scholarly journals Malignancy prediction of cutaneous and subcutaneous neoplasms in canines using B-mode ultrasonography, Doppler, and ARFI elastography

2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Igor Cezar Kniphoff da Cruz ◽  
Rafael Kretzer Carneiro ◽  
Andrigo Barboza de Nardi ◽  
Ricardo Andrés Ramirez Uscategui ◽  
Eduarda Mazzardo Bortoluzzi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Shear Wave Velocity ◽  
Invasive Technique ◽  
Malignant Neoplasms ◽  
Adequate Treatment ◽  
Non Invasive ◽  
Metastatic Lesions ◽  
Evaluation Protocol ◽  
Long Time ◽  
Arfi Elastography

Abstract Background Cutaneous and subcutaneous neoplasms are highly prevalent in dogs, ranging from benign to highly aggressive and metastatic lesions. The diagnosis is obtained through histopathology, however it is an invasive technique that may take a long time to obtain the result, delaying the beginning of the adequate treatment. Thus, there is a need for non-invasive tests that can help in the early diagnosis of this type of cancer. The aim of this study was to verify the accuracy of B-mode ultrasonography, Doppler, and ARFI elastography to predict malignancy in cutaneous and subcutaneous canine neoplasms. In addition, we aim to propose an ultrasonography evaluation protocol and perform the neoplasms characterization using these three proposed techniques. Results Twenty-one types of specific neoplasm were diagnosed, and using B-mode, we verified the association between heterogeneous echotexture, invasiveness, presence of hyperechoic spots, and cavity areas with malignancy. An increased pulsatility was verified in malignant neoplasms using Doppler (cut-off value > 0.93). When using the elastography, malignancy was associated with non-deformable tissues and shear wave velocity > 3.52 m/s. Evaluation protocols were proposed associating 4, 5, 6, or 7 malignancy predictive characteristics, and characterization was done for all tumors with at least two cases. Conclusions We concluded that ultrasonography methods are promising and effective in predicting malignancy in these types of tumors, and the association of methods can increase the specificity of the results.

scholarly journals Characterization of Cutaneous and Subcutaneous Neoplasms in Canines and Malignancy Prediction Using B-Mode Ultrasonography, Doppler, and ARFI Elastography

2021 ◽  
Author(s):  
Igor Cezar Kniphoff Cruz ◽  
Rafael Kretzer Carneiro ◽  
Andrigo Barboza Nardi ◽  
Ricardo Andrés Ramirez Uscategui ◽  
Eduarda Mazzardo Bortoluzzi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Invasive Technique ◽  
Malignant Neoplasms ◽  
Adequate Treatment ◽  
Non Invasive ◽  
Metastatic Lesions ◽  
Evaluation Protocol ◽  
Long Time ◽  
Arfi Elastography

Abstract Background Cutaneous and subcutaneous neoplasms are highly prevalent in dogs, ranging from benign to highly aggressive and metastatic lesions. The diagnosis is obtained through histopathology, however it is an invasive technique that may take a long time to obtain the result, delaying the beginning of the adequate treatment. Thus, there is a need for non-invasive tests that can help in the early diagnosis of this type of cancer. The aim of this study was to verify the accuracy of ultrasonography methods to predict malignancy in cutaneous and subcutaneous canine neoplasms. In addition, we aim to propose an ultrasonography evaluation protocol and perform the neoplasms characterization using these three proposed techniques. Results Twenty-one types of specific neoplasm were diagnosed, and using B-mode, we verified the association between heterogeneous echotexture, invasiveness, presence of hyperechoic spots, and cavity areas with malignancy. An increased pulsatility was verified in malignant neoplasms using Doppler (cut-off value >0.93). When using the elastography, malignancy was associated with non-deformable tissues and shear wave velocity >3.52 m/s. Evaluation protocols were proposed associating 4, 5, 6, or 7 malignancy predictive characteristics, and characterization was done for all tumors with at least two cases. Conclusions We concluded that ultrasonography methods are promising and effective in predicting malignancy in these types of tumors, and the association of methods can increase the specificity of the results.

scholarly journals Pelvic and Lumbar Pain Revealing Bone Sarcoidosis: A Case Report

2021 ◽  
Vol 14 ◽  
pp. 117954762110147
Author(s):  
Yahya Charifi ◽  
Younes Dkhissi ◽  
Meryem Haloua ◽  
Youssef Alaoui Lamrani ◽  
Ghizlane Berrady ◽  
...  
Keyword(s):  
Lumbar Pain ◽  
Invasive Technique ◽  
Bone Lesions ◽  
Non Invasive ◽  
Metastatic Lesions ◽  
Bone Infiltration ◽  
Extent Of Damage ◽  
Weighted Sequences ◽  
Fluorodeoxyglucose Pet ◽  
Bone Sarcoidosis

A 54-years-old woman suffered from a bilateral pelvic and lumbar pain. She had a systemic investigation shows a diffuse bone lesions. A biopsy of iliac bone was done and revealed sarcoidosis. Bony manifestations of sarcoidosis are rare and challenging to diagnose. Our report shows that MRI with diffusion weighted sequences is a simple and non invasive technique to evaluate bone infiltration. It helps to distinguish inflammatory disease from metastatic lesions and to guide the osseous biopsy. Moreover, fluorodeoxyglucose PET scan, are useful in establishing the extent of damage and measuring disease activity.

scholarly journals Dielectrophoresis-based microfluidic device for separation of potential cancer cells

2020 ◽  
Vol 9 (6) ◽  
pp. 2270-2277
Author(s):  
Nur Fatien Najwa Mohamad Narji ◽  
Mohd Ridzuan Ahmad
Keyword(s):  
Microfluidic Device ◽  
Current Method ◽  
Ct Scanning ◽  
Main Channel ◽  
Invasive Technique ◽  
Cell Capture ◽  
Non Invasive ◽  
Cancerous Cell ◽  
Long Time ◽  
Potential Cancer

Cancer is a leading cause of death that adversely affects all ages and genders around the world. There is a range of approaches such as CT scanning and mammography to diagnose cancer. Although the current method has many benefits, most of it share similar drawbacks as the result of detection takes long time and can lead to over diagnosis. Dielectrophoresis (DEP) is a method that can be used to obtain the cell electrical properties such as capacitance, conductivity, and permittivity. A device was designed in this study using a pair of electrodes and main channel with two inlets and two outlets. COMSOL software is adopted to analyze channel particle flow. Results show the configuration of microfluidic device and its dimensions. For potential application, DEP may be used as a non-invasive technique to distinguish normal cell from cancerous cell, which can lead to early detection as it offers a real-time warning. The simulations reveal that the electrodes captured the particles successfully and sorted them within specific time. The chance of cell capture and the ability of the electrodes to sort the cells is around 80%. In addition, an ideal design of the microfluidic chip was established, incorporating the cell and dielectric properties.

scholarly journals Modern prostate cancer biomarkers. Prospects for EN2 in the prostate cancer diagnosis

2020 ◽  
Vol 16 (3) ◽  
pp. 165-173
Author(s):  
A. S. Tarabayeva ◽  
A. B. Zhubanturliyeva ◽  
I. M. Okhas
Keyword(s):  
Prostate Cancer ◽  
Early Diagnosis ◽  
Cancer Diagnosis ◽  
Cancer Biomarkers ◽  
Malignant Neoplasms ◽  
Prostate Cancer Diagnosis ◽  
Non Invasive ◽  
Diagnostic Capabilities ◽  
Risk Of Relapse ◽  
Tissue Biomarkers

Prostate cancer is one of the most common forms of malignant neoplasms in men. In this regard, it is relevant to search for diagnostic markers that allow the creation of inexpensive, effective tests for early diagnosis of the disease, predicting the risk of relapse and assessing the effectiveness of the therapy. Existing invasive methods for diagnosing prostate cancer present some difficulties for patients. This article discusses the diagnostic capabilities of tissue biomarkers of prostate cancer obtained by non-invasive methods.

USING DOPPLER TO ASSESS THE FETAL HEALTH FOR THE PREDICTION OF GESTATIONAL OUTCOME

2014 ◽  
pp. 9-18
Author(s):  
Thi Linh Giang Truong ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Umbilical Artery ◽  
Functional Method ◽  
Invasive Technique ◽  
Routine Practice ◽  
Fetal Health ◽  
Uterine Arteries ◽  
Non Invasive ◽  
Key Words Doppler

Background: Assessment of fetal health plays the most important role in prenatal care because of influence of the prediction of gestational outcome. One of the main aims of routine antenatal care is to identify the ‘ at risk ‘ fetus in order to apply clinical interventions which could results in reduced perinatal morbidity and mortality. Doppler ultrasound is a non invasive technique whereby the movement of blood is studied by detecting the change in frequence of reflected sound, Doppler blood flow velocity waves form of fetal side (umbilical artery, middle cerebral artery ...) and maternal side ( uterine arteries) are discussed and monograms for routine practice are presented. Recently this method is important tool for qualifying high risk pregnancies and help early forecasts the health of the babies and mothers disorder. Doppler sonography in obstetrics is a widely accepted functional method of examining the prediction of gestational outcome. Key words: Doppler, umbilical artery, middle cerebral artery, uterine arteries

scholarly journals Music for Monkeys: Building Methods to Design with White-Faced Sakis for Animal-Driven Audio Enrichment Devices

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1768
Author(s):  
Roosa Piitulainen ◽  
Ilyena Hirskyj-Douglas
Keyword(s):  
Longitudinal Study ◽  
Electronic Music ◽  
Computer Systems ◽  
Interactive System ◽  
Novelty Effect ◽  
Non Invasive ◽  
Long Period ◽  
Long Time ◽  
Audio System ◽  
Computer Interaction

Computer systems for primates to listen to audio have been researched for a long time. However, there is a lack of investigations into what kind of sounds primates would prefer to listen to, how to quantify their preference, and how audio systems and methods can be designed in an animal-focused manner. One pressing question is, if given the choice to control an audio system, would or could primates use such a system. In this study, we design an audio enrichment prototype and method for white-faced sakis that allows them to listen to different sounds in their regular zoo habitat while automatically logging their interactions. Focusing on animal-centred design, this prototype was built from low fidelity testing of different forms within the sakis’ enclosure and gathering requirements from those who care for and view the animal. This process of designing in a participatory manner with the sakis resulted in an interactive system that was shown to be viable, non-invasive, highly interactive, and easy to use in a zoo habitat. Recordings of the sakis’ interactions demonstrated that the sakis triggered traffic audio more than silence, rain sounds, zen, and electronic music. The data and method also highlight the benefit of a longitudinal study within the animals’ own environment to mitigate against the novelty effect and the day-to-day varying rhythm of the animals and the zoo environment. This study builds on animal-centred methods and design paradigms to allow the monitoring of the animals’ behaviours in zoo environments, demonstrating that useful data can be yielded from primate-controlled devices. For the Animal-Computer Interaction community, this is the first audio enrichment system used in zoo contexts within the animals own environment over a long period of time that gives the primate control over their interactions and records this automatically.

Point-of-Care Testing Using Invasive and Non-Invasive Hemoglobinometers: Reliable and Valid Method for Estimation of Hemoglobin among Children 6–59 Months

2020 ◽  
Author(s):  
Gomathi Ramaswamy ◽  
Kashish Vohra ◽  
Kapil Yadav ◽  
Ravneet Kaur ◽  
Tripti Rai ◽  
...  
Keyword(s):  
Point Of Care ◽  
Venous Blood ◽  
Public Health Problem ◽  
Outpatient Department ◽  
Point Of Care Testing ◽  
Adequate Treatment ◽  
Non Invasive ◽  
Hematology Analyzer ◽  
The Mean ◽  
Study Participants

Abstract Introduction Globally around 47.4% of children and in India, 58% of children aged 6–59 months are anemic. Diagnosis of anemia in children using accurate technologies and providing adequate treatment is essential to reduce the burden of anemia. Point-of-care testing (POCT) devices is a potential option for estimation of hemoglobin in peripheral and field settings were the hematology analyzer and laboratory services are not available. Objectives To access the validity of the POCTs (invasive and non-invasive devices) for estimation of hemoglobin among children aged 6–59 months compared with hematology analyzer. Methods The study participants were enrolled from the pediatric outpatient department in Haryana, India, from November 2019 to January 2020. Hemoglobin levels of the study participants were estimated in Sahli’s hemoglobinometer and invasive digital hemoglobinometers (DHs) using capillary blood samples. Hemoglobin levels in non-invasive DH were assessed from the finger/toe of the children. Hemoglobin levels measured in POCTs were compared against the venous blood hemoglobin estimated in the hematology analyzer. Results A total of 120 children were enrolled. The mean (SD) of hemoglobin (g/dl) estimated in auto-analyzer was 9.4 (1.8), Sahli’s hemoglobinometer was 9.2 (1.9), invasive DH was 9.7 (1.9), and non-invasive DH was 11.9 (1.5). Sahli’s hemoglobinometer (95.5%) and invasive DH (92.2%) had high sensitivity for the diagnosis of anemia compared with non-invasive DH (24.4%). In contrast, non-invasive DH had higher specificity (96.7%) compared with invasive DH (83.3%) and Sahli’s hemoglobinometer (70%). Invasive DH took the least time (2–3 min) for estimation of hemoglobin per participant, followed by Sahli’s (4–5 min) and non-invasive DH (5–7 min). Conclusion All three POCT devices used in this study are reasonable and feasible for estimating hemoglobin in under-5 children. Invasive DHs are potential POCT devices for diagnosis of anemia among under-5 children, while Sahli’s can be considered as a possible option, where trained and skilled technicians are available. Further research and development are required in non-invasive DH to improve accuracy. Lay summary In India, anemia is a serious public health problem, where 58% of the children aged 6–59 months are anemic. Point-of-care testing (POCT) using digital hemoglobinometers (DHs) has been recommended as one of the key interventions by the Anemia Mukt Bharat program since 2018 in India. These POCT devices are easy to use, less invasive, can be carried to field, require minimal training and results are available immediately. Therefore this study assessed the validity of POCT devices—invasive DH, non-invasive DH and Sahli’s hemoglobinometer among 6–59 months children in facility setting compared with the gold standard hematology analyzer. A total of 120 children under 6–59 months of age were enrolled from the pediatric outpatient department in Haryana, India, from November 2019 to January 2020. The (mean hemoglobin in g/dl) invasive (9.7) and non-invasive DH (11.9) overestimated hemoglobin value, while Sahli’s (9.2) underestimated hemoglobin compared with hematology analyzer (9.4). Invasive DH (92.2%) and Sahli’s hemoglobinometer (95.5%) reported high ability to correctly identify those with anemia compared with non-invasive DH (24.4%). In contrast, non-invasive DH (96.73%) had higher ability to correctly identify those without the anemia compared with invasive DH (83.3%) and Sahli’s (70%).

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