scholarly journals Peripheral Uric Acid as a Biomarker in Individuals with Bipolar Disorder

2020 ◽  
Author(s):  
Zhe Lu ◽  
Yingtan Wang ◽  
Guanglei Xun
Keyword(s):  
Bipolar Disorder ◽  
Uric Acid ◽  
Drug Use ◽  
Acute Stage ◽  
Free Subgroup ◽  
Healthy Controls ◽  
Unipolar Disorder ◽  
Subgroup Differences ◽  
Drug Naïve

Abstract Background: At present, no well-established biomarkers were ever found to distinguish unipolar disorder (UD) and bipolar disorder (BD). This study aimed to explore whether uric acid (UA) could be a biomarker to distinguish UD and BD. Methods: Peripheral UA of 119 patients with BD in acute stage (AS) and 77 in remission stage (RS), and 95 patients with UD in AS and 61 in RS were measured, so were 180 healthy controls. Results: UA levels in BD group were higher than UD and HC groups regardless of the AS or RS, while differences in UA levels between UD group and HC group were not significant. Differences of UA levels between BD-M and BD-D subgroups were not significant, and UA levels of BD-M and BD-D subgroups were higher than UD and HC groups. Only in UD group, UA levels of drug-use subgroup were higher than drug-naïve/free subgroup, but differences disappeared when analyzed stratified by sex; whether in drug-use or drug-naïve/free subgroup, differences of UA levels between BD-M and BD-D groups were not significant.Conclusion: The study suggests UA levels may be a biomarker of BD to distinguish from UD.

scholarly journals Peripheral Uric Acid as a Biomarker in Individuals With Bipolar Disorder: A Case Control Study

2021 ◽  
Author(s):  
Zhe Lu ◽  
Yingtan Wang ◽  
Guanglei Xun
Keyword(s):  
Bipolar Disorder ◽  
Uric Acid ◽  
Drug Use ◽  
Bipolar Depression ◽  
Acute Stage ◽  
Free Subgroup ◽  
Continuous Variables ◽  
Chi Square ◽  
Unipolar Disorder ◽  
Drug Naïve

Abstract Background: At present, no well-established biomarkers were ever found to distinguish unipolar disorder (UD) and bipolar disorder (BD). This study aimed to explore whether uric acid (UA) could be a biomarker to distinguish UD and BD. Methods: Peripheral UA of 119 patients with BD in acute stage (AS) and 77 in remission stage (RS), and 95 patients with UD in AS and 61 in RS were measured, so were 180 healthy controls. Differences in continuous variables among groups were assessed by the independent samples t-test and one-way analysis of variance. The chi-square test was applied to categorical data such as gender. Results: UA levels in BD group were higher than UD and HC groups regardless of the AS or RS, while differences in UA levels between UD group and HC group were not significant. Differences of UA levels between BD-M (bipolar mania/hypomania) and BD-D (bipolar depression) subgroups were not significant, and UA levels of BD-M and BD-D subgroups were higher than UD and HC groups. Only in UD group, UA levels of drug-use subgroup were higher than drug-naïve/free subgroup, but differences disappeared when analyzed stratified by sex; whether in drug-use or drug-naïve/free subgroup, differences of UA levels between BD-M and BD-D groups were not significant.Conclusion: The study suggests UA levels may be a biomarker of BD to distinguish from UD.

scholarly journals Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations

2019 ◽  
Vol 10 ◽  
Author(s):  
Jing-Xu Chen ◽  
Li-Gang Zhang ◽  
Ke-Zhi Liu ◽  
Hong-Mei Chen ◽  
Shuang-Jiang Zhou ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Drug Naïve

scholarly journals Exposure to obstetric complications and subsequent development of bipolar disorder

2006 ◽  
Vol 189 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Jan Scott ◽  
Yvonne McNeill ◽  
Jonathan Cavanagh ◽  
Mary Cannon ◽  
Robin Murray
Keyword(s):  
Bipolar Disorder ◽  
Odds Ratio ◽  
Reference Lists ◽  
Subsequent Development ◽  
Obstetric Complications ◽  
Healthy Controls ◽  
Inclusion Criteria ◽  
Unipolar Disorder ◽  
Pooled Data ◽  
Robust Evidence

BackgroundResearch has suggested an association between obstetric complications and bipolar disorder. However, no quantitative evaluation has been made of the pooled data from existing studies.AimsTo systematically review studies comparing exposure to obstetric complications in cases of bipolar disorder v. non-psychiatric controls, and in cases of bipolar disorder v. cases of other mental disorders.MethodPublications were identified by computer searches of seven databases, by hand searches of reference lists and from raw data received from researchers.ResultsForty-six studies were identified, of which 22 met the inclusion criteria. The pooled odds ratio for exposure to obstetric complications and subsequent development of bipolar disorder was 1.01 (95% Cl 0.76–1.35) compared with healthy controls, 1.13 (95% Cl 0.64–1.99) compared with cases of unipolar disorder and 0.61 (95% Cl 0.39–0.95) compared with those who developed schizophrenia.ConclusionsThere is no robust evidence that exposure to obstetric complications increases the risk of developing bipolar disorder. However, the range of events regarded as obstetric complications and methodological inadequacies make definitive conclusions difficult.

scholarly journals Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

2020 ◽  
Author(s):  
Zhe Lu ◽  
Tianyang Wen ◽  
Yingtan Wang ◽  
Weijing Kan ◽  
Guanglei Xun
Keyword(s):  
Acute Stage ◽  
Free Subgroup ◽  
Antioxidant Systems ◽  
Enzymatic Antioxidants ◽  
Healthy Controls ◽  
Significant Difference ◽  
Before And After ◽  
Schizophrenic Patients ◽  
Oxidation System

Abstract Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidants between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB, and TBIL of 107 schizophrenic patients in the acute stage and 101 in the remission stage were measured respectively, so were 273 healthy controls. Results: The levels of UA ( P =0.020) and TBIL ( P <0.001) of schizophrenic patients in acute stage were higher than those of healthy controls, while the level of ALB ( P <0.001) was lower. Similar results were detected form schizophrenic patients in the remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA ( P =0.001) in the antipsychotics-use subgroup was higher than that in the antipsychotics-naïve/free subgroup, while the level of TBIL ( P =0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in the acute stage were followed up, and there was no significant difference in the level of UA before and after treatment, but levels of ALB ( P <0.001) and TBIL ( P <0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of the peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia.

scholarly journals Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

2019 ◽  
Author(s):  
Zhe Lu ◽  
Tianyang Wen ◽  
Yingtan Wang ◽  
Weijing Kan ◽  
Guanglei Xun
Keyword(s):  
Acute Stage ◽  
Free Subgroup ◽  
Antioxidant Systems ◽  
Enzymatic Antioxidants ◽  
Healthy Controls ◽  
Significant Difference ◽  
Before And After ◽  
Schizophrenic Patients ◽  
Oxidation System

Abstract Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated the differences of non-enzymatic antioxidant between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB and TBIL were measured respectively in 107 schizophrenic patients in acute stage and in 101 schizophrenic patients in remission stage, as well as in 273 healthy controls. Results: The levels of UA (P=0.020) and TBIL (P<0.001) in schizophrenic patients in acute stage were higher than healthy controls, and the level of ALB (P<0.001) was lower. Similar results were detected in schizophrenic patients in remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA (P=0.001) in antipsychotics-use subgroup was higher than that in antipsychotics-naïve/free subgroup, while the level of TBIL (P=0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in acute stage were followed up, and there was no significant difference in level of UA before and after treatment, but levels of ALB (P<0.001) and TBIL (P<0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of peripheral non-enzymatic anti-oxidation system might be involved the pathogenesis of schizophrenia. Keywords: Schizophrenia; Uric acid; Albumin; Total bilirubin

scholarly journals Increased uric acid levels in drug-naïve subjects with bipolar disorder during a first manic episode

2010 ◽  
Vol 34 (6) ◽  
pp. 819-821 ◽  
Author(s):  
Giacomo Salvadore ◽  
Carlos I. Viale ◽  
David A. Luckenbaugh ◽  
Vanessa C. Zanatto ◽  
Luiz V. Portela ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Uric Acid ◽  
Manic Episode ◽  
Drug Naïve

scholarly journals Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

2019 ◽  
Author(s):  
Zhe Lu ◽  
Tianyang Wen ◽  
Yingtan Wang ◽  
Weijing Kan ◽  
Guanglei Xun
Keyword(s):  
Acute Stage ◽  
Free Subgroup ◽  
Antioxidant Systems ◽  
Enzymatic Antioxidants ◽  
Healthy Controls ◽  
Significant Difference ◽  
Before And After ◽  
Schizophrenic Patients ◽  
Oxidation System

Abstract Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidant between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB and TBIL of 107 schizophrenic patients in acute stage and 101 in remission stage were measured respectively, so were 273 healthy controls. Results: The levels of UA (P=0.020) and TBIL (P<0.001) of schizophrenic patients in acute stage were higher than those of healthy controls, while the level of ALB (P<0.001) was lower. Similar results were detected form schizophrenic patients in remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA (P=0.001) in antipsychotics-use subgroup was higher than that in antipsychotics-naïve/free subgroup, while the level of TBIL (P=0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in acute stage were followed up, and there was no significant difference in level of UA before and after treatment, but levels of ALB (P<0.001) and TBIL (P<0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia. Keywords: Schizophrenia; Uric acid; Albumin; Total bilirubin

scholarly journals Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

2020 ◽  
Author(s):  
Zhe Lu ◽  
Tianyang Wen ◽  
Yingtan Wang ◽  
Weijing Kan ◽  
Guanglei Xun
Keyword(s):  
Acute Stage ◽  
Free Subgroup ◽  
Antioxidant Systems ◽  
Enzymatic Antioxidants ◽  
Healthy Controls ◽  
Significant Difference ◽  
Before And After ◽  
Schizophrenic Patients ◽  
Oxidation System

Abstract Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidant between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB and TBIL of 107 schizophrenic patients in acute stage and 101 in remission stage were measured respectively, so were 273 healthy controls. Results: The levels of UA ( P =0.020) and TBIL ( P <0.001) of schizophrenic patients in acute stage were higher than those of healthy controls, while the level of ALB ( P <0.001) was lower. Similar results were detected form schizophrenic patients in remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA ( P =0.001) in antipsychotics-use subgroup was higher than that in antipsychotics-naïve/free subgroup, while the level of TBIL ( P =0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in acute stage were followed up, and there was no significant difference in level of UA before and after treatment, but levels of ALB ( P <0.001) and TBIL ( P <0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia. Keywords: Schizophrenia; Uric acid; Albumin; Total bilirubin

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