scholarly journals Chemogenetic stimulation of hippocampal adult-born neurons improves long-term memory accuracy

2021 ◽  
Author(s):  
marie lods ◽  
Pierre Mortessagne ◽  
Emilie Pacary ◽  
Geoffrey Terral ◽  
Fanny Farrugia ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Memory Performance ◽  
Remote Memory ◽  
Long Term Memory ◽  
Memory Accuracy ◽  
Memory Problems ◽  
Neuron Populations ◽  
Adult Born Neurons ◽  
Stimulation Of

Abstract Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of adult neurogenesis can improve memory performance remains unclear. Here, using a chemogenetic approach that combines selective tagging and specific activation of distinct adult-born neuron populations, we demonstrate that this activation can improve remote memory accuracy and strength. These results open up new avenues for remedying memory problems that may arise over time.

Short- and long-term memory tasks predict working memory performance, and vice versa.

2019 ◽  
Vol 73 (2) ◽  
pp. 79-93 ◽  
Author(s):  
Ian Neath ◽  
Jean Saint-Aubin ◽  
Tamra J. Bireta ◽  
Andrew J. Gabel ◽  
Chelsea G. Hudson ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Long Term Memory ◽  
Term Memory ◽  
Short And Long Term

scholarly journals Expert radiologists have improved memory performance for images with focal abnormalities

2019 ◽  
Author(s):  
Hayden Schill ◽  
Jeremy Wolfe ◽  
Timothy F. Brady
Keyword(s):  
Working Memory ◽  
Prior Knowledge ◽  
Memory Performance ◽  
Memory Capacity ◽  
Current Work ◽  
Long Term Memory ◽  
Attentional Processing ◽  
Term Memory ◽  
Focal Abnormality

Memory capacity depends on prior knowledge, both in working memory and in long-term memory. For example, radiologists have improved long-term memory for medical images compared to novices. Furthermore, people tend to remember abnormal or surprising items best. This is often claimed to arise primarily because such items attract additional attention at encoding. How do expertise and abnormality interact when experts are actively searching for abnormalities; e.g. radiologists looking at mammograms? In the current work, we investigate whether expert radiologists (N=32) show improved memory performance for abnormal images compared to novice participants (N=60). We consider two types of “abnormality.” A mammogram can have a focal abnormality that can be localized or it could simply be the mammogram of a woman known to have cancer (e.g. the image of the breast contralateral to the focal abnormality). Must an image have a focal abnormality for additional attentional processing to be engaged? We found that experts have better memory for mammograms than novice participants and enhanced memory for abnormal images relative to normal images. Overall, radiologists showed no memory benefit for the contralateral-abnormal images and did not discriminate them from normal images, but had enhanced memory for images with focal abnormalities. Our results suggest that focal abnormalities play an important role in enhancing memory of expert observers.

scholarly journals Dissociating refreshing and elaboration and their impacts on memory

2018 ◽  
Author(s):  
Lea M. Bartsch ◽  
Vanessa M. Loaiza ◽  
Lutz Jäncke ◽  
Klaus Oberauer ◽  
Jarrod A. Lewis-Peacock
Keyword(s):  
Older Adults ◽  
Memory Performance ◽  
Ethics Committees ◽  
Fmri Data ◽  
Ethical Review ◽  
Long Term Memory ◽  
List Type ◽  
Term Memory ◽  
Age Related

AbstractMaintenance of information in working memory (WM) is assumed to rely on refreshing and elaboration, but clear mechanistic descriptions of these cognitive processes are lacking, and it is unclear whether they are simply two labels for the same process. This fMRI study investigated the extent to which refreshing, elaboration, and repeating of items in WM are distinct neural processes with dissociable behavioral outcomes in WM and long-term memory (LTM). Multivariate pattern analyses of fMRI data revealed differentiable neural signatures for these processes, which we also replicated in an independent sample of older adults. In some cases, the degree of neural separation within an individual predicted their memory performance. Elaboration improved LTM, but not WM, and this benefit increased as its neural signature became more distinct from repetition. Refreshing had no impact on LTM, but did improve WM, although the neural discrimination of this process was not predictive of the degree of improvement. These results demonstrate that refreshing and elaboration are separate processes that differently contribute to memory performance.HighlightsRepeated reading, refreshing, and elaboration are differentiable in brain activation patterns in both young and older adults.Elaboration selectively improved long-term memory for young adults, and the size of the benefit was related to the neural separability of elaboration from other processes.Older adults implemented a sub-optimal form of elaboration, and this may be a factor contributing to age-related deficits in long-term memory.Ethics statementThe study was approved by the ethical review board of the canton of Zurich (BASEC-No. 2017-00190) and all subjects gave informed written consent in accordance with the Declaration of Helsinki.Data and code availability statementAll behavioral data and analysis scripts can be assessed on the Open Science Framework (osf.io/p2h8b/). The fMRI data that support the findings of this study are available on request from the corresponding author, LMB. The fMRI data are not publicly available due to restrictions of the Swiss Ethics Committees on research involving humans regarding data containing information that could compromise the privacy of research participants.

scholarly journals The Significance of Warm Colour in the Quran and Its Roles on Memory Performance

2020 ◽  
Vol 16 ◽  
pp. 1-15
Author(s):  
Norwardatun Mohamed Razali
Keyword(s):  
Memory Performance ◽  
Sensory Memory ◽  
Long Term Memory ◽  
Short Term ◽  
Yellow Colour ◽  
Term Memory ◽  
Human Psychology ◽  
Inductive Approach

Colours are mentioned many times in the Holy Qur’an. Some are mentioned as colours in general, and some of them in specific; yellow, white, black, red, green and blue. Each colour has its special connotations in the Holy Qur’an and among these colours, yellow and red are considered as warm colours. This study aimed to find the significance of warm colours in the Holy Qur’an and its relationship to human psychology; focusing on memory performance. This research had used an inductive approach in terms of selecting Quranic verses; in which yellow and red colour were mentioned. These verses were then analysed by referring to the books of exegetical considerations in order to know the implications of these colours’ usage, as well as referring to psychology books and scientific articles. The research found that yellow and red colour in the Holy Qur’an mostly indicate attracting attention or pleasing viewers. Some examples included the yellow colour in resemblance to the colour of the cow, attention to decay and destruction such as yellow colour in the withering plants, and attention to resurrection like the red colour resembling scene of the Day of Resurrection. This indication in the Holy Qur’an is consistent with psychologists’ discovery; warm colours such as red and yellow are more effective and attractive in the process of transferring information from external to sensory memory, and thus to short-term and long-term memory.

Benefits of training working memory in amnestic mild cognitive impairment: specific and transfer effects

2012 ◽  
Vol 25 (4) ◽  
pp. 617-626 ◽  
Author(s):  
Barbara Carretti ◽  
Erika Borella ◽  
Silvia Fostinelli ◽  
Michela Zavagnin
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Fluid Intelligence ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Long Term Memory ◽  
Transfer Effects ◽  
Memory Problems

ABSTRACTBackground:A growing number of studies are attempting to understand how effective cognitive interventions may be for patients with amnestic mild cognitive impairment (aMCI), particularly in relation to their memory problems.Methods:The present study aimed to explore the benefits of a working memory (WM) training program in aMCI patients. Patients (N= 20) were randomly assigned to two training programs: the experimental group practiced with a verbal WM task, while the active control group conducted educational activities on memory.Results:Results showed that the aMCI patients completing the WM training obtained specific gains in the task trained with some transfer effects on other WM measures (visuospatial WM) and on processes involved in or related to WM, e.g. fluid intelligence (the Cattell test) and long-term memory. This was not the case for the aMCI control group, who experienced only a very limited improvement.Conclusion:This pilot study suggests that WM training could be a valuable method for improving cognitive performance in aMCI patients, possibly delaying the onset of Alzheimer's disease.

scholarly journals The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks

2008 ◽  
Vol 80 (1) ◽  
pp. 115-127 ◽  
Author(s):  
Iván Izquierdo ◽  
Martín Cammarota ◽  
Weber C. Da Silva ◽  
Lia R.M. Bevilaqua ◽  
Janine I. Rossato ◽  
...  
Keyword(s):  
Long Term Potentiation ◽  
Brain Regions ◽  
Memory Formation ◽  
Long Term Memory ◽  
Ca1 Region ◽  
Term Potentiation ◽  
The One ◽  
Similar Task ◽  
Stimulation Of

Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hypothesis: a) memory formation of one-trial avoidance learning depends on a series of molecular steps in the CA1 region of the hippocampus almost identical to those of LTP in the same region; b)hippocampal LTP in this region accompanies memory formation of that task and of another similar task. However, CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions(amygdala, entorhinal cortex, parietal cortex) are also necessary for memory formation of the one-trial task, and perhaps of many others.

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