scholarly journals Study of Lipid Profile in Patients of Polycystic Ovarian Syndrome Before and After Metformin Therapy

2017 ◽  
Vol 4 (4) ◽  
pp. A415-A418
Author(s):  
Noora Saeed ◽  
Nishat Afroz ◽  
SheeluShafiq Siddiqi ◽  
Aaliya Ehsan ◽  
Mohd Rafey
Keyword(s):  
Lipid Profile ◽  
Polycystic Ovarian Syndrome ◽  
Metformin Therapy ◽  
Before And After ◽  
Ovarian Syndrome

scholarly journals Effectiveness of Metformin and its Combination with Probiotic in Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial

2021 ◽  
pp. 268-274
Author(s):  
Urooj Zafar ◽  
Syeda Amber Zaidi ◽  
Hafiz Syed Muhammad Osama Jafri ◽  
Sana Imran ◽  
Afreen Bhatty ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Sampling Technique ◽  
Abnormal Uterine Bleeding ◽  
High Serum ◽  
Reproductive Age ◽  
Serum Prolactin ◽  
Combination Group ◽  
Metformin Therapy ◽  
Before And After ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder that predominantly affects women of the reproductive age. Anovulation and abnormal uterine bleeding are caused by hyperprolactinemia, which affects the hypothalamic-pituitary-ovarian axis. Aim: In this study, the efficacy of combined Probiotic and Metformin therapy on hyperprolactinemia levels in PCOS patients was compared to Metformin therapy alone. Methodology: 102 participants having hyperprolactinemia were enrolled via convenient sampling technique between January 2019 to August 2019. Out of them women having Polycystic Ovarian Syndrome (PCOS) and high serum prolactin levels were randomly assigned to one of two groups: group one received oral Metformin tablet 500 mg T.D. for three months, and group two received oral Metformin tablet 500 mg T.D  and Probiotic capsule 180 mg O.D for three months. Serum prolactin levels in both groups were compared before and after treatment. Results: 54 (53%) of the 102 hyperprolactinemia women had PCOS. The Combination group showed improvement in reduction in hyperprolactinemia levels after 12 weeks of intervention. Conclusion: The addition of Probiotic to Metformin improved prolactin levels in women with polycystic ovarian syndrome with hyperprolactinemia more than Metformin alone.

scholarly journals Influence of ovarian manipulation on reproductive endocrinology in polycystic ovarian syndrome and regularly cycling women

2013 ◽  
Vol 169 (4) ◽  
pp. 503-510 ◽  
Author(s):  
M L Hendriks ◽  
T König ◽  
R S Soleman ◽  
T Korsen ◽  
R Schats ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Transvaginal Ultrasound ◽  
Ovarian Hormones ◽  
Pulse Interval ◽  
Hormonal Changes ◽  
Before And After ◽  
Mechanical Manipulation ◽  
Lh Secretion ◽  
Late Follicular Phase ◽  
Ovarian Syndrome

ObjectiveLittle is known about the function of the ovarian neuronal network in humans. In many species, copulation influences endocrinology through this network. As a first step, the possible influence of ovarian mechanical manipulation on pituitary and ovarian hormones was evaluated in polycystic ovarian syndrome (PCOS) and regularly cycling women. DesignProspective case–control study (2008–2010).MethodsTen PCOS women (Rotterdam criteria) undergoing ovulation induction with recombinant-FSH and ten normal ovulatory controls were included in an academic fertility clinic. In the late follicular phase blood was drawn every 10 min for 6 h. After 3 h the ovaries were mechanically manipulated by moving a transvaginal ultrasound probe firmly over each ovary ten times. Main outcome measures were LH and FSH pulsatility and ovarian hormones before and after ovarian manipulation.ResultsAll PCOS patients showed an LH decline after the ovarian manipulation (before 13.0 U/l and after 10.4 U/l, P<0.01), probably based on a combination of a longer LH pulse interval and smaller amplitude (P=0.07). The controls showed no LH change (before 9.6 U/l and after 9.3 U/l, P=0.67). None of the ovarian hormones (estradiol, progesterone, anti-Müllerian hormone, inhibin B, androstenedione and testosterone) changed in either group.ConclusionsOvarian mechanical manipulation lowers LH secretion immediately and typically only in preovulatory PCOS patients. The immediate LH change after the ovarian manipulation without any accompanying ovarian hormonal changes point to nonhormonal communication from the ovaries to the pituitary. A neuronal pathway from the ovaries communicating to the hypothalamic–pituitary system is the most reasonable explanation.

scholarly journals The effect of progressive muscle relaxation on depression in polycystic ovarian syndrome

2018 ◽  
Vol 7 (8) ◽  
pp. 3029
Author(s):  
Jyoti Parle ◽  
Aishwarya D. Savant
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Muscle Relaxation ◽  
Progressive Muscle Relaxation ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Exclusion Criteria ◽  
Before And After ◽  
Muscle Groups ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Authors explored the effects of progressive muscle relaxation (PMR) on depression in females with polycystic ovarian syndrome (PCOS).Methods: In a 4-week study duration in which the intervention was for three times a week, 30 females which were selected according to the inclusion and exclusion criteria received a PMR protocol in which subjects were taught to contract and relax 16 muscle groups. The Becks Depression Inventory (BDI) was taken before and after the intervention as a depression analysis tool.Results: After 4 weeks of intervention, the patients showed significant improvement in depression (P < 0.05).Conclusions: In conclusion, this study suggests that PMR practice is effective in improving depression, in patients with PCOS.

scholarly journals Metformin throughout Pregnancy in Women with Polycystic Ovary Syndrome: Safety and Advantages

2011 ◽  
Vol 2 (2) ◽  
pp. 61-64 ◽  
Author(s):  
Bharti Bansal ◽  
Rutvij Jay Dalal ◽  
P Palshetkar Nandita ◽  
D Pai Hrishikesh ◽  
Takhtani Manisha ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Maternal Complications ◽  
Ovary Syndrome ◽  
Trimester Abortion ◽  
Metformin Therapy ◽  
High Incidence ◽  
Ovarian Syndrome ◽  
In Pregnancy

ABSTRACT Objective To study the incidence of spontaneous abortions, congenital malformations, neonatal and maternal hypoglycemia after metformin therapy in pregnancy. Design Prospective study. Setting Outpatient. Patient(s) 56 women previously oligomenorrheic, nondiabetic women with polycystic ovarian syndrome, who conceived while on metformin. Intervention(s) Metformin 1 to 1.5 gm/day throughout pregnancy. Main outcome Incidence of 1st trimester abortions, gestational diabetes, teratogenicity and maternal complications, like gastritis and hypoglycemia. Results On metformin, the incidence of 1st trimester abortion was 11% and the incidence of gestational diabetes was 7%, which is much lower than the incidence otherwise cited for PCOS women. No major congenital abnormalities were observed. Conclusion Metformin therapy in pregnancy reduces the otherwise high incidence of 1st trimester abortions, and gestational diabetes in PCOS women is tolerated well and is not found to be teratogenic.

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