Tomosynthesis Breast Imaging: Early Detection and Characterization of Breast Cancer

Background: Breast cancer is the most common cancer in women. While mammography is the standard for early detection in women older than 50 years of age, there is no standard for younger women. The aim of this prospective pilot study was to assess liquid crystal contact thermography, using the Braster device, as a means for the early detection of breast cancer. The device is intended to be used as a complementary tool to standard of care (sonography, mammography, etc). Patients and Methods: A total of 274 consecutive women presenting at Polish breast centers for prophylactic breast examination were enrolled to receive thermography; 19 were excluded for errors in thermographic image acquisition. The women were divided according to age (n = 135, <50 years; n = 120, ≥50 years). A control population was included (n = 40, <50 years; n = 23, ≥50 years). The primary endpoint, stratified by age group, was the C-statistic for discrimination between breast cancer and noncancer. Results: In women with abnormal breast ultrasound (n = 95, <50 years; n = 87, ≥50 years), the C-statistic was 0.85 and 0.75, respectively ( P = .20), for discrimination between breast cancer and noncancer. Sensitivity did not differ ( P = .79) between the younger (82%) and older women (78%), while specificity was lower in the older women (60% vs 87%, P = .025). The false-positive rate was similar in women with normal and abnormal breast ultrasound. Positive thermographic result in women with Breast Imaging Reporting and Data System (BIRADS) 4A on ultrasound increased the probability of breast cancer by over 2-fold. Conversely, a negative thermographic result decreased the probability of cancer more than 3-fold. Breast size and structure did not affect the thermography performance. No adverse events were observed. Conclusions: Thermography performed well in women <50 years of age, while its specificity in women ≥50 years was inadequate. These promising findings suggest that the Braster device deserves further investigation as a supporting tool for the early detection of breast cancer in women younger than 50 years of age.

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Use of FCC-NMRD relaxometry for early detection and characterization of ex-vivo murine breast cancer

Scientific Reports ◽

10.1038/s41598-019-41154-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Enza Di Gregorio ◽

Giuseppe Ferrauto ◽

Stefania Lanzardo ◽

Eliana Gianolio ◽

Silvio Aime

Keyword(s):

Breast Cancer ◽

Early Detection ◽

Ex Vivo

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Detection of early breast cancer beyond mammographic screening: a promising biomarker panel

Biomarkers in Medicine ◽

10.2217/bmm-2019-0085 ◽

2019 ◽

Vol 13 (13) ◽

pp. 1107-1117 ◽

Cited By ~ 1

Author(s):

Moritz Hamann ◽

Sabine Grill ◽

Joachim Struck ◽

Andreas Bergmann ◽

Oliver Hartmann ◽

...

Keyword(s):

Breast Cancer ◽

Early Detection ◽

Breast Imaging ◽

Human Growth ◽

Mammographic Screening ◽

Precise Determination ◽

Cancer Surveillance ◽

Individual Risk ◽

Biomarker Panel ◽

Individual Risk Assessment

Aim: We assessed the suitability of a biomarker panel to improve early detection and individual risk assessment in breast cancer (BC) patients. Materials & methods: PENK, pro-SP, hGH and CA15-3 of 204 BC patients and 68 healthy controls were measured. Results: PENK and human growth hormone concentrations were significantly lower and pro-SP values higher in BC patients compared with controls. C-index increased from 0.628 for CA15-3 alone to 0.754 when all three biomarkers were added to the model. Conclusion: This biomarker panel may improve early detection of BC and influence the assessment of breast imaging. It might be useful for a risk-adapted cancer surveillance or primary prevention program by a more precise determination of an individualized BC risk.

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Role of Breast Imaging Radiologists as Advocates for Screening Mammography

Journal of Breast Imaging ◽

10.1093/jbi/wbaa017 ◽

2020 ◽

Vol 2 (3) ◽

pp. 259-263 ◽

Cited By ~ 3

Author(s):

Toma S Omofoye ◽

Jay R Parikh

Keyword(s):

Breast Cancer ◽

Health Care ◽

Patient Satisfaction ◽

Early Detection ◽

Community Health ◽

Breast Imaging ◽

Health Care Team ◽

Screening Mammography ◽

Common Cancer

Abstract The objective of this article is to outline opportunities for breast imaging radiologists to advocate for screening mammography. Despite breast cancer being the second most common cancer in women and screening mammography’s ability to reduce mortality from this disease, there remains suboptimal utilization in the community. The different guidelines for screening presented by respected organizations has created confusion for patients and referring clinicians and the eventual underutilization of screening mammography. As experts in the value of early detection, breast radiologists are well suited to take on the role of screening advocates. Using specific action steps and examples, we create a template for a radiologist to utilize in the promotion of screening among the breast imaging team, clinicians, administrators, and the community at large. By deliberately filling the role of screening mammography advocate, one can satisfy the mandate for radiologists to bring increased value to the health care team while contributing to community health and patient satisfaction.

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Presumed prevalence analysis on suspected and highly suspected breast cancer lesions in São Paulo using BIRADS® criteria

Sao Paulo Medical Journal ◽

10.1590/s1516-31802007000400003 ◽

2007 ◽

Vol 125 (4) ◽

pp. 210-214 ◽

Cited By ~ 5

Author(s):

Vivian Milani ◽

Suzan Menasce Goldman ◽

Flora Finguerman ◽

Marianne Pinotti ◽

Celso Scazufka Ribeiro ◽

...

Keyword(s):

Breast Cancer ◽

Early Detection ◽

Diagnostic Imaging ◽

Breast Imaging ◽

Sao Paulo ◽

São Paulo ◽

Screening Programs ◽

Cancer Early Detection ◽

Fourth Decade ◽

Municipal Health

CONTEXT AND OBJECTIVE: Breast cancer screening programs are critical for early detection of breast cancer. Early detection is essential for diagnosing, treating and possibly curing breast cancer. Since there are no data on the incidence of breast cancer, nationally or regionally in Brazil, our aim was to assess women by means of mammography, to determine the prevalence of this disease. DESIGN AND SETTING: The study protocol was designed in collaboration between the Department of Diagnostic Imaging (DDI), Institute of Diagnostic Imaging (IDI) and São Paulo Municipal Health Program. METHODS: A total of 139,945 Brazilian women were assessed by means of mammography between April 2002 and September 2004. Using the American College of Radiology (ACR) criteria (Breast Imaging Reporting and Data System, BIRADS®), the prevalence of suspected and highly suspected breast lesions were determined. RESULTS: The prevalence of suspected (BIRADS® 4) and highly suspected (BIRADS® 5) lesions increased with age, especially after the fourth decade. Accordingly, BIRADS® 4 and BIRADS® 5 lesions were more prevalent in the fourth, fifth, sixth and seventh decades. CONCLUSION: The presumed prevalence of suspected and highly suspected breast cancer lesions in the population of São Paulo was 0.6% and it is similar to the prevalence of breast cancer observed in other populations.

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