A Series Circuit from CA1 of Dorsal Hippocampus to Basolateral Amygdala via Postrhinal Cortex Participates in Conditioned Context-Induced Retrieval of Morphine Withdrawal Memory

2019 ◽  
Author(s):  
Qianqian Ma ◽  
Yali Fu ◽  
Zixuan Cao ◽  
Da Shao ◽  
Jiaojiao Song ◽  
...  
Keyword(s):  
Basolateral Amygdala ◽  
Dorsal Hippocampus ◽  
Morphine Withdrawal ◽  
Postrhinal Cortex

scholarly journals A Conditioning-Strengthened Circuit From CA1 of Dorsal Hippocampus to Basolateral Amygdala Participates in Morphine-Withdrawal Memory Retrieval

2020 ◽  
Vol 14 ◽  
Author(s):  
Qianqian Ma ◽  
Yali Fu ◽  
Zixuan Cao ◽  
Da Shao ◽  
Jiaojiao Song ◽  
...  
Keyword(s):  
Memory Retrieval ◽  
Basolateral Amygdala ◽  
Dorsal Hippocampus ◽  
Morphine Withdrawal

scholarly journals Auditory Thalamus, Dorsal Hippocampus, Basolateral Amygdala, and Perirhinal Cortex Role in the Consolidation of Conditioned Freezing to Context and to Acoustic Conditioned Stimulus in the Rat

1999 ◽  
Vol 19 (21) ◽  
pp. 9570-9578 ◽  
Author(s):  
Benedetto Sacchetti ◽  
Carlo Ambrogi Lorenzini ◽  
Elisabetta Baldi ◽  
Giovanna Tassoni ◽  
Corrado Bucherelli
Keyword(s):  
Conditioned Stimulus ◽  
Basolateral Amygdala ◽  
Dorsal Hippocampus ◽  
Perirhinal Cortex ◽  
Auditory Thalamus ◽  
Conditioned Freezing

scholarly journals Differential Regulation of MAPK Phosphorylation in the Dorsal Hippocampus in Response to Prolonged Morphine Withdrawal-Induced Depressive-Like Symptoms in Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66111 ◽  
Author(s):  
Wei Jia ◽  
Rui Liu ◽  
Jianguo Shi ◽  
Bin Wu ◽  
Wei Dang ◽  
...  
Keyword(s):  
Dorsal Hippocampus ◽  
Differential Regulation ◽  
Morphine Withdrawal ◽  
Mapk Phosphorylation

GABA-cannabinoid interplays in the dorsal hippocampus and basolateral amygdala mediate morphine-induced amnesia

2020 ◽  
Vol 157 ◽  
pp. 61-68 ◽  
Author(s):  
Khadijeh Alsadat Sharifi ◽  
Ameneh Rezayof ◽  
Sakineh Alijanpour ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Basolateral Amygdala ◽  
Dorsal Hippocampus

scholarly journals Context-induced relapse to drug seeking: a review

2008 ◽  
Vol 363 (1507) ◽  
pp. 3233-3243 ◽  
Author(s):  
Hans S Crombag ◽  
Jennifer M Bossert ◽  
Eisuke Koya ◽  
Yavin Shaham
Keyword(s):  
Basolateral Amygdala ◽  
Dorsal Hippocampus ◽  
Dorsal Striatum ◽  
Self Administration ◽  
Occasion Setting ◽  
Drug Seeking ◽  
Psychological Mechanisms ◽  
History Of ◽  
Study Context

In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studies by Bouton & Bolles on context-induced ‘renewal’ of learned behaviours, we developed a procedure to study context-induced relapse to drug seeking. In this procedure, rats are first trained to self-administer drug in one context. Next, drug-reinforced lever responding is extinguished in a different (non-drug) context. Subsequently, context-induced reinstatement of drug seeking is assessed by re-exposing rats to the drug-associated context. Using variations of this procedure, we and others reported reliable context-induced reinstatement in rats with a history of heroin, cocaine, heroin–cocaine combination, alcohol and nicotine self-administration. Here, we first discuss potential psychological mechanisms of context-induced reinstatement, including excitatory and inhibitory Pavlovian conditioning, and occasion setting. We then summarize results from pharmacological and neuroanatomical studies on the role of several neurotransmitter systems (dopamine, glutamate, serotonin and opioids) and brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, dorsal hippocampus and lateral hypothalamus) in context-induced reinstatement. We conclude by discussing the clinical implications of rat studies on context-induced reinstatement of drug seeking.

scholarly journals Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Vishvesh H. Shende ◽  
Simon McArthur ◽  
Glenda E. Gillies ◽  
Jolanta Opacka-Juffry
Keyword(s):  
Nucleus Accumbens ◽  
Basolateral Amygdala ◽  
Brain Volume ◽  
Dorsal Hippocampus ◽  
Morphological Changes ◽  
Primary Process ◽  
Total Brain Volume ◽  
Cell Numbers ◽  
Total Brain ◽  
Process Length

The long-term effects of antenatal dexamethasone treatment on brain remodelling in 3-month-old male Sprague Dawley rats whose mothers had been treated with dexamethasone were investigated in the present study. Dorsal hippocampus, basolateral amygdala and nucleus accumbens volume, cell numbers, and GFAP-immunoreactive astroglial cell morphology were analysed using stereology. Total brain volume as assessed by micro-CT was not affected by the treatment. The relative volume of the dorsal hippocampus (% of total brain volume) showed a moderate, by 8%, but significant reduction in dexamethasone-treated versus control animals. Dexamethasone had no effect on the total and GFAP-positive cell numbers in the hippocampal subregions, basolateral amygdala, and nucleus accumbens. Morphological analysis indicated that numbers of astroglial primary processes were not affected in any of the hippocampal subregions analysed but significant reductions in the total primary process length were observed in CA1 by 32%, CA3 by 50%, and DG by 25%. Mean primary process length values were also significantly decreased in CA1 by 25%, CA3 by 45%, and DG by 25%. No significant astroglial morphological changes were found in basolateral amygdala and nucleus accumbens. We propose that the dexamethasone-dependent impoverishment of hippocampal astroglial morphology is the case of maladaptive glial plasticity induced prenatally.

scholarly journals Effect of the aerobic exercise and the environmental enrichment on the reduction of the anxiety levels in the aging

2015 ◽  
Vol 5 (2) ◽  
pp. 197-208
Author(s):  
Patricia Sampedro
Keyword(s):  
Aerobic Exercise ◽  
Hpa Axis ◽  
Environmental Enrichment ◽  
Basolateral Amygdala ◽  
Dorsal Hippocampus ◽  
Brain Activity ◽  
Brain Regions ◽  
Bed Nucleus ◽  
Hypothalamic Pituitary Axis ◽  
Anxiety Levels

The environmental enrichment (EE) and the aerobic exercise (EX) are interventions capable of reducing anxiety levels in the aging, but few is known about how they modulating the projections to the hypothalamic-pituitary axis (HPA). We studied the effect of an EE and EX programs carried out during two months in 18 month-old Wistar rats assigned to 3 groups: (CO, N=6), EE (N=8) y EX (N=8). The EX program was carried out during 15min/day and the EE group was housed in a big cage with different objects frequently changed. Through the cytochrome c oxidase histochemistry (COx), we analysed the metabolic activity of several brain regions involved in the anxiety response. The EE reduced the brain activity of regions involved in the activation of the HPA axis (infralimbic cortex, basolateral amygdala and the hypothalamic paraventricular nucleus (p<0.05). On the other hand, the EX program increased the activity of brain regions involved in the inhibition of the HPA axis (cingulate cortex, bed nucleus of the stria terminalis and the dorsal hippocampus (p<0.05). In conclusion, it seemed that the EE and the EX modulate in different way the activity of brain regions that project to the HPA axis and they could constitute successful interventions to reduce the anxiety levels in the aging.

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