scholarly journals Quantitative method for whole body autoradiography and application to tissue distribution study of FO-1561 in rats.

1988 ◽  
Vol 3 (6) ◽  
pp. 747-760
Author(s):  
Eiichi NAKAJIMA ◽  
Yoshie YASUKAWA ◽  
Hayao SHINOZAKI ◽  
Yukio MATSUBARA ◽  
Shigeto FUJISHITA ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Quantitative Method ◽  
Whole Body ◽  
Distribution Study ◽  
Whole Body Autoradiography ◽  
Tissue Distribution Study

Pharmacokinetics and Tissue Distribution Study of Ferruginol in Wistar Rat by High-performance Liquid Chromatography

2018 ◽  
Vol 15 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Guiyun Cao ◽  
Suqiao Han ◽  
Keke Li ◽  
Li Shen ◽  
Xiaohong Wang ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Mobile Phase ◽  
High Performance ◽  
Wistar Rat ◽  
Freezing And Thawing ◽  
Promising Candidate ◽  
Distribution Study ◽  
Substance Loss ◽  
Tissue Distribution Study ◽  
The Brain

Background: Ferruginol (FRGN) exhibits a broad range of pharmacological properties which make it a promising candidate for chemoprevention. However, little is known about its absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. Methods: A rapid, sensitive and specific HPLC-DAD method was established to quantify FRGN in the plasma and tissues of Wistar rats. After extraction of FRGN with ethyl acetate (EtOAc), chromatographic separation was performed on a YMC ODS C18 column (250 × 4.6 mm I.D., 5 µm) with a mobile phase consisting of methanol-water (92:8, v/v) at a flow rate of 0.9 mL/min. Detection was conducted with a wavelength of 273 nm at 25 °C. Results: The calibration curves for FRGN were linear in the concentration range of 0.5-20 µg/mL for plasma, 0.5-10 µg/mL for heart, liver, spleen, lung, kidney, stomach, intestine, brain and muscle. After three cycles of freezing and thawing, the concentration variations were within ± 7% of nominal concentrations, indicating no significant substance loss during repeated thawing and freezing. The assay was applied to pharmacokinetic and tissue distribution study in rats. Results suggested that lung, heart, liver, spleen and kidney were the major distribution tissues of FRGN in rats, and FRGN could permeate the blood-brain barrier to distribute in the brain of rats. Conclusion: The information provided by this research is very useful for gaining knowledge of the pharmacokinetic process and tissue distribution of FRGN.

Pharmacokinetic, bioavailability and tissue distribution study of MP3950, a new gastroprokinetic candidate compound, in rat using UPLC-MS/MS

2018 ◽  
Vol 1092 ◽  
pp. 95-105
Author(s):  
Yu Zhao ◽  
Min Zhao ◽  
Qi Jiang ◽  
Feng Qin ◽  
Chengying Wang ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Distribution Study ◽  
Tissue Distribution Study

scholarly journals Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats

2020 ◽  
Vol 72 (8) ◽  
pp. 1061-1071 ◽  
Author(s):  
Meiyun Shi ◽  
Mengyao Xu ◽  
Lei Yin
Keyword(s):  
Tissue Distribution ◽  
Distribution Study ◽  
Tissue Distribution Study
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