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The breast tumor microenvironment (TME) promotes drug resistance through an elaborated interaction of TME
components mediated by reactive oxygen species (ROS). Despite a massive accumulation of data concerning the targeting
the ROS, but little is known about the ROS-responsive nanomedicine for targeting breast TME. This review submits the
ROS landscape in breast TME, including ROS biology, ROS mediated carcinogenesis, reprogramming of stromal and
immune cells of TME. We also discussed ROS-based precision strategies for imaging TME, including molecular imaging
techniques with advanced probes, multiplexed methods, and multi-omic profiling strategies. ROS-responsive nanomedicine
also describes various therapies, such as chemo-dynamic, photodynamic, photothermal, sono-dynamic, immune, and gene
therapy for BC. We expound ROS-responsive primary delivery systems for chemotherapeutics, phytochemicals, and
immunotherapeutics. This review also presents recent updates on nano-theranostics for simultaneous diagnosis and
treatment of BCs. We assume that review on this advancing field will be beneficial to the development of ROS-based nanotheranostics for BC.
siRNA-loaded poly(histidine-arginine)6-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis
