Narrow-Band Reflectance Spectrophotometry for the Assessment of Erythematous and Hyperpigmented Skin Lesions in Localized Scleroderma: A Preliminary Study

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem. Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented. Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome. Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

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Localized scleroderma manifesting with skin lesions associated with mechanical stress

European Journal of Dermatology ◽

10.1684/ejd.2019.3601 ◽

2019 ◽

Vol 29 (4) ◽

pp. 439-440

Author(s):

Satoshi Toyama ◽

Shinichi Sato ◽

Yoshihide Asano

Keyword(s):

Mechanical Stress ◽

Skin Lesions ◽

Localized Scleroderma

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Evaluation of gastric cancer diagnosis using new ultrathin transnasal endoscopy with narrow-band imaging: Preliminary study

Journal of Gastroenterology and Hepatology ◽

10.1111/jgh.12797 ◽

2014 ◽

Vol 29 ◽

pp. 33-36 ◽

Cited By ~ 6

Author(s):

Takashi Kawai ◽

Kyosuke Yanagizawa ◽

Sakiko Naito ◽

Hiroko Sugimoto ◽

Masakatsu Fukuzawa ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Diagnosis ◽

Narrow Band ◽

Narrow Band Imaging ◽

Transnasal Endoscopy ◽

Preliminary Study

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FRI0462 Nasal Mucosa Narrow Band Imaging (NBI) in Granulomatosis with Poliangiitis (Wegener Granulomatosis): A Preliminary Study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.4452 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 554.2-554

Author(s):

C. Campochiaro ◽

E.P. Bozzolo ◽

M. Trimarchi ◽

M. Tiraboschi ◽

F. Pilolli ◽

...

Keyword(s):

Nasal Mucosa ◽

Narrow Band ◽

Narrow Band Imaging ◽

Wegener Granulomatosis ◽

Preliminary Study

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Effect of retinoic acid combined with narrow-band ultraviolet B on matrix metalloprotein 13（MMP13）in psoriasis

10.21203/rs.3.rs-285084/v1 ◽

2021 ◽

Author(s):

Chan XI ◽

Chuanxi XIONG ◽

Huiping WANG ◽

Yuanjun LIU ◽

Suju Luo

Keyword(s):

Retinoic Acid ◽

Mouse Model ◽

Narrow Band ◽

Inflammatory Diseases ◽

Skin Lesions ◽

Ultraviolet B ◽

Serum Samples ◽

Uvb Irradiation ◽

Protein Levels ◽

Mmp13 Expression

Abstract Matrix metalloproteinase 13 (MMP13) is a zinc-containing endopeptidase secreted by keratinocytes and skin fibroblasts and participates in many inflammatory diseases. Drugs for retinoic acid include tazarotene and acitretin. Tazarotene/acitretin and narrow-band ultraviolet B (NB-UVB) irradiation are used as a general treatment for psoriasis. However, their impact on MMP13 expression has yet to be determined. In this study, we measured the expression of MMP13 in patients with psoriasis, and investigated the effects of tazarotene and/or NB-UVB on MMP13 expression in a mouse model of psoriasis. After exposure to acitretin and/or NB-UVB, immortalized human HaCaT keratinocytes were analyzed for viability and MMP13 expression. Our results showed that MMP13 protein levels increased in skin lesions and serum samples in patients with psoriasis. Treatment with acitretin and NB-UVB irradiation alone or in combination suppressed cell viability and MMP13 expression in HaCaT cells. Consistently, tazarotene treatment and/or NB-UVB irradiation attenuated imiquimod-induced psoriasis-like dermatitis and inhibited MMP13 expression in a mouse model. Taken together, these results indicate that tazarotene/acitretin and NB-UVB irradiation can inhibit the expression of MMP13 in keratinocytes and psoriasis mouse models. Targeting MMP13 may represent a promising therapeutic strategy against psoriasis.

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New Features for Measuring Disease Activity in Pediatric Localized Scleroderma

The Journal of Rheumatology ◽

10.3899/jrheum.171381 ◽

2018 ◽

Vol 45 (12) ◽

pp. 1680-1688 ◽

Cited By ~ 9

Author(s):

Suzanne C. Li ◽

Xiaohu Li ◽

Elena Pope ◽

Katie Stewart ◽

Gloria C. Higgins ◽

...

Keyword(s):

Disease Activity ◽

Age Of Onset ◽

Skin Lesions ◽

Inactive Disease ◽

Localized Scleroderma ◽

Relative Importance ◽

Skin Texture ◽

Disease Patterns ◽

Disease Extension ◽

Multicenter Prospective Study

Objective.To identify clinical features that define disease activity in pediatric localized scleroderma (LS), and determine their specificity and importance.Methods.We conducted a multicenter prospective study of patients with active and inactive LS skin lesions. A standardized evaluation of a single designated study lesion per subject was performed at 3 visits. We evaluated the pattern and correlation between assessed features and physician’s global assessments of activity (PGA-A).Results.Ninety of 103 subjects had evaluable data; 66 had active and 24 inactive disease. Subjects had similar age of onset, sex, and disease patterns. Linear scleroderma was the most common subtype. Features specific for active disease included erythema, violaceous color, tactile warmth, abnormal skin texture, and disease extension. Scores for these variables changed over time and correlated with PGA-A of the lesion. Active and inactive lesions could not be distinguished by the presence or level of skin thickening, either of lesion edge or center. However, in active lesions, skin thickening scores did correlate with PGA–A scores. Regression analysis identified the combination of erythema, disease extension, violaceous color, skin thickening, and abnormal texture as predictive of PGA-A at study entry. Damage features were common irrespective of activity status.Conclusion.We identified variables strongly associated with disease activity, expanding upon those used in current measures, and determined their relative importance in physician activity scoring. Skin thickening was found to lack specificity for disease activity. These results will help guide development of a sensitive, responsive activity tool to improve care of patients with LS.

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Clinical Manifestations of Scleroderma

Pediatrics in Review ◽

10.1542/pir.16.2.49 ◽

1995 ◽

Vol 16 (2) ◽

pp. 49-49

Author(s):

Patricia L. Haber

Keyword(s):

Systemic Sclerosis ◽

Connective Tissue ◽

Clinical Manifestations ◽

Skin Lesions ◽

Localized Scleroderma ◽

Unknown Etiology ◽

Collagen Deposition ◽

Muscle Fibrosis ◽

Favorable Prognosis ◽

Organ Systems

Scleroderma is a connective tissue disease of unknown etiology. Its most characteristic feature is thickening of the skin due to increased collagen deposition. However, the disease may involve multiple other organ systems. Two broad categories of scleroderma have been defined: localized and systemic. Although all forms of scleroderma are rare, localized scleroderma occurs more frequently than systemic sclerosis and has a more favorable prognosis. Several types of localized scleroderma exist. Morphea is characterized by the presence of one or more patches of hard, ivory-colored skin lesions. They begin with erythema and progress to nonpitting edema before becoming sclerotic. The margins of active lesions often have a violaceous hue. Underlying muscle fibrosis and atrophy may occur.

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