scholarly journals γ-Cyclodextrin Metal-Organic Framework as a Carrier to Deliver Triptolide for the Treatment of Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Zhe Li ◽  
Gang Yang ◽  
Rong Wang ◽  
Yuanyuan Wang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Water Solubility ◽  
Metal Organic Framework ◽  
Cell Internalization ◽  
The Poor ◽  
Metal Organic ◽  
Tumor Drugs ◽  
Organic Framework

Abstract Triptolide (TPL) has been employed to treat hepatocellular carcinoma (HCC). However, the poor water-solubility of TPL restrict its applications. Therefore, we prepared TPL loaded cyclodextrin-based metal-organic framework (TPL@CD-MOF) to improve the solubility and bioavailability of TPL, thus enhancing the anti-tumor effect on HCC. The BET surface and the pore size of TPL@CD-MOF were 1134.5 m2·g−1 and 1.6 nm, respectively. The results of XRD indicated that TPL in TPL@CD-MOF was encapsuled. TPL@CD-MOF showed a slower release than free TPL in vitro. Moreover, the CD-MOF improved the cell internalization and bioavailability of TPL. TPL@CD-MOF also showed higher anti-tumor efficacy in vitro and in vivo compared to free TPL. As a carrier, CD-MOF improved the solubility and bioavailability of TPL. In addition, TPL@CD-MOF exhibited improved anti-tumor effects in vitro and in vivo, indicating great potential as a carrier for insoluble anti-tumor drugs.

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal-Organic Framework Nanoparticles

2014 ◽  
Vol 21 (6) ◽  
pp. 2508-2518 ◽  
Author(s):  
Àngels Ruyra ◽  
Amirali Yazdi ◽  
Jordi Espín ◽  
Arnau Carné-Sánchez ◽  
Nerea Roher ◽  
...  
Keyword(s):  
Culture Medium ◽  
Zebrafish Embryo ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Embryo Toxicity ◽  
Medium Stability ◽  
Organic Framework

The cascade catalysis of the porphyrinic zirconium metal-organic framework PCN-224-Cu for CO2 conversion to alcohols

2021 ◽  
Author(s):  
Shi-Chao Qi ◽  
Zhi-Hui Yang ◽  
Rong-Rong Zhu ◽  
Xiao-Jie Lu ◽  
Ding-Ming Xue ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Co2 Conversion ◽  
Cascade System ◽  
The Past ◽  
Highly Efficient ◽  
Metal Organic ◽  
Zirconium Metal ◽  
Organic Framework ◽  
Cascade Catalysis

Reproducing the highly efficient catalytic cascade system to mimic life behaviors in vitro has been intensively investigated over the past few decades. However, except the biocatalysis with enzymes, most chemocatalytic...

Immobilization ofl-methioninase on a zirconium-based metal–organic framework as an anticancer agent

2019 ◽  
Vol 7 (20) ◽  
pp. 3268-3278 ◽  
Author(s):  
Amany A. Hassabo ◽  
Amria M. Mousa ◽  
Hassan Abdel-Gawad ◽  
Mohsen H. Selim ◽  
Reda M. Abdelhameed
Keyword(s):  
Tumor Growth ◽  
Anticancer Agent ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
And Storage ◽  
Organic Framework

A new composite (METase@UiO-66) was prepared froml-methioninase and UiO-66-(COOH), which exhibited enhanced thermostability, pH and storage lifetime compared tol-methioninase. Moreover,in vivoexperiments showed that the drug inhibited tumor growth in mice.

In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework

scholarly journals The Development of Novel Organotin Anti-Tumor Drugs: Structure and Activity

1998 ◽  
Vol 5 (4) ◽  
pp. 179-188 ◽  
Author(s):  
Dick de Vos ◽  
Rudolph Willem ◽  
Marcel Gielen ◽  
Kyra E. van Wingerden ◽  
Kees Nooter
Keyword(s):  
Water Solubility ◽  
Solubility In Water ◽  
In Vivo Testing ◽  
Polar Substituents ◽  
Tumor Drugs ◽  
Separate Class ◽  
Structure And Activity ◽  
Very High

An overview of the development of anti-tumor organotin derivatives in selected classes of compounds is presented and discussed. High to very high in vitro activity has been found, sometimes equaling that of doxorubicin. Solubility in water is an important issue, dominating the in vivo testing of compounds with promising in vitro properties. The cytotoxicity of the compounds was increased by the presence of a bulky group, an active substituent or one or more polar substituents. Polar substituents may also improve the water solubility. Although organotin derivatives constitute a separate class of compounds, the comparison with cisplatin is inevitable. Among the observed toxicities, neurotoxicity, known from platinum cytostatics, and gastrointestinal toxicity, typical for many oncology drugs, have been detected. Further research to develop novel, useful organotin anti-tumor compounds should be carried out.

scholarly journals In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1211 ◽  
Author(s):  
Gongsen Chen ◽  
Xin Leng ◽  
Juyuan Luo ◽  
Longtai You ◽  
Changhai Qu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Carrier ◽  
In Vitro Cytotoxicity ◽  
In Vitro Toxicity ◽  
Porous Iron ◽  
Dapi Staining ◽  
Toxicological Assessment ◽  
Metal Organic ◽  
Organic Framework

A MIL series metal‒organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological assessment was performed using two different cell lines: human normal liver cells (HL-7702) and hepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT assay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. The safe dose of MIL-100(Fe) was 80 μg/mL. It exhibited good biocompatibility, low cytotoxicity, and high cell survival rate (HL-7702 cells’ viability >85.97%, HepG2 cells’ viability >91.20%). Therefore, MIL-100(Fe) has a potential application as a drug carrier.

In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework
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