scholarly journals Invasive Micropapillary Carcinoma of Mixed Breast Cancer Metastasizing Faster Into Thyroid: A Rare Case Report

2021 ◽  
Author(s):  
Yupei Yu ◽  
Ruifeng Wang ◽  
Junqi Deng ◽  
Jiayu Zhou ◽  
Haiyan Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Thyroid Gland ◽  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Metastatic Breast ◽  
Thyroid Tumor ◽  
Axillary Lymph ◽  
Invasive Micropapillary Carcinoma ◽  
Micropapillary Carcinoma ◽  
Cervical Lymph Nodes

Abstract Background: The incidence of metastatic breast cancer tumors in the thyroid gland is very rare, however, invasive micropapillary carcinoma of breast metastasizes to thyroid gland is rarer. As far as we know, there has never been reported that both invasive ductal carcinoma– no special type (IDC-NST) and invasive micropapillary carcinoma (IMPC) exist in breast whereas only the latter metastasizes into the thyroid gland.Case presentation: we report a case of a 59-year-old Chinese woman first diagnosed as IDC-NST of breast with involvement of axillary lymph node, grade 2 in 2015. However, five years later, blood tests revealed increased tumor markers. Multiple solid nodules were found in both side of thyroid gland by imaging. Total thyroidectomy and bilateral cervical lymph nodes dissection were presentation: the findings showed both IDC-NST and IMPC in lymph nodes but only the later in thyroid gland. Immunohistochemically, these tumor cells were positive for ER, PR, GATA3 and Mammaglobin, but negative for TG and TTF-1. Ultimately, the patient was diagnosed as mixed breast cancer with metastatic IMPC in thyroid and radiation therapy was still continued.Conclusion: Apart from the possibility of metastatic no special type of breast cancer to thyroid tumor, IMPC of breast metastasis must be taken into consideration, especially when the patient has a history of breast cancer and thyroid nodes. Accurate diagnose of metastatic breast carcinoma is vital for precise treatment and can improve the prognosis for patients.

scholarly journals Synchronous thyroid gland metastases from breast cancer. Case reports

2021 ◽  
Vol 23 (2) ◽  
pp. 280-286
Author(s):  
Nikolai A. Ognerubov ◽  
Tatyana S. Antipova ◽  
Elena E. Palkina
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Thyroid Gland ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
Metastatic Breast ◽  
Distant Metastases ◽  
Luminal A ◽  
Cervical Lymph Nodes ◽  
Pet Ct

Background. Breast cancer is the leading cause of death in women. Distant metastases in different organs, including the thyroid gland, are still an urgent problem. Distant metastases are very rare in clinical practice. Nevertheless, the accumulated clinical and surgical experience in treatment has shown that breast cancer is the second most common primary tumor, leading to thyroid gland metastases, after kidney cancer. Aim. Present the clinical observations of synchronous thyroid gland metastases from breast cancer. Materials and methods. We observed two patients, aged 55 and 72 years, suffering from metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical and mediastinal lymph nodes, to the lungs, to the ovaries and to the bones. Results. A 55-year-old woman with a left sided neck mass and hoarseness has been suffering from the metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical lymph nodes, to the lungs, to the ovaries and to the bones. The biopsy of the primary tumor has been performed. The tumor has the structure of invasive ductal carcinoma, G2, luminal A subtype, HER2-negative type in histological and immunohistochemical analysis. The spread of the tumor has been determined by positron emission tomography/computed tomography (PET/CT). Metastases from breast cancer have been cytologically proven during thin needle biopsy. A 72-year-old woman with a mass in the region of thyroid gland has been suffering from breast cancer with metastases to the thyroid gland, to the mediastinal and cervical lymph nodes, to the bones, and to determine this process PET/CT, the thyroid fine needle aspiration biopsy and core biopsy of primary tumor have been applied. The histological variant was represented by invasive ductal cancer, G2, luminal A subtype, HER-2 negative type. Taking into account the spread of the process, the patients were given polychemotherapy, targeted therapy and hormone therapy. There is no disease progression for 6 months. Conclusion. Synchronous thyroid gland metastases in case of primary breast tumors are rare. In such cases, PET/CT is the important diagnostic method. The main therapeutic option in this case is systemic therapy, including chemotherapy, targeted and hormone therapy, the nature of the agent depends on the biological variant of the tumor.

scholarly journals Intra-mammary lymph nodes, an overlooked breast cancer prognostic tool?

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tarek Hashem ◽  
Ahmed Abdelmoez ◽  
Ahmed Mohamed Rozeka ◽  
Hazem Abdelazeem
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Percutaneous Biopsy ◽  
Preoperative Imaging ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pathological Features ◽  
Breast Cancer Patients ◽  
Surgical Data

Abstract Background Due to the high variability of incidence and prevalence of intra-mammary lymph nodes (IMLNs), they might be overlooked during clinical and radiological examinations. Properly characterizing pathological IMLNs and detecting the factors that might influence their prevalence in different stages of breast cancer might aid in proper therapeutic decision-making and could be of possible prognostic value. Methods Medical records were reviewed for all breast cancer patients treated at the National Cancer Institute of Cairo University between 2013 and 2019. Radiological, pathological, and surgical data were studied. Results Intra-mammary lymph nodes were described in the final pathology reports of 100 patients. Five cases had benign breast lesion. Three cases had phyllodes tumors and two cases had ductal carcinoma in situ (DCIS). All ten cases were excluded. The remaining 90 cases all had invasive breast cancer and were divided into two groups: one group for patients with malignant IMLNs (48) and another for patients with benign IMLNs (42). Pathological features of the malignant IMLN group included larger mean tumor size in pathology (4.7 cm), larger mean size of the IMLN in pathology (1.7 cm), higher incidence of lympho-vascular invasion (65.9%), and higher rate of extracapsular extension in axillary lymph nodes (57.4%). In addition, the pathological N stage was significantly higher in the malignant IMLN group. Conclusion Clinicians frequently overlook intra-mammary lymph nodes. More effort should be performed to detect them during preoperative imaging and during pathological processing of specimens. A suspicious IMLN should undergo a percutaneous biopsy. Malignant IMLNs are associated with advanced pathological features and should be removed during surgery.

scholarly journals Prostate-Specific Ets (PSE) factor: a novel marker for detection of metastatic breast cancer in axillary lymph nodes

2002 ◽  
Vol 86 (6) ◽  
pp. 899-904 ◽  
Author(s):  
M Mitas ◽  
K Mikhitarian ◽  
L Hoover ◽  
M A Lockett ◽  
L Kelley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

scholarly journals Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

2018 ◽  
Vol 128 (4) ◽  
pp. 1355-1370 ◽  
Author(s):  
Ikram Ullah ◽  
Govindasamy-Muralidharan Karthik ◽  
Amjad Alkodsi ◽  
Una Kjällquist ◽  
Gustav Stålhammar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Evolutionary History ◽  
Metastatic Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
History Of

scholarly journals A Case Report of Metastatic Breast Cancer Treated with Korean Medicine Therapy as a Substitute for Chemotherapy

2017 ◽  
Vol 10 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Dong-hyun Lee ◽  
Sung-su Kim ◽  
Shin Seong
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Case Report ◽  
Ductal Carcinoma ◽  
Metastatic Breast ◽  
Metastatic Lesion ◽  
Axillary Lymph ◽  
Axillary Lymph Node Metastases ◽  
Korean Medicine ◽  
Breast Invasive Ductal Carcinoma

The purpose of this case report is to show the potential benefit of Korean medicine therapy for treating multiple metastatic breast cancer. A 45-year-old Korean woman was diagnosed with right breast invasive ductal carcinoma in August 2012 but did not receive any treatment until October 2015 when she was diagnosed with stage 4 right breast cancer with multiple liver, bone, mesentery, retroperitoneum, and axillary lymph node metastases. After chemo-port insertion, she was treated with palliative chemotherapy and the first line of trastuzumab and paclitaxel, and the port was removed due to port infection. To treat sepsis, vancomycin and tazoperan were administered, before the third line of trastuzumab and paclitaxel was carried out. However, the patient gave up chemotherapy due to vancomycin-resistant enterococci and general weakness. Later, she received Korean medicine therapy with wild ginseng pharmacopuncture, distilled Soramdan S, Hae, and Jeobgoldan for 8 months, which led to a significant decrease of the multiple metastases. The patient was able to start walking again with the help of a walking stick. However, a new metastatic lesion was found on the right adrenal gland. This case suggests that the combination of chemotherapy and Korean medicine therapy may be valuable. Further research is indicated.

scholarly journals Breast Cancer with Internal Mammary Node Metastases: A Case Presented in a Tumor Board Session and Decision Making

2019 ◽  
pp. 156-160
Author(s):  
Léamarie Meloche-Dumas ◽  
Erica Patocskai ◽  
Kerianne Boulva ◽  
Moishe Liberman ◽  
Younan Rami
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Metastatic Breast ◽  
Tumor Board ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Internal Mammary Chain ◽  
Internal Mammary

Background: There are several therapeutic options available for breast cancer treatment, now incorporating innovative targeted molecular therapies. Metastatic breast cancer is usually treated with chemotherapy and/or hormonotherapy. Surgery has not been shown to improve survival. Adjuvant radiotherapy (RT) has been proven to be effective in the treatment of locally advanced breast cancer, reducing locoregional recurrence. The optimal treatment of internal mammary lymph nodes (IMN) metastases remains controversial. Case presentation: A 48-year-old woman was diagnosed with invasive breast cancer with ipsilateral metastases to axillary lymph nodes and a contralateral IMN metastasis. This case was presented twice during the tumor board sessions of the Surgical Oncology Service at the Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Canada. Question: Does the internal mammary chain (IMC) dissection could be used as a treatment approach in breast cancer with IMC metastasis? Conclusion: Internal mammary chain dissection should be discussed in tumor board sessions on a case-by-case basis. There are no strong guidelines on the management of IMN metastasis in breast cancer, but there is growing evidence that these women should be treated with curative intent.

scholarly journals Rare localisation of breast cancer metastasis to thyroid gland

2012 ◽  
Vol 69 (12) ◽  
pp. 1106-1108
Author(s):  
Daniela Kolarevic ◽  
Zorica Tomasevic ◽  
Ivan Markovic ◽  
Milan Zegarac ◽  
Gordana Pupic
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Thyroid Gland ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Previous History ◽  
Radical Mastectomy ◽  
Surgical Removal ◽  
Histopathological Analysis ◽  
Axillary Lymph

Introduction. Metastases to the thyroid gland are very rare. They are usually seen in malignant melanoma, kidney, breast cancer and lung cancer. Case report. We presented a 54- years-old female patient with breast cancer diagnosed in 2002. The adequate surgical procedure was done and the tumor and axillary lymph nodes were removed. The patient also received adjuvant postoperative chemotherapy. After seven years of a disease free period, the first relapse of the disease was detected as thyroid gland tumor with axillary lymphadenopathy. The patient had a good response to systemic treatment so the surgical removal of thyroid gland and enlarged lymph nodes was performed. Histopathological analysis confirmed metastasis with breast cancer origin. Radical mastectomy was also preformed. Second relapse of the disease was detected 10 months later, while the patient was on hormonal therapy. It was manifested as the appearance of bone and skin metastases, pleural effusion and lymphadenopathy. Conclusion. This case report emphasized the importance of detailed examination of any new onset of thyroid swelling in a patient with previous history of malignancy.

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