Expression of PDL-1 and Its Correlation with TIL in Triple Negative Cases of Breast Carcinoma

Background: In the present study, we aimed to determine the expression of PDL1 and its correlation with TIL in Triple Negative (ER, PR and Her 2neu negative) cases of breast carcinoma (immune-histochemical study) Methods: Expression of PD-L1 was seen on 40 proven triple negative cases of breast carcinomas (TNBC) and to correlate it with other parameters affecting prognosis of the disease. All the cases were infiltrating ductal carcinoma NOS (not otherwise specified) Result: Maximum cases were Grade III (67.5%) followed by Grade II (32.5%). PD-L1 positivity was seen in 32.5% cases whereas TIL was positive for PD-L1 in 27.5 %. 5 cases were positive for both epithelial cell and TIL. Out of 13 PD-L1 positive tumors, 38.5% cases showed TIL positivity whereas out of 27 PD-L1 negative tumors, only 22.2% were TIL positive. PD-L1 expression in TIL was seen in 38.5% of cases however there was no statistically significant correlation between PD-L1 positivity and TIL positivity. PDL-1 positivity was more in Grade III (33.3%) as compared to Grade II (23%) lesions. Thus, it was observed that PD-L1 positivity increased from grade II to grade III lesions. Conclusion: Intra-tumoral expression of PD-L1 is directly proportional to histological grade, aggressive subtypes in TNBC cases however there was no statistically significant correlation between PD-L1 positivity in tumor cells and TIL positivity. We thus postulate that measurement of PD-L1 expression in TNBC cases could enhance the accuracy of predicting patient prognosis and allow for optimal treatment selection.

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Invasive Carcinoma Mammae dengan Metastasis Orbita, Tulang, dan Paru

Jurnal Kesehatan Andalas ◽

10.25077/jka.v8i1s.932 ◽

2019 ◽

Vol 8 (1S) ◽

pp. 89

Author(s):

Putri Avryna ◽

Irza Wahid ◽

Fauzar Fauzar

Keyword(s):

Breast Carcinoma ◽

Invasive Ductal Carcinoma ◽

Invasive Carcinoma ◽

Ductal Carcinoma ◽

Invasive Breast Carcinoma ◽

Not Otherwise Specified ◽

Grade Ii ◽

Carboplatin Auc

Carcinoma mammae (kanker payudara) merupakan penyakit keganasan yang paling banyak terjadi pada wanita di negara berkembang dan merupakan penyebab kematian wanita kedua di Amerika Serikat.Pada tahun 2014, terdapat 232.000 kasus baru pada wanita di Amerika Serikat dan dengan angka kematian 40.000 jiwa. Invasive breast carcinoma paling banyak berasal dari epitel duktus dan lebih dari 75% merupakan invasive ductal carcinoma not otherwise specified (IDC-NOS). Angka kejadian metastasis orbita 2-9% dari semua kasus keganasan pada dewasa dan 8-10% berasal dari kanker payudara. Pada kasus ini, wanita 36 tahun datang dengan keluhan sesak napas dan terdapat benjolan pada mata kiri sejak 2 bulan yang lalu. Pasien telah dikenal menderita Ca Mammae dengan hasil biopsy jaringan ditemukan invasive carcinoma mammae of no special type (NST) Grade II sejak 1,5 tahun sebelumnya, namun menolak pengobatan dan kemoterapi. Saat ini telah terjadi metastasis di orbita, metastasis tulang dan paru. Pasien diberikan kemoterapi dengan regimen Carboplatin (AUC 6) dan Paclitaxel 170 mg/m2 dan mengalami perbaikan secara signifikan.

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Breast Carcinoma with Osteoclast-Like Giant Cells: Immunohistochemical and Ultrastructural Study of a Case and Review of the Literature

Tumori Journal ◽

10.1177/030089169508100213 ◽

1995 ◽

Vol 81 (2) ◽

pp. 135-141 ◽

Cited By ~ 9

Author(s):

Paolo Viacava ◽

Antonio Giuseppe Naccarato ◽

Vincenzo Nardini ◽

Generoso Bevilacqua

Keyword(s):

Electron Microscopy ◽

Breast Carcinoma ◽

Tumor Cells ◽

Unusual Case ◽

Ductal Carcinoma ◽

Benign Lesion ◽

Giant Cells ◽

Review Of The Literature ◽

Not Otherwise Specified ◽

Infiltrating Ductal Carcinoma

We describe an unusual case of infiltrating ductal carcinoma, not otherwise specified, containing numerous benign stromal osteoclast giant cells (OGCs). Macroscopically, the tumor appeared as a well-outlined dark brown mass and was initially interpreted as a benign lesion on the mammograms. OGCs were uniformly distributed in the tumor and were found in vascularized, hemorrhagic stroma often abutted on the nests of tumor cells. Electron microscopy supported a histiocytic origin of the OGCs, but immunohistochemistry failed to confirm the observation. The patient was alive and well 30 months following the operation. A review of the literature concerning breast carcinoma with OGCs is also presented.

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Clinicopathologic characteristics at diagnosis and the survival of patients with medullary breast carcinoma in China: a comparison with infiltrating ductal carcinoma-not otherwise specified

World Journal of Surgical Oncology ◽

10.1186/1477-7819-11-91 ◽

2013 ◽

Vol 11 (1) ◽

pp. 91 ◽

Cited By ~ 14

Author(s):

A-Yong Cao ◽

Min He ◽

Liang Huang ◽

Zhi-Ming Shao ◽

Gen-Hong Di

Keyword(s):

Breast Carcinoma ◽

Ductal Carcinoma ◽

Clinicopathologic Characteristics ◽

Not Otherwise Specified ◽

Infiltrating Ductal Carcinoma

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IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i1.4687 ◽

2021 ◽

Vol 71 (1) ◽

pp. 7-11

Author(s):

Amna Ameer ◽

Farhan Akhtar ◽

Hafeez Ud Din ◽

Rabia Ahmad

Keyword(s):

Androgen Receptor ◽

Breast Carcinoma ◽

Triple Negative ◽

Histological Grade ◽

Armed Forces ◽

Receptor Expression ◽

Androgen Receptor Expression ◽

Breast Carcinomas ◽

Immunohistochemical Expression ◽

Triple Negative Breast Carcinoma

Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triplenegative breast carcinoma. Study Design: Cross sectional study. Duration and Place of Study: This study included 30 cases confirmed as triple negative breast carcinoma atArmed Forces Institute of Pathology Rawalpindi, from Jan to Jul 2018. Methodology: Anti-androgen receptor antibody was applied and assessed. Positive expression was defined asgreater and equal to 10% nuclear immunostaining. SPSS-24 was used for analyzing data. Results: Out of 30 cases of triple negative breast carcinoma (TNBC), all patients were female. Patients’ agesranged between 21-72 years with a mean age of 46.35 years and a standard deviation of ± 13.4. Androgen receptor expression was positive in 8 cases (27%) of all triple negative breast carcinomas. Out of these androgen receptor (AR) triple negative breast carcinomas; all 8 cases were of histological subtype invasive ductal (mammary) carcinoma, non special type, 7 cases (23%) were of histological grade 3 and 1 was of histological grade 2. Conclusion: Androgen receptor expression is observed in 8 cases (27%) of triple negative breast carcinoma cases. Such patients can be selected as candidates for anti- androgen receptor targeted therapy.

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Estrogen and progesterone receptor expression in breast carcinoma

Journal of Pathology of Nepal ◽

10.3126/jpn.v1i2.5401 ◽

1970 ◽

Vol 1 (2) ◽

pp. 100-103 ◽

Cited By ~ 1

Author(s):

TB Pathak ◽

R Bashyal ◽

CB Pun ◽

S Shrestha ◽

S Bastola ◽

...

Keyword(s):

Estrogen Receptor ◽

Breast Carcinoma ◽

Progesterone Receptor ◽

Histological Grade ◽

Receptor Expression ◽

Inverse Association ◽

Progesterone Receptor Expression ◽

Grade Ii ◽

Grade Iii ◽

Estrogen And Progesterone Receptor

Background: Breast carcinoma is the most common malignancy diagnosed among women worldwide and second leading cause of cancer mortality. One of the hallmarks of the disease is expression of estrogen receptor and progesterone receptor that ultimately drives prognosis and treatment modalities of the patient. The objective of this study was to determine the Estrogen and Progesterone receptor status in relation to histological grade of tumor. Materials and Methods: This was an observational study, carried out in the department of Pathology, BP Koirala Memorial cancer Hospital, Bharatpur, from January 2010 to December 2010. A total of 136 patients with histological proven diagnosis of breast carcinoma was included in this study. These cases were graded according to the modified Bloom and Richardson criteria into three histological grades. We used immunohistochemistry to evaluate the expression of Estrogen and Progesterone in relation to histological grade of tumor. Results: Out of 136 cases, there were 131 (96%) cases of infiltrating ductal carcinoma with mean age of 48 years. Majority of cases were grade II (59%) followed by grade III (21%) and grade I (20%). Estrogen Receptor and Progesterone Receptor expression were seen in 28% and 19% respectively. In grade I, 16 (59%) and 10 (37%) cases out of 27 were Estrogen Receptor and Progesterone Receptor positive respectively. In grade II, 21 (26%) and 15(19%) out of 80 cases were Estrogen Receptor and Progesterone Receptor positive respectively. In grade III, 1(3%) and 1 (3%) cases were positive for Estrogen Receptor and Progesterone Receptor respectively. Conclusions: Expression of estrogen and progesterone is comparable to west with Estrogen and Progesterone showing inverse association with histological grades of tumor. Keywords: Breast carcinoma; Estrogen receptor; Progesterone receptor DOI: http://dx.doi.org/10.3126/jpn.v1i2.5401 JPN 2011; 1(2): 100-103

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Isolated right adrenal metastasis from an invasive ductal breast carcinoma.

10.32512/jmr/2.2.2019/10.13 ◽

2019 ◽

pp. 10-13

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Invasive Ductal Carcinoma ◽

Adrenal Glands ◽

Ductal Carcinoma ◽

Adrenal Metastasis ◽

Breast Carcinomas ◽

Invasive Ductal Breast Carcinoma ◽

Invasive Breast Carcinomas ◽

Histopathological Type

Invasive ductal carcinoma (IDC) is the most common histopathological type of breast cancer, accounting for up to 85% of all invasive breast carcinomas [1]. It spreads usually to the bone first. Solitary metastasis is commonly located in the lung, liver or brain [2]. Adrenal glands locations are extremely rare [3]. We report a case of isolated metachronous right adrenal metastasis, diagnosed four years after breast IDC management. The aim is to highlight clinical, diagnostic and therapeutic characteristics of this entity.

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CLINICAL AND HISTOPATHOLOGICAL REVIEW OF INVASIVE BREAST CARCINOMA IN A TERITARY CARE CENTRE.

10.36106/5735570 ◽

2021 ◽

pp. 18-21

Author(s):

A. Gomathy ◽

Muruganantham Arunagirinathan ◽

I. Nithya

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Cancer Survival ◽

Histological Grade ◽

Lymph Node Involvement ◽

Left Breast ◽

Invasive Breast Carcinoma ◽

Indian Women ◽

Node Involvement ◽

Grade Ii

BACKGROUND: Breast cancer accounts for 14% of all cancers in Indian women, that can occur at any age. Cancer survival becomes more difcult in higher stages of tumour, hence in order to improve the survival of affected persons, early diagnosis of breast cancer is critical. METHODS: Retrospective study of 48 mastectomy specimens with relevant clinical details and respective H&E stained slides were reviewed. CONCLUSION: This review showed that occurrence of Invasive Breast Carcinoma(IBC) peaks in the age group of 41-50years (35.4% ) with right and left breast being affected equally in the ratio of R:L – 1 : 1. Most of the IBC (91.6%) were of No Special Type (NST), with 75% of tumours were of Histological Grade II. 58.3% of tumours were of tumour stage T along with lymph node involvement in equal number of cases.

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p63 expression is associated with high histological grade, aberrant p53 expression and TP53 mutation in HER2-positive breast carcinoma

Journal of Clinical Pathology ◽

10.1136/jclinpath-2020-206643 ◽

2020 ◽

pp. jclinpath-2020-206643

Author(s):

Shuangping Guo ◽

Yingmei Wang ◽

Joseph Rohr ◽

Li Shang ◽

Jing Ma

Keyword(s):

Breast Carcinoma ◽

Neoadjuvant Therapy ◽

Histological Grade ◽

Clinicopathological Features ◽

Breast Carcinomas ◽

Her2 Positive ◽

P53 Expression ◽

High Histological Grade ◽

Younger Age ◽

Significant Difference

Aimp63, a member of the p53 family, is a myoepithelial cell marker usually expressed in metaplastic breast carcinoma and its expression suggests a myoepithelial phenotype. However, its expression and association with clinicopathological features of human epidermal growth factor receptor 2 (HER 2)-positive breast carcinoma is poorly investigated.Materials and methodsSixty-seven patients with oestrogen receptor-negative and progesterone receptor-negative, HER2-positive breast carcinoma who received anti-HER2-based neoadjuvant±adjuvant therapy was retrospectively analysed.ResultsTwenty cases were p63-positive and 47 cases were p63-negative. The clinicopathological features and tumour responses after neoadjuvant therapy and outcomes were analysed. Among HER2-positive tumours, expression of p63 was significantly associated with younger age (42.5 vs 55.9; p=0.010). Expression of p63 was also significantly associated with histological grade 3 (11/20 (55%) vs 11/47 (23.4%); p=0.012) and negatively associated with grade 2 (9/20 (45%) vs 36/47 (76.6%); p=0.012). Intriguingly, p63-positive breast carcinomas showed significant aberrant p53 expression by immunohistochemistry (16/18 (88.9%) vs 29/47 (61.7%); p=0.03) and of TP53 mutation by Sanger sequencing (15/16 (93.8%) vs 12/22 (54.5%); p=0.009). No significant difference in tumour response after anti-HER2 neoadjuvant therapy nor in survival were found between p63-positive and p63-negative breast carcinomas.ConclusionExpression of p63 in HER2-positive breast carcinoma is significantly associated with younger age, poor differentiation, high histological grade and aberrant expression of p53 and of TP53 mutation. HER2-positive breast carcinoma with a myoepithelial immunophenotype shows distinctive clinicopathological features representing a distinct subtype of HER2-positive breast carcinoma. Further, these findings suggest an interaction between p63 and mutant p53 in the tumorigenesis of HER2-positive breast carcinomas.

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