scholarly journals Association of PM2.5 and its Components with Lengths of Hospital Stay for Hand Foot and Mouth Disease in Children

Author(s):  
Wei Li ◽  
Jieguo Wang ◽  
Kai Zhou ◽  
Ye Tian ◽  
Feiran Wei ◽  
...  

Abstract Background Hand foot and mouth disease (HFMD) is a public health concern. Studies on air pollution and the lengths of hospital stay (LOS) of HFMD are scarce. Methods We characterized the clinic demographic features of 5135 hospitalized HFMD in Nanjing, China from 2012 to 2017, and analyzed the association between short-term exposure to PM2.5 as well as its components (OM, BC, SO42−, NH4+, NIT, SOIL and SS) and the LOS of HFMD. Results Among them 98.62% were aged 0–6 years old, and 3772 (73.46%) were hospitalized for seven days or less. The LOS of HFMD children was different in different ages, illness onset years and illness onset seasons (P<0.01). For per IQR increase in PM2.5 concentrations, LOS of HFMD increased by 0.52(0.33, 0.71), 0.50 (95% CI, 0.31–0.69) and 0.46 (95% CI, 0.28–0.65) day in adjusted models at lag 3 days, lag 7days and lag 14 days, respectively. In addition, per IQR increase of BC, SO42−, NH4+, NIT and SOIL were also significantly associated with the LOS of HFMD. Conclusions Our findings corroborated the hypothesis that short-term PM2.5 exposure was associated with increased the LOS of HFMD, and its components (BC, SO42−, NH4+, NIT and SOIL) of PM2.5 might play a key role in the prolonged LOS of HFMD.

2021 ◽  
Author(s):  
Wei Li ◽  
Jieguo Wang ◽  
Kai Zhou ◽  
Ye Tian ◽  
Feiran Wei ◽  
...  

Abstract Background Hand foot and mouth disease (HFMD) is a public health concern. Studies on air pollution and the lengths of hospital stay (LOS) of HFMD are scarce. Methods We characterized the clinic demographic features of 5135 hospitalized HFMD in Nanjing, China from 2012 to 2017, and analyzed the association between short-term exposure to PM2.5 as well as its components (OM, BC, SO42−, NH4+, NIT, SOIL and SS) and the LOS of HFMD. Results Among them 98.62% were aged 0–6 years old, and 3772 (73.46%) were hospitalized for seven days or less. The LOS of HFMD children was different in different ages, illness onset years and illness onset seasons (P<0.01). For per IQR increase in PM2.5 concentrations, LOS of HFMD increased by 0.52(0.33, 0.71), 0.50 (95% CI, 0.31–0.69) and 0.46 (95% CI, 0.28–0.65) day in adjusted models at lag 3 days, lag 7days and lag 14 days, respectively. In addition, per IQR increase of BC, SO42−, NH4+, NIT and SOIL were also significantly associated with the LOS of HFMD. Conclusions Our findings corroborated the hypothesis that short-term PM2.5 exposure was associated with increased the LOS of HFMD, and its components (BC, SO42−, NH4+, NIT and SOIL) of PM2.5 might play a key role in the prolonged LOS of HFMD.


2013 ◽  
Vol 58 (7) ◽  
pp. 1605-1614 ◽  
Author(s):  
Chun Chen ◽  
Hualiang Lin ◽  
Xiaoquan Li ◽  
Lingling Lang ◽  
Xincai Xiao ◽  
...  

2015 ◽  
Vol 143 (14) ◽  
pp. 3094-3102 ◽  
Author(s):  
Y. Y. ZHAO ◽  
H. JIN ◽  
X. F. ZHANG ◽  
B. WANG

SUMMARYHand, foot and mouth disease (HFMD) associated with enterovirus 71 (EV71) is a growing public health concern. This study aimed to estimate the case-fatality of HFMD associated with EV71 on the basis of a meta-analysis. We searched PubMed, Cochrane, Web of Science, Elsevier, CNKI, Wanfang, and VIP databases. Two authors independently selected relevant studies. The pooled estimate of case-fatality was calculated using a random-effects model. Potential sources of heterogeneity were explored using subgroup analysis, sensitivity analysis and meta-regression. We identified 14 eligible studies with a total population of 112 546. The random-effects pooled case-fatality was 1·7% (95% confidence interval 1·2–2·4). The funnel plot was asymmetrical. The estimate of case-fatality was highest in mainland China (1·8%). Removal of eight local Chinese studies decreased the original estimate. The pooled case-fatality in the period of 1998–2007 (1·5%) was lower than that in the period 2008–2012 (1·8%). Control measures for HFMD associated with EV71 are essential because of the increased case-fatality over time, especially in East Asia.


2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Narayanan Krishnaswamy ◽  
Sakthivel Jeyakumar ◽  
R. P. Tamil Selvan ◽  
G. R. Gowane ◽  
Priyanka Mahadappa ◽  
...  

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S18
Author(s):  
Yien Ling Hii ◽  
Joacim Rocklöv ◽  
Nawi Ng

2021 ◽  
Author(s):  
Guijie Luan ◽  
Shaonan Liu ◽  
Weiyan Zhang ◽  
Long Zhai ◽  
Yingjie Zhang ◽  
...  

Abstract The burden of disease caused by ambient high temperature has become a public health concern, but the association between high temperature and hand, foot and mouth disease (HFMD) remain indistinct. We used Distributed Lag Non-linear Model (DLNM) to estimate the burden of disease attribute to high temperature, adjusting for long-term trend and weather confounders. Total 18167455 cases were reported in 31 Chinese provinces, the incidence of HFMD showed a gradually increasing trend from 2008 to 2017 in China. Minimum Mortality Temperature (MMT) was mainly concentrated at 17°C to 23°C in the age group less than 5 years old, 18°C to 25°C in the age group 6~10 years old and 19°C to 27°C in the age group above 10 years old. The greatest RR in age group 0~5 years old was 2.06 (95%CI: 1.85~2.30) in Heilongjiang, and the lowest RR was 1.02 (95%CI: 1.00~1.05) in Guangdong; the greatest RR in age group 6~10 years old was 2.24 (95%CI: 1.72~2.91) in Guizhou, and the lowest RR was 1.01 (95%CI: 0.97~1.12) in Tianjin; the greatest RR in the age group over 10 years old was 2.53 (95%CI: 1.66~3.87) in Heilongjiang, and the lowest RR 1.02 (95%CI: 0.71~1.46) in Henan. We found the positive association between high temperature and HFMD in China.


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