scholarly journals 99mTc-HMPAO SPECT imaging reveals brain hypoperfusion during status epilepticus

2020 ◽  
Author(s):  
Pablo Bascuñana ◽  
Bettina J. Wolf ◽  
Ina Jahreis ◽  
Mirjam Brackhan ◽  
Luis García-García ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Neuronal Damage ◽  
Statistical Parametric Mapping ◽  
Small Animal ◽  
Brain Perfusion ◽  
Spect Imaging ◽  
Hmpao Spect ◽  
Activity Onset ◽  
Ct System ◽  
Oxygen Requirements

Abstract Status epilepticus (SE) is a clinical emergency with high mortality. SE can trigger neuronal death or injury and alteration of neuronal networks resulting in long-term cognitive decline or epilepsy. Among the multiple factors contributing to this damage, imbalance between oxygen and glucose requirements and brain perfusion during SE has been proposed. Herein, we aimed to quantify by neuroimaging the spatiotemporal course of brain perfusion during and after lithium-pilocarpine-induced SE in rats. To this purpose, animals underwent 99mTc-HMPAO SPECT imaging at different time points during and after SE using a small animal SPECT/CT system. 99mTc-HMPAO regional uptake was normalized to the injected dose. In addition, voxel-based statistical parametric mapping was performed. SPECT imaging showed an increase of cortical perfusion before clinical seizure activity onset followed by regional hypo-perfusion starting with the first convulsive seizure and during SE. Twenty-four hours after SE, brain 99mTc-HMPAO uptake was widely decreased. Finally, chronic epileptic animals showed regionally decreased perfusion affecting hippocampus and cortical sub-regions. Despite elevated energy and oxygen requirements, brain hypo-perfusion is present during SE. Our results suggest that insufficient compensation of required blood flow might contribute to the neuronal damage and neuroinflammation, and ultimately to chronic epilepsy generated by SE.

scholarly journals 99mTc-HMPAO SPECT imaging reveals brain hypoperfusion during status epilepticus

2021 ◽  
Author(s):  
Pablo Bascuñana ◽  
Bettina J. Wolf ◽  
Ina Jahreis ◽  
Mirjam Brackhan ◽  
Luis García-García ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Neuronal Damage ◽  
Statistical Parametric Mapping ◽  
Small Animal ◽  
Brain Perfusion ◽  
Spect Imaging ◽  
Hmpao Spect ◽  
Activity Onset ◽  
Ct System ◽  
Oxygen Requirements

AbstractStatus epilepticus (SE) is a clinical emergency with high mortality. SE can trigger neuronal death or injury and alteration of neuronal networks resulting in long-term cognitive decline or epilepsy. Among the multiple factors contributing to this damage, imbalance between oxygen and glucose requirements and brain perfusion during SE has been proposed. Herein, we aimed to quantify by neuroimaging the spatiotemporal course of brain perfusion during and after lithium-pilocarpine-induced SE in rats. To this purpose, animals underwent 99mTc-HMPAO SPECT imaging at different time points during and after SE using a small animal SPECT/CT system. 99mTc-HMPAO regional uptake was normalized to the injected dose. In addition, voxel-based statistical parametric mapping was performed. SPECT imaging showed an increase of cortical perfusion before clinical seizure activity onset followed by regional hypo-perfusion starting with the first convulsive seizure and during SE. Twenty-four hours after SE, brain 99mTc-HMPAO uptake was widely decreased. Finally, chronic epileptic animals showed regionally decreased perfusion affecting hippocampus and cortical sub-regions. Despite elevated energy and oxygen requirements, brain hypo-perfusion is present during SE. Our results suggest that insufficient compensation of required blood flow might contribute to neuronal damage and neuroinflammation, and ultimately to chronic epilepsy generated by SE.

scholarly journals Subcortical Hypoperfusion following Surgery For Aneurysmal Subarachnoid Haemorrhage: Implications For Cognitive Performance?

2000 ◽  
Vol 12 (1-2) ◽  
pp. 39-51 ◽  
Author(s):  
C. L. Tooth ◽  
W. B. Tindale ◽  
M. Hadjivassiliou ◽  
C. A. J. Romanowski ◽  
E. Hunt ◽  
...  
Keyword(s):  
Subarachnoid Haemorrhage ◽  
Patient Group ◽  
Cognitive Deficits ◽  
Neuropsychological Testing ◽  
Statistical Parametric Mapping ◽  
Spect Imaging ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Post Surgery ◽  
Hmpao Spect ◽  
One Year

The incidence and severity of cognitive deficits after surgery for aneurysmal subarachnoid haemorrhage and their relationship to aneurysm site remains controversial. The aim of this study was to investigate the pattern of regional cerebral blood flow which exists in patients one year post-surgery and to identify whether different patterns exist which may be related to the type of cognitive deficit or the location of the aneurysm. 62 patients underwent cognitive assessment and HMPAO SPECT imaging at a mean time of 12 months following surgery. Results were compared to those from healthy control subjects (n= 55 for neuropsychological testing;n= 14 for SPECT imaging). In the patient group, significant stable cognitive deficits occurred in all cognitive domains but no cognitive measure differentiated aneurysm site. On SPECT images, statistical parametric mapping identified a large common area of subcortical hypoperfusion in the patient group as a whole. The findings of this study suggest a possible link between reduced subcortical function and the extent and severity of cognitive deficits.

Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

1989 ◽  
Vol 28 (05) ◽  
pp. 181-186
Author(s):  
A. Ludolph ◽  
O. Schober ◽  
G. Lottes ◽  
I. Böttger ◽  
H.-F. Beer ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Brain Area ◽  
Brain Perfusion ◽  
Partial Epilepsy ◽  
Cerebral Lesion ◽  
Receptor Ligand ◽  
Receptor Mapping ◽  
Hmpao Spect ◽  
99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

Atlas of 99mTc-HMPAO SPECT brain perfusion in pediatric brain disorders

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Saleh A Othman ◽  
Keyword(s):  
Blood Flow ◽  
Neuronal Activity ◽  
Pediatric Patients ◽  
Brain Perfusion ◽  
Brain Disorders ◽  
Hmpao Spect ◽  
Perfusion Scan ◽  
Pediatric Brain ◽  
The Brain ◽  
99Mtc Hmpao

Background: Blood flow to the brain is in parallel with brain metabolism in almost all brain disorders except in brain tumors and therefore regional cerebral blood flow can be used as a marker of metabolic brain activity and hence it is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in different areas of the brain. Purpose: The aim of this work is to demonstrate to pediatrician in general and pediatric neurologist in particular the variations in cerebral perfusion during normal development which should be taken into consideration at the time of interpreting SPECT brain perfusion scan in different pediatric brain disorders. Method: Brain SPECT was performed 10 minutes after an intravenous injection of 11.1 MBq/kg (0.3 mCi/kg), and the minimum dose is 185 MBq (5 mCi) of 99mTc-HMPAO (4). Results: This was a retrospective analysis of SPECT brain perfusion scan of pediatric patients performed between October 2015 and December 2019 at our institution. We selected normal and abnormal studies in pediatric population with age range (5 months - 14 years). Conclusion: Although anatomic cross sectional imaging give details of neurological structural changes, SPECT perfusion mirrors indirectly both metabolic and neuronal activity changes. Therefore, accurate interpretation of SPECT perfusion will consolidate its role as part of the diagnostic protocol and used when the findings of other imaging modalities do not explain the symptoms or fail partially or completely in determining the etiology of brain disorders in pediatric patients.

Evaluation of Timepix3 based CdTe photon counting detector for fully spectroscopic small animal SPECT imaging

2018 ◽  
Vol 13 (01) ◽  
pp. C01001-C01001 ◽  
Author(s):  
E. Trojanova ◽  
J. Jakubek ◽  
D. Turecek ◽  
V. Sykora ◽  
P. Francova ◽  
...  
Keyword(s):  
Photon Counting ◽  
Small Animal ◽  
Spect Imaging ◽  
Photon Counting Detector

scholarly journals Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus

2020 ◽  
Vol 15 (5) ◽  
pp. 936 ◽  
Author(s):  
Ri-Sheng Liang ◽  
Dong-Qi Lin ◽  
Xin-Ying Cai ◽  
Chun-Hua Wang ◽  
Bin Yang
Keyword(s):  
Status Epilepticus ◽  
Neuronal Damage ◽  
Optimal Concentration

Histamine 1 receptor knock out mice show age-dependent susceptibility to status epilepticus and consequent neuronal damage

2012 ◽  
Vol 100 (1-2) ◽  
pp. 80-92 ◽  
Author(s):  
Tiina-Kaisa Kukko-Lukjanov ◽  
Maria Grönman ◽  
Minnamaija Lintunen ◽  
Hanna B. Laurén ◽  
Kimmo A. Michelsen ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Neuronal Damage ◽  
Knock Out ◽  
Age Dependent ◽  
Knock Out Mice
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