scholarly journals Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients

2020 ◽  
Author(s):  
Caidong Liu ◽  
Ziyu Wang ◽  
Wei Wu ◽  
Changgang Xiang ◽  
Lingxiang Wu ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Support Vector Machine Model ◽  
Early Stage ◽  
Laboratory Data ◽  
Training Dataset ◽  
Support Vector ◽  
Machine Model ◽  
Testing Dataset ◽  
Risk Stratification Model ◽  
Probability Of Death

Abstract The progression from mild to critical illness is the main reason leading to the death of COVID-19 patients. Rapid risk-stratification at admission is important for precise management of COVID-19. Here, we developed a practical admission stratification model to predict the severity during hospitalization of COVID-19 patients using laboratory data from 3563 patients, including 548 patients in the training dataset, and 3015 patients in the testing dataset. We first identified the significant laboratory indicators related to the severity of COVID-19 in the training dataset. Neutrophils percentage (NEUT%), lymphocytes percentage (LYMPH%), creatinine (CREA), and blood urea nitrogen (BUN) with AUC greater than 0.7 were included in the model. These indicators were further used to build a support vector machine model to classify patients into low-risk and high-risk at admission. Results showed that this model could stratify the patients in the testing dataset effectively (AUC=0.89). Moreover, laboratory indicators detected in the first week after admission were able to estimate the probability of death (AUC=0.95). Besides, we could diagnose COVID-19 and differentiated it from other kinds of viral pneumonia based on laboratory indicators (accuracy=0.97). Our risk-stratification model based on laboratory indicators could help to diagnose, monitor, and predict severity at an early stage of COVID-19.

scholarly journals Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients

2021 ◽  
Author(s):  
Caidong Liu ◽  
Ziyu Wang ◽  
Wei Wu ◽  
Changgang Xiang ◽  
Lingxiang Wu ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Stratification ◽  
Early Stage ◽  
Case Series ◽  
Low Risk ◽  
Training Dataset ◽  
Support Vector ◽  
Machine Model ◽  
Testing Dataset ◽  
Probability Of Death

Abstract Objectives: To classify COVID-19 patients into low-risk and high-risk at admission by laboratory indicators.Design, Setting, and Patients: This is a case series of patients from a China healthcare system in Wuhan. In this retrospective cohort, 3563 patients confirmed COVID-19 pneumonia, including 548 patients in the training dataset, and 3015 patients in the testing dataset.Interventions: NoneMeasurements and Main Results:We first identified the significant laboratory indicators related to the severity of COVID-19 in the training dataset. Neutrophils percentage, lymphocytes percentage, creatinine, and blood urea nitrogen with AUC greater than 0.7 were included in the model. These indicators were further used to build a support vector machine model to classify patients into low-risk and high-risk at admission. Results showed that this model could stratify the patients in the testing dataset effectively (AUC=0.89). Moreover, laboratory indicators detected in the first week after admission were able to estimate the probability of death (AUC=0.95). Besides, we could diagnose COVID-19 and differentiated it from other kinds of viral pneumonia based on laboratory indicators (accuracy=0.97).Conclusions:Our risk-stratification model based on laboratory indicators could help to diagnose, monitor, and predict severity at an early stage of COVID-19.

scholarly journals Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients

2021 ◽  
Author(s):  
Caidong Liu ◽  
Ziyu Wang ◽  
Wei Wu ◽  
Changgang Xiang ◽  
Lingxiang Wu ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Stratification ◽  
Early Stage ◽  
Case Series ◽  
Low Risk ◽  
Training Dataset ◽  
Support Vector ◽  
Machine Model ◽  
Testing Dataset ◽  
Probability Of Death

Abstract Aims: To classify COVID-19 patients into low-risk and high-risk at admission by laboratory indicators.Design, Setting, and Patients: This is a case series of patients from a China healthcare system in Wuhan. In this retrospective cohort, 3563 patients confirmed COVID-19 pneumonia, including 548 patients in the training dataset, and 3015 patients in the testing dataset.Interventions: NoneMeasurements and Main Results: We first identified the significant laboratory indicators related to the severity of COVID-19 in the training dataset. Neutrophils percentage, lymphocytes percentage, creatinine, and blood urea nitrogen with AUC greater than 0.7 were included in the model. These indicators were further used to build a support vector machine model to classify patients into low-risk and high-risk at admission. Results showed that this model could stratify the patients in the testing dataset effectively (AUC=0.89). Moreover, laboratory indicators detected in the first week after admission were able to estimate the probability of death (AUC=0.95). Besides, we could diagnose COVID-19 and differentiated it from other kinds of viral pneumonia based on laboratory indicators (accuracy=0.97).Conclusions: Our risk-stratification model based on laboratory indicators could help to diagnose, monitor, and predict severity at an early stage of COVID-19.

scholarly journals Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Caidong Liu ◽  
Ziyu Wang ◽  
Wei Wu ◽  
Changgang Xiang ◽  
Lingxiang Wu ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
High Risk ◽  
Risk Stratification ◽  
Random Sampling ◽  
Early Stage ◽  
Viral Pneumonia ◽  
Low Risk ◽  
Training Dataset ◽  
Support Vector ◽  
Testing Dataset

Objective: To distinguish COVID-19 patients and non-COVID-19 viral pneumonia patients and classify COVID-19 patients into low-risk and high-risk at admission by laboratory indicators.Materials and methods: In this retrospective cohort, a total of 3,563 COVID-19 patients and 118 non-COVID-19 pneumonia patients were included. There are two cohorts of COVID-19 patients, including 548 patients in the training dataset, and 3,015 patients in the testing dataset. Laboratory indicators were measured during hospitalization for all patients. Based on laboratory indicators, we used the support vector machine and joint random sampling to risk stratification for COVID-19 patients at admission. Based on laboratory indicators detected within the 1st week after admission, we used logistic regression and joint random sampling to develop the survival mode. The laboratory indicators of COVID-10 and non-COVID-19 were also compared.Results: We first identified the significant laboratory indicators related to the severity of COVID-19 in the training dataset. Neutrophils percentage, lymphocytes percentage, creatinine, and blood urea nitrogen with AUC >0.7 were included in the model. These indicators were further used to build a support vector machine model to classify patients into low-risk and high-risk at admission in the testing dataset. Results showed that this model could stratify the patients in the testing dataset effectively (AUC = 0.89). Our model still has good performance at different times (Mean AUC: 0.71, 0.72, 0.72, respectively for 3, 5, and 7 days after admission). Moreover, laboratory indicators detected within the 1st week after admission were able to estimate the probability of death (AUC = 0.95). We identified six indicators with permutation p < 0.05, including eosinophil percentage (p = 0.007), white blood cell count (p = 0.045), albumin (p = 0.041), aspartate transaminase (p = 0.043), lactate dehydrogenase (p = 0.002), and hemoglobin (p = 0.031). We could diagnose COVID-19 and differentiate it from other kinds of viral pneumonia based on these laboratory indicators.Conclusions: Our risk-stratification model based on laboratory indicators could help to diagnose, monitor, and predict severity at an early stage of COVID-19. In addition, laboratory findings could be used to distinguish COVID-19 and non-COVID-19.

scholarly journals An Improved Whale Algorithm for Support Vector Machine Prediction of Photovoltaic Power Generation

Symmetry ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 212
Author(s):  
Yu-Wei Liu ◽  
Huan Feng ◽  
Heng-Yi Li ◽  
Ling-Ling Li
Keyword(s):  
Support Vector Machine ◽  
Prediction Model ◽  
Output Power ◽  
Input Data ◽  
Support Vector Machine Model ◽  
Weather Conditions ◽  
Clean Energy ◽  
Support Vector ◽  
Machine Model ◽  
Photovoltaic Power

Accurate prediction of photovoltaic power is conducive to the application of clean energy and sustainable development. An improved whale algorithm is proposed to optimize the Support Vector Machine model. The characteristic of the model is that it needs less training data to symmetrically adapt to the prediction conditions of different weather, and has high prediction accuracy in different weather conditions. This study aims to (1) select light intensity, ambient temperature and relative humidity, which are strictly related to photovoltaic output power as the input data; (2) apply wavelet soft threshold denoising to preprocess input data to reduce the noise contained in input data to symmetrically enhance the adaptability of the prediction model in different weather conditions; (3) improve the whale algorithm by using tent chaotic mapping, nonlinear disturbance and differential evolution algorithm; (4) apply the improved whale algorithm to optimize the Support Vector Machine model in order to improve the prediction accuracy of the prediction model. The experiment proves that the short-term prediction model of photovoltaic power based on symmetry concept achieves ideal accuracy in different weather. The systematic method for output power prediction of renewable energy is conductive to reducing the workload of predicting the output power and to promoting the application of clean energy and sustainable development.

Research on SVM Line Loss Rate Prediction Based on Heuristic Algorithm

2013 ◽  
Vol 291-294 ◽  
pp. 2164-2168 ◽  
Author(s):  
Li Tian ◽  
Qiang Qiang Wang ◽  
An Zhao Cao
Keyword(s):  
Support Vector Machine ◽  
Heuristic Algorithm ◽  
Support Vector Machine Model ◽  
Loss Rate ◽  
Heuristic Algorithms ◽  
Support Vector ◽  
Machine Model ◽  
Rate Prediction ◽  
Line Loss

With the characteristic of line loss volatility, a research of line loss rate prediction was imperatively carried out. Considering the optimization ability of heuristic algorithm and the regression ability of support vector machine, a heuristic algorithm-support vector machine model is constructed. Case study shows that, compared with other heuristic algorithms’, the search efficiency and speed of genetic algorithm are good, and the prediction model is with high accuracy.

Sign in / Sign up

Export Citation Format

Share Document