Is Breast Tissue from Women Who Carry Germ-Line BRCA1 or BRCA2 Mutations Normal"? An Immuno-Histopathological Study"

2002 ◽  
Author(s):  
William D. Foulkes ◽  
L. Alpert ◽  
J. Deschenes ◽  
G. Tremblay
Keyword(s):  
Breast Tissue ◽  
Germ Line ◽  
Histopathological Study ◽  
Brca2 Mutations

Is Breast Tissue from Women Who Carry Germ-Line BRCA1 or BRCA2 Mutations Normal"? - An Immuno-Histopathological Study"

2003 ◽  
Author(s):  
William D. Foulkes ◽  
Lesley Alpert ◽  
Louise Quenneville ◽  
Gilles Tremblay
Keyword(s):  
Breast Tissue ◽  
Germ Line ◽  
Histopathological Study ◽  
Brca2 Mutations

scholarly journals Risk Estimation as a Decision-Making Tool for Genetic Analysis of the Breast Cancer Susceptibility Genes

1999 ◽  
Vol 15 (1-3) ◽  
pp. 53-65 ◽  
Author(s):  
Jenny Chang-Claude ◽  
Heiko Becher ◽  
Maria Caligo ◽  
Diana Eccles ◽  
Gareth Evans ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Familial Breast Cancer ◽  
Genetic Model ◽  
Germ Line ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Cancer Gene ◽  
Brca2 Mutations ◽  
Breast Cancer Gene

For genetic counselling of a woman on familial breast cancer, an accurate evaluation of the probability that she carries a germ-line mutation is needed to assist in making decisions about genetic-testing.We used data from eight collaborating centres comprising 618 families (346 breast cancer only, 239 breast or ovarian cancer) recruited as research families or counselled for familial breast cancer, representing a broad range of family structures. Screening was performed in affected women from 618 families for germ-line mutations in BRCA1 and in 176 families for BRCA2 mutations, using different methods including SSCP, CSGE, DGGE, FAMA and PTT analysis followed by direct sequencing. Germ-line BRCA1 mutations were detected in 132 families and BRCA2 mutations in 16 families. The probability of being a carrier of a dominant breast cancer gene was calculated for the screened individual under the established genetic model for breast cancer susceptibility, first, with parameters for age-specific penetrances for breast cancer only [7] and, second, with age-specific penetrances for ovarian cancer in addition [20]. Our results indicate that the estimated probability of carrying a dominant breast cancer gene gives a direct measure of the likelihood of detecting mutations in BRCA1 and BRCA2. For breast/ovarian cancer families, the genetic model according to Narod et al. [20] is preferable for calculating the proband's genetic risk, and gives detection rates that indicate a 50% sensitivity of the gene test. Due to the incomplete BRCA2 screening of the families, we cannot yet draw any conclusions with respect to the breast cancer only families.

scholarly journals Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations

2006 ◽  
Vol 94 (7) ◽  
pp. 1021-1028 ◽  
Author(s):  
M Bramley ◽  
R B Clarke ◽  
A Howell ◽  
D G R Evans ◽  
T Armer ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Brca1 And Brca2 ◽  
Brca2 Mutations ◽  
Brca1 And Brca2 Mutations

scholarly journals Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutations

2014 ◽  
Vol 132 (2) ◽  
pp. 280-286 ◽  
Author(s):  
James R. Conner ◽  
Emily Meserve ◽  
Ellen Pizer ◽  
Judy Garber ◽  
Michael Roh ◽  
...  
Keyword(s):  
Risk Reduction ◽  
Germ Line ◽  
Brca2 Mutations

Novel germ line BRCA2 mutations in familial esophageal squamous cell carcinoma

2011 ◽  
Vol 44 (13) ◽  
pp. S209
Author(s):  
Abbaszadegan Mohammad Reza ◽  
Saidi Ramin ◽  
Moaven Omeed ◽  
A\'rabi Azadeh ◽  
Homaie-shandiz Fatemeh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Germ Line ◽  
Brca2 Mutations

One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations

2004 ◽  
Vol 40 (3) ◽  
pp. 422-428 ◽  
Author(s):  
S. Malander ◽  
M. Ridderheim ◽  
A. Måsbäck ◽  
N. Loman ◽  
U. Kristoffersson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Germ Line ◽  
Brca2 Mutations

Germ line BRCA1 & BRCA2 mutations in Greek breast/ovarian cancer families: 5382insC is the most frequent mutation observed

2002 ◽  
Vol 185 (1) ◽  
pp. 61-70 ◽  
Author(s):  
A. Ladopoulou ◽  
C. Kroupis ◽  
I. Konstantopoulou ◽  
L. Ioannidou-Mouzaka ◽  
A.C. Schofield ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Germ Line ◽  
Frequent Mutation ◽  
Brca2 Mutations ◽  
Brca1 Brca2

Correlation of germ-line BRCA2 mutations with aggressive prostate cancer and outcome.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 1517-1517 ◽  
Author(s):  
E. Castro ◽  
C. L. Goh ◽  
D. Olmos ◽  
D. Leongamornlert ◽  
E. Saunders ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Germ Line ◽  
Aggressive Prostate Cancer ◽  
Brca2 Mutations

scholarly journals A Nonpalpable Nodule in Ectopic Axillary Breast Tissue: Consider Phyllodes Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Eva Ruvalcaba-Limón ◽  
Verónica Bautista-Piña ◽  
Julio Ramírez-Bollas ◽  
Ruby Espejo-Fonseca ◽  
Sergio Rodríguez-Cuevas
Keyword(s):  
Breast Imaging ◽  
Breast Tissue ◽  
Phyllodes Tumor ◽  
Screening Mammography ◽  
Histopathological Study ◽  
Surgical Specimen ◽  
Ectopic Breast Tissue ◽  
Intraoperative Radiography ◽  
Reporting Data

Benign and malignant pathology can develop in ectopic axillary breast tissue, such as fibroadenomas, phyllodes tumors, and breast cancer. We present a rare case of an asymptomatic 43-year-old woman with an axillary nodule which was identified during screening mammography within ectopic axillary breast tissue, initially considered as a suspicious lymph node. Radiologic studies were considered as Breast Imaging-Reporting Data System (BI-RADS) 4. A hyperdense, lobular, and well-circumscribed nodule was identified in mammogram while the nodule by ultrasound (US) was hypoechoic with indistinct microlobular margins, without vascularity by Doppler, and measuring 1.26×1 cm. Core-needle biopsy reported a fibroepithelial neoplasm. The patient was submitted to local wide-needle excision located in intraoperative radiography of the surgical specimen and margin evaluation. Final histopathological study reported a 1.8×1.2 cm benign phyllodes tumor, with irregular, pushing, and clear wide margins within normal ectopic breast tissue. The patient without surgical complications continued annual screening without recurrence during a follow-up that took place 24 months later.

Sign in / Sign up

Export Citation Format

Share Document