scholarly journals Correlations Between Visual Acuity, Presenting Symptoms and Histopathological Findings in Enucleated Eyes with Uveal Melanoma

2021 ◽  
Author(s):  
Elin Asplund ◽  
Tony Pansell ◽  
Rune Brautaset ◽  
Maria Nilsson ◽  
Gustav Stålhammar
Keyword(s):  
Visual Acuity ◽  
Tumor Cell ◽  
Uveal Melanoma ◽  
Histopathological Examination ◽  
Vasculogenic Mimicry ◽  
Tumor Thickness ◽  
Cell Type ◽  
Basal Diameter ◽  
Presenting Symptoms ◽  
Blurry Vision

Abstract Visual outcomes after treatment of uveal melanoma have been investigated repeatedly. In this paper, we evaluate the correlation between visual acuity (VA) prior to enucleation, presenting symptoms and findings upon histopathological examination of eyes and tumors. Sixty nine patients were included. Their mean best corrected visual acuity (BCVA) prior to enucleation was LogMAR 0.80 (SD 0.70). Patients that reported low VA or blurry vision did not have lower BCVA upon refraction (p=0.34). Patients with low BCVA had tumors with greater apical tumor thickness (p=0.027), basal diameter (p=0.012) and stage (p=0.014). The experience of a shadow in the visual field correlated with presence of vasculogenic mimicry in the tumor (p<0.001). In multivariate Cox regressions with tumor thickness and diameter as covariates, tumor cell type and infiltration of the optic nerve head were associated with increased hazard for melanoma-related mortality (3.2 and 3.6, respectively). We conclude that patients that report low VA do not necessarily have worse BCVA. The latter do however have tumors with larger dimensions, at more advanced stage. A shadow in the VF correlates with presence of vasculogenic mimicry, which is an independent predictor for poor prognosis along with tumor infiltration of the optic disc and tumor cell type.

scholarly journals Vasculogenic Mimicry Correlates to Presenting Symptoms and Mortality in Uveal Melanoma

2021 ◽  
Author(s):  
Shiva Sabazade ◽  
Viktor Torgny Gill ◽  
Christina Herrspiegel ◽  
Gustav Stålhammar
Keyword(s):  
Visual Field ◽  
Uveal Melanoma ◽  
Poor Prognosis ◽  
Periodic Acid ◽  
Vasculogenic Mimicry ◽  
Clinicopathological Parameters ◽  
Tumor Diameter ◽  
Blurred Vision ◽  
Periodic Acid Schiff ◽  
Presenting Symptoms

Abstract PurposeFluid-conducting extracellular matrix patterns known as vasculogenic mimicry (VM) have been associated with poor prognosis in uveal melanoma and other cancers. We investigate the correlations between VM, presenting symptoms, mortality and the area density of periodic acid-Schiff positive histological patterns (PAS density).MethodsSixty-nine patients that underwent enucleation for uveal melanoma between 2000 and 2007 were included. Clinicopathological parameters, presenting symptoms and outcomes were collected. Histological tumor sections were evaluated for VM and PAS density was quantified with digital image analysis.ResultsThirty-four patients (49 %) presented with blurred vision. 18 (26 %) with a shadow in the visual field, 7 (10 %) with photopsia and/or floaters and 2 (3 %) with metamorphopsia. Nine patients (13 %) had no symptoms at all. Median follow-up was 16.7 years (SD 2.6). A shadow in the visual field, but no other symptom, was positively correlated with the presence of VM (φ 0.70, p<0.001) and greater PAS density (p<0.001). In multivariate regression, retinal detachment (RD), presence of VM and PAS density ≥ median were independent predictors of a shadow, but not tumor distance to the macula, tumor apical thickness, tumor diameter or ciliary body engagement. Presence of VM was associated with significantly shorter cumulative disease-specific survival (Wilcoxon p=0.04), but not PAS density ≥ median, presenting symptoms or RD (p>0.28).ConclusionTumors from uveal melanoma patients that report a visual field shadow are likely to display VM and greater PAS density, likely explaining the previously reported association between this symptom and poor prognosis.

scholarly journals Vasculogenic mimicry correlates to presenting symptoms and mortality in uveal melanoma

2021 ◽  
Author(s):  
Shiva Sabazade ◽  
Viktor Gill ◽  
Christina Herrspiegel ◽  
Gustav Stålhammar
Keyword(s):  
Visual Field ◽  
Uveal Melanoma ◽  
Poor Prognosis ◽  
Periodic Acid ◽  
Vasculogenic Mimicry ◽  
Clinicopathological Parameters ◽  
Tumor Diameter ◽  
Blurred Vision ◽  
Periodic Acid Schiff ◽  
Presenting Symptoms

Abstract Purpose Fluid-conducting extracellular matrix patterns known as vasculogenic mimicry (VM) have been associated with poor prognosis in uveal melanoma and other cancers. We investigate the correlations between VM, presenting symptoms, mortality, and the area density of periodic acid-Schiff positive histological patterns (PAS density). Methods Sixty-nine patients that underwent enucleation for uveal melanoma between 2000 and 2007 were included. Clinicopathological parameters presenting symptoms and outcomes were collected. Histological tumor sections were evaluated for VM and PAS density was quantified with digital image analysis. Results Thirty-four patients (49%) presented with blurred vision. 18 (26%) with a shadow in the visual field, 7 (10%) with photopsia and/or floaters, and 2 (3%) with metamorphopsia. Nine patients (13%) had no symptoms at all. Median follow-up was 16.7 years (SD 2.6). A shadow in the visual field, but no other symptom, was positively correlated with the presence of VM (φ 0.70, p < 0.001) and greater PAS density (p < 0.001). In multivariate regression, retinal detachment (RD), presence of VM, and PAS density ≥ median were independent predictors of a shadow, but not tumor distance to the macula, tumor apical thickness, tumor diameter, or ciliary body engagement. The presence of VM was associated with significantly shorter cumulative disease-specific survival (Wilcoxon p = 0.04), but not PAS density ≥ median, presenting symptoms or RD (p > 0.28). Conclusion Tumors from uveal melanoma patients that report a visual field shadow are likely to display VM and greater PAS density, likely explaining the previously reported association between this symptom and poor prognosis.

scholarly journals Ischemia Is Related to Tumour Genetics in Uveal Melanoma

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1004 ◽  
Author(s):  
Niels J. Brouwer ◽  
Annemijn P. A. Wierenga ◽  
Gülçin Gezgin ◽  
Marina Marinkovic ◽  
Gregorius P. M. Luyten ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Messenger Rna ◽  
Tumour Size ◽  
Hypoxia Inducible Factor ◽  
The Cancer Genome Atlas ◽  
Basal Diameter ◽  
Von Hippel Lindau ◽  
The Status ◽  
Using Data ◽  
Tumour Genetics

Hypoxia-inducible factor 1-alpha (HIF1a) and its regulator von Hippel–Lindau protein (VHL) play an important role in tumour ischemia. Currently, drugs that target HIF1a are being developed to treat malignancies. Although HIF1a is known to be expressed in uveal melanoma (UM), it is as yet unknown which factors, such as tumour size or genetics, determine its expression. Therefore, we aimed to determine which tumour characteristics relate to HIF1a expression in UM. Data from 64 patients who were enucleated for UM were analysed. Messenger RNA (mRNA) expression was determined with the Illumina HT-12 v4 chip. In 54 cases, the status of chromosomes 3 and 8q, and BRCA1-associated protein 1 (BAP1) protein expression (immunohistochemistry) were determined. Findings were corroborated using data of 80 patients from the Cancer Genome Atlas (TCGA) study. A significantly increased expression of HIF1a, and a decreased expression of VHL were associated with monosomy 3/loss of BAP1 expression. The relationship between BAP1 loss and HIF1a expression was independent of chromosome 3. The largest basal diameter and tumour thickness showed no relationship with HIF1a. HIF1a expression related to an increased presence of infiltrating T cells and macrophages. From this study, we conclude that HIF1a is strongly related to tumour genetics in UM, especially to loss of BAP1 expression, and less to tumour size. Tumour ischemia is furthermore related to the presence of an inflammatory phenotype.

The prognostic value of uveal melanoma cell type

2021 ◽  
Vol 83 (4) ◽  
pp. 14
Author(s):  
V.A. Yarovaya ◽  
A.V. Shatskikh ◽  
A.R. Zaretsky ◽  
I.A. Levashov ◽  
D.P. Volodin ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Prognostic Value ◽  
Cell Type ◽  
Uveal Melanoma Cell

Tumor cell markers in uveal melanoma

1997 ◽  
Author(s):  
G Wirnsberger ◽  
R Kleinert ◽  
G Langmann ◽  
U Fuchs
Keyword(s):  
Tumor Cell ◽  
Uveal Melanoma ◽  
Cell Markers

Expression of insulin-like growth factor-1 receptor in metastatic uveal melanoma and implications for potential autocrine and paracrine tumor cell growth

2014 ◽  
Vol 27 (2) ◽  
pp. 297-308 ◽  
Author(s):  
Makoto Yoshida ◽  
Senthamil Selvan ◽  
Peter A. McCue ◽  
Tiziana DeAngelis ◽  
Renato Baserga ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Tumor Cell ◽  
Uveal Melanoma ◽  
Insulin Like Growth Factor ◽  
Tumor Cell Growth

scholarly journals Influence of organ site and tumor cell type on MUC1-specific tumor immunity

2001 ◽  
Vol 13 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Keita Morikane ◽  
Richard M. Tempero ◽  
Connie L. Sivinski ◽  
Shimichi Kitajima ◽  
Sandra J. Gendler ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Immunity ◽  
Cell Type ◽  
Specific Tumor ◽  
Organ Site

Bilateral fungal infection inducing a serpiginous-like picture

2020 ◽  
pp. 112067212090872
Author(s):  
Alvaro Fernández-Vega González ◽  
Carlos Fernández-Vega González ◽  
Beatriz Fernández-Vega Sanz ◽  
María Teresa Peláez ◽  
Jesús Merayo-Lloves
Keyword(s):  
Visual Acuity ◽  
Fungal Infection ◽  
Inflammatory Diseases ◽  
Histopathological Examination ◽  
Clinical Findings ◽  
Blood Analysis ◽  
Retinal Pigmented Epithelium ◽  
Pigmented Epithelium ◽  
Laboratory Investigations ◽  
The Right

Purpose: To report the clinical findings of a patient who presented with an atypical bilateral fungal retinitis that was established by retinochoroidal biopsy. Methods: Case report. Results: A 56-year-old systemically healthy man presented with progressive visual loss in his left eye for 3 weeks. Visual acuity was 20/40 in the left eye, and 20/20 in the right eye and fundus examination showed macular retinal pigmented epithelium changes in his left eye. Over the following four months, his lesions progressed to serpiginous-like widespread retinal pigmented epithelium atrophy and his visual acuity decreased to 20/100, but no signs of ocular inflammation were found. Treatment with oral corticoids, valganciclovir and trimethoprim/sulfamethoxazole showed no efficacy. Blood analysis and cultures, laboratory investigations, and imaging tests were carried out looking for infectious and inflammatory diseases, but all tests were negative. Two months later, the patient presented with the same kind of lesions in the other eye (right eye), so he was subjected to retinochoroidal biopsy. Histopathological examination of specimen revealed the presence of intraretinal and choroidal fungal hyphae. Oral voriconazole was initiated achieving clinical remission, but no visual improvement was obtained. The source of the infection remains unknown since all tests results were negative. However, his profession as brewmaster might be related to the origin of the infection. Conclusion: Diagnosis of intraocular fungal infection can be challenging. Retinochoroidal biopsy may be useful to establish the diagnosis in those atypical cases with nonrevealing workup and inflammation localized to the retina.

Sign in / Sign up

Export Citation Format

Share Document