scholarly journals The Impact of Different Simulation Modalities on Target Volume Delineation in Breast-Conserving Radiotherapy

2021 ◽  
Vol Volume 13 ◽  
pp. 5633-5640
Author(s):  
Meng Jin ◽  
Xia Liu ◽  
Jiabin Ma ◽  
Xiansong Sun ◽  
Hongnan Zhen ◽  
...  
Keyword(s):  
Target Volume ◽  
Target Volume Delineation ◽  
Volume Delineation ◽  
The Impact

scholarly journals FDG-PET/CT in the Radiotherapy Treatment Planning of Locally Advanced Anal Cancer: A Monoinstitutional Experience

2021 ◽  
Vol 11 ◽  
Author(s):  
Clelia Di Carlo ◽  
Maika di Benedetto ◽  
Lisa Vicenzi ◽  
Sara Costantini ◽  
Francesca Cucciarelli ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Anal Cancer ◽  
Dose Escalation ◽  
Locally Advanced ◽  
Target Volume ◽  
Target Volume Delineation ◽  
18Fdg Pet ◽  
Volume Delineation ◽  
Pet Ct ◽  
The Impact

AimsRadiotherapy with concurrent 5-fluorouracil/mitomycin-C based chemotherapy has been established as definitive standard therapy approach for anal cancer. Intensity Modulated Radiotherapy (IMRT) leads to a precise treatment of the tumor, allowing dose escalation on Gross Tumor Volume (GTV), with a surrounding healthy tissues sparing. Our study assessed the impact of 18-Fluorodeoxyglucose positron emission tomography (18FDG-PET/CT) on the radiotherapy contouring process and its contribution to lymphatic spread detection, resulting to a personalization of Clinical Target Volume (CTV) and dose prescription.MethodsThirty-seven patients, with histologically proven squamous cell carcinoma of the anal canal (SCCAC) were analyzed. All patients were evaluated with history and physical examination, trans-anal endoscopic ultrasound, pelvis magnetic resonance imaging (MRI), computed tomography (CT) scans of the chest, abdomen and pelvis and planning 18FDG-PET/CT. The GTV and CTV were drawn on CT, MRI and 18FDG-PET/CT fused images.ResultsThirty-four (91%) out of 37 patients presented lymph nodes involvement, in one or more areas, detected on 18FDG-PET/CT and/or MRI. The 18FDG-PET/CT showed positive lymph nodes not detected on MRI imaging (PET+, MRI−) in 14/37 patients (38%). In 14 cases, 18FDG-PET/CT allowed to a dose escalation in the involved nodes. The 18FDG-PET/CT fused images led to change the stage in 5/37(14%) cases: four cases from N0 to N1 (inguinal lymph nodes) and in one case from M0 to M1 (common iliac lymph nodes).ConclusionsThe 18FDG-PET/CT has a potentially relevant impact in staging and target volume delineation/definition in patients affected by anal cancer. In our experience, clinical stage variation occurred in 14% of cases. More investigations are needed to define the role of 18FDG-PET/CT in the target volume delineation of anal cancer.

scholarly journals The impact of a radiologist-led workshop on MRI target volume delineation for radiotherapy

2018 ◽  
Vol 65 (4) ◽  
pp. 300-310 ◽  
Author(s):  
Shivani Kumar ◽  
Lois Holloway ◽  
Dale Roach ◽  
Elise Pogson ◽  
Jacqueline Veera ◽  
...  
Keyword(s):  
Target Volume ◽  
Target Volume Delineation ◽  
Volume Delineation ◽  
The Impact

Technical illustration of Volumetric arc conformal radiotherapy planning in a case of paratesticular sarcoma

2021 ◽  
pp. 1-6
Author(s):  
Anil Gupta ◽  
Rambha Pandey ◽  
Seema Sharma ◽  
Vivek Ghosh ◽  
Ekta Dhamija ◽  
...  
Keyword(s):  
Organs At Risk ◽  
Target Volume ◽  
Radiotherapy Planning ◽  
Current Evidence ◽  
Lower Grade ◽  
Malignant Tumours ◽  
Target Volume Delineation ◽  
Volume Delineation ◽  
Delivery Technique ◽  
Technical Illustration

Abstract Introduction: Paratesticular sarcoma are extremely rare malignant tumours. Unlike other sites, they tend to be lower grade and have higher propensity of lymphatic spread. They tend to fail locally and occasionally in the regional lymph nodes. In the absence of target volume delineation guidelines and technical illustration of conformal planning, we have made an attempt to illustrate conformal planning methodology and define target volume based on current evidence in a case of paratesticular sarcoma. Methods: We are presenting a case of 62-year-old male who presented with 15-cm scrotal swelling and underwent high inguinal orchidectomy with ligation of spermatic cord. Histopathology presented a well-differentiated leiomyosarcoma of epididymis. Post-operative radiotherapy target volume included the tumour bed, ipsilateral inguinal nodes and lower pelvic nodes as the clinical target volume. Conclusion: Adjuvant radiotherapy using advanced delivery technique such as volumetric arc technique can provide good dose distribution with good sparing of organs at risk. The downside of conformal radiation delivery is that it is a resource-intensive and has no established target volume delineation guidelines.

scholarly journals Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer: a multi-center study from China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiao Chang ◽  
Wei Deng ◽  
Xin Wang ◽  
Zongmei Zhou ◽  
Jun Yang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Gross Tumor Volume ◽  
Tumor Volume ◽  
Interobserver Variability ◽  
Target Volume ◽  
Thoracic Esophageal Cancer ◽  
Target Volume Delineation ◽  
Cancer Centers ◽  
Definitive Radiotherapy ◽  
Volume Delineation

Abstract Purpose To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies. Methods Sixteen cancer centers throughout China participated in this study. In Phase 1, three suitable cases with upper, middle, and lower TEC were chosen, and participants were asked to contour a group of gross tumor volume (GTV-T), nodal gross tumor volume (GTV-N) and clinical target volume (CTV) for each case based on their routine experience. In Phase 2, the same clinicians were instructed to follow a contouring protocol to re-contour another group of target volume. The variation of the target volume was analyzed and quantified using dice similarity coefficient (DSC). Results Sixteen clinicians provided routine volumes, whereas ten provided both routine and protocol volumes for each case. The IOV of routine GTV-N was the most striking in all cases, with the smallest DSC of 0.37 (95% CI 0.32–0.42), followed by CTV, whereas GTV-T showed high consistency. After following the protocol, the smallest DSC of GTV-N was improved to 0.64 (95% CI 0.45–0.83, P = 0.005) but the DSC of GTV-T and CTV remained constant in most cases. Conclusion Variability in target volume delineation was observed, but it could be significantly reduced and controlled using mandatory interventions.

Sign in / Sign up

Export Citation Format

Share Document