Development of an integral assessment approach of health status in patients with obstructive airway diseases: the CORONA study [Corrigendum]

AbstractChronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA. The study population was stratified by age (i.e., 15–44, 45–64, and ≥ 65 years) and gender. We performed cluster analysis, including all chronic conditions recorded in primary care electronic health records and hospital discharge reports. More than 75% of the patients had multimorbidity (co-existence of two or more chronic conditions). We identified associations of dermatologic diseases with musculoskeletal disorders and anxiety, cardiometabolic diseases with mental health problems, and substance use disorders with neurologic diseases and neoplasms, amongst others. The number and complexity of the multimorbidity clusters increased with age in both genders. The cluster with the highest likelihood of mortality was identified in men aged 45 to 64 years and included associations between substance use disorder, neurologic conditions, and cancer. Large-scale epidemiological studies like ours could be useful when planning healthcare interventions targeting patients with chronic obstructive airway diseases and multimorbidity.

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Respiratory Disorders, 5. Oral Drugs for Obstructive Airway Diseases (R03)

Ullmann's Encyclopedia of Industrial Chemistry ◽

10.1002/14356007.w23_w04 ◽

2018 ◽

pp. 1-6

Author(s):

Bernhard Kutscher

Keyword(s):

Oral Drugs ◽

Respiratory Disorders ◽

Airway Diseases ◽

Obstructive Airway Diseases

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Hepcidin and MELD-XI score as markers of multiple organ failure in patients with heart failure with preserved and reduced ejection fraction

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2020-2529 ◽

2020 ◽

Vol 19 (3) ◽

pp. 2529

Author(s):

V. I. Podzolkov ◽

N. A. Dragomiretskaya ◽

S. K. Stolbova ◽

A. V. Tolmacheva

Keyword(s):

Heart Failure ◽

Body Mass Index ◽

Ejection Fraction ◽

Cardiac Arrhythmias ◽

Multiple Organ ◽

Left Ventricular ◽

Chronic Obstructive ◽

Hepcidin Level ◽

Airway Diseases ◽

Obstructive Airway Diseases

Data on the changes in hepcidin levels in heart failure (HF) patients are contradictory and do not give an answer about its effect on the progression of multiple organ failure. Since the model of end-stage liver disease excluding INR (MELD-XI) reflects the severity of liver and kidney dysfunction, these markers have been suggested to be associated with decompensated HF.Aim. To assess the MELD-XI score and serum hepcidin levels in patients with decompensated HF with different values of left ventricular ejection fraction (EF).Material and methods. The study included 68 patients (29 women, 39 men; mean age 72,3±11,7 years) hospitalized due to decompensated HF. Patients were divided into three groups: reduced (HFrEF) (n=20), mid-range (HFmrEF) (n=23), and preserved EF (HFpEF) (n=24)). Upon admission, along with standard diagnostic tests, all patients were examined for hepcidin-25 levels by enzyme-linked immunosorbent assay. MELD-XI score was calculated. Statistical processing was carried out using the software package Statistica 8.0.Results. Hepcidin levels in the HFrEF group (31,63 ng/ml [22,0; 71,6]) were significantly higher than in the HFmrEF (23,89 ng/ml [21,1; 27,9]) (p<0,05) and HFpEF (26,91 ng/ml [18,6; 31,1]) (p<0,05) groups. In HFpEF, there was a correlation of hepcidin level with body mass index (r=0,47, p<0,05) and chronic obstructive airway diseases (r=0,44, p<0,05). A correlation of hepcidin level with significant cardiac arrhythmias (r=0,61, p<0,05) was revealed in HFmrEF patients. MELD-XI score were significantly increased from 9,44±3,96 for HFpEF and 11,53±3,82 for HFmrEF to 14,3±4,3 for HFrEF (p<0,005). We also revealed correlation of MELD-XI score with hepcidin levels (r=0,3, p<0,05) and EF (r=-0,43, p<0,0003). Patients with a MELD-XI score of >10,4 were more likely to have NYHA class III-IV HF, HFrEF and significantly higher levels of hepcidin (p<0,05 for all) These patients were also more likely to have chronic kidney disease (p<0,05).Conclusion. Hepcidin level and MELD-XI score in patients with decompensated HF are inversely related to left ventricular EF. There is a direct relationship between hepcidin levels and other clinical parameters: body mass index, the presence of chronic obstructive airway diseases and cardiac arrhythmias.

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Role of the nitric oxide–soluble guanylyl cyclase pathway in obstructive airway diseases

Pulmonary Pharmacology & Therapeutics ◽

10.1016/j.pupt.2014.07.004 ◽

2014 ◽

Vol 29 (1) ◽

pp. 1-6 ◽

Cited By ~ 31

Author(s):

Lisa L. Dupont ◽

Constantinos Glynos ◽

Ken R. Bracke ◽

Peter Brouckaert ◽

Guy G. Brusselle

Keyword(s):

Nitric Oxide ◽

Guanylyl Cyclase ◽

Soluble Guanylyl Cyclase ◽

Airway Diseases ◽

Obstructive Airway Diseases

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Prevalence of Asthma and COPD and Blood Eosinophil Count in a Middle-Aged Belgian Population

Journal of Clinical Medicine ◽

10.3390/jcm8081122 ◽

2019 ◽

Vol 8 (8) ◽

pp. 1122 ◽

Cited By ~ 4

Author(s):

Sara R. A. Wijnant ◽

Lies Lahousse ◽

Marc L. De Buyzere ◽

Guy G. Brusselle ◽

Ernst R. Rietzschel

Keyword(s):

Eosinophil Count ◽

Respiratory Health ◽

Disease Status ◽

Chronic Obstructive ◽

Blood Eosinophil ◽

Middle Aged ◽

Blood Eosinophil Count ◽

Current Asthma ◽

Airway Diseases ◽

Obstructive Airway Diseases

Various phenotypes exist in asthma and Chronic Obstructive Pulmonary Disease (COPD). These are important to identify in order to guide treatment decisions. We aim to investigate the prevalence and clinical characteristics of obstructive airway diseases in the middle-aged population. We estimated the prevalence of COPD and/or asthma in the Asklepios cohort study (Belgium), using information from the third European Community Respiratory Health Survey (ECRHS3), medical records, and spirometry. Respiratory symptoms, respiratory medication, and current disease status distinguished clinical from sub-clinical cases. In addition, we compared the blood eosinophil count/µL (median [IQR]) between cases and controls. Of the 2221 participants (mean age 56.1 ± 5.9 years; 48.7% males), 138 (6.2%) participants had clinical current asthma, 22 (1.0%) participants had sub-clinical ever asthma, 102 (4.6%) had sub-clinical spirometry-defined COPD, 104 (4.6%) participants had clinical spirometry-confirmed COPD, and 11 (0.5%) had asthma and COPD overlap (ACO). Clinical current asthma (160.0 [110.0–250.0]), sub-clinical ever asthma (170.0 [110.0–230.0]), and clinical COPD (160.0 [110.0–220.0])—but less sub-clinical COPD (140.0 [90.0–210.0])—had higher eosinophil counts, compared to controls (130.0 [80.0–200.0]). We conclude that obstructive airway diseases are prevalent in the middle-aged Asklepios cohort. Moreover, the systemic eosinophil count is increased in clinical COPD cases, and in asthma cases regardless of clinical remission.

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