scholarly journals Multiparametric CMR Imaging of Myocardial Structure and Function Changes in Diabetic Mini-pigs With Preserved LV Function : A Preliminary Study

2021 ◽  
Author(s):  
Guozhu Shao ◽  
Yukun Cao ◽  
Yue Cui ◽  
Xiaoyu Han ◽  
Jia Liu ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
T1 Mapping ◽  
Extracellular Volume ◽  
Left Ventricular ◽  
Structure And Function ◽  
Lv Function ◽  
Myocardial Structure ◽  
And Function ◽  
Mini Pigs

Abstract Background: The purpose of this study is to dynamically monitor the myocardial structure and function changes in diabetic mini-pigs by 1.5T cardiac magnetic resonance. Methods: Cardiac magnetic resonance (CMR) T1 mapping was performed in three male streptozotocin-induced diabetic mini-pigs. T1-mapping and ECV-mapping were acquired at basal, mid and apical segments. CMR feature-tracking (CMR-FT) is used to quantify left ventricle global longitudinal (LVGLS), circumferential (LVGCS) and radial strain(LVGRS). Epicardial adipose tissue (EAT) was evaluated using a commercially available software.Results: Left ventricular mass (LVM), myocardial T1 value and extracellular volume (ECV) value increased gradually after 3, 4.5 and 6 months of modeling, while LVGLS decreased gradually after 3 months of modeling（Modeling 3M VS 1.5M：LVM，34.0 ± 1.9 VS 26.4 ± 1.3，P=0.027；T1，1012.3 ± 9.6 VS 1002.2 ± 11.4, P=0.014; ECV，24.3 ± 1.6 VS 22.4 ± 1.6，P=0.014；GLS：-20.8 ± 1.3 VS -23.0 ± 1.6，P=0.014；Modeling 4.5M VS 3M：LVM，37.5 ± 1.3 VS 34.0 ± 1.9，P=0.005；T1, 1017.8 ± 9.5 VS 1012.3 ± 9.6, P＜0.001；ECV，26.2 ± 1.5 VS 24.3 ± 1.6，P=0.037；GLS：-19.4 ± 1.4 VS -20.8 ± 1.3，P=0.016；Modeling 6M VS 4.5M：LVM，42.9 ± 1.6 ± 1.9 VS 37.5 ± 1.3，P=0.008；T1，1026.6 ± 10.2 VS 1017.8 ± 9.5, P=0.003；ECV，28.6 ± 1.8 VS 26.2 ± 1.5，P=0.016；GLS：-17.9 ± 1.1 VS -19.4 ± 1.4，P=0.019). EAT did not increase significantly until the sixth month (Modeling 6M VS 4.5M, EAT: 24.1 ± 3.1 VS 20.2 ± 2.4, P= 0.043).Conclusion: The progressive impairments in LV structure and myocardial deformation occurs in diabetic mini-pigs. T1 mapping and CMR-FT technology are promising to monitor abnormal changes of diabetic myocardium in early stage of diabetic cardiomyopathy.

scholarly journals Detection of intracellular histological abnormalities using cardiac magnetic resonance T1 mapping in patients with Danon disease: a case series

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Hideaki Suzuki ◽  
Yoshiaki Morita ◽  
Ryoko Saito ◽  
Shunsuke Tatebe ◽  
Tetsuya Niihori ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
T1 Mapping ◽  
Extracellular Volume ◽  
Case Series ◽  
Left Ventricular ◽  
Musculoskeletal Symptoms ◽  
Danon Disease ◽  
Autophagic Vacuoles ◽  
Native T1

Abstract Background Danon disease is an X-linked dominant disorder with defects in the lysosome-associated membrane protein 2 (LAMP2) gene and is characterized histologically by intracellular autophagic vacuoles in skeletal and cardiac muscles. Cardiac magnetic resonance (CMR) T1 mapping potentially allows to differentiate intracellular and extracellular cardiac abnormalities with a combination of native T1 value and extracellular volume (ECV) fraction. Case summary We assessed CMR T1 mapping in two Danon disease patients (a 22-year-old man and his 48-year-old mother), who had a LAMP2 c.864G>A p. Val288Val mutation, and two blood relatives without Danon disease (his 47-year-old maternal aunt and 49-year-old father). The male patient underwent a left ventricular (LV) assist device implantation at 15 months after the image acquisition because he was inotrope dependent (INTERMACS profile 3) and had no noticeable psychological or musculoskeletal symptoms. His mother was in New York Heart Association Class II with mildly reduced LV ejection fraction (46%). The Danon group showed late gadolinium enhancement (LGE) in the anterior and posterolateral LV walls. In the interventricular wall, where evident LGE was not noted, the Danon group had high native T1 value, compared with the T1 value in the non-Danon group, and normal ECV fraction. Cardiac biopsy from the interventricular wall showed intracytoplasmic autophagic vacuoles, which are characteristics of Danon disease. Discussion This characteristic pattern of high native T1 and normal ECV fraction in the areas without LGE, which may reflect the existence of intracytoplasmic autophagic vacuoles, may support the differential diagnosis of Danon disease from other cardiomyopathies.

scholarly journals Changes of Cardiac Magnetic Resonance T1 and ECV Values in Healthy Adults of Different Gender and Age

2021 ◽  
Author(s):  
Shumei Huang ◽  
Meng Zhang ◽  
Kanghui Yu ◽  
Xiaofen Ma ◽  
Chunlong Li ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
T1 Mapping ◽  
Healthy Adult ◽  
Extracellular Volume ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Healthy Adults ◽  
Left Ventricular Myocardium ◽  
3T Mri

Abstract BackgroundThe correlation between T1 and ECV value and myocardial fibrosis has been confirmed. In healthy adult, many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and gender.MethodsWe recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. ResultsUnder 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only gender (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while gender (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. Significant differences were observed between the middle segments of T1 value (P = 0.001) but not between the middle of the ECV value of each segment (P = 0.068). Lastly, there was no statistical difference between each segment in the apical of the T1 (P = 0.756) and ECV value (P = 0.344).ConclusionsUnder 3T MRI, the T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.

scholarly journals Characterisation of myocardial structure and function in adult-onset growth hormone deficiency using cardiac magnetic resonance

Endocrine ◽  
2016 ◽  
Vol 54 (3) ◽  
pp. 778-787 ◽  
Author(s):  
Julia D.J. Thomas ◽  
Abhishek Dattani ◽  
Filip Zemrak ◽  
Thomas Burchell ◽  
Scott A. Akker ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Structure And Function ◽  
Hormone Deficiency ◽  
Adult Onset ◽  
Myocardial Structure ◽  
And Function

scholarly journals Changes of Cardiac Magnetic Resonance T1 and ECV Values in Healthy Adults of Different Gender and Age

2021 ◽  
Author(s):  
Shumei Huang ◽  
Meng Zhang ◽  
Kanghui Yu ◽  
Chunlong Li ◽  
Zhihong Lan ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
T1 Mapping ◽  
Healthy Adult ◽  
Extracellular Volume ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Healthy Adults ◽  
Left Ventricular Myocardium ◽  
3T Mri

Abstract purposeThe correlation between T1 and ECV value and myocardial fibrosis has been confirmed. In healthy adult, many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and gender.Methods We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. resultsUnder 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only gender (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while gender (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. Significant differences were observed between the middle segments of T1 value (P = 0.001) but not between the middle of the ECV value of each segment (P = 0.068). Lastly, there was no statistical difference between each segment in the apical of the T1 (P = 0.756) and ECV value (P = 0.344).ConclusionsUnder 3T MRI, the T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.

Abstract 17007: Cardiac Magnetic Resonance Assessment of Right Ventricular Remodeling After Anthracycline Therapy

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Thiago Ferreira de Souza ◽  
Thiago Quinaglia ◽  
Ligia Antunes-Correa ◽  
Zsofia Drobni ◽  
Felipe Costa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Right Ventricular ◽  
Ventricular Remodeling ◽  
Troponin T ◽  
Extracellular Volume ◽  
Left Ventricular ◽  
Anthracycline Therapy ◽  
And Function

Introduction: There are limited data characterizing the effect of anthracyclines on right ventricular (RV) structure and function. Hypothesis: The goal of this study was to test the effect of anthracyclines on RV myocardial remodeling using cardiac magnetic resonance (CMR). Methods: This was a prospective CMR and serum biomarker study of 27 women with breast cancer (BC) (51.8±8.9 years) who underwent a CMR prior, and up to 3-times after anthracycline therapy (240 mg/m 2 ). The primary measure of interest was the RV extracellular volume (ECV) and cardiomyocyte mass index (1-ECV). Additional measures of interest were the left ventricular (LV) ECV, and the LV and RV mass. Biomarkers included high-sensitive troponin T, and creatinine-kinase MB isoenzyme (CKMB). Results: Before anthracyclines, all subjects had normal LV ejection fraction (EF) (69.4±3.6%) and RVEF (55.6±9%). At 351-700 days after anthracyclines, the LVEF and LV mass index declined to 58±6% (P<0.001) and 36±6g/m 2 (P<0.001). Similarly, the RVEF and RV mass index also decreased, reaching 46.3±6.8% at (222-350] days (P<0.001) and 8.13±2g/m 2 at (350-700] days (P<0.001) after anthracycline, respectively (Figure 1). At (350-700] days after anthracycline, both LV and RV ECV increased by 0.037 to 0.36±0.04 (P=0.004) and by 0.12 to 0.40±0.07 (P<0.001), respectively (Figure 2). In parallel, both the LV and RV cardiomyocyte mass also decreased after anthracyclines (Figure 2). Conclusions: In a prospective observational study among women with breast cancer, anthracyclines were associated with a decrease in the RV EF, an increase in the RV ECV and a decrease in the RV cardiomyocyte mass.

scholarly journals Cardiac involvement in cystic fibrosis evaluated using cardiopulmonary magnetic resonance

2022 ◽  
Author(s):  
Jakub Lagan ◽  
Josephine H. Naish ◽  
Joshua Bradley ◽  
Christien Fortune ◽  
Charlie Palmer ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Pulmonary Disease ◽  
Cardiac Involvement ◽  
Extracellular Volume ◽  
Left Ventricular ◽  
Structure And Function ◽  
Airflow Limitation ◽  
Myocardial Oedema ◽  
And Function

AbstractCystic fibrosis (CF) transmembrane conductance regulator is expressed in myocardium, but cardiac involvement in CF remains poorly understood. The recent development of a combined cardiopulmonary magnetic resonance imaging technology allows for a simultaneous interrogation of cardiac and pulmonary structure and function. The aim of this study was to investigate myocardial manifestations in adults with CF, both in a stable state and during an acute respiratory exacerbation, and to investigate the relationship between cardiac and pulmonary disease. Healthy adult volunteers (n = 12) and adults with CF (n = 10) were studied using a multiparametric cardiopulmonary magnetic resonance protocol. CF patients were scanned during an acute respiratory exacerbation and re-scanned when stable. Stable CF was associated with left ventricular dilatation and hypertrophy (LVH; left ventricular mass: CF 59 ± 9 g/m2 vs. control 50 ± 8 g/m2; p = 0.028). LVH was predominantly driven by extracellular myocardial matrix expansion (extracellular matrix mass: CF 27.5 ± 3.4 g vs. control 23.6 ± 5.2 g; p = 0.006; extracellular volume [ECV]: CF 27.6 [24.7–29.8]% vs. control 24.8 [22.9–26.0]%; p = 0.030). Acute CF was associated with an acute reduction in left ventricular function (ejection fraction: acute 57 ± 3% vs. stable 61 ± 5%; p = 0.025) and there was a suggestion of myocardial oedema. Myocardial oedema severity was strongly associated with the severity of airflow limitation (r = − 0.726, p = 0.017). Multiparametric cardiopulmonary magnetic resonance technology allows for a simultaneous interrogation of cardiac and pulmonary structure and function. Stable CF is associated with adverse myocardial remodelling, including left ventricular systolic dilatation and hypertrophy, driven by myocardial fibrosis. CF exacerbation is associated with acute myocardial contractile dysfunction. There is also a suggestion of myocardial oedema in the acute period which is related to pulmonary disease severity.

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