scholarly journals Effectiveness of Metformin and its Combination with Probiotic in Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial

2021 ◽  
pp. 268-274
Author(s):  
Urooj Zafar ◽  
Syeda Amber Zaidi ◽  
Hafiz Syed Muhammad Osama Jafri ◽  
Sana Imran ◽  
Afreen Bhatty ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Sampling Technique ◽  
Abnormal Uterine Bleeding ◽  
High Serum ◽  
Reproductive Age ◽  
Serum Prolactin ◽  
Combination Group ◽  
Metformin Therapy ◽  
Before And After ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder that predominantly affects women of the reproductive age. Anovulation and abnormal uterine bleeding are caused by hyperprolactinemia, which affects the hypothalamic-pituitary-ovarian axis. Aim: In this study, the efficacy of combined Probiotic and Metformin therapy on hyperprolactinemia levels in PCOS patients was compared to Metformin therapy alone. Methodology: 102 participants having hyperprolactinemia were enrolled via convenient sampling technique between January 2019 to August 2019. Out of them women having Polycystic Ovarian Syndrome (PCOS) and high serum prolactin levels were randomly assigned to one of two groups: group one received oral Metformin tablet 500 mg T.D. for three months, and group two received oral Metformin tablet 500 mg T.D  and Probiotic capsule 180 mg O.D for three months. Serum prolactin levels in both groups were compared before and after treatment. Results: 54 (53%) of the 102 hyperprolactinemia women had PCOS. The Combination group showed improvement in reduction in hyperprolactinemia levels after 12 weeks of intervention. Conclusion: The addition of Probiotic to Metformin improved prolactin levels in women with polycystic ovarian syndrome with hyperprolactinemia more than Metformin alone.

scholarly journals Reproductive Endocrinologic Pattern in Infertile Black Women with Polycystic Ovarian Syndrome

2021 ◽  
pp. 230-236
Author(s):  
Tawaqualit Abimbola Ottun ◽  
Faosat Olayiwola Jinadu ◽  
Ayokunle Moses Olumodeji ◽  
Adeniyi Abiodun Adewunmi ◽  
Fatimat Motunrayo Akinlusi ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
High Serum ◽  
Reproductive Hormones ◽  
Reproductive Age ◽  
Serum Prolactin ◽  
Polycystic Ovaries ◽  
Nigerian Women ◽  
Infertile Women ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Background: Polycystic ovarian syndrome (PCOS) is a very common endocrine cause of infertility affecting about 10% of women of reproductive age. We evaluated the pattern of reproductive hormones in infertile Nigerian women with PCOS. Methods: This was a prospective cross-sectional study at the Lagos State University Teaching Hospital over a 6-month period in which One hundred and fifty infertile women, with diagnosis of PCOS using the Rotterdam’s criteria, had quantitative assessment of their reproductive hormones like Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Progesterone, Testosterone, Prolactin and Thyroid Stimulating Hormone (TSH), with relevant socio-demographic and clinical data noted in the study proforma. Z test, chi-square and correlation tests were used as appropriate to analyse the data with p<0.05 significance level. Results: The mean age of infertile women with PCOS was 26.50±4.4years; all the women had either oligomenorrhea (62%) or secondary amenorrhea (38%), 56.5% were obese and 33.3% had hirsutism. While 37.7% of the women had abnormally elevated serum LH, 16.4% had high serum FSH, 39% had LH:FSH ratio> 2.5, 96% had low serum progesterone, 29% had high serum prolactin, 17.4% had high serum TSH values and 92% had features of polycystic ovaries on trans-vaginal ultrasound. Correlation of age and BMI with serum FSH, LH and prolactin values were weak and insignificant. Conclusion: PCOS is common among young Nigerian women presenting for infertility treatment; with dominant features of oligomenorrhea and polycystic ovaries. Hormonal abnormalities are common, varied and not associated with other clinical characteristics.

scholarly journals Study of cutaneous manifestations of polycystic ovarian syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 1627
Author(s):  
Sukhleen Kaur ◽  
Sunil K. Gupta ◽  
Sunil K. Juneja ◽  
Sukhjot Kaur ◽  
Monika Rani
Keyword(s):  
Insulin Resistance ◽  
Acanthosis Nigricans ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Reproductive Age ◽  
Common Finding ◽  
Serum Prolactin ◽  
Endocrine Disorders ◽  
Cutaneous Manifestations ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most frequently encountered endocrine disorders that occurs in as many as 4 to 10% of women of reproductive age group. It presents with a series of skin changes including acne, hirsutism, seborrhea, androgenetic alopecia (AGA) and acanthosis nigricans. Aim of the study was to determine the prevalence and frequency of different cutaneous manifestations in PCOS patients and to correlate them with the degree of hormonal abnormalities.Methods: A total 100 patients with features of PCOS who presented to department of dermatology, gynecology (January 2018-December 2019) with cutaneous manifestations were recorded and diagnosis of PCOS was made using Rotterdam’s criteria. Pregnant women and diagnosed cases of any other endocrine disorder were excluded. Hirsutism was assessed using Ferriman-Gallwey score and AGA according to Ludwig’s classification. Serum hormonal profile including FSH, LH, prolactin, testosterone (free), DHEAS, TSH, FBS, fasting insulin were done. Insulin resistance was determined by calculating HOMA-IR score.Results: Among cutaneous manifestations of PCOS, hirsutism (85%) was the most common finding followed by acne (73%), seborrhea (50%), AGA (36%), acanthosis nigricans (29%) and acrochordons (9%). The most common hormonal abnormality was insulin resistance in 53% patients, followed by raised free testosterone in 19% and serum prolactin in 18% patients. A statistically significant association was present between AGA and insulin resistance, hirsutism and raised prolactin levels, seborrhea and raised body mass index (p < 0.05).Conclusions: Dermatological manifestations of PCOS play a significant role in making the diagnosis and constitute a substantial portion of the symptoms experienced by women with this syndrome.

scholarly journals The effect of progressive muscle relaxation on depression in polycystic ovarian syndrome

2018 ◽  
Vol 7 (8) ◽  
pp. 3029
Author(s):  
Jyoti Parle ◽  
Aishwarya D. Savant
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Muscle Relaxation ◽  
Progressive Muscle Relaxation ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Exclusion Criteria ◽  
Before And After ◽  
Muscle Groups ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Authors explored the effects of progressive muscle relaxation (PMR) on depression in females with polycystic ovarian syndrome (PCOS).Methods: In a 4-week study duration in which the intervention was for three times a week, 30 females which were selected according to the inclusion and exclusion criteria received a PMR protocol in which subjects were taught to contract and relax 16 muscle groups. The Becks Depression Inventory (BDI) was taken before and after the intervention as a depression analysis tool.Results: After 4 weeks of intervention, the patients showed significant improvement in depression (P < 0.05).Conclusions: In conclusion, this study suggests that PMR practice is effective in improving depression, in patients with PCOS.

scholarly journals Study of Lipid Profile in Patients of Polycystic Ovarian Syndrome Before and After Metformin Therapy

2017 ◽  
Vol 4 (4) ◽  
pp. A415-A418
Author(s):  
Noora Saeed ◽  
Nishat Afroz ◽  
SheeluShafiq Siddiqi ◽  
Aaliya Ehsan ◽  
Mohd Rafey
Keyword(s):  
Lipid Profile ◽  
Polycystic Ovarian Syndrome ◽  
Metformin Therapy ◽  
Before And After ◽  
Ovarian Syndrome

scholarly journals Effectiveness of structured teaching programme regarding polycystic ovarian syndrome among adolescent girls

2021 ◽  
Vol 10 (7) ◽  
pp. 2818
Author(s):  
Soniya John
Keyword(s):  
Adolescent Girls ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Sampling Technique ◽  
Reproductive Age ◽  
Teaching Programme ◽  
Structured Teaching ◽  
Prevention And Health Promotion ◽  
Quasi Experimental ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome is an endocrine disorder that affects approximately 5% of all women. It occurs amongst all races and nationalities. It is the most common hormonal disorder among women of reproductive age and is a leading cause of infertility. As polycystic ovarian syndrome is an ovarian disorder marked by a lack of estrogen, hyperandrogenaemia, obesity, hyper insulinaemia and starts early in the adolescent period. So, we should teach them regarding the clinical features treatment and prevention.Methods: A quasi experimental one group pre-test post design was adopted to assess the effectiveness of structured teaching programme on knowledge regarding polycystic ovarian syndrome among adolescent girls, Bangalore. A sample of 60 adolescent girls was selected from NRI higher secondary school, Bangalore by purposive sampling technique. Collected data was analysed by using descriptive and inferential statistics.Results: More than half 54 (90.0%) were having inadequate knowledge and 6 (10%) were having moderate knowledge regarding PCOS before STP.Conclusions: Structured teaching programme was significantly effective in increasing the knowledge of polycystic ovarian syndrome. The most important role of the nurse is to provide awareness on prevention and health promotion. 

The burden of the probable polycystic ovarian syndrome and its associated factor among college going late adolescents and young adults: a cross sectional analytical study in urban Puducherry, South India

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Devipriyaa Suresh ◽  
Venkatachalam Jayaseelan ◽  
Sudheera Sulgante ◽  
Gayathri Surendran ◽  
Gautam Roy
Keyword(s):  
Low Income ◽  
Polycystic Ovarian Syndrome ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Cross Sectional ◽  
College Going ◽  
Co Morbidity ◽  
Menstrual History ◽  
Ovarian Syndrome

AbstractObjectivesPolycystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. In low income and developing countries like India, there are very high chances of developing PCOS due to marked variation between culture, ethnic groups, diet, lifestyle and genetic factors. This study aims to determine the burden of probable PCOS among college going students in Puducherry.MethodsA cross sectional study was carried out among students aged 18 years and above in a Government College for Women located in urban Puducherry. A total of 610 students were selected through a cluster random sampling technique. A pretested validated proforma was administered after obtaining informed consent.Results25.1% (21.8–28.7) of women were having probable PCOS, 18.7% (15.8–22.0) had irregular menstrual history, 8.4% (6.4–10.8) had Hirsutism and 2% (1.8–3.3) had both the symptoms. Regarding food habits, 43.1% were vegetarians and were having probable PCOS and this association was found to be statistically significant. No significant association was found between prevalence of probable PCOS and factors such as higher age, parental income, higher BMI and physical inactivity.ConclusionsThe present study found a high prevalence of probable PCOS among college going students, especially among study respondents who were obese, physically inactive and vegetarians compared to the counterpart. Earlier detection and proper management of the symptoms can avoid some major co-morbidity in the future. Therefore, screening is an important part in the diagnosis and management of PCOS among adolescent girls.

Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations

2018 ◽  
Vol 25 (15) ◽  
pp. 1792-1804 ◽  
Author(s):  
Silvana R. Ferreira ◽  
Alicia B. Motta
Keyword(s):  
Endometrial Cancer ◽  
Adhesion Molecules ◽  
Polycystic Ovarian Syndrome ◽  
Cellular Proliferation ◽  
Steroid Receptors ◽  
Reproductive Age ◽  
Present Review ◽  
Implantation Failure ◽  
Uterine Function ◽  
Ovarian Syndrome

Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. Methods: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress. We selected the articles based on their titles and abstracts, then we analyzed the full text and classified the articles depending on the information provided according to the sections of the present review. Results: The endocrine and metabolic abnormalities displayed in women with PCOS promote complex effects on the endometrium, leading to a low rate of implantation and even infertility. Women with PCOS show alterations in the Hypothalamic-Pituitary- Ovarian axis, which results in constant circulating levels of estrogen, similar to those at the early follicular phase, and a deficiency in the withdrawal of estrogen and progesterone. Besides this deficiency in the withdrawal of estrogen and progesterone, the insulin/ glucose pathway, adhesion molecules, cytokines and the inflammatory cascade, together with the establishment of a pro-oxidative status, lead to an imbalance in the uterine function, which in turn leads to implantation failure or even endometrial cancer. Conclusion: Women with PCOS display a dysregulation of the Hypothalamic-Pituitary- Ovarian axis, which alters the steroid pathway. In addition, the deficiency in the withdrawal of estrogen and progesterone in the endometrium results in abnormal endometrial cellular proliferation. The imbalance in adipose tissue observed in PCOS patients reinforces the increase in circulating hormones. The present review describes the role of hormones, metabolites, cytokines, adhesion molecules and the insulin/glucose pathway related to the uterine endometrium in women with PCOS and their role in implantation failure and development of endometrial cancer.

scholarly journals To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome

2017 ◽  
Vol 9 (4) ◽  
pp. 336-340 ◽  
Author(s):  
Richa Singh ◽  
Meenal Jain ◽  
Poonam Yadav ◽  
Sarvesh Awasthi ◽  
Pallavi Raj
Keyword(s):  
Statistical Analysis ◽  
Ovulation Induction ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Reproductive Age ◽  
Multiple Pregnancies ◽  
Laparoscopic Ovarian Drilling ◽  
Ovarian Drilling ◽  
Ovarian Syndrome

ABSTRACT Introduction The polycystic ovary syndrome (PCOS) is the most common condition associated with chronic anovulation affecting 4 to 6% of reproductive age women. Aim To compare the effectiveness of laparoscopic ovarian drilling (LOD) for ovulation induction with gonadotropins in clomiphene-resistant PCOS in terms of ovulation, pregnancy, live birth, abortion, multiple pregnancies, and complication like ovarian hyperstimulation syndrome (OHSS). Setting and design A prospective hospital-based randomized trial. Materials and methods It was a prospective study, which was carried out from January 2012 to May 2015. Totally, 89 women were evaluated in the study, out of which 44 women were in gonadotropin group and 45 were in LOD group. Statistical analysis Standard statistical analysis was done and significance of difference in results was tested by chi-square test. Results Ovulation rate in gonadotropin group was 75.0% at 6 months, whereas in LOD group, it was 20% at 3 months and was increased up to 66.66% after addition of clomiphene citrate and gonadotropin. The primary outcome in terms of pregnancy in gonadotropin group was 45.45% after 6 cycles and in LOD group was 11.11% after 3 cycles and 40.00% after 6 cycles with supplementation of clomiphene citrate and gonadotropin. Conclusion The ongoing pregnancy rate from ovulation induction with LOD alone was significantly less but if supplemented by clomiphene citrate and gonadotropin, it seems equivalent to ovulation induction with gonadotropin, but the former procedure carries a lower risk of multiple pregnancies. How to cite this article Yadav P, Singh S, Singh R, Jain M, Awasthi S, Raj P. To Study the Effect on Fertility Outcome by Gonadotropins vs Laparoscopic Ovarian Drilling in Clomiphene-resistant Cases of Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):336-340.

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