Neonatal cry signal prediction and classification via dense convolution neural network

The study of neonatal cry signals is always an interesting topic and still researcher works interminably to develop some module to predict the actual reason for the baby cry. It is really hard to predict the reason for their cry. The main focus of this paper is to develop a Dense Convolution Neural network (DCNN) to predict the cry. The target cry signal is categorized into five class based on their sound as “Eair”, “Eh”, “Neh”, “Heh” and “Owh”. Prediction of these signals helps in the detection of infant cry reason. The audio and speech features (AS Features) were exacted using Mel-Bark frequency cepstral coefficient from the spectrogram cry signal and fed into DCNN network. The systematic DCNN architecture is modelled with modified activation layer to classify the cry signal. The cry signal is collected in different growth phase of the infants and tested in proposed DCNN architecture. The performance of the system is calculated through parameters accuracy, specificity and sensitivity are calculated. The output of proposed system yielded a balanced accuracy of 92.31%. The highest accuracy level 95.31%, highest specificity level 94.58% and highest sensitivity level 93% attain through proposed technique. From this study, it is concluded that the proposed technique is more efficient in detecting cry signal compared to the existing techniques.

The Expenses Needed for the Effect of Restricted Group Sandplay on Interpersonal Sensitivity in College Students

This study aims to investigate the intervention effect of group sandplay on the interpersonal sensitivity of college students and analyze the relationship between the theme and interactive behavior characteristics and the intervention effect of group sandplay especially during the period of COVID-19. Sixty college students were randomly assigned to the experimental group (group sandplay) or the control group (neutral task interventions). The results showed that the interpersonal sensitivity level of the experimental group was significantly lower than that of the control group. For the experimental group, the variation in the interpersonal sensitivity level was significantly negatively correlated with the change in warm, supportive behavior during group sandplay interaction. These findings suggest that group sandplay is effective in improving the interpersonal sensitivity level of college students, and this effect can be positively predicted by warm and supportive interaction behaviors in group sandplay.

Sensing Glucose Concentration Using Symmetric Metasurfaces under Oblique Incident Terahertz Waves

In this article, a planar metamaterial sensor designed at terahertz (THz) frequencies is utilized to sense glucose concentration levels that cover hypoglycemia, normal, and hyperglycemia conditions that vary from 54 to 342 mg/dL. The sensor was developed using a symmetric complementary split rectangular resonator at an oblique incidence angle. The resonance frequency shift was used as a measure of the changes in the glucose level of the samples. The increase in the glucose concentration level exhibited clear and noticeable redshifts in the resonance frequency. For instance, a 67.5 GHz redshift has been observed for a concentration level of 54 mg/dL and increased up to 122 GHz for the 342 mg/dL concentration level. Moreover, a high sensitivity level of 75,700 nm/RIU was observed for this design. In the future, the proposed THz sensors may have potential applications in diagnosing hypocalcemia and hyperglycemia cases.

Towards a New μ→eγ Search with the MEG II Experiment: From Design to Commissioning

The MEG experiment represents the state of the art in the search for the Charged Lepton Flavour Violating μ+→e+γ decay. With its first phase of operations at the Paul Scherrer Institut (PSI), MEG set the most stringent upper limit on the BR (μ+→e+γ)≤4.2×10−13 at 90% confidence level, imposing one of the tightest constraints on models predicting LFV-enhancements through new physics beyond the Standard Model. An upgrade of the MEG experiment, MEG II, was designed and it is presently in the commissioning phase, aiming at a sensitivity level of 6×10−14. The MEG II experiment relies on a series of upgrades, which include an improvement of the photon detector resolutions, brand new detectors on the positron side with better acceptance, efficiency and performances and new and optimized trigger and DAQ electronics to exploit a muon beam intensity twice as high as that of MEG (7×107 μ+/s). This paper presents a complete overview of the MEG II experimental apparatus and the current status of the detector commissioning in view of the physics data taking in the upcoming three years.

Climate vulnerability assessment in semi-arid and arid region of Rajasthan, India: An enquiry into the disadvantaged districts

This paper assesses the district level climate vulnerability in the state of Rajasthan using largescale data on climate and socio-economic variables.More than thirty indicators segregated into four components of exposure, sensitivity, adaptive capacity and crop production loss were combined to develop a composite index of vulnerability and homogenous districts were clustered into three categories, viz.low, medium and high.Wide inter-district variations were observed across the calculated indices. The result reveals that highest production losses occurred in Ganganagar district followed by Hanumangarh and Bharatpur. Pali was least exposed to the climatic variability, whereas Bundi had the maximum exposure.Jaisalmer rated the maximum sensitivity level. Further, Pratapgarh followed by Jaisalmer and Banswara had the lowest degree of adaptive capacity. On the whole, districts like Hanumangarh, Jaisalmer, Ganganagar, Bundi, Bharatpur, Jodhpur, Bikaner, Chittorgarh, Alwar, Baran and Pratapgarh exhibit high level of vulnerability to climatic change. While on the other spectrum Sirohi district was least vulnerable due to lower exposure, sensitivity, crop production loss and high adaptive capacity. The analysis, suggests the need for prioritizing vulnerable areas to arrest regional imbalances by encouraging need/location based interventions for moderating the degree of vulnerability, whilst making agro-ecosystem in Rajasthan resilient to climatic aberrations.

Post-Induction Undetectable Minimal Residual Disease at 10 -5 Sensitivity Level within Marrow and/or Stem Cell Graft Overrides Cytogenetic High Risk

Introduction: Post-induction minimal residual disease (MRD) within but not outside (peripheral blood/stem cell graft) of marrow among transplant eligible patients with multiple myeloma (MM) is currently recognized as poor-prognostic. Emerging number of studies are evaluating MRD within the context of cytogenetic risk. In this study we aimed to quantify circulating plasma cells (PCs) by flow in apheresis products (graft=gMRD) and compare with marrow MRD(mMRD) and outcome according to cytogenetics. Patients & Methods: Four hundred eleven subsequent newly diagnosed multiple myeloma (NDMM) patients transplanted (AHCT) between September 2006 - June 2021 were included prospectively. Standard-risk cytogenetics(SR) is defined as t(11;14), t(6;14), or a normal karyotype , whereas del(17p13), t(4;14), t(14;16), t(14;20), + 1q21 and complex findings are high-risk cytogenetics (HR). In the sample drawn for HPSC quantification of the graft and bone marrow, the number of clonal PCs were quantified by Flow. CD27 PC7 orCD27 A750, CD56 A700, CD19 ECD, CD38 FITC orCD38 A750, CD138 APC, CD45 KO, CD81 PE, CD117 PC7, polyclonal Rabbit Anti-Human Kappa or Lambda Chains /FITC antibodies and acquisition of at least 10 5 cells per tube Analysis was performed using the Navios Flow Cytometer (3L10C, Beckman Coulter) using the Kaluza software (Beckman Coulter, USA) according to the criteria defined by Montero et al and also abnormal distribution of kappa vs. Lambda expression. Undetectable MRD was defined as absence of clonal PCs at a sensitivity of 10 -4 prior to 2017(n=217) and 10 -5 after 2017(n=131). MRD assessment is similar in the graft and marrow. Impact of postinduction MRD analysis was performed in 131 patients with MRD data of 10 -5 sensitivity level. Results were reported in the intention-to-treat (ITT) population for mMRD. Results: Median follow-up after AHCT was 61.5 months (range:3.2-168) (prior to 2017) and 17.7 months (range: 3-47.4) (after 2017). Induction regimen consisted of bortezomib without or with immunomodulatory drug (IMID) 78.8%, 2.8% (prior to 2017) and 74.1%, 22.9% (after 2017). Consolidation 18% (n=39/217), 22.1% (n=29/131) (prior and after 2017) and maintenance 21.2% (n=46/217), 35.1% (n=46/131) (prior and after 2017) were administered based on the response to AHCT. Cytogenetically HR was observed 14.1% (n=47) (among total cohort) and 15.8% (n=19) (after 2017 cohort). Post-induction biochemical response distribution among patients with undetectable MRD are shown in Table-1. MRD assessments were performed at a sensitivity of 10 -4 and 10 -5 in graft (n=147 and 76), marrow (n=18 and 4) or both (n=52 and 51). A statistically significant correlation was detected between marrow and graft MRD only at sensitivity level 10 -5 (SE: 0.638, p<0.001). Additionally, correlations between CR and gMRD (Kappa coefficient (SE): -0.284, p=0.03); CR and mMRD (SE: -0.452, p:0.001) were found. Since marrow and graft MRD results are correlated, all graft and marrow results were merged for the multivariate analysis (MVA) (Table-2). Having undetectable vs detectable MRD in either graft or marrow estimates a 2 years-PFS of 83.6% vs 46.5% (p=0.007). Among 42 MRD(-) patients, only four (two with HR)have relapsed. There is a tendency for better two year probability of PFS with undetectable mMRD vs gMRD at 10-5 ( not reached vs 84.7% ; ns)(Figure 1). The patients (after 2017) are divided into four groups according to MRD status and cytogenetic risk stratification: MRD(-)SR (n=35; 29.2%), MRD(-)HR (n=7; 5.8%), MRD(+)SR (n=66; 55%), MRD(+)HR (n=12; 10%). Kaplan-Meier curves revealed significant differences in PFS among these groups (p=0.03) (Figure-2). Conclusion: Our real-world triplet drug induction-based experience shows for the first-time post-induction mMRD and MRD to be correlated with each other and with PFS. PFS with MRD(-) at 10 -5 results have displayed a better outcome compared to 10 -4. MVA showed MRD and age to determine PFS, independent from post-induction CR, ISS and cytogenetic risk. Although observed less frequently, achieving post-induction MRD(-) either in graft or marrow may ameliorate the poor prognosis of HR. With improvement in induction it may be possible to achieve more frequent MRD(-) and thus analyze the impact of each cytogenetics risk group ie 1q amplification separately. Furthermore, MRD in graft may be a non-invasive therapeutic efficacy tool which is subject to less sampling variation. Figure 1 Figure 1. Disclosures Beksac: Amgen,Celgene,Janssen,Takeda,Oncopeptides,Sanofi: Consultancy, Speakers Bureau.

The design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS

The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components of the JUNO scintillator system work to specifications and only neutrino-grade scintillator is filled into the JUNO Central Detector. The aspired sensitivity level of $$10^{-16}\hbox { g/g}$$ 10 - 16 g/g of $$^{238}\hbox {U}$$ 238 U and $$^{232}\hbox {Th}$$ 232 Th requires a large ($$\sim 20\,\hbox {m}^3$$ ∼ 20 m 3 ) detection volume and ultralow background levels. The present paper reports on the design and major components of the OSIRIS detector, the detector simulation as well as the measuring strategies foreseen and the sensitivity levels to U/Th that can be reached in this setup.

Akurasi Diagnostik Kecacingan Metode Direct Slidedan Kato Katzpada Penderita Helminthiasis Di Kota Mataram

Worms are diseases caused by the entry of parasites (in the form of worms) into the human body. The types of worms that are often found to cause infection are roundworms (Ascarislumbricoides), whipworms (Trichuris trichiura) and hookworms (Necatoramericanus) which are transmitted through the soil (Soil Transmitted Helminthiasis. Examination of helminth infections can be done qualitativelyand quantitative. The qualitative examination that is often used is the Direct slide method. while the quantitative examination that is often used is the Kato Katz method. This study aims to compare the accuracy of the worm infection examination between the Direct slide method and the Kato Katz method by examining stool samples. This research was conducted on 47 Ampenan Elementary School Students located on the coast in Mataram City, where the coastal area is one of the good breeding grounds for worms. This study used a comparative analytical research design with a cross sectional approach. To establish the diagnosis of helminthiasis and the type of worm that infects, an examination of worm eggs in stool samples is carried out using the Direct slide and Kato Katz methods. The results showed that the number of samples infected with STH was more commonly found by the Kato-Katz method. The results of measurements using the Direct slide method and the Kato Katz method showed that the highest prevalence of STH infection was Ascaris lumbricoides infection. Direct slide method produces a sensitivity level of 95.16% and a specificity of 100%.