CLINICAL AND HISTOPATHOLOGICAL REVIEW OF INVASIVE BREAST CARCINOMA IN A TERITARY CARE CENTRE.

BACKGROUND: Breast cancer accounts for 14% of all cancers in Indian women, that can occur at any age. Cancer survival becomes more difcult in higher stages of tumour, hence in order to improve the survival of affected persons, early diagnosis of breast cancer is critical. METHODS: Retrospective study of 48 mastectomy specimens with relevant clinical details and respective H&E stained slides were reviewed. CONCLUSION: This review showed that occurrence of Invasive Breast Carcinoma(IBC) peaks in the age group of 41-50years (35.4% ) with right and left breast being affected equally in the ratio of R:L – 1 : 1. Most of the IBC (91.6%) were of No Special Type (NST), with 75% of tumours were of Histological Grade II. 58.3% of tumours were of tumour stage T along with lymph node involvement in equal number of cases.

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Correlation Between Breast Tumor Size and Lymph Node Involvement in Patients Referring to the Pathology Department of Rasoul Akram Hospital in Iran

Thrita ◽

10.5812/thrita.110659 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Maryam Mohammadhosseini ◽

Ahmad Majd ◽

Hamidreza Mirzaei ◽

Mona Farhadi ◽

Nasrin Shayanfar

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Breast Carcinoma ◽

Cancer Progression ◽

Tumor Size ◽

Ductal Carcinoma ◽

Histological Grade ◽

Lymph Node Involvement ◽

Ductal Breast Carcinoma ◽

Node Involvement

Background: Breast cancer has the highest mortality rate, second to gastric cancer, among Iranian women and is one of the most common cancers in the world. The incidence of breast cancer in women is increasing gradually. Meanwhile, ductal breast carcinoma experiences more increases than other malignancies and is one of the most important health problems. Objectives: This study aimed at evaluating women with ductal breast carcinoma because of the significance of pathological factors and their association with breast cancer progression. Methods: This retrospective study was conducted using data of ductal breast carcinoma women during the years 2018 and 2019. In this cross-sectional study, demographic data (age, sex, and pathology of breast mass) of 50 patients referring to Rasoul Akram hospital (Tehran, Iran) were gathered. Then, the data were analyzed by SPSS 26 software using the t test and Levene's test. The results were presented using descriptive statistics. Results: Fifty patients with ductal carcinoma were assessed based on their pathological information. The examination of factors including tumor size, involvement/non-involvement of lymph nodes, histological grade, and age of patients revealed a significant direct relationship between tumor size and lymph node involvement (P

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Immunostaining status of anaplastic lymphokinase in female breast cancer.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.08.4536 ◽

2020 ◽

Vol 27 (08) ◽

pp. 1777-1783

Author(s):

Syed Naqeeb Ali ◽

Syed Liaquat Ali ◽

Ghazala Panhwar ◽

Sarwat Batool ◽

Anila Qureshi ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Breast Carcinoma ◽

Histological Grade ◽

Lymph Node Involvement ◽

Female Breast Cancer ◽

Skin Involvement ◽

Female Breast ◽

Node Involvement ◽

Relationship Of

Objectives: To determine the status of ALK immunostaining in female breast cancer and to find out the relationship of ALK expression with clinicopathological variables. Study Design: Cross Sectional study. Setting: Department of Pathology Al Tibri Medical College and Hospital Karachi and BMSI Jinnah Post Graduate Medical Centre, Karachi. Period: October 2016 to March 2017. Material & Methods: Total of 110 female cases with breast carcinoma by using non-probability purposive sampling technique. After taking informed consent from the patients, tissue samples were taken from received specimen of mastectomy for hematoxylin and eosin stain. The immunohistochemistry for ALK was assessed by using a DAKO monoclonal antibody using the paraffin embedded blocks of the diagnosed cases of breast carcinoma. Chi square test was used to find out the significance of differences among the variables. Results: Total of 110 cases with different histological classifications of breast cancer were observed i-e invasive ductal carcinoma 95(86%), invasive lobular carcinoma 9(8%), invasive medullary carcinoma 4(3.6%) and papillary carcinoma 2(1.8%). ALK expression was positive in 71(64%) and negative in 39 (35%) patients. Significant association was observed between ALK expression with histological grade (p=0.003), lymph node involvement (p=0.042) and skin involvement (p=0.025). Conclusion: Present study shows higher positive ALK expressions. Present study also indicates significant relationship of ALK with histological grade, lymph node involvement and skin involvement.

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A STUDY ON HORMONE RECEPTOR STATUS IN BREAST CANCER IN RELATION TO HISTOLOGICAL GRADING, AGE AND LYMPH NODE INVOLVEMENT

10.36106/ijar/1601400 ◽

2021 ◽

pp. 41-44

Author(s):

R. Rani Suganya ◽

M. Annapoorani ◽

C. Naveen Kumar

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Hormone Receptor ◽

Histological Grade ◽

Systemic Disease ◽

Lymph Node Involvement ◽

Hormone Receptor Status ◽

Major Health Problem ◽

Receptor Status ◽

Node Involvement

Breast cancer is the major health problem for the women throughout the world.Management of breast cancer has evolved to include both surgery for local disease and medical therapy for systemic disease. Multiple treatment options are available depending on various factors such as histological grade, hormone receptor status etc. The aim of this study is to correlate the hormone receptor status with prognostic factors such as lymph node involvement, tumour grading and age among patients diagnosed with breast cancer in our institution. The results of this study serve to prognosticate the severity of disease among various strata of patients.

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Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection

Frontiers in Oncology ◽

10.3389/fonc.2021.570208 ◽

2021 ◽

Vol 11 ◽

Author(s):

Wen Li ◽

Guangzhi Ma ◽

Yunfu Deng ◽

Wenjie Chen ◽

Zhenkun Liu ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factor ◽

Cancer Patients ◽

Histological Grade ◽

Lymph Node Involvement ◽

Breast Cancer Patients ◽

Optimal Cutoff ◽

Cutoff Value ◽

Post Surgery ◽

Node Involvement

BackgroundThe preoperative systemic immune-inflammation index (SII) is correlated with prognosis in several malignancies. The aim of this study was to investigate the prognosis value of SII in patients with resected breast cancer.Materials and MethodsA total of 784 breast cancer patients who underwent surgical resection were consecutively investigated. The optimal cutoff value of SII was evaluated using the receiver operating characteristic (ROC) curve. The collection of SII with clinicopathological characteristic and prognosis was further evaluated.ResultsThe optimal cutoff value for SII in the prediction of survival was 514 according to ROC curve analysis. A high SII was significantly correlated with younger age (P = 0.037), PR status (P < 0.001), and HER2 status (P = 0.035). Univariate analysis revealed that SII (P < 0.001), T-stage (P < 0.001), lymph node involvement post-surgery (P = 0.024), and histological grade (P < 0.001) were significantly related to DFS, and SII (P < 0.001), T-stage (P = 0.003), lymph node involvement post-surgery (P = 0.006), and histological grade (P < 0.001) were significantly associated with OS. In multivariate analysis, a high SII was an independent worse prognostic factor for DFS (HR, 4.530; 95% CI, 3.279-6.258; P < 0.001) and OS (HR, 3.825; 95% CI, 2.594-5.640; P < 0.001) in all the enrolled patients. Furthermore, subgroup analysis of molecular subtype revealed that SII was significantly associated with prognosis in all subtypes.ConclusionPreoperative SII is a simple and useful prognostic factor for predicting long-term outcomes for breast cancer patients undergoing surgery.

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Comparison of ER, PR, Ki67 and HER-2/neu Reactivity Pattern with Patients’ Age, Histologic Grade, Tumor Size and Lymph Node Status in Invasive Ductal Breast Cancer

International Journal of Cancer Management ◽

10.5812/ijcm.98325 ◽

2020 ◽

Vol 13 (6) ◽

Author(s):

Mahsa Ahadi ◽

Motahareh Heibatollahi ◽

Sara Zahedifard

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Tumor Size ◽

Histological Grade ◽

Lymph Node Involvement ◽

Lymph Node Status ◽

Invasive Ductal Breast Cancer ◽

Ductal Breast Cancer ◽

Node Involvement ◽

Her 2

Background: Breast cancer is the most prevalent neoplasm diagnosed in Iranian women. Objectives: The current study was performed to measure the hormone receptor status and its possible connection with the patient’s age, tumor size, histological grade, and lymph node status and involvement in patients with invasive ductal breast cancer (IDBC) Methods: A total of 103 women with IDBC recently diagnosed at the Department of Pathology of Shohada-E-Tajrish Hospital were entered into this study. The mean age of the patients was 48.4 years, and 59.2% of cases were 50 years old or less. Results: Most lesions (78.6%) were more than 2 cm at their greatest dimension. Grade-II lesions were observed in a large number of patients and 59.8% of cases had lymph node involvement. Positive ER, PR, and HER-2/neu were detected in 59%, 57%, and 29% of patients, respectively. A significant correlation was found between patients’ age and histologic score, tumor dimension and both histologic score and nuclear grade, and, finally, between lymph node involvement and nuclear grade. Conclusions: According to previous studies, the evaluation of hormone receptor status in patients with breast cancer is strongly recommended. Here, by studying its possible connection with the patient’s age, tumor size, histological grade, and lymph node metastasis, we detected some biomarkers, which could be used as prognostic indices in these patients. These biomarkers could help us in the clinical management of patients with IDBC by providing the best therapeutic options.

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Correlation of plasma D-dimer levels with breast carcinoma

International Surgery Journal ◽

10.18203/2349-2902.isj20214755 ◽

2021 ◽

Vol 8 (12) ◽

pp. 3622

Author(s):

Amruthavarshini Satish Halugodu ◽

Vidhyasagar M. Sharma

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Lymphovascular Invasion ◽

Histopathological Examination ◽

Histological Grade ◽

Tumour Size ◽

Lymph Node Involvement ◽

Advanced Stage ◽

Node Involvement ◽

D Dimer

Background: Breast cancer is the most commonly occurring cancer in women. There is a correlation between cancer and hyper coagulation. Carcinoma increases the level of cross-linked fibrin degradation product (plasma D-dimer), indicative of systemic activation of fibrinolysis, hemostasis and angiogenesis. This study attempted to correlate raised plasma D-dimer in breast cancer.Methods: A retrospective study was conducted in the department of general surgery in GCS hospital, Ahmedabad where in patients admitted and treated for breast cancer between July 2020 to June 2021 were selected. Plasma D-dimer levels were correlated with final histopathological examination of breast specimen.Results: Plasma D-dimer levels were increased with advancing stage of disease, lymph node involvement and lymphovascular invasion. There was no significant relationship with increase in tumour size and histopathological grade of tumour.Conclusions: Plasma D-dimer levels are elevated in breast cancer, especially with advanced stage. It is an important marker of clinical stage, lymphovascular invasion, lymph node involvement. However it does not correlate with tumour size and histological grade. So pre- operative plasma D-dimer level is a safe, cost effective and convenient method for prediction of advanced stage in breast cancer.

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Lymphangiogenesis in breast carcinoma is present but insufficient for metastatic spread

Journal of Health Sciences ◽

10.17532/jhsci.2014.138 ◽

2014 ◽

Vol 4 (1) ◽

pp. 4-11

Author(s):

Mirsad Dorić ◽

Suada Kuskunović-Vlahovljak ◽

Svjetlana Radović ◽

Ajna Hukić ◽

Mirsad Babić ◽

...

Keyword(s):

Breast Cancer ◽

Cell Proliferation ◽

Breast Carcinoma ◽

Histological Grade ◽

Lymphatic Vessels ◽

Lymphatic Endothelial Cell ◽

Breast Disease ◽

Invasive Breast Carcinoma ◽

Endothelial Cell Proliferation ◽

Fibrocystic Breast Disease

Introduction: The lymphatic vasculature is an important route for the metastatic spread of human cancer. However, the extent to which this depends on lymphangiogenesis or on invasion of existing lymph vessels remains controversial. The goal of this study was to investigate the existence of lymphangiogenesis in invasive breast carcinoma: by measuring the lymphatic vessels density (LVD) and lymphatic endothelial cell proliferation (LECP) and their correlation with various prognostic parameters in breast cancer, including lymphovascular invasion (LVI).Methods: Lymphatic vessels density was investigated in 75 specimens of invasive breast carcinoma by immunostaining for D2-40 using the Chalkley counting method. Endothelial proliferation in lymphatic vessels was analyzed by dual-color immunohistochemistry with D2-40 and Ki-67.Results: Decrease of intra and peritumoral LVD in invasive breast carcinoma compared to fibrocystic breast disease was detected (p=0.002). Lymphatic endothelial cell proliferation was significantly higher in invasive breast cancer (p=0.008) than in the fibrocystic breast disease. LECP showed a correlation with histological grade of the tumor (p=0.05). Involvement of axillary lymph nodes with metastatic tissue was in strong correlation only with existence of lymphatic vascular invasion (p=0.0001).Conclusion: These results suggest that development of breast cancer promotes proliferation of lymphatic endothelial cells whose level correlates with histological grade of tumor, but in a scope that is insufficient to follow growth of tumor tissue that invades them and destruct them. This might explain the decrease of lymphatic vessels density.

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