The Tyrosine Kinase Inhibitor Nilotinib Selectively Inhibits CYP2C8 Activities in Human Liver Microsomes

2013 ◽  
Vol 28 (6) ◽  
pp. 462-467 ◽  
Author(s):  
Min-Jung Kim ◽  
Jae-Won Lee ◽  
Kyung-Suk Oh ◽  
Chang-Soo Choi ◽  
Kwang Hee Kim ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Human Liver ◽  
Kinase Inhibitor ◽  
Liver Microsomes ◽  
Human Liver Microsomes

scholarly journals Identifying Metabolic Pathways of c‐MET Tyrosine Kinase Inhibitor Tepotinib in Human and Mouse Liver Microsomes

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
Feng Li ◽  
Kevin R. MacKenzie ◽  
Pranavanand Nyshadham ◽  
Kimberly A. Kerlec ◽  
Martin M. Matzuk
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Metabolic Pathways ◽  
Mouse Liver ◽  
Kinase Inhibitor ◽  
Liver Microsomes ◽  
Human And Mouse

The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes

2015 ◽  
Vol 43 (12) ◽  
pp. 1934-1937 ◽  
Author(s):  
Kushari Burns ◽  
Pramod C. Nair ◽  
Andrew Rowland ◽  
Peter I. Mackenzie ◽  
Kathleen M. Knights ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Human Liver ◽  
Kinase Inhibitors ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Nonspecific Binding

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study

Tyrosine kinase inhibitor (TKI) treatment outcome of stage IV-C thyroid differentiated cancer (analyzed by lesion evaluation)

2018 ◽  
Author(s):  
Hiroyuki Iwasaki ◽  
Haruhiko Yamazaki ◽  
Nobuyasu Suganuma ◽  
Yuko Sugawara ◽  
Naoki Gotoh ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Stage Iv ◽  
Tki Treatment
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