Early Detection of Breast Cancer via Multiplane Correlation Breast Imaging

2007 ◽  
Author(s):  
Amarpreet Chawla ◽  
Ehsan Samei
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Breast Imaging

scholarly journals A Prospective Pilot Study on Use of Liquid Crystal Thermography to Detect Early Breast Cancer

2020 ◽  
Vol 19 ◽  
pp. 153473542091577
Author(s):  
Diana Hodorowicz-Zaniewska ◽  
Stefano Zurrida ◽  
Agnieszka Kotlarz ◽  
Piotr Kasprzak ◽  
Jan Skupień ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liquid Crystal ◽  
Pilot Study ◽  
Early Detection ◽  
Older Women ◽  
Breast Imaging ◽  
Breast Ultrasound ◽  
Breast Size ◽  
Prospective Pilot Study ◽  
C Statistic

Background: Breast cancer is the most common cancer in women. While mammography is the standard for early detection in women older than 50 years of age, there is no standard for younger women. The aim of this prospective pilot study was to assess liquid crystal contact thermography, using the Braster device, as a means for the early detection of breast cancer. The device is intended to be used as a complementary tool to standard of care (sonography, mammography, etc). Patients and Methods: A total of 274 consecutive women presenting at Polish breast centers for prophylactic breast examination were enrolled to receive thermography; 19 were excluded for errors in thermographic image acquisition. The women were divided according to age (n = 135, <50 years; n = 120, ≥50 years). A control population was included (n = 40, <50 years; n = 23, ≥50 years). The primary endpoint, stratified by age group, was the C-statistic for discrimination between breast cancer and noncancer. Results: In women with abnormal breast ultrasound (n = 95, <50 years; n = 87, ≥50 years), the C-statistic was 0.85 and 0.75, respectively ( P = .20), for discrimination between breast cancer and noncancer. Sensitivity did not differ ( P = .79) between the younger (82%) and older women (78%), while specificity was lower in the older women (60% vs 87%, P = .025). The false-positive rate was similar in women with normal and abnormal breast ultrasound. Positive thermographic result in women with Breast Imaging Reporting and Data System (BIRADS) 4A on ultrasound increased the probability of breast cancer by over 2-fold. Conversely, a negative thermographic result decreased the probability of cancer more than 3-fold. Breast size and structure did not affect the thermography performance. No adverse events were observed. Conclusions: Thermography performed well in women <50 years of age, while its specificity in women ≥50 years was inadequate. These promising findings suggest that the Braster device deserves further investigation as a supporting tool for the early detection of breast cancer in women younger than 50 years of age.

Detection of early breast cancer beyond mammographic screening: a promising biomarker panel

2019 ◽  
Vol 13 (13) ◽  
pp. 1107-1117 ◽  
Author(s):  
Moritz Hamann ◽  
Sabine Grill ◽  
Joachim Struck ◽  
Andreas Bergmann ◽  
Oliver Hartmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Breast Imaging ◽  
Human Growth ◽  
Mammographic Screening ◽  
Precise Determination ◽  
Cancer Surveillance ◽  
Individual Risk ◽  
Biomarker Panel ◽  
Individual Risk Assessment

Aim: We assessed the suitability of a biomarker panel to improve early detection and individual risk assessment in breast cancer (BC) patients. Materials & methods: PENK, pro-SP, hGH and CA15-3 of 204 BC patients and 68 healthy controls were measured. Results: PENK and human growth hormone concentrations were significantly lower and pro-SP values higher in BC patients compared with controls. C-index increased from 0.628 for CA15-3 alone to 0.754 when all three biomarkers were added to the model. Conclusion: This biomarker panel may improve early detection of BC and influence the assessment of breast imaging. It might be useful for a risk-adapted cancer surveillance or primary prevention program by a more precise determination of an individualized BC risk.

scholarly journals Role of Breast Imaging Radiologists as Advocates for Screening Mammography

2020 ◽  
Vol 2 (3) ◽  
pp. 259-263 ◽  
Author(s):  
Toma S Omofoye ◽  
Jay R Parikh
Keyword(s):  
Breast Cancer ◽  
Health Care ◽  
Patient Satisfaction ◽  
Early Detection ◽  
Community Health ◽  
Breast Imaging ◽  
Health Care Team ◽  
Screening Mammography ◽  
Common Cancer

Abstract The objective of this article is to outline opportunities for breast imaging radiologists to advocate for screening mammography. Despite breast cancer being the second most common cancer in women and screening mammography’s ability to reduce mortality from this disease, there remains suboptimal utilization in the community. The different guidelines for screening presented by respected organizations has created confusion for patients and referring clinicians and the eventual underutilization of screening mammography. As experts in the value of early detection, breast radiologists are well suited to take on the role of screening advocates. Using specific action steps and examples, we create a template for a radiologist to utilize in the promotion of screening among the breast imaging team, clinicians, administrators, and the community at large. By deliberately filling the role of screening mammography advocate, one can satisfy the mandate for radiologists to bring increased value to the health care team while contributing to community health and patient satisfaction.

scholarly journals Presumed prevalence analysis on suspected and highly suspected breast cancer lesions in São Paulo using BIRADS® criteria

2007 ◽  
Vol 125 (4) ◽  
pp. 210-214 ◽  
Author(s):  
Vivian Milani ◽  
Suzan Menasce Goldman ◽  
Flora Finguerman ◽  
Marianne Pinotti ◽  
Celso Scazufka Ribeiro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Diagnostic Imaging ◽  
Breast Imaging ◽  
Sao Paulo ◽  
São Paulo ◽  
Screening Programs ◽  
Cancer Early Detection ◽  
Fourth Decade ◽  
Municipal Health

CONTEXT AND OBJECTIVE: Breast cancer screening programs are critical for early detection of breast cancer. Early detection is essential for diagnosing, treating and possibly curing breast cancer. Since there are no data on the incidence of breast cancer, nationally or regionally in Brazil, our aim was to assess women by means of mammography, to determine the prevalence of this disease. DESIGN AND SETTING: The study protocol was designed in collaboration between the Department of Diagnostic Imaging (DDI), Institute of Diagnostic Imaging (IDI) and São Paulo Municipal Health Program. METHODS: A total of 139,945 Brazilian women were assessed by means of mammography between April 2002 and September 2004. Using the American College of Radiology (ACR) criteria (Breast Imaging Reporting and Data System, BIRADS®), the prevalence of suspected and highly suspected breast lesions were determined. RESULTS: The prevalence of suspected (BIRADS® 4) and highly suspected (BIRADS® 5) lesions increased with age, especially after the fourth decade. Accordingly, BIRADS® 4 and BIRADS® 5 lesions were more prevalent in the fourth, fifth, sixth and seventh decades. CONCLUSION: The presumed prevalence of suspected and highly suspected breast cancer lesions in the population of São Paulo was 0.6% and it is similar to the prevalence of breast cancer observed in other populations.

scholarly journals Assessment and Improvement Strategies for a Breast Cancer Early Detection Program in Rural South Africa

2018 ◽  
Vol 4 (Supplement 3) ◽  
pp. 16s-16s
Author(s):  
Megan E. Hadley ◽  
Lisa A. Mullen ◽  
Lindsay Dickerson ◽  
Susan C. Harvey
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Breast Imaging ◽  
Documentation System ◽  
Middle Income ◽  
Cancer Early Detection ◽  
Detection Program ◽  
Ibm Watson ◽  
Early Detection Program

Purpose More than one half of breast cancer deaths occur in low- and middle-income countries, where survival rates are 60% at best. Appropriate programs that improve detection, diagnosis, and treatment in low- and middle-income countries are essential to improving breast cancer outcomes. The sustainability of such programs requires ongoing efforts, yet there remains a lack of literature on follow-up to assure long-term program success. Our study aimed to understand what needs developed in the year after the implementation of an early detection program and to evaluate potential solutions. Methods A WHO-endorsed RAD-AID Radiology Readiness Assessment evaluated clinic resources. In addition, in 5 weeks of observation we identified resource deficiencies and reviewed existing documentation methods. On the basis of stakeholders’ input and the Breast Imaging Reporting and Data System, we developed new documentation systems. Training was followed by a survey that assessed feasibility and provider acceptance. Results Resource limitations included a lack of computers, unpredictable electrical supply, and inconsistent Internet. Assessment revealed incomplete documentation of breast clinical examinations and history, breast lesions, and follow-up. In addition, limitations negatively impacted communication between providers. Three solutions were developed: a paper patient history form, a paper clinical findings form, and a computerized patient-tracking database that was compliant with the Breast Imaging Reporting and Data System. Three nurses, three nursing assistants, and one counselor completed the survey. Seventy-one percent (five of seven respondents) indicated positive or very positive general attitudes. One hundred percent of respondents agreed or strongly agreed to the following statement: the documentation system is easy, useful, and improves overall quality of care, follow-up, decision making, access to clinical information, and communication between clinicians and patients. Five of seven providers reported that the system increased visit time, but three of these five felt that the process was valuable. Conclusion Implementing a breast cancer early detection program in resource-limited regions is challenging and continued assessment is essential. As a result of identified needs, we developed a documentation system that was broadly accepted. Potential future steps should focus on increasing efficiency, evaluating provider attitudes on a long-term basis, and clinical impact. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc . Susan C. Harvey Honoraria: Hologic Inc, IBM Watson Imaging Consulting or Advisory Role: IBM Watson, Hologic Inc Research Funding: IBM Watson

scholarly journals Automatic Detection of the Circulating Cell-Free Methylated DNA Pattern of GCM2, ITPRIPL1 and CCDC181 for Detection of Early Breast Cancer and Surgical Treatment Response

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1375
Author(s):  
Sheng-Chao Wang ◽  
Li-Min Liao ◽  
Muhamad Ansar ◽  
Shih-Yun Lin ◽  
Wei-Wen Hsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Early Detection ◽  
Treatment Response ◽  
Breast Imaging ◽  
Dynamic Monitoring ◽  
Aberrant Methylation ◽  
Combined Analysis ◽  
A Genome ◽  
Sensitivity Level

The early detection of cancer can reduce cancer-related mortality. There is no clinically useful noninvasive biomarker for early detection of breast cancer. The aim of this study was to develop accurate and precise early detection biomarkers and a dynamic monitoring system following treatment. We analyzed a genome-wide methylation array in Taiwanese and The Cancer Genome Atlas (TCGA) breast cancer (BC) patients. Most breast cancer-specific circulating methylated CCDC181, GCM2 and ITPRIPL1 biomarkers were found in the plasma. An automatic analysis process of methylated ccfDNA was established. A combined analysis of CCDC181, GCM2 and ITPRIPL1 (CGIm) was performed in R using Recursive Partitioning and Regression Trees to establish a new prediction model. Combined analysis of CCDC181, GCM2 and ITPRIPL1 (CGIm) was found to have a sensitivity level of 97% and an area under the curve (AUC) of 0.955 in the training set, and a sensitivity level of 100% and an AUC of 0.961 in the test set. The circulating methylated CCDC181, GCM2 and ITPRIPL1 was also significantly decreased after surgery (all p < 0.001). The aberrant methylation patterns of the CCDC181, GCM2 and ITPRIPL1 genes means that they are potential biomarkers for the detection of early BC and can be combined with breast imaging data to achieve higher accuracy, sensitivity and specificity, facilitating breast cancer detection. They may also be applied to monitor the surgical treatment response.

Enhancing mammography: Digital optical breast imaging for the early detection of breast cancer — The infra-red technology

2004 ◽  
Vol 2 (3) ◽  
pp. 94
Author(s):  
W Gatzemeier ◽  
M Scelsi ◽  
K Galetti ◽  
L Villani ◽  
C Tinterri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Breast Imaging ◽  
Infra Red
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