Sequence Variants in Estrogen Receptors and Risk for Prostate Cancer

2004 ◽  
Author(s):  
Bao-Li Chang
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptors ◽  
Sequence Variants

1075: ATM Sequence Variants are Predictive of the Development of Erectile Dysfunction Among Patients Treated for Prostate Cancer with 125Iodine Brachytherapy

2005 ◽  
Vol 173 (4S) ◽  
pp. 291-292
Author(s):  
Jamie A. Cesaretti ◽  
Richard G. Stock ◽  
Nelson N. Stone ◽  
Steven Lehrer ◽  
David A. Atencio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Erectile Dysfunction ◽  
Sequence Variants

Hypoxia and Inflammation in Prostate Cancer Progression. Cross-talk with Androgen and Estrogen Receptors and Cancer Stem Cells

2017 ◽  
Vol 16 (4) ◽  
pp. 235-248 ◽  
Author(s):  
Matteo Russo ◽  
Linda Ravenna ◽  
Laura Pellegrini ◽  
Elisa Petrangeli ◽  
Luisa Salvatori ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Estrogen Receptors ◽  
Cancer Progression ◽  
Cross Talk ◽  
Prostate Cancer Progression

scholarly journals Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent

2013 ◽  
Vol 14 (6) ◽  
pp. 347-355 ◽  
Author(s):  
E N Rogers ◽  
D Z Jones ◽  
N C Kidd ◽  
S Yeyeodu ◽  
G Brock ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
African Descent ◽  
Prostate Cancer Risk ◽  
Sequence Variants ◽  
Toll Like Receptor

scholarly journals Phosphodiesterase sequence variants may predispose to prostate cancer

2015 ◽  
Vol 22 (4) ◽  
pp. 519-530 ◽  
Author(s):  
Rodrigo B de Alexandre ◽  
Anelia D Horvath ◽  
Eva Szarek ◽  
Allison D Manning ◽  
Leticia F Leal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Immunohistochemical Analysis ◽  
Cyclic Guanosine Monophosphate ◽  
Genome Project ◽  
Guanosine Monophosphate ◽  
Sequence Variants ◽  
Sequencing Data ◽  
Sequence Variations ◽  
Novel Variants ◽  
Somatic State

We hypothesized that mutations that inactivate phosphodiesterase (PDE) activity and lead to increased cAMP and cyclic guanosine monophosphate levels may be associated with prostate cancer (PCa). We sequenced the entire PDE coding sequences in the DNA of 16 biopsy samples from PCa patients. Novel mutations were confirmed in the somatic or germline state by Sanger sequencing. Data were then compared to the 1000 Genome Project. PDE, CREB and pCREB protein expression was also studied in all samples, in both normal and abnormal tissue, by immunofluorescence. We identified three previously described PDE sequence variants that were significantly more frequent in PCa. Four novel sequence variations, one each in thePDE4B,PDE6C,PDE7BandPDE10Agenes, respectively, were also found in the PCa samples. Interestingly,PDE10AandPDE4Bnovel variants that were present in 19 and 6% of the patients were found in the tumor tissue only. In patients carrying PDE defects, there was pCREB accumulation (P<0.001), and an increase of the pCREB:CREB ratio (patients 0.97±0.03; controls 0.52±0.03;P-value <0.001) by immunohistochemical analysis. We conclude that PDE sequence variants may play a role in the predisposition and/or progression to PCa at the germline and/or somatic state respectively.

Atm sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer

2004 ◽  
Vol 60 (1) ◽  
pp. S325
Author(s):  
J.A. Cesaretti ◽  
R.G. Stock ◽  
D.A. Atencio ◽  
J.L. Bernstein ◽  
N.N. Stone ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sequence Variants

Effect of the simultaneous blockade of androgen and estrogen receptors on prostate cancer: Preliminary results.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 168-168 ◽  
Author(s):  
R. Nunez-Nateras ◽  
E. P. Castle
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Synergistic Effect ◽  
Estrogen Receptors ◽  
Cell Lines ◽  
Simultaneous Administration ◽  
Normal Prostate ◽  
Androgen Receptor Antagonist ◽  
Receptor Modulator ◽  
Drug Concentrations

168 Background: Androgens and estrogens have been shown to play an important role in normal prostate development and function as well as carcinogenesis and development of the castration resistant phenotype of disease. The aim of this study was to evaluate the effect of a simultaneous administration of an androgen receptor antagonist (bicalutamide) and a selective estrogen receptor modulator (raloxifene) on both androgen sensitive and androgen insensitive prostate cancer cell lines. Methods: Experiments were performed on LNCaP, PC3 and DU145 cell lines. Western blot was utilized for the identification of androgen and estrogen receptors (a andb) in the cell lines. Drug concentrations required to achieve IC 50 were obtained using the MTT assay; such concentrations were identified for the drugs individually and when used in combination. The effect of the drugs on apoptosis was assessed using flow cytometry. Results: Results of the IC 50 for the drugs alone and in combination by each cell line are shown in the table. An enhanced effect was observed when the drugs were used in combination in all the cell lines. It was evident that the combination of the drugs decreased the total drug required to achieve the IC50 decreases considerably. Apoptosis rates were also affected by the simultaneous administration of bicalutamide and raloxifene. The synergistic effect of the combination was reflected in the increase of the apoptosis rate in all cell lines. Conclusions: The simultaneous administration of bicalutamide and raloxifene has a synergistic effect on cell death and apoptosis of DU145, PC3 and LNCaP cell lines. The pathway(s) responsible for this observation may be independent of the androgen receptor as both AR negative cell lines were still affected by the combination over the SERM alone. [Table: see text] No significant financial relationships to disclose.

scholarly journals Sequence variants of elaC homolog 2 (Escherichia coli) ( ELAC2 ) gene and susceptibility to prostate cancer in the Health Professionals Follow-Up Study

2008 ◽  
Vol 29 (5) ◽  
pp. 999-1004 ◽  
Author(s):  
Yen-Ching Chen ◽  
Edward Giovannucci ◽  
Peter Kraft ◽  
David J.Hunter
Keyword(s):  
Prostate Cancer ◽  
Escherichia Coli ◽  
Health Professionals ◽  
Sequence Variants ◽  
Follow Up Study

scholarly journals Germline BCL-2 sequence variants and inherited predisposition to prostate cancer

2006 ◽  
Vol 9 (3) ◽  
pp. 284-292 ◽  
Author(s):  
L R Kidd ◽  
A Coulibaly ◽  
T M Templeton ◽  
W Chen ◽  
L O Long ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sequence Variants ◽  
Inherited Predisposition
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