scholarly journals Characterization of Cutaneous and Subcutaneous Neoplasms in Canines and Malignancy Prediction Using B-Mode Ultrasonography, Doppler, and ARFI Elastography

2021 ◽  
Author(s):  
Igor Cezar Kniphoff Cruz ◽  
Rafael Kretzer Carneiro ◽  
Andrigo Barboza Nardi ◽  
Ricardo Andrés Ramirez Uscategui ◽  
Eduarda Mazzardo Bortoluzzi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Invasive Technique ◽  
Malignant Neoplasms ◽  
Adequate Treatment ◽  
Non Invasive ◽  
Metastatic Lesions ◽  
Evaluation Protocol ◽  
Long Time ◽  
Arfi Elastography

Abstract Background Cutaneous and subcutaneous neoplasms are highly prevalent in dogs, ranging from benign to highly aggressive and metastatic lesions. The diagnosis is obtained through histopathology, however it is an invasive technique that may take a long time to obtain the result, delaying the beginning of the adequate treatment. Thus, there is a need for non-invasive tests that can help in the early diagnosis of this type of cancer. The aim of this study was to verify the accuracy of ultrasonography methods to predict malignancy in cutaneous and subcutaneous canine neoplasms. In addition, we aim to propose an ultrasonography evaluation protocol and perform the neoplasms characterization using these three proposed techniques. Results Twenty-one types of specific neoplasm were diagnosed, and using B-mode, we verified the association between heterogeneous echotexture, invasiveness, presence of hyperechoic spots, and cavity areas with malignancy. An increased pulsatility was verified in malignant neoplasms using Doppler (cut-off value >0.93). When using the elastography, malignancy was associated with non-deformable tissues and shear wave velocity >3.52 m/s. Evaluation protocols were proposed associating 4, 5, 6, or 7 malignancy predictive characteristics, and characterization was done for all tumors with at least two cases. Conclusions We concluded that ultrasonography methods are promising and effective in predicting malignancy in these types of tumors, and the association of methods can increase the specificity of the results.

scholarly journals Malignancy prediction of cutaneous and subcutaneous neoplasms in canines using B-mode ultrasonography, Doppler, and ARFI elastography

2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Igor Cezar Kniphoff da Cruz ◽  
Rafael Kretzer Carneiro ◽  
Andrigo Barboza de Nardi ◽  
Ricardo Andrés Ramirez Uscategui ◽  
Eduarda Mazzardo Bortoluzzi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Shear Wave Velocity ◽  
Invasive Technique ◽  
Malignant Neoplasms ◽  
Adequate Treatment ◽  
Non Invasive ◽  
Metastatic Lesions ◽  
Evaluation Protocol ◽  
Long Time ◽  
Arfi Elastography

Abstract Background Cutaneous and subcutaneous neoplasms are highly prevalent in dogs, ranging from benign to highly aggressive and metastatic lesions. The diagnosis is obtained through histopathology, however it is an invasive technique that may take a long time to obtain the result, delaying the beginning of the adequate treatment. Thus, there is a need for non-invasive tests that can help in the early diagnosis of this type of cancer. The aim of this study was to verify the accuracy of B-mode ultrasonography, Doppler, and ARFI elastography to predict malignancy in cutaneous and subcutaneous canine neoplasms. In addition, we aim to propose an ultrasonography evaluation protocol and perform the neoplasms characterization using these three proposed techniques. Results Twenty-one types of specific neoplasm were diagnosed, and using B-mode, we verified the association between heterogeneous echotexture, invasiveness, presence of hyperechoic spots, and cavity areas with malignancy. An increased pulsatility was verified in malignant neoplasms using Doppler (cut-off value > 0.93). When using the elastography, malignancy was associated with non-deformable tissues and shear wave velocity > 3.52 m/s. Evaluation protocols were proposed associating 4, 5, 6, or 7 malignancy predictive characteristics, and characterization was done for all tumors with at least two cases. Conclusions We concluded that ultrasonography methods are promising and effective in predicting malignancy in these types of tumors, and the association of methods can increase the specificity of the results.

scholarly journals Accuracy of shear wave elastography in characterization of thyroid nodules in children and adolescents

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mohammed Hazem ◽  
Ossama M. Zakaria ◽  
Mohamed Yasser Ibrahim Daoud ◽  
Ibrahim Khalid Al Jabr ◽  
Abdulwahab A. AlYahya ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Shear Wave ◽  
Diagnostic Performance ◽  
Thyroid Nodules ◽  
Shear Wave Elastography ◽  
Invasive Technique ◽  
Predictive Values ◽  
Patients Âgés ◽  
Non Invasive

Abstract Background Thyroid nodules are an important health problem in children and adolescents. They possess a higher risk of malignancy in comparison to adults. This fact forms a great dilemma for clinicians. The aim of this study was to evaluate the reliability of shear wave elastography (SWE) as a non-invasive technique in the characterization of thyroid nodules in children and adolescents. Methods This prospective study included 56 patients with thyroid nodules. All the patients underwent clinical assessment, laboratory investigations, ultrasound, and Doppler examination, followed by an SWE assessment. Statistical analysis was performed and the best cut-off value to differentiate benign from malignant nodules was determined using the ROC curve and AUC. Results Seventy-two nodules were detected in the examined patients (ages ranged from 11 to 19 years, with mean age of 14.89 ± 2.3 years). Fifty-eight nodules (80.6%) were benign, and fourteen nodules (19.4%) were malignant (histopathologically proved). Highly suspicious criteria for prediction of malignancy by ultrasound and Doppler were hypoechoic echopattern, internal or internal and peripheral vascularity, microcalcifications, taller-than-wide dimensions, irregular outlines, and absence of halo (p < 0.05). The diagnostic performance for their summation was 70.69% sensitivity, 82.8% specificity, 80.45% accuracy, a 63.79% positive predictive value (PPV), and 87.9% negative predictive values (NPV). Regarding SWE, our results showed that 42.2 kPa was the best cut-off value, with AUC = 0.921 to differentiate malignant from benign nodules; the diagnostic performance was 85.71% sensitivity, 94.83% specificity, 93.06% accuracy, 76.9% PPV, and 93.2% NPV. Conclusion Shear wave elastography is a non-invasive technique that can assist in the diagnosis of malignant thyroid nodules among children and adolescents.

scholarly journals Role of Acoustic Radiation Force Impulse Elastography in the Characterization of Focal Solid Hepatic Lesions

2018 ◽  
Vol 8 ◽  
pp. 5 ◽  
Author(s):  
Harshavardhan Nagolu ◽  
Sudhakar Kattoju ◽  
Chidambaranathan Natesan ◽  
Meera Krishnakumar ◽  
Sunil Kumar
Keyword(s):  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Benign Lesions ◽  
Metastatic Lesions ◽  
Arfi Elastography ◽  
Malignant Lesions ◽  
2D Imaging

Objective: The purpose of the study is to investigate the usefulness of acoustic radiation force impulse (ARFI) elastography in the characterization of focal solid liver lesions as benign, malignant, or metastatic using ARFI two-dimensional (2D) imaging and ARFI quantification (shear wave velocities [SWVs]). Materials and Methods: Sixty lesions were included in this study. The lesions were classified into three groups: Group I included benign lesions (n = 25), Group II included malignant lesions (n = 27), and Group III included metastatic lesions (n = 8). ARFI elastography was performed in all these patients using a Siemens ACUSON S 2000™ ultrasound machine. Stiffness and size of the lesions were assessed on ARFI 2D images in correlation with B-mode ultrasound images. SWVs were obtained in these lesions for the quantification of stiffness. Results: In ARFI 2D images, malignant lesions were predominantly stiffer and larger, while benign lesions were softer and similar in size (P < 0.05). The mean SWVs in benign, malignant, and metastatic lesions were 1.30 ± 0.35 m/s, 2.93 ± 0.75 m/s, and 2.77 ± 0.90 m/s, respectively. The area under receiver operating characteristic curve of SWV for differentiating benign from malignant lesions was 0.877, suggesting fair accuracy (95% confidence interval: 0.777–0.976); with a cutoff value of 2 m/s, showing sensitivity: 92%; specificity: 96%; positive predictive value: 96%; negative predictive value: 93% (P < 0.05). Statistically significant difference exists in SWV of benign and malignant or metastatic lesions. Conclusion: ARFI elastography with 2D imaging and quantification might be useful in the characterization of benign and malignant liver lesions.

scholarly journals Pelvic and Lumbar Pain Revealing Bone Sarcoidosis: A Case Report

2021 ◽  
Vol 14 ◽  
pp. 117954762110147
Author(s):  
Yahya Charifi ◽  
Younes Dkhissi ◽  
Meryem Haloua ◽  
Youssef Alaoui Lamrani ◽  
Ghizlane Berrady ◽  
...  
Keyword(s):  
Lumbar Pain ◽  
Invasive Technique ◽  
Bone Lesions ◽  
Non Invasive ◽  
Metastatic Lesions ◽  
Bone Infiltration ◽  
Extent Of Damage ◽  
Weighted Sequences ◽  
Fluorodeoxyglucose Pet ◽  
Bone Sarcoidosis

A 54-years-old woman suffered from a bilateral pelvic and lumbar pain. She had a systemic investigation shows a diffuse bone lesions. A biopsy of iliac bone was done and revealed sarcoidosis. Bony manifestations of sarcoidosis are rare and challenging to diagnose. Our report shows that MRI with diffusion weighted sequences is a simple and non invasive technique to evaluate bone infiltration. It helps to distinguish inflammatory disease from metastatic lesions and to guide the osseous biopsy. Moreover, fluorodeoxyglucose PET scan, are useful in establishing the extent of damage and measuring disease activity.

scholarly journals Dielectrophoresis-based microfluidic device for separation of potential cancer cells

2020 ◽  
Vol 9 (6) ◽  
pp. 2270-2277
Author(s):  
Nur Fatien Najwa Mohamad Narji ◽  
Mohd Ridzuan Ahmad
Keyword(s):  
Microfluidic Device ◽  
Current Method ◽  
Ct Scanning ◽  
Main Channel ◽  
Invasive Technique ◽  
Cell Capture ◽  
Non Invasive ◽  
Cancerous Cell ◽  
Long Time ◽  
Potential Cancer

Cancer is a leading cause of death that adversely affects all ages and genders around the world. There is a range of approaches such as CT scanning and mammography to diagnose cancer. Although the current method has many benefits, most of it share similar drawbacks as the result of detection takes long time and can lead to over diagnosis. Dielectrophoresis (DEP) is a method that can be used to obtain the cell electrical properties such as capacitance, conductivity, and permittivity. A device was designed in this study using a pair of electrodes and main channel with two inlets and two outlets. COMSOL software is adopted to analyze channel particle flow. Results show the configuration of microfluidic device and its dimensions. For potential application, DEP may be used as a non-invasive technique to distinguish normal cell from cancerous cell, which can lead to early detection as it offers a real-time warning. The simulations reveal that the electrodes captured the particles successfully and sorted them within specific time. The chance of cell capture and the ability of the electrodes to sort the cells is around 80%. In addition, an ideal design of the microfluidic chip was established, incorporating the cell and dielectric properties.

scholarly journals Modern prostate cancer biomarkers. Prospects for EN2 in the prostate cancer diagnosis

2020 ◽  
Vol 16 (3) ◽  
pp. 165-173
Author(s):  
A. S. Tarabayeva ◽  
A. B. Zhubanturliyeva ◽  
I. M. Okhas
Keyword(s):  
Prostate Cancer ◽  
Early Diagnosis ◽  
Cancer Diagnosis ◽  
Cancer Biomarkers ◽  
Malignant Neoplasms ◽  
Prostate Cancer Diagnosis ◽  
Non Invasive ◽  
Diagnostic Capabilities ◽  
Risk Of Relapse ◽  
Tissue Biomarkers

Prostate cancer is one of the most common forms of malignant neoplasms in men. In this regard, it is relevant to search for diagnostic markers that allow the creation of inexpensive, effective tests for early diagnosis of the disease, predicting the risk of relapse and assessing the effectiveness of the therapy. Existing invasive methods for diagnosing prostate cancer present some difficulties for patients. This article discusses the diagnostic capabilities of tissue biomarkers of prostate cancer obtained by non-invasive methods.

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