Innovative Statistical Approaches to Modeling Multiple Outcome Data from the NSABP BCPT

2000 ◽  
Author(s):  
Lisa Weissfeld ◽  
Kiros Berhane
2020 ◽  
Author(s):  
George (Jeb) S Brown ◽  
Christophe Cazauvieilh

Abstract: Aim, Methods, Results, DiscussionAim: This paper presents analyses of outcome data for 317 therapists treating 14,161 patients over a three-year period to determine if therapists’ effect sizes increased over time. Each therapist treated at least 5 patients in each of their first two years of using outcome measures. Multiple outcome questionnaires were employed. All measures also included a brief alliance scale administered concurrently. Method: A severity adjusted effect size was calculated for each patient using intake scores and diagnostic group as predictors. The mean severity adjusted effect size for each therapist was calculated for their first and second years of using the outcome tools. This was done using a hierarchical linear model to control for sample size in each year, with a minimum sample of 5 cases in each year. Therapist engagement in receiving feedback was measured by counting the number of times the therapist logged into the online platform to view their results in each of the two years.Results: Therapists who logged in the view their data at least 24 times in the second year (n=123; 37%) averaged .92 effect size compared to .82 effect size for those seen by therapists who reviewed their results less frequently (n=214; 63%). Login frequency during the first year was not predictive of effect size during the second year. Discussion: The data provides evidence that effect sizes can trend upwards with measurement and feedback. Therapists’ engagement in receiving feedback appears to increase the likelihood of effect size gain.


Author(s):  
Mina Nicole Händel ◽  
Ramune Jacobsen ◽  
Fanney Thorsteinsdottir ◽  
Amélie Cléo Keller ◽  
Maria Stougaard ◽  
...  

By utilizing historical changes in Danish legislation related to mandatory vitamin D fortification of margarine, which was implemented in the mid 1930s and abruptly abandoned in June 1985, the studies in the D-tect project investigated the effects of vitamin D on health outcomes in individuals, who during gestation were exposed or unexposed to extra vitamin D from fortified margarine. This paper reviews and narratively summarizes the analytic approaches alongside the results of the societal fortification experiment studies from the D-tect project and addresses the challenges in designing societal experiment studies and evaluating their results. The latter are discussed as lessons learned that may be useful for designers of similar studies, expected to be extensively utilized while researching the health consequences of the COVID-19 pandemic by comparing individuals born before and after the epidemic. In the D-tect project, 16 articles based on the societal fortification experiment were published analyzing 10 different outcomes and using different statistical approaches. Lessons learned included the detail of the analysis of the historical information on the exposure, availability and validity of the outcome data, variety of analytical approaches, and specifics concerning vitamin D effect evaluation, such as consideration of the influence of sunshine or season. In conclusion, the D-tect project clearly demonstrated the cost-effectiveness and research potential of natural- or societal-experiment-based studies.


2019 ◽  
Vol 4 (5) ◽  
pp. 814-824 ◽  
Author(s):  
Bonnie E. Smith ◽  
Ruth Huntley Bahr ◽  
Hector N. Hernandez

Purpose The purpose of this study was to determine the attendance and success rates for seniors in voice therapy, identify any contributing patient-related factors, and compare results to existing findings for younger patients. Method This retrospective study included information from the voice records of 50 seniors seen by the same speech-language pathologist in a private practice. Analysis of attendance and outcome data divided participants into 6 groups. Outcomes for Groups 1–3 (64% of patients) were considered successful (positive voice change), while outcomes for Groups 4–6 (36% of patients) were considered unsuccessful. These data were compared to similar data collected for younger adults in a previous study. Results The attendance and success rates for seniors in this study were higher than those previously reported for younger patients. Further consideration of patient factors revealed that reports of increased stress, Reflux Symptom Index scores > 13, and higher Voice Handicap Index functional subscale scores were significant in distinguishing between patients in the successful and unsuccessful treatment outcome groups. Conclusions The relatively high attendance and success rates among this sample of seniors suggest the desire to achieve voice improvement does not diminish with age, and chances for success in voice therapy among nonfrail seniors may be greater than for younger patients.


2010 ◽  
Vol 15 (3) ◽  
pp. 1-7
Author(s):  
Richard T. Katz

Abstract This article addresses some criticisms of the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) by comparing previously published outcome data from a group of complete spinal cord injury (SCI) persons with impairment ratings for a corresponding level of injury calculated using the AMA Guides, Sixth Edition. Results of the comparison show that impairment ratings using the sixth edition scale poorly with the level of impairments of activities of daily living (ADL) in SCI patients as assessed by the Functional Independence Measure (FIM) motor scale and the extended FIM motor scale. Because of the combinations of multiple impairments, the AMA Guides potentially overrates the impairment of paraplegics compared with that of quadriplegics. The use and applicability of the Combined Values formula should be further investigated, and complete loss of function of two upper extremities seems consistent with levels of quadriplegia using the SCI model. Some aspects of the AMA Guides contain inconsistencies. The concept of diminishing impairment values is not easily translated between specific losses of function per organ system and “overall” loss of ADLs involving multiple organ systems, and the notion of “catastrophic thresholds” involving multiple organ systems may support the understanding that variations in rating may exist in higher rating cases such as those that involve an SCI.


2000 ◽  
Vol 3 ◽  
pp. np
Author(s):  
William C. Follette ◽  
Dirk Revenstorf ◽  
Donald H. Baucom ◽  
Kurt Hahlweg ◽  
Gayla Margolin

Sign in / Sign up

Export Citation Format

Share Document