Correlation of Histological Grade with Harmone Receptors and Her 2 Neu In Carcinoma Breast - A Tertiary Centre Study

Background: GATA3 plays an essential role in the normal development and function of the mammary gland where it promotes the luminal transcriptional program. Its loss is implicated in the pathogenesis of breast cancer. We proposed to study the expression of GATA3 in carcinoma breast by immunohistochemistry and determine its correlation with prognostic parameters. Methods: The expression pattern of GATA3 was evaluated by immunohistochemistry in 30 cases of invasive breast carcinoma. GATA3 scoring was done and a score of ≥ 1+ was considered positive. Patient characteristics, including age, tumour laterality, tumour size, lymph node status, tumour grade, histological type, molecular subtypes were collected. The relationships between protein expression and clinicopathological variables were analysed. Statistical significance was determined by Pearson’s chi-square test and Mann Whitney U test (for age). Result: 46.7% of cases (14/30) scored positive for GATA3 expression in tumour cells including 63% of luminal subtypes, 14% of Her-2 neu enriched carcinomas and 20% of triple negative carcinomas. Most positive cases (35.7%) demonstrated 3+ staining. GATA3 expression showed an inverse association with histological grade (P = 0.012) and HER-2 overexpression (P = 0.038), and a direct association with ER expression (P =0.017) and PR expression (P =0.009). Conclusion: GATA3 is luminal marker as it shows strong association with ER and PR in breast cancers. High GATA3 expression is also correlated good prognostic parameters like low tumour grade. Our findings advocate for GATA3 as a promising new breast-specific immunomarker.

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A study on the role of receptor (ER,PR,HER-2/neu) in patients of carcinoma breast

International Journal Of Medical Science And Clinical Invention ◽

10.18535/ijmsci/v4i10.03 ◽

2017 ◽

Vol 4 (10) ◽

Author(s):

Dr Pankaj Singh ◽

Keyword(s):

Carcinoma Breast ◽

Her 2

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Role of progesterone receptor status (PR) as predictive factor of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer (BC) patients (pts)

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.637 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 637-637

Author(s):

J. M. Perez Garcia ◽

C. Saura ◽

E. Muñoz ◽

G. Sanchez-Olle ◽

P. Gomez ◽

...

Keyword(s):

Predictive Factor ◽

Multivariate Analyses ◽

Histological Grade ◽

Statistical Significance ◽

Univariate Analysis ◽

Complete Response ◽

Her 2 ◽

Few Data

637 Background: While estrogen receptor (ER) negativity has been consistently associated to higher pCR rates after NACT in BC, few data regarding the association of PR with pCR has been reported. PR positivity has been related to taxol resistance in in vitro chemosensitivity assays. Our aim was to investigate the putative role of PR in the prediction of pCR in a cohort of BC pts receiving NACT. Methods: Medical reports of all pts receiving NACT and breast surgery between 2004 and 2006 in our institution were reviewed. Baseline clinical and histological features, along with type of preoperative therapy were examined as variables for association with pCR (no invasive tumor in breast and axilla) using univariate and multivariate analyses. Results: 128 pts were included. 73.4% received anthracycline and taxanes (A&Tx) based CT and 9.4% also received trastuzumab (T). PR+ (≥ 10%) was significantly associated with low histological grade (HG), low Ki67 (<10%), HER-2- (Herceptest 0,1,or 2 with FISH-) and ER+ (≥10%). Overall pCR rate was 18.8%. No PR+ patient achieved pCR. In univariate analysis, high HG, ER-, PR-, HER-2-, high Ki67, T therapy, and number of CT cycles were significantly associated with pCR. In multivariate analysis only HER-2 and PR status were statistically significant. Similarly, PR and HER-2 status were independently related to pCR in the subgroup of pts receiving A&Tx (N = 94, 20.2%pCR). In the HER-2- subgroup (n = 89, 9%pCR) only ER independently predicted pCR, while in the HER-2+ subgroup (n = 33, 42.4%pCR, 57.1%pCR with T), both PR- and T therapy were the only predictive factors for pCR in the univariate and multivariate analyses. When the 24 HER-2+ pts treated with A&Tx (23 taxol/1 taxotere) ± T were separately analyzed, only PR retained statistical significance in the multivariate model. Conclusions: In our cohort of BC pts treated with NACT, PR status independently predicts pCR in the whole population as well as in the A&Tx-treated and in the HER-2+ subgroups. In the HER-2+ pts receiving A&Tx ± T PR negativity was the only factor associated with pCR. PR status merits further investigation as a predictive factor for pCR to NACT, in particular in HER-2+ population. No significant financial relationships to disclose.

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Correlation of hormone receptors with her-2 neu protein expression and the histological grade in invasive breast cancers in a cohort of saudi arabia

Turkish Journal of Pathology ◽

10.5146/tjpath.2012.01095 ◽

2012 ◽

Vol 28 (1) ◽

pp. 38 ◽

Cited By ~ 1

Author(s):

Maha Arafah

Keyword(s):

Saudi Arabia ◽

Protein Expression ◽

Hormone Receptors ◽

Histological Grade ◽

Breast Cancers ◽

Her 2

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Comparison of ER, PR, Ki67 and HER-2/neu Reactivity Pattern with Patients’ Age, Histologic Grade, Tumor Size and Lymph Node Status in Invasive Ductal Breast Cancer

International Journal of Cancer Management ◽

10.5812/ijcm.98325 ◽

2020 ◽

Vol 13 (6) ◽

Author(s):

Mahsa Ahadi ◽

Motahareh Heibatollahi ◽

Sara Zahedifard

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Tumor Size ◽

Histological Grade ◽

Lymph Node Involvement ◽

Lymph Node Status ◽

Invasive Ductal Breast Cancer ◽

Ductal Breast Cancer ◽

Node Involvement ◽

Her 2

Background: Breast cancer is the most prevalent neoplasm diagnosed in Iranian women. Objectives: The current study was performed to measure the hormone receptor status and its possible connection with the patient’s age, tumor size, histological grade, and lymph node status and involvement in patients with invasive ductal breast cancer (IDBC) Methods: A total of 103 women with IDBC recently diagnosed at the Department of Pathology of Shohada-E-Tajrish Hospital were entered into this study. The mean age of the patients was 48.4 years, and 59.2% of cases were 50 years old or less. Results: Most lesions (78.6%) were more than 2 cm at their greatest dimension. Grade-II lesions were observed in a large number of patients and 59.8% of cases had lymph node involvement. Positive ER, PR, and HER-2/neu were detected in 59%, 57%, and 29% of patients, respectively. A significant correlation was found between patients’ age and histologic score, tumor dimension and both histologic score and nuclear grade, and, finally, between lymph node involvement and nuclear grade. Conclusions: According to previous studies, the evaluation of hormone receptor status in patients with breast cancer is strongly recommended. Here, by studying its possible connection with the patient’s age, tumor size, histological grade, and lymph node metastasis, we detected some biomarkers, which could be used as prognostic indices in these patients. These biomarkers could help us in the clinical management of patients with IDBC by providing the best therapeutic options.

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Incidence of Expression of ER, PR and Her 2 Neu in Infiltrating Ductal Carcinoma Breast: A Cohort Study

Indian Journal of Pathology Research and Practice ◽

10.21088/ijprp.2278.148x.8619.5 ◽

2019 ◽

Vol 8 (6) ◽

pp. 745-753

Author(s):

Neha Sharma ◽

◽

Bhupinder Kaur Batth ◽

Mridu Manjari ◽

Arshdeep Kaur ◽

...

Keyword(s):

Cohort Study ◽

Ductal Carcinoma ◽

Carcinoma Breast ◽

Infiltrating Ductal Carcinoma ◽

Her 2

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Clinical profile, management and outcomes of patients with pulmonary embolism: a retrospective tertiary centre study in Angola

CardioVascular Journal of Africa ◽

10.5830/cvja-2017-017 ◽

2017 ◽

Vol 28 (6) ◽

pp. 356-361

Author(s):

Ana Manuel ◽

Adelina Aufico ◽

Rui Africano ◽

Tomáz Peralta ◽

Abel Salas ◽

...

Keyword(s):

Pulmonary Embolism ◽

Clinical Profile ◽

Centre Study ◽

Tertiary Centre ◽

Profile Management

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Clinico pathological profile of carcinoma breast in Odisha: a mining state of eastern India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20211431 ◽

2021 ◽

Vol 9 (5) ◽

pp. 1323

Author(s):

Dipti Rani Samanta ◽

Surendra Nath Senapati ◽

Suresh Kumar Rout ◽

Tapas Kumar Dash

Keyword(s):

Lymph Node ◽

Pathological Finding ◽

Lymph Node Involvement ◽

Advanced Stage ◽

Duct Carcinoma ◽

Indian Women ◽

Carcinoma Breast ◽

Cancer Breast ◽

Number Of Patients ◽

Her 2

Background: Carcinoma of the breast is the commonest malignancy in indian women. It is a serious health issue, producing increased mortality among indian women. Breast carcinoma is a heterogeneous disease with wide difference in clinico pathological presentation in different parts of the world. This study had been undertaken to evaluate the clinico pathological presentation of carcinoma breast in Odisha which is one of the important mining belts of eastern India.Methods: It was a retrospective analysis of 1000 eligible histopathology proved non metastatic, post-operative carcinoma breast, treated at Acharya Harihar post graduate institute of cancer, a tertiary cancer hospital of Odisha. The data were retrieved with respect to clinical presentation, pathological finding, stage of the disease and receptor status of the cancer breast patients from the hospital records.Results: Among 1000 patients the mean age of presentation was 47.25 years, among them 99.2% of the patient were female. Upper outer quadrant lesion was 66.6%. 96.5% of patient presented with invasive duct carcinoma (IDC). Multicentricity was 1.9%. 36.5% presented with lympho vascular space invasion and 23% with perineural invasion. Mean tumor size was 4.24±2.07. 59.6% patient had lymph node involvement. Mean number of lymph node positive was 3.67. Extracapsular invasion was 19.9%. Majority of the patient presented with advanced stage of the disease. ER+, PR+, HER-2 neu negative breast cancer was only 21.5%, triple negative 47.9%, ER-, PR- HER-2 neu ± 15.2%, triple positive 9.1%.Conclusions: The patient of carcinoma breast in this part of world presented at younger age with advanced stage of the disease having triple negativity and HER-2 neu positive in a greater number of patients which are biologically aggressive, needs early detection and aggressive treatment.

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