Realizing the Translational Potential of Telomere Length Variation as a Tissue-Based Prognostic Marker for Prostate Cancer

2013 ◽  
Author(s):  
Elizabeth A. Platz
Keyword(s):  
Prostate Cancer ◽  
Telomere Length ◽  
Prognostic Marker ◽  
Length Variation

scholarly journals Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769223 ◽  
Author(s):  
Ulrika Svenson ◽  
Göran Roos ◽  
Pernilla Wikström
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Telomere Length ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Risk Groups ◽  
Leukocyte Telomere Length ◽  
Cancer Specific Survival ◽  
Control Subjects ◽  
Relative Telomere Length

Previous studies have suggested that leukocyte telomere length is associated with risk of developing prostate cancer. Investigations of leukocyte telomere length as a prognostic factor in prostate cancer are, however, lacking. In this study, leukocyte telomere length was investigated both as a risk marker, comparing control subjects and patient risk groups (based on serum levels of prostate-specific antigen, tumor differentiation, and tumor stage), and as a prognostic marker for metastasis-free and cancer-specific survival. Relative telomere length was measured by a well-established quantitative polymerase chain reaction method in 415 consecutively sampled individuals. Statistical evaluation included 162 control subjects without cancer development during follow-up and 110 untreated patients with newly diagnosed localized prostate cancer at the time of blood draw. Leukocyte telomere length did not differ significantly between control subjects and patients, or between patient risk groups. Interestingly, however, and in line with our previous results in breast and kidney cancer patients, relative telomere length at diagnosis was an independent prognostic factor. Patients with long leukocyte telomeres (⩾median) had a significantly worse prostate cancer–specific and metastasis-free survival compared to patients with short telomere length. In contrast, for patients who died of other causes than prostate cancer, long relative telomere length was not coupled to shorter survival time. To our knowledge, these results are novel and give further strength to our hypothesis that leukocyte telomere length might be used as a prognostic marker in malignancy.

scholarly journals The association between relative leukocyte telomere length of prostate cancer patients at diagnosis with cancer prognostic parameters

2021 ◽  
Vol 42 (1) ◽  
pp. 27-33
Author(s):  
Thiraphat Saengmearnuparp ◽  
◽  
Bannakij Lojanapiwat ◽  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Telomere Length ◽  
Prognostic Marker ◽  
Quantitative Polymerase Chain Reaction ◽  
Leukocyte Telomere Length ◽  
Current Recommendation ◽  
Cancer Specific Survival ◽  
Free Survival ◽  
Pertinent Data

Objectives: In this study, relative leukocyte telomere length (LTL) was investigated as a prognostic marker to evaluate association of LTL at the time of diagnosis and prostate cancer-specific survival, metastasis-free survival, overall survival, with castrate-resistant prostate cancer (CRPC). Materials and Methods: In this retrospective cohort study, pertinent data from 81 patients were collected. Patients underwent prostate cancer (PCa) treatment procedures determined by staging and current recommendation. Blood samples from suspected PCa patients were obtained before the initiation of diagnosis and treatment. LTL was determined by the quantitative polymerase chain reaction method. Relative LTL was compared to the main clinical outcome measures. Prostate cancer-specific survival, metastasis-free survival, overall survival and CRPC were calculated retrospectively, for a mean follow-up period of 30 months. Results: This analysis showed relative LTL was not associated with tumor stage, Gleason score, grade group, metabolic disease, or smoking. However, older age was significantly associated with short LTL (p < 0.001). All main outcomes were not associated with LTL. In contrast, a subgroup analysis of patients who underwent primary androgen deprivation therapy (ADT) showed a CRPC association with relatively long LTL (p = 0.039). To our knowledge, these results are novel and give further strength to our hypothesis that relative LTL might be used as a prognostic marker in PCa especially in patients who will receive primary ADT. Conclusion: Aging was significantly associated with relatively short LTL. There was no significant association between LTL in PCa patients at diagnosis and cancer-specific survival, metastasis-free survival, or overall survival. However, patients who underwent ADT treatment alone showed CRPC associated with relatively long LTL.

386: Nuclear Localization of ERBB3: A Potential Diagnostic/Prognostic Marker of Prostate Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 105-106
Author(s):  
Ismaël H. Koumakpayi ◽  
Jean-Simon Diallo ◽  
Cecile Le Page ◽  
Laurent Lessard ◽  
Martin E. Gleave ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Nuclear Localization

1068: TP53 Gene Mutations as a Prognostic Marker for PSA Progression in Early Stage Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 282-282
Author(s):  
Markus D. Sachs ◽  
Horst Schlechte ◽  
Katrin Schiemenz ◽  
Severin V. Lenk ◽  
Dietmar Schnorr ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Early Stage ◽  
Gene Mutations ◽  
Tp53 Gene ◽  
Psa Progression ◽  
Tp53 Gene Mutations

scholarly journals Natural variation in plant telomere length is associated with flowering time

2021 ◽  
Author(s):  
Jae Young Choi ◽  
Liliia R Abdulkina ◽  
Jun Yin ◽  
Inna B Chastukhina ◽  
John T Lovell ◽  
...  
Keyword(s):  
Life History ◽  
Telomere Length ◽  
Flowering Time ◽  
Dna Sequences ◽  
Genome Wide Association Study ◽  
Genomic Analysis ◽  
Life History Strategies ◽  
Length Variation ◽  
Chromosomal Structure ◽  
Chromosome Integrity

Abstract Telomeres are highly repetitive DNA sequences found at the ends of chromosomes that protect the chromosomes from deterioration during cell division. Here, using whole genome re-sequencing and terminal restriction fragment assays, we found substantial natural intraspecific variation in telomere length in Arabidopsis thaliana, rice (Oryza sativa), and maize (Zea mays). Genome-wide association study (GWAS) mapping in A. thaliana identified 13 regions with GWAS-significant associations underlying telomere length variation, including a region that harbors the telomerase reverse transcriptase (TERT) gene. Population genomic analysis provided evidence for a selective sweep at the TERT region associated with longer telomeres. We found that telomere length is negatively correlated with flowering time variation not only in A. thaliana, but also in maize and rice, indicating a link between life history traits and chromosome integrity. Our results point to several possible reasons for this correlation, including the possibility that longer telomeres may be more adaptive in plants that have faster developmental rates (and therefore flower earlier). Our work suggests that chromosomal structure itself might be an adaptive trait associated with plant life history strategies.

scholarly journals Prostate-derived Ets transcription factor (PDEF) is a potential prognostic marker in patients with prostate cancer

The Prostate ◽  
2011 ◽  
Vol 71 (11) ◽  
pp. 1178-1188 ◽  
Author(s):  
Ali Ghadersohi ◽  
Satish Sharma ◽  
Shaozeng Zhang ◽  
Rami G. Azrak ◽  
Gregory E. Wilding ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transcription Factor ◽  
Prognostic Marker ◽  
Ets Transcription Factor

Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer

2013 ◽  
Vol 1831 (10) ◽  
pp. 1579-1587 ◽  
Author(s):  
Christopher J. Fowler ◽  
Andreas Josefsson ◽  
Lina Thors ◽  
Sui Chu Chung ◽  
Peter Hammarsten ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Vascular Density ◽  
Expression Levels
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