The Relationship between IL-1β, IL-17, IL-33 and Bcl-2 and the Development of Diabetic Nephropathy
Abstract Background: Diabetic nephropathy (DN) is among the main complications of diabetes mellitus, and it has been the major factor of renal failure. The current investigation aims to address the association between beta-cell lymphoma-2 (Bcl-2), interleukin (IL)-1β, IL-17, and IL-33 with the development of DN. Methods: In this study, twenty healthy volunteers plus hundred patients have been signed up. According to their biochemical markers, patients were categorized into 5 groups; diabetic, chronic renal disease, diabetic chronic renal disease, end-stage renal disease, and diabetic end-stage renal disease. Results: Our results showed a noticeable elevation in IL-1β and IL-17 levels and a reduce in IL-33 and Bcl-2 levels in all investigated groups relative to the healthy group. Positive correlations were reported between IL-1β with FBS and creatinine levels, IL-17, with HbA1c% and sodium levels. However, negative correlations were exerted between IL-33 with urea and sodium concentration, Bcl2 with HbA1c%, and creatinine levels.Conclusion: The present data revealed a marked relationship between Bcl-2, IL-1β, IL-17, and IL-33 levels and the progression of DN. Therefore, understanding the molecular pathways of inflammatory and apoptotic activities-related DN could be translated into the development of therapeutic strategies.