Usefulness of narrow-band reflectance spectrophotometry in the assessment of activity/infammation in localized scleroderma skin lesions

2021 ◽  
Author(s):  
Michał Szczepanek
Keyword(s):  
Narrow Band ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Reflectance Spectrophotometry

scholarly journals Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area

2020 ◽  
Vol 23 (3) ◽  
pp. 165-173
Author(s):  
Elena S. Snarskaya ◽  
Yulia A. Semenchak
Keyword(s):  
Clinical Symptoms ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Steady Increase ◽  
Family Doctors ◽  
Topographic Features ◽  
Anogenital Area ◽  
Clinical Variants ◽  
Limited Scleroderma ◽  
And Gender

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem. Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented. Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome. Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

Localized scleroderma manifesting with skin lesions associated with mechanical stress

2019 ◽  
Vol 29 (4) ◽  
pp. 439-440
Author(s):  
Satoshi Toyama ◽  
Shinichi Sato ◽  
Yoshihide Asano
Keyword(s):  
Mechanical Stress ◽  
Skin Lesions ◽  
Localized Scleroderma

scholarly journals Effect of retinoic acid combined with narrow-band ultraviolet B on matrix metalloprotein 13（MMP13）in psoriasis

2021 ◽  
Author(s):  
Chan XI ◽  
Chuanxi XIONG ◽  
Huiping WANG ◽  
Yuanjun LIU ◽  
Suju Luo
Keyword(s):  
Retinoic Acid ◽  
Mouse Model ◽  
Narrow Band ◽  
Inflammatory Diseases ◽  
Skin Lesions ◽  
Ultraviolet B ◽  
Serum Samples ◽  
Uvb Irradiation ◽  
Protein Levels ◽  
Mmp13 Expression

Abstract Matrix metalloproteinase 13 (MMP13) is a zinc-containing endopeptidase secreted by keratinocytes and skin fibroblasts and participates in many inflammatory diseases. Drugs for retinoic acid include tazarotene and acitretin. Tazarotene/acitretin and narrow-band ultraviolet B (NB-UVB) irradiation are used as a general treatment for psoriasis. However, their impact on MMP13 expression has yet to be determined. In this study, we measured the expression of MMP13 in patients with psoriasis, and investigated the effects of tazarotene and/or NB-UVB on MMP13 expression in a mouse model of psoriasis. After exposure to acitretin and/or NB-UVB, immortalized human HaCaT keratinocytes were analyzed for viability and MMP13 expression. Our results showed that MMP13 protein levels increased in skin lesions and serum samples in patients with psoriasis. Treatment with acitretin and NB-UVB irradiation alone or in combination suppressed cell viability and MMP13 expression in HaCaT cells. Consistently, tazarotene treatment and/or NB-UVB irradiation attenuated imiquimod-induced psoriasis-like dermatitis and inhibited MMP13 expression in a mouse model. Taken together, these results indicate that tazarotene/acitretin and NB-UVB irradiation can inhibit the expression of MMP13 in keratinocytes and psoriasis mouse models. Targeting MMP13 may represent a promising therapeutic strategy against psoriasis.

scholarly journals New Features for Measuring Disease Activity in Pediatric Localized Scleroderma

2018 ◽  
Vol 45 (12) ◽  
pp. 1680-1688 ◽  
Author(s):  
Suzanne C. Li ◽  
Xiaohu Li ◽  
Elena Pope ◽  
Katie Stewart ◽  
Gloria C. Higgins ◽  
...  
Keyword(s):  
Disease Activity ◽  
Age Of Onset ◽  
Skin Lesions ◽  
Inactive Disease ◽  
Localized Scleroderma ◽  
Relative Importance ◽  
Skin Texture ◽  
Disease Patterns ◽  
Disease Extension ◽  
Multicenter Prospective Study

Objective.To identify clinical features that define disease activity in pediatric localized scleroderma (LS), and determine their specificity and importance.Methods.We conducted a multicenter prospective study of patients with active and inactive LS skin lesions. A standardized evaluation of a single designated study lesion per subject was performed at 3 visits. We evaluated the pattern and correlation between assessed features and physician’s global assessments of activity (PGA-A).Results.Ninety of 103 subjects had evaluable data; 66 had active and 24 inactive disease. Subjects had similar age of onset, sex, and disease patterns. Linear scleroderma was the most common subtype. Features specific for active disease included erythema, violaceous color, tactile warmth, abnormal skin texture, and disease extension. Scores for these variables changed over time and correlated with PGA-A of the lesion. Active and inactive lesions could not be distinguished by the presence or level of skin thickening, either of lesion edge or center. However, in active lesions, skin thickening scores did correlate with PGA–A scores. Regression analysis identified the combination of erythema, disease extension, violaceous color, skin thickening, and abnormal texture as predictive of PGA-A at study entry. Damage features were common irrespective of activity status.Conclusion.We identified variables strongly associated with disease activity, expanding upon those used in current measures, and determined their relative importance in physician activity scoring. Skin thickening was found to lack specificity for disease activity. These results will help guide development of a sensitive, responsive activity tool to improve care of patients with LS.

Clinical Manifestations of Scleroderma

1995 ◽  
Vol 16 (2) ◽  
pp. 49-49
Author(s):  
Patricia L. Haber
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Unknown Etiology ◽  
Collagen Deposition ◽  
Muscle Fibrosis ◽  
Favorable Prognosis ◽  
Organ Systems

Scleroderma is a connective tissue disease of unknown etiology. Its most characteristic feature is thickening of the skin due to increased collagen deposition. However, the disease may involve multiple other organ systems. Two broad categories of scleroderma have been defined: localized and systemic. Although all forms of scleroderma are rare, localized scleroderma occurs more frequently than systemic sclerosis and has a more favorable prognosis. Several types of localized scleroderma exist. Morphea is characterized by the presence of one or more patches of hard, ivory-colored skin lesions. They begin with erythema and progress to nonpitting edema before becoming sclerotic. The margins of active lesions often have a violaceous hue. Underlying muscle fibrosis and atrophy may occur.

scholarly journals Localized scleroderma: assessment of the therapeutic response to phototherapy

2012 ◽  
Vol 87 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Roberta Buense ◽  
Ida Alzira Gomes Duarte ◽  
Marcio Bouer
Keyword(s):  
Therapeutic Response ◽  
Skin Lesions ◽  
Therapeutic Modality ◽  
Localized Scleroderma ◽  
Treatment Comparison ◽  
Dermal Thickness ◽  
Evolutive Stage ◽  
Skin Ultrasound ◽  
Development Literature ◽  
Chronic Autoimmune Disease

BACKGROUND: Scleroderma is a chronic autoimmune disease characterized by progressive connective tissue sclerosis and microcirculatory changes. Localized scleroderma is considered a limited disease. However, in some cases atrophic and deforming lesions may be observed that hinder the normal development. Literature reports indicate phototherapy as a therapeutic modality with favorable response in cutaneous forms of scleroderma. OBJECTIVES: This study had the purpose of assessing the phototherapy treatment for localized scleroderma. METHODS: Patients with localized scleroderma were selected for phototherapy treatment. They were classified according to the type of localized scleroderma and evolutive stage of the lesions. Clinical examination and skin ultrasound were used to demonstrate the results thus obtained. RESULTS: Some clinical improvement was observed after an average of 10 phototherapeutic sessions. All skin lesions were softer at clinical palpation with scores reduction upon pre and post treatment comparison. The ultrasound showed that most of the assessed lesions presented a decrease in dermal thickness, and only five maintained their previous measure. Treatment response was similar regardless of the type of phototherapeutic treatment employed. CONCLUSIONS: The proposed treatment was effective for all lesions, regardless of the phototherapeutic modality employed. The improvement was observed in all treated skin lesions and confirmed by clinical evaluation and skin ultrasound.

Effect of narrow band ultraviolet B on survivin in psoriatic skin lesions

2011 ◽  
Vol 21 (6) ◽  
pp. 866-869 ◽  
Author(s):  
Noha Abdel Rehim Nagui ◽  
Rania Mounir Abdel Hay ◽  
Laila Ahmed Rashed
Keyword(s):  
Narrow Band ◽  
Skin Lesions ◽  
Ultraviolet B ◽  
Psoriatic Skin

scholarly journals 312-nanometer Ultraviolet B Light (Narrow-Band UVB) Induces Apoptosis of  T Cells within Psoriatic Lesions

1999 ◽  
Vol 189 (4) ◽  
pp. 711-718 ◽  
Author(s):  
Maki Ozawa ◽  
Katalin Ferenczi ◽  
Toyoko Kikuchi ◽  
Irma Cardinale ◽  
Lisa M. Austin ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Narrow Band ◽  
Annexin V ◽  
Skin Lesions ◽  
Ultraviolet B ◽  
T Cell Apoptosis ◽  
Psoriatic Lesions

Narrow-band (312 nm) ultraviolet B light (UVB) is a new form of therapy for psoriasis, but its mechanism of action is unknown. In a bilateral comparison clinical study, daily exposure of psoriatic plaques to broad-band UVB (290–320 nm) or 312-nm UVB depleted T cells from the epidermis and dermis of psoriatic lesions. However, 312-nm UVB was significantly more depleting in both tissue compartments. To characterize the mechanism of T cell depletion, assays for T cell apoptosis were performed on T cells derived from UVB-irradiated skin in vivo and on T cells irradiated in vitro with 312-nm UVB. Apoptosis was induced in T cells exposed to 50–100 mJ/cm2 of 312-nm UVB in vitro, as measured by increased binding of fluorescein isothiocyanate (FITC)–Annexin V to CD3+ cells and by characteristic cell size/granularity changes measured by cytometry. In vivo exposure of psoriatic skin lesions to 312-nm UVB for 1–2 wk also induced apoptosis in T cells as assessed by the terminal deoxynucleotidyl transferase–mediated dUTP-biotin nick end labeling (TUNEL) reaction in tissue sections, by binding of FITC–Annexin V to CD3+ T cells contained in epidermal cell suspensions, and by detection of apoptosis-related size shifts of CD3+ cells. Induction of T cell apoptosis could be the main mechanism by which 312-nm UVB resolves psoriasis skin lesions.

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