to 11.5 %.Methods: The present study was undertaken to assess the incidence of GDM among antenatal mothers admitted in Goa Medical College for a period of 18 months and also to study the risk factors associated with GDM amongst such cases.Results: Present study revealed that among 7717 antenatal mothers who were admitted and delivered in our Hospital, 424 women were diagnosed with GDM. Of these women diagnosed with GDM, almost one third were in the age group of 31- 35 years (35.8%); 56.2 % of these women were multigravidas. Advancing maternal age, rising parity, obesity, family history of Diabetes Mellitus (DM) and past history of GDM were among the risk factors found to be significantly associated with GDM.Conclusions: The incidence of GDM in present study population was 5.49%. Advancing maternal age, maternal obesity, family history of DM and past history of GDM were found to be important determinants of GDM.

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