Cross-Talk of Different Dimensional Methylation Modification Regulators Alters Tumor Microenvironment Infiltration and Immunotherapy Response in Renal Cancer

2021 ◽  
Author(s):  
Xin Qin ◽  
Ling Pan ◽  
Jing Wang ◽  
Zhengfang Liu ◽  
Lei Yan ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Renal Cancer ◽  
Cross Talk

scholarly journals Semaphorin Signaling in Cancer-Associated Inflammation

2019 ◽  
Vol 20 (2) ◽  
pp. 377 ◽  
Author(s):  
Giulia Franzolin ◽  
Luca Tamagnone
Keyword(s):  
Immune Response ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Disease Progression ◽  
Tumor Cells ◽  
Cross Talk ◽  
Immune Cells ◽  
Major Element ◽  
Inflammatory Cells ◽  
Anti Cancer

The inflammatory and immune response elicited by the growth of cancer cells is a major element conditioning the tumor microenvironment, impinging on disease progression and patients’ prognosis. Semaphorin receptors are widely expressed in inflammatory cells, and their ligands are provided by tumor cells, featuring an intense signaling cross-talk at local and systemic levels. Moreover, diverse semaphorins control both cells of the innate and the antigen-specific immunity. Notably, semaphorin signals acting as inhibitors of anti-cancer immune response are often dysregulated in human tumors, and may represent potential therapeutic targets. In this mini-review, we provide a survey of the best known semaphorin regulators of inflammatory and immune cells, and discuss their functional impact in the tumor microenvironment.

Metabolic Cross Talk Between Cancer Cells and Tumor Microenvironment

2020 ◽  
pp. 55-63
Author(s):  
Satish S. Poojary ◽  
Maryam Ghufran ◽  
Ananya Choudhary ◽  
Mehreen Aftab
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cross Talk

scholarly journals Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

2019 ◽  
Vol 79 (6) ◽  
pp. 1239-1251 ◽  
Author(s):  
Tao Sun ◽  
Rameshwar Patil ◽  
Anna Galstyan ◽  
Dmytro Klymyshyn ◽  
Hui Ding ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cross Talk ◽  
Laminin 411

scholarly journals A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Andrew J. Gentles ◽  
Angela Bik-Yu Hui ◽  
Weiguo Feng ◽  
Armon Azizi ◽  
Ramesh V. Nair ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cross Talk ◽  
Human Lung ◽  
Lung Tumor ◽  
Cell Type ◽  
Human Lung Tumor ◽  
Relevant Cell Type

scholarly journals Role of Exosomic MicroRNAs in Cancer Cell Cross‐Talk within the Tumor Microenvironment

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Muller Fabbri ◽  
Petra Wise ◽  
Mariam Murtadha ◽  
Paolo Neviani ◽  
Kishore Challagundla
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cell ◽  
Cross Talk
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